Clinical trials: Common Mental Disorders
Post Partum Depression
Improving Outcomes for Low-Income Mothers With Depression
This is a randomized comparative effectiveness trial to improve outcomes among pregnant and post-partum women with symptoms of depression.
- Trial name
- NCT03221556
- Testing
- Engagement-Focused Care Coordination (EFCC), Problem Solving Education (PSE)
- Where
- United States
- Volunteers
- 231 people
- Sponsor
- Boston Medical Center
Anxiety, Depression
Metacognitive Therapy and Work Interventions for Patients on Sick Leave Due to Common Mental Disorders
Common mental health disorders such as anxiety and depression are leading causes of sickness absence and disability in Norway. Despite tremendous costs for individual and society, effective treatment is lacking.
- Trial name
- NCT03301922
- Testing
- Metacognitive therapy and work-focused interventions, Waiting list
- Where
- Norway
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Multiple Sclerosis, Anxiety
Using Patient-Reported Outcomes To Improve the Care of People With Multiple Sclerosis
The proposed trial is a prospective, randomized (1:1) trial plan examining whether more routine and frequent measurement of Patient Related Outcome Measures (PROMs) in the care of patients with MS improves patient depression and…
- Conditions
- Multiple Sclerosis, Anxiety, Depression, Patient Satisfaction
- Trial name
- NCT04979546
- Testing
- Intensive Use of Patient Reported Outcome Measures and Open PROM Availability to Treating Neurologist, Conservative Use of Patient Reported Outcome Measures and Blinded PROM Availability to Treating Neurologist
- Where
- Canada
- Volunteers
- 237 people
- Sponsor
- University of Alberta
Colorectal Cancer, Shared Decision Making
Preoperative 3D Models and Shared Decision-making
The objectives of this study will be to quantify, using validated scales, the effects of 3D-printed models on shared decision-making and patient anxiety during the pre-operative consent and education process.
- Conditions
- Colorectal Cancer, Shared Decision Making, Anxiety, Informed Consent
- Trial name
- NCT06625008
- Testing
- 3D-printed model
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Vanderbilt University Medical Center
Bibliotherapy
Guided Self-help for Common Mental Disorders
Common mental disorders (CMDs) like depression and anxiety account for a large proportion of disability worldwide. Access to effective treatments like cognitive-behavioral therapy (CBT) is limited and has not reduced the public…
- Trial name
- DWM (NCT04870099)
- Testing
- Doing What Matters in Times of Stress: An Illustrated Guide
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Indiana University
Post Traumatic Stress Disorder PTSD
Shared Decision Making in PTSD Treatment
The purpose of this research study is to learn about how Shared Decision Making, when used to decide treatment, impacts treatment engagement, retention, and outcomes for active duty military personnel seeking treatment for…
- Trial name
- NCT06953687
- Testing
- Prolonged Exposure Therapy, Cognitive Processing Therapy, Written Exposure Therapy
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Delirium
Rate of Postoperative Delirium and Postoperative Cognitive Dysfunction After Spinal Anesthesia
The aim of this investigation is to compare the standard of general anesthesia used in these patients with these short-acting local anesthetics (Chloroprocain (Ampres®) and Prilocain (Takipril®)) for spinal anesthesia as well as…
- Trial name
- NCT03715244
- Testing
- Spinal anesthesia with short-acting local anesthetics, General anesthesia (current standard)
- Where
- Germany
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
HIV, Common Mental Health Problems
Mpata Yathu Trial for Young Women in Zambia
This randomized controlled trial evaluates Mpata Yathu ("Our Space"), a trauma-informed, church-based counseling intervention for adolescent girls and young women in Lusaka, Zambia who have experienced gender-based violence and…
- Conditions
- HIV, Common Mental Health Problems, PTSD - Post Traumatic Stress Disorder, Depression Disorder
- Trial name
- MYT (NCT07132905)
- Testing
- Mpata Yathu ("Our Space")
- Where
- 2 sites in Zambia
- Volunteers
- 180 people
- Sponsor
- University of California, San Francisco
Depression, Anxiety
Low-intensity Stepped Care for Internalizing Distress
The purpose of this study is to test the feasibility and efficacy of combining a single session intervention, COMET, with a self-help intervention, Doing what matters in times of stress. In step I, all individuals receive COMET.
- Conditions
- Depression, Anxiety, Emotion Regulation
- Trial name
- COMET-DWM (NCT05441111)
- Testing
- Common Elements Toolbox, Doing What Matters in Times of Stress: An Illustrated Guide, Guided self-help
- Where
- United States
- Volunteers
- 275 people
- Sponsor
- Indiana University
Depression, Anxiety
Online Wellness Intervention for College Students
We are evaluating the effects of an online single-session mental health intervention (the Common Elements Toolbox; COMET). To evaluate COMET, we are conducting a randomized controlled trial with college students attending…
- Conditions
- Depression, Anxiety, Well-being
- Trial name
- NCT04740411
- Testing
- The Common Elements Toolbox (COMET)
- Where
- United States
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Psychological Distress, Traumatic Stress
Problem Management Plus With Emotional Processing (PM+EP) for Forcibly Displaced Youth
The goal of this feasibility randomized controlled trial is to learn about the feasibility and acceptability of scalable psychological interventions in Sweden.
- Trial name
- PM+EP (NCT06878092)
- Testing
- Problem Management Plus (PM+), Problem Management Plus with Emotional Processing Module (PM+EP), Care as usual
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska Institutet
Pain Syndrome, Dizziness
Postoperative Analgesia Between Paravertebral Block and Epidural Block in Esophageal Surgery
Prevention of postoperative pain is essential for the recovery of esophageal surgery. Epidural analgesia is a traditional and standard perioperative pain management for these patients.
- Conditions
- Pain Syndrome, Dizziness, Vomiting, Itching
- Trial name
- NCT06704698
- Testing
- Liposomal bupivacaine, Bupivacaine Hydrochloride
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Zhejiang Cancer Hospital
Common Diseases, Joint Prevention
The Role of After-school Exercise Services in Promoting Myopia and Physical and Mental Health in Children
This project is a prospective cohort study to evaluate the impact of after-school extended physical education services on the visual health, physical health indicators, and mental health of children and adolescents participating…
- Conditions
- Common Diseases, Joint Prevention, Students, After-school Extended Sports Service
- Trial name
- NCT06619925
- Testing
- after-school extended sports service, non-after school extended sports service
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Fangbiao Tao
Sick Leave, Occupational Health
Evaluation of Return to Work Rehabilitation
Long-term sick-listing from work has considerable impact on social function, on the families of the sick-listed persons, the companies they work for, and society as a whole.
- Trial name
- NCT01926574
- Testing
- long rehabilitation program, short rehabilitation program, Acceptance and commitment therapy (ACT)
- Where
- 2 sites in Norway
- Volunteers
- 300 people
- Sponsor
- Norwegian University of Science and Technology
Neurodevelopmental Disorders, Autism Spectrum Disorder
Shared Interactive Book Reading in Preschool Children With Neurodevelopmental Disorders: Effects on Language Development and Reading Habits
The goal of this observational retrospective study is to explore the effects of a parent-based book reading intervention on children with neurodevelopmental disorders.
- Conditions
- Neurodevelopmental Disorders, Autism Spectrum Disorder, Intellectual Disabilities, Language Disorders in Children
- Trial name
- NCT06852989
- Testing
- Shared book reading intervention
- Where
- Italy
- Volunteers
- 53 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Depression, Anxiety, Healthy
Integrins and Protocadherins in Glutamatergic Circuits: Identification of Common Signaling Pathways and Molecular Targets in Anxiety and Major Depressive Disorders (GAPsy)
The aim of this study is to identify biologically viable targets for the treatment of major depressive disorder (MDD) and anxiety disorder (AD) with the ultimate goal of guiding physicians' therapeutic strategies and identifying…
- Trial name
- GAPsy (NCT06167590)
- Testing
- GAPsy protocol
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Substance Use Disorders
STOP (Shared Decision Making to Treat Or Prevent) HIV in Justice Populations
This study seeks to compare the effectiveness of two Patient Navigation models of care to evaluate the proportion who initiate PrEP/ART and substance use/substance use disorder (SU/SUD) treatment.
- Trial name
- NCT06439329
- Testing
- Standard PN, Patient Choice
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Yale University
Common Mental Disorder
Coaching Intervention in Women At-risk of Common Mental Disorders
This study aims to provide preventative intervention to 60 women who are at risk of common mental disorders in Hong Kong.
- Trial name
- NCT03751696
- Testing
- Group Coaching, SMS self-help tips
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
Depression, Anxiety
A Feasibility Study of an Emotion-Focused Mindfulness Group
Living with symptoms of mental illness is associated with psychosocial impairment as it can affect someone's ability to work, their relationships and level of functioning. This also has high economic costs on a societal level.
- Trial name
- NCT02987582
- Testing
- Emotion-focused mindfulness group
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Toronto Practice Based Research Network
Anxiety Disorders, Major Depression
CBT Versus a Return to Work Intervention for Patients With Common Mental Illness in Primary Care
Background: Common mental illness, such as anxiety disorders and depression, is the main cause for sick leave in Sweden. Cognitive behavior therapy (CBT) has been shown to be effective in alleviating target symptoms of these…
- Conditions
- Anxiety Disorders, Major Depression, Stress Disorders, Primary Insomnia
- Trial name
- CBT vs RTW I (NCT01636791)
- Testing
- Cognitive behavior therapy, Return to work
- Where
- Sweden
- Volunteers
- 211 people
- Sponsor
- Karolinska Institutet