Clinical trials: Community-Acquired Pneumonia
Antimicrobial Resistance (AMR)
NCCR AntiResist:: New Approaches to Combat Antibiotic-resistant Bacteria
This is an explorative, mono-center study including prospectively collected patient samples from the University Hospital of Basel.
- Trial name
- AntiResist (NCT05017766)
- Testing
- analysis of antimicrobial resistance
- Where
- Switzerland
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Community-acquired Pneumonia
Procalcitonin Versus C-reactive Protein to Guide Therapy in Community Acquired Pneumonia
In this study the investigators aim to test if C-reactive protein (CRP) or procalcitonin(PCT) - guided strategy allows to reduce the antibiotic use in patients wiht community-acquired pneumonia.
- Trial name
- CAP-Marker (NCT01018199)
- Testing
- CRP, PCT
- Where
- Brazil
- Sponsor
- Federal University of Minas Gerais
Community Acquired Pneumonia
Clinical Pediatric Pneumonia Score in Critically Ill Children
The purpose of the study is to create a clinical pneumonia tool that can be used to predict the cause of community-acquired pneumonia, which is a lung infection that began outside of the hospital in critically ill children…
- Trial name
- NCT02139384
- Where
- United States
- Sponsor
- Loma Linda University
Pneumonia, Respiratory Failure
CPAP Versus HFNO for the Treatment of Acute Hypoxemic Respiratory Failure Due to Community Acquired Pneumonia
the study compares two non-invasive respiratory support modalities ie CPAP and High Flow nasal cannula oxygen for the treatment of severe hypoxemic respiratory failure attributed to Community acquired Pneumonia.
- Trial name
- NCT05755425
- Testing
- CPAP, HFNO
- Where
- 2 sites in Greece
- Volunteers
- 100 people
- Sponsor
- Evangelismos Hospital
Multiplex Respiratory PCR Results in Diabetic Pneumonia Cases
Multiplex Respiratory PCR Results in Diabetic Pneumonia Cases
Multiplex respiratory polymerase chain reaction (PCR) test has gained wide acceptance as an alternative to conventional culture methods for the detection of the causative agent of community-acquired pneumonia (CAP).
- Trial name
- PCR (NCT06459713)
- Testing
- multiplex respiratory polymerase chain reaction test
- Where
- Turkey (Türkiye)
- Volunteers
- 151 people
- Sponsor
- Hisar Intercontinental Hospital
Community-Acquired Pneumonia
Corticoids in Severe Community-Acquired Pneumonia (CAP)
The purpose of this study is to assess the efficacy of glucocorticoids as an adjuvant therapy in patients with severe community-acquired pneumonia (CAP) (Fine V).
- Trial name
- NCT00908713
- Testing
- methylprednisolone
- Where
- 3 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Hospital Clinic of Barcelona
Community Acquired Pneumonia
Study to Proof the Clinical and Bacteriological Non-inferiority of Ampicillin/Amoxicillin Versus Moxifloxacin in Hospitalized Patients With Non-severe Community-acquired Pneumonia
The purpose of this study is to prove the clinical and bacteriological non-inferiority of ampicillin/amoxicillin versus moxifloxacin in hospitalized patients with non-severe community-acquired pneumonia.
- Trial name
- PENCAP (NCT00887276)
- Testing
- Moxifloxacin, Ampicillin;Amoxicillin
- Where
- 8 sites in Germany
- Volunteers
- 290 people
- Sponsor
- University of Ulm
Pneumonia, Acute-Phase Reaction
Acute Phase Reactant in Non-COVID-19 Bacterial Pneumonia
This study is a cross-sectional study, was conducted at Chest department of Kasr Al-ainy Hospital, Cairo university during the period between October 2020 and April 2021.
- Trial name
- NCT05926089
- Testing
- Blood sampling
- Where
- Egypt
- Volunteers
- 51 people
- Sponsor
- Cairo University
Infectious Pneumonia, Severe COVID-19
Reparixin add-on Therapy to Standard Care to Limit Progression in Pts With COVID19 & Other Community Acquired Pneumonia
Primary objective: To compare the efficacy of reparixin vs. placebo in the proportion of patients dead or requiring IMV (or ECMO) by Day 28.
- Trial name
- NCT05254990
- Testing
- Reparixin
- Where
- 74 sites in United States, Argentina and 5 more
- Volunteers
- 414 people
- Sponsor
- Dompé Farmaceutici S.p.A
Community-acquired Pneumonia, Antibiotic Resistance
Correlation Between Antibiotic Resistance and Incidence of Sepsis in Community Acquired Pneumonia
Correlation between antibiotic resistance and incidence of sepsis in community acquired pneumonia in RICU patients.
- Conditions
- Community-acquired Pneumonia, Antibiotic Resistance, Sepsis
- Trial name
- NCT05606627
- Volunteers
- 48 people
- Sponsor
- Assiut University
Acute Hypoxemic Respiratory Failure, Non Invasive Ventilation (NIV)
Evaluation of Physical Capacity and Energy Requirements in Patients With Hypoxemic Acute Respiratory Failure
NIVAR01 (Multimodal evaluation of physical capacity and energy requirements in patients with hypoxemic acute respiratory failure and community acquired pneumonia under non invasive ventilation support) aims to comprehensively…
- Conditions
- Acute Hypoxemic Respiratory Failure, Non Invasive Ventilation (NIV), Bioimpedance Measurement Capacity, Calorimetry, Indirect
- Trial name
- NIVAR01 (NCT07178483)
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital Universitari de Bellvitge
Community-acquired Pneumonia
Potential Role for Echocardiography in Adult Patients With Community-Acquired Pneumonia
Despite the efficacy of modern treatment, community-acquired pneumonia (CAP) is the the leading cause of death. Prognostic scores have been developed to estimate the risk of adverse outcome.
- Trial name
- NCT02441855
- Testing
- echocardiography
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people
- Sponsor
- Muğla Sıtkı Koçman University
Infections
Evaluation of Ceftaroline Fosamil Versus a Comparator in Adult Subjects With Community-acquired Bacterial Pneumonia (CABP) With Risk for Methicillin-resistant Staphylococcus Aureus
The purpose of this study is to determine whether ceftaroline is effective and safe for the treatment of patients with Community-acquired Bacterial Pneumonia (CABP) at risk for infection due to Methicillin-resistant…
- Trial name
- NCT01645735
- Testing
- Ceftaroline fosamil, Ceftriaxone plus vancomycin
- Where
- 31 sites in United States, Georgia and 6 more
- Volunteers
- 49 people
- Sponsor
- Forest Laboratories
Community-acquired Pneumonia
AntiThrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia
This is an international, open-label, stratified randomized controlled trial with Bayesian adaptive stopping rules to compare the effects of therapeutic-dose heparin vs.
- Trial name
- ATTACC-CAP (NCT05848713)
- Testing
- Heparin
- Where
- 68 sites in United States, Brazil and 2 more
- Volunteers
- 4,000 people
- Sponsor
- University of Manitoba
Inflammation, Community Acquired Pneumonia (CAP)
Targeting Vascular INflammation in Patients With Community-Acquired Pneumonia
The goal of this clinical trial is to learn if icosapent ethyl (Vascepa) works to lessen the amount of inflammation in adults diagnosed with Community-Acquired Pneumonia (CAP).
- Conditions
- Inflammation, Community Acquired Pneumonia (CAP), Inflammation Plaque, Atherosclerotic
- Trial name
- TIN-CAP (NCT06710080)
- Testing
- Icosapent Ethyl 1000 MG Oral Capsule [Vascepa]
- Where
- Canada
- Volunteers
- 168 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Pneumonia
Managing Bacterial Pneumonia in Children Without Antimicrobials
Retrospective cohort analysis of children hospitalized for pneumonia comparing disease severity on admission, clinical course, treatment and outcomes and prospective telephone based Follow-Up assessement.
- Trial name
- NCT03256474
- Testing
- Multimodal Therapy
- Where
- Germany
- Volunteers
- 350 people
- Sponsor
- ARCIM Institute Academic Research in Complementary and Integrative Medicine
Community-acquired Pneumonia
The Optimal Antibiotic Treatment Duration for Community-acquired Pneumonia in Adults Diagnosed in General Practice in Denmark (CAP-D)
The aim of this randomised controlled trial is to identify the optimal treatment duration with phenoxymethylpenicillin for community-acquired pneumonia diagnosed in general practice.
- Trial name
- CAP-D (NCT06295120)
- Testing
- Phenoxymethylpenicillin 1.2 MIE 4 times daily
- Where
- Denmark
- Volunteers
- 307 people
- Sponsor
- Research Unit for General Practice in Aalborg
Antimicrobial Stewardship, Exacerbation of Allergic Asthma
POCT PCT in Outpatient LRTI
Lower respiratory tract infections (LRTI) in patients with chronic lung diseases are a common acute reason to consult respiratory practitioners and often lead to inadequate prescription of antibiotics.
- Conditions
- Antimicrobial Stewardship, Exacerbation of Allergic Asthma, Exacerbation Copd, Community-acquired Pneumonia
- Trial name
- POCT-PCT (NCT05380869)
- Testing
- Point-of-care Test
- Where
- Germany
- Volunteers
- 114 people
- Sponsor
- Hannover Medical School
Community-acquired Pneumonia, Bacterial Pneumonia
A 2-Part First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of CMTX-101
CMTX-101 is a bacterial biofilm disrupting monoclonal antibody being developed as an adjunct therapy with standard of care antibiotics.
- Trial name
- NCT05629741
- Testing
- CMTX-101
- Where
- 8 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Clarametyx Biosciences, Inc.
Community-Acquired Infections
Community Acquired Bacteremic Syndromes in Young Nigerian Children
To define the etiologic agents of community acquired bacteremic syndromes (defined as septicemia, bacteremia, pneumonia and/or meningitis) in a malaria endemic setting.
- Trial name
- CABSYNC (NCT02946775)
- Where
- Nigeria
- Volunteers
- 29,146 people
- Sponsor
- University of Nebraska