Clinical trials: Community-Acquired Pneumonia
Pneumonia
Randomised Evaluation of COVID-19 Therapy
RECOVERY is a randomised trial of treatments to prevent death in patients hospitalised with pneumonia. The treatments being investigated are: COVID-19: Lopinavir-Ritonavir, Hydroxychloroquine, Corticosteroids, Azithromycin…
- Trial name
- RECOVERY (NCT04381936)
- Testing
- Lopinavir-Ritonavir, Corticosteroid, Hydroxychloroquine
- Where
- 16 sites in Belgium, Estonia and 14 more
- Volunteers
- 70,000 people
- Sponsor
- University of Oxford
Community Acquired Pneumonia (CAP), Sinusitis
Reducing Antibiotic Use by Implementation of Stewardship in Primary and Urgent Care
The goal of this project is to reduce unnecessary antibiotic use for children with ARTIs (Acute Respiratory Tract Infections) by implementing "outpatient antibiotic stewardship" across the Children's Hospital of Philadelphia…
- Conditions
- Community Acquired Pneumonia (CAP), Sinusitis, Strep Pharyngitis, Acute Otitis Media (AOM)
- Trial name
- RAISIN (NCT07217002)
- Testing
- Online Educational Modules, Prescribing Feedback Reports, Clinical Decision Support
- Where
- United States
- Volunteers
- 420 people
- Sponsor
- Children's Hospital of Philadelphia
Community-acquired Pneumonia
Amoxicillin Alone Versus Amoxicillin/Clavulanate for Community-acquired Pneumonia in Patients Aged 65 Years or Older, and Hospitalized in a Non-intensive Care Unit Ward
Reduce inappropriate antibiotic use is a priority of public health agencies. Community-acquired pneumonia (CAP) is one of the most important indications for antibiotic prescriptions.
- Trial name
- CAPTAIN (NCT06229288)
- Testing
- Amoxicillin, Amoxicillin/clavulanate
- Where
- 19 sites in France
- Volunteers
- 326 people
- Sponsor
- Nantes University Hospital
Community-acquired Pneumonia
Safety and Efficacy of AON-D21 in Severe Community-Acquired Pneumonia.
The goal of this clinical trial is to compare the safety and efficacy of AON-D21 versus placebo, both on top of standard of care, in patients with severe community acquired pneumonia admitted to ICU (or similar unit).
- Trial name
- NCT05962606
- Testing
- AON-D21
- Where
- 27 sites in United States, Belgium and 4 more
- Volunteers
- 150 people
- Sponsor
- Aptarion Biotech AG
Community Acquired Pneumonia (CAP)
Comparing Hydrocortisone and Prednisolone for Community Acquired Pneumonia (CAP)
The goal of this cluster randomized controlled trial is to determine the optimal treatment for community aquired pneumonia (CAP).
- Trial name
- NCT06892197
- Testing
- Methylprednisolone (drug), hydrocortisone
- Where
- 14 sites in Denmark
- Volunteers
- 1,600 people
- Sponsor
- Copenhagen Respiratory Research
Community Acquired Pneumonia (CAP)
Effect of tNGS on CAP Patients With Initial Treatment Failure
This is a multicenter, randomized controlled trial designed to evaluate the impact of tNGS in patients with community-acquired pneumonia who experience initial treatment failure.
- Trial name
- NCT07472114
- Testing
- Targeted next-generation sequencing, Conventional microbiological testing, Follow-up at Day 30
- Where
- China
- Volunteers
- 524 people
- Sponsor
- Capital Medical University
Community Acquired Pneumonia in Children
Short Versus Standard of Care Antibiotic Duration for Children Hospitalized for CAP
The goal of this open label, randomized, non-inferiority clinical trial is to compare the treatment success of a 5 day antibiotic course versus a standard antibiotic course (usually 7-14 days of antibiotics) in hospitalized…
- Trial name
- NCT06494072
- Testing
- Ampicillin for Injection, Ceftriaxone for Injection, Amoxicillin
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Medical College of Wisconsin
Community-Acquired Pneumonia, Fraility
Frailty and Outcomes in Older Emergency Department Patients With Pneumonia
Pneumonia is one of the leading causes of infection-related mortality in the older population. Traditional severity scores used in emergency departments, such as the Pneumonia Severity Index (PSI) and CURB-65, primarily focus on…
- Conditions
- Community-Acquired Pneumonia, Fraility, Hospitalizations
- Trial name
- NCT07442656
- Testing
- Clinical frailty scale, Clinical Frailty Scale (CFS)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Ege University
Community-acquired Pneumonia
Swab Testing to Optimize Pneumonia Treatment With Empiric Vancomycin
This is a single center, pragmatic, randomized clinical trial (pRCT) examining whether reporting the results of a negative rapid PCR back to the provider via a pager alert results in decreased vancomycin utilization for…
- Trial name
- STOP-Vanc (NCT06272994)
- Testing
- MRSA Nasal Swab PCR
- Where
- United States
- Volunteers
- 277 people
- Sponsor
- Vanderbilt University Medical Center
Pneumonia, Pneumonia - Bacterial
Derivation and Validation of the Risk Evaluation Score for Pneumonia Involving Resistant Entities (RESPIRE)
This is a single-center, non-profit observational study with two sequential phases: an initial retrospective phase followed by a prospective phase. Patients were enrolled during two consecutive, non-overlapping periods.
- Conditions
- Pneumonia, Pneumonia - Bacterial, Multi Drug Resistant, Multi Drug Resistant Organisms
- Trial name
- RESPIRE (NCT07425561)
- Testing
- RESPIRE score
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Lower Respiratory Tract Infections, Community Acquired Pneumonia (CAP)
Lower Respiratory Tract Infections Managed in Primary Care in France
Primary aim: To describe participant characteristics at the time of the index lower respiratory tract infection (LRTI) episode in adults managed in primary care in France, using anonymized electronic health records from routine…
- Conditions
- Lower Respiratory Tract Infections, Community Acquired Pneumonia (CAP), Acute Bronchitis, Acute Exacerbation Chronic Obstructive Pulmonary Disease
- Trial name
- NCT07416266
- Volunteers
- 230,066 people
- Sponsor
- Hôpital Raymond Poincaré
Community Acquired Pneumonia (CAP), Community Acquired Pneumonia
Comparing Antibiotic Treatment Strategies for Children With Pneumonia in Outpatient Settings: (STAMPP)
The goal of this clinical trial is to determine if a "watch and wait" antibiotic strategy, called Safety Net Antibiotic Prescribing (SNAP), can safely reduce unnecessary antibiotic use while ensuring that children diagnosed with…
- Trial name
- STAMPP (NCT06986148)
- Testing
- Immediate Antibiotic Prescribing Group Instructions, Safety Net Antibiotic Prescribing (SNAP) Group Instructions
- Where
- 4 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Community Acquired Pneumonia, Bronchiolitis
HVNI vs CPAP in Children With Acute Respiratory Distress
Acute breathing problems are a common reason for children to be admitted to the pediatric intensive care unit, and many of these children need breathing support without a breathing tube.
- Trial name
- P-HVNI-CPAP (NCT07336121)
- Testing
- High Velocity Nasal Insufflation (HVNI), Nasal Continuous Positive Airway Pressure (Nasal CPAP)
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Acute Respiratory Failure, Community-Acquired Pneumonia
Early Inflammatory-Immune Stratification and Precision Glucocorticoid Intervention in Acute Respiratory Failure Induced by Community-Acquired Pneumonia
This is a prospective, multicenter, interventional cohort study aimed at constructing a high-quality, dynamic multimodal database for patients with acute respiratory failure caused by community-acquired pneumonia (CAP-ARF).
- Trial name
- NCT07357935
- Testing
- Methylprednisolone
- Volunteers
- 500 people
- Sponsor
- Qingyuan Zhan
Angina, Acute Bronchiolitis
Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care
Antimicrobial resistance (AMR), considered one of the greatest global threats by the WHO, justifies the development of initiatives to promote appropriate antibiotic use-especially in primary care, where most antibiotics in France…
- Conditions
- Angina, Acute Bronchiolitis, Acute Bronchitis, COPD Exacerbation (AECOPD)
- Trial name
- GRASP (NCT07359287)
- Testing
- Antibiotic prescribing according to guidelines
- Where
- France
- Volunteers
- 4,500 people
- Sponsor
- University Hospital, Caen
Adenovirus Infections, Human
Adaptive RCT of Corticosteroids for Severe Adenovirus Pneumonia in Adults
Severe community-acquired pneumonia caused by adenovirus (hereafter referred to as severe adenovirus pneumonia) is one of the common forms of severe community-acquired pneumonia in immunocompetent adults.
- Trial name
- CAPSTONE-AD (NCT07152600)
- Testing
- Saline (0.9%, sterile, for infusion), low dose Methylprednisolone, Moderate dose Methylprednisolone
- Volunteers
- 262 people
- Sponsor
- Qingyuan Zhan
Community Acquired Pneumonia (CAP), Pneumococcal Pneumonia
Pneumococcal Community-Acquired Pneumonia Requiring Hospitalization Among Colombian Adults
Pneumococcal Community-Acquired Pneumonia Requiring Hospitalization Among Adults in Colombia (Pneumo-CAP Colombia) This study aims to learn more about pneumococcal community-acquired pneumonia (CAP) caused by Streptococcus…
- Trial name
- PneumoCAP (NCT07354425)
- Where
- 11 sites in Colombia
- Volunteers
- 688 people
- Sponsor
- Universidad de la Sabana
Influenza
Adaptive RCT of Corticosteroids for Severe Influenza Pneumonia in Adults
Severe community-acquired pneumonia caused by influenza virus (hereafter referred to as severe influenza pneumonia) is a major etiology of community-acquired pneumonia leading to acute respiratory failure and ICU admission.
- Trial name
- CAPSTONE-IFV (NCT07351500)
- Testing
- Saline (0.9%, sterile, for infusion), low dose Methylprednisolone, Moderate dose Methylprednisolone
- Volunteers
- 496 people
- Sponsor
- Qingyuan Zhan
Psittacosis
Adaptive RCT of Corticosteroids for Severe Chlamydia Psittaci Pneumonia in Adults
Severe community-acquired pneumonia caused by psittacosis is a form of atypical-pathogen community-acquired pneumonia that often requires critical care management.
- Trial name
- NCT07352865
- Testing
- Saline (0.9%, sterile, for infusion), low dose Methylprednisolone, Moderate dose Methylprednisolone
- Volunteers
- 100 people
- Sponsor
- Qingyuan Zhan
Acute Hypoxemic Respiratory Failure, Non Invasive Ventilation (NIV)
Evaluation of Physical Capacity and Energy Requirements in Patients With Hypoxemic Acute Respiratory Failure
NIVAR01 (Multimodal evaluation of physical capacity and energy requirements in patients with hypoxemic acute respiratory failure and community acquired pneumonia under non invasive ventilation support) aims to comprehensively…
- Conditions
- Acute Hypoxemic Respiratory Failure, Non Invasive Ventilation (NIV), Bioimpedance Measurement Capacity, Calorimetry, Indirect
- Trial name
- NIVAR01 (NCT07178483)
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital Universitari de Bellvitge