Clinical trials: Comorbid Depression
MDD
A Retrospective Study to Evaluate NeuroStar® Advanced Therapy in Adolescents
To assess the real-world effectiveness of transcranial magnetic stimulation (TMS) for depression in large adolescent and young adult samples.
- Trial name
- NCT06699940
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 7,690 people
- Sponsor
- Neuronetics
ASTHMA, ANXIETY
Biofeedback for Asthma Comorbid With Anxiety or Depression
Twenty patients with a history of treatment, within the past year, of both asthma and either depression or an anxiety disorder will be recruited for this study.
- Trial name
- ASANX (NCT03030326)
- Testing
- heart rate variability biofeedback
- Sponsor
- Rutgers, The State University of New Jersey
Major Depression
A Study of Quetiapine Fumarate Sustained Release in Major Depression With Comorbid Fibromyalgia Syndrome
To compare the efficacy of Quetiapine SR versus placebo over 8 weeks in unipolar non-psychotic adult outpatients depression and comorbid fibromyalgia.
- Trial name
- NCT00675896
- Testing
- Quetiapine Fumarate Sustained Release
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Dr Alexander McIntyre Inc.
Arthritis, Asthma
Integrating Behavioral Health and Primary Care for Comorbid Behavioral and Medical Problems
Behavioral problems are part of many of the chronic diseases that cause the majority of illness, disability and death. Tobacco, diet, physical inactivity, alcohol, drug abuse, failure to take treatment, sleep problems, anxiety…
- Conditions
- Arthritis, Asthma, Chronic Obstructive Lung Disease, Diabetes
- Trial name
- IBHPC (NCT02868983)
- Testing
- Integration
- Where
- United States
- Volunteers
- 4,025 people
- Sponsor
- University of Vermont
Inflammatory Bowel Disease, Depressive Disorder
Gut Microbiota in IBD With Comorbid Depressive Disorder
Inflammatory bowel disease (IBD) is often comorbid with depressive disorder, and the development and progression of both conditions are closely related to the composition of gut microbiota and metabolites.
- Trial name
- NCT07252427
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fang Tang
Major Depressive Disorder, Chronic Pain
Pain and Major Depressive Disorder
This study will examine the effects of brain stimulation on pain symptoms associated with Major depressive disorder. This study will enroll 54 Subjects.
- Trial name
- NCT04556890
- Testing
- Active rTMS/Active iTBS
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of California, Los Angeles
Depression in Old Age, Psychotherapy
Engage for Late-Life Depression and Comorbid Executive Dysfunction
Although there are an increasing number of mental health treatment adaptations for older adults, there are still a number of factors to consider when making these adaptations.
- Conditions
- Depression in Old Age, Psychotherapy, Mild Cognitive Impairment, Executive Dysfunction
- Trial name
- NCT05356611
- Testing
- Engage
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Nevada, Las Vegas
Posttraumatic Stress Disorder (PTSD), Depression - Major Depressive Disorder
To Investigate the Change of Brain and Autonomic Function From Different Protocols of Repeated Transcranial Magnetic Stimulation Therapy for Patients With Post-traumatic Stress Disorder Comorbid Major Depressive Disorder
This study aims to investigate the immediate neurophysiological and autonomic effects of two noninvasive brain stimulation protocols-prolonged intermittent theta-burst stimulation (prolonged iTBS) and high-frequency repetitive…
- Trial name
- NCT07327385
- Testing
- Prolonged Intermittent Theta-Burst Stimulation (prolonged iTBS), High-Frequency Repetitive Transcranial Magnetic Stimulation (HF-rTMS)
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Hoarding Disorder, Hoarding
Neuromodulation for Comorbid Hoarding Disorder and Depression
The primary goal of this study is to evaluate whether intermittent theta burst stimulation (iTBS) is effective for treating depression in people who have depression and chronic hoarding disorder (HD).
- Conditions
- Hoarding Disorder, Hoarding, Depression
- Trial name
- NCT05985356
- Testing
- iTBS
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of California, San Diego
Insomnia, Depression
Effects of Group Cognitive Behavioural Therapy on Comorbid Insomnia and Depression in Youth
Major depressive disorder (MDD) is among the most common psychiatric disorders among adolescents, and is associated with considerable psychosocial and functional impairments and an elevated risk of suicidal behaviour and…
- Trial name
- NCT03438331
- Testing
- Cognitive Behavioural Therapy for Insomnia (CBT-I), Cognitive Behavioural Therapy for Depression (CBT-D)
- Where
- Hong Kong
- Volunteers
- 133 people
- Sponsor
- The University of Hong Kong
Major Depressive Disorder, Generalized Anxiety Disorder
Efficacy of Extended-release Quetiapine (Seroquel XR) as Adjunctive Therapy to Cognitive Behavioral Therapy in the Treat
The primary objective of the study is to determine whether quetiapine extended-release in combination with cognitive behavioral therapy (CBT) is more effective than CBT plus placebo in treating depressive and anxiety symptoms in…
- Trial name
- NCT01971203
- Testing
- seroquel xr, CBT
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Posttraumatic Stress Disorder, Major Depressive Disorder
Behavioral Activation + Cognitive Processing Therapy for PTSD and Comorbid MDD
This study is a randomized controlled trial comparing an integrated treatment, Behavioral Activation + Cognitive Processing Therapy (BA + CPT), to CPT alone among active-duty service members with posttraumatic stress disorder…
- Trial name
- NCT02874131
- Testing
- Behavioral Activation, Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Panic Disorder, Major Depressive Disorder
Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Panic Disorder With Comorbid Major Depression
This study will evaluate the efficacy of 1-Hz rTMS applied to the right Dorsolateral Prefrontal Cortex (DLPFC) in patients with Panic Disorder (PD) and comorbid Major Depressive Disorder (MDD) who have not fully responded to…
- Trial name
- rTMS (NCT00521352)
- Testing
- Active Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder, Mild Neurocognitive Disorder
Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV
A phase II, randomized, open-label, two-arm clinical trial evaluating the safety and efficacy of pramipexole extended release (ER) versus escitalopram for the treatment of major depressive disorder (MDD) and comorbid MDD with…
- Conditions
- Major Depressive Disorder, Mild Neurocognitive Disorder, HIV
- Trial name
- NCT06705478
- Testing
- Pramipexole ER, Escitalopram
- Where
- 41 sites in United States, Botswana and 12 more
- Volunteers
- 186 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Major Depressive Disorder, Alzheimer Disease
Deep TMS for Comorbid Depression and Cognitive Impairment in Older Adults
In this study, the investigators will be examining the effects of the deep repetitive transcranial magnetic stimulation (rTMS) using the H1 coil in patients over the age of 60 diagnosed with mild to early-moderate Alzheimer's…
- Conditions
- Major Depressive Disorder, Alzheimer Disease, Mild Cognitive Impairment
- Trial name
- NCT03665831
- Testing
- Brainsway H1-Coil Deep TMS System
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- Rotman Research Institute at Baycrest
Acute Coronary Syndrome, Depressive Disorder
Comorbid Mental Disease and Heart Disease in Men
Mood disorders, anxiety disorders, and trauma-related stress (MD\AD\TRS) are common among men, particularly those suffering from heart disease (HD).
- Conditions
- Acute Coronary Syndrome, Depressive Disorder, Anxiety Disorders, Stress Disorders, Post-Traumatic
- Trial name
- MindTheHeart (NCT03354351)
- Testing
- Stepped-care model
- Volunteers
- 3,000 people
- Sponsor
- Universite de Moncton
Epilepsy, Depression
A Registration Study on Depression in Patients With Epilepsy
The aim of this study is to register the drug treatment of depression in patients with epilepsy in East China.
- Trial name
- NCT03247764
- Where
- 7 sites in China
- Volunteers
- 320 people
- Sponsor
- Shanghai Zhongshan Hospital
Fibromyalgia
A Phase 3b Multicenter Study of Pregabalin in Fibromyalgia Subjects Who Have Comorbid Depression
The intent of this study is to identify and treat fibromyalgia subjects with comorbid depression who are receiving an SSRI (selective serotonin reuptake inhibitor) or SNRI (selective norepinephrine reuptake inhibitor) primarily…
- Trial name
- NCT01432236
- Testing
- Pregabalin
- Where
- 37 sites in United States, Canada and 2 more
- Volunteers
- 197 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Perinatal Depression, Substance Use
Sober Network IPT for Perinatal Women With Comorbid Substance Use and Depression
This study will evaluate the effectiveness of Sober Network Interpersonal Psychotherapy (IPT) in treating women with depression and comorbid substance abuse.
- Trial name
- NCT01550913
- Testing
- Sober Network Interpersonal Psychotherapy (IPT), Treatment as Usual
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Alcohol-Related Disorders, Depressive Disorder
Psilocybin in Alcohol Use Disorder With Comorbid Depression
Up to 40% of people with alcohol use disorder (AUD) experience depression. Depression is a risk factor for early relapse of AUD after withdrawal in a controlled environment.
- Conditions
- Alcohol-Related Disorders, Depressive Disorder, Addiction
- Trial name
- PAD (NCT06235411)
- Testing
- Psilocybin therapy, Inactive Psilocybin therapy, Electroencephalogram
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes