Clinical trials: Comorbid Depression
Insomnia, Anxiety
Treating Comorbid Insomnia in Transdiagnostic Internet-Delivered Cognitive Behaviour Therapy
Transdiagnostic Internet-delivered Cognitive Behaviour Therapy (ICBT) is an efficacious treatment option for anxiety and depression; however, not all patients benefit equally and some leave treatment before program completion.
- Conditions
- Insomnia, Anxiety, Depression
- Trial name
- NCT04512768
- Testing
- Transdiagnostic Internet-delivered Cognitive Behaviour Therapy, Brief Internet-Delivered Cognitive Behaviour Therapy for Insomnia
- Where
- Canada
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- University of Regina
Post-Traumatic Stress Disorders, Major Depressive Disorder
Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veterans
Co-occurring post-traumatic stress disorder (PTSD) and major depressive disorder (MDD) is the most common response to trauma; it is associated with poor clinical outcomes and substantial human disability.
- Trial name
- NCT04032301
- Testing
- Ketamine, Normal Saline
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Major Depressive Disorder, Insomnia
A Study to Evaluate the Safety, Tolerability, and Efficacy of SAGE-217 Compared to Placebo in Adult Participants With Comorbid Major Depressive Disorder (MDD) and Insomnia
This study is a randomized, double-blind, placebo-controlled study of the safety, tolerability, and efficacy of SAGE-217 compared to placebo in adult participants with comorbid major depressive disorder (MDD) and insomnia.
- Trial name
- NCT03771664
- Testing
- SAGE-217
- Where
- 28 sites in United States
- Volunteers
- 87 people
- Sponsor
- Biogen
Depression, Overweight
Integrated Treatment for Comorbid Depression and Obesity in Adolescents
Lifetime prevalence of major depression is estimated at 28% by age 18 (Lewinsohn et al., 1999), with higher cumulative rates in females (35%) than males (19%).
- Trial name
- NCT01128764
- Testing
- CBT for depression and healthy lifestyle plus exercise, CBT for depression
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Brown University
Cigarette Smoking
Tailored Tobacco Quitline for Rural Veterans
The proposed work is designed to help increase access to tobacco cessation services among rural veterans and to develop more effective treatment services that better address comorbid issues commonly experienced by rural smokers.
- Trial name
- NCT01592695
- Testing
- Nicotine replacement therapy - transdermal nicotine patch, Tailored behavioral intervention, Tobacco quit line referral
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Iowa City Veterans Affairs Medical Center
Chronic Disease, Depressive Symptoms
Bio-psycho-social Pathways Underlying the Effects of Qigong Among Comorbid Depressed Elderly With Chronic Conditions
Depression and chronic medical conditions are common in older adults. Qigong is increasingly documented to have anti-depressive effects for older adults. Nevertheless, the scientific concepts behind qigong remain a mystery.
- Trial name
- NCT03591211
- Testing
- Qigong Training, Cognitive Training
- Where
- Hong Kong
- Volunteers
- 35 people
- Sponsor
- The Hong Kong Polytechnic University
TBI, Major Depression
Lexapro for the Treatment of Traumatic Brain Injury (TBI) Depression & Other Psychiatric Conditions
This research is being done to see if a drug called escitalopram (Lexapro) is helpful to people who are suffering from depression after traumatic brain injury (TBI).
- Conditions
- TBI, Major Depression, Other Psychiatric Disorders
- Trial name
- NCT01368432
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Johns Hopkins University
Randomized Controlled Trial
Cost-utility and Physiological Effects of ACT and BATD in Patients With Chronic Pain and Depression
Objectives: (1) To analyze the effectiveness of adding a group-based form of Acceptance and Commitment Therapy (ACT) or a behavioural activation program for depression (TACD) to the treatment as usual (TAU) for patients diagnosed…
- Trial name
- IMPACT (NCT04140838)
- Testing
- Acceptance and Commitment Therapy (ACT), Behavioral Activation Therapy for Depression (BATD), Treatment as Usual (TAU)
- Where
- 2 sites in Spain
- Volunteers
- 234 people
- Sponsor
- Fundació Sant Joan de Déu
Anxiety Disorders, Depressive Disorders
Short-term, Intensive Psychodynamic Group Therapy Versus Cognitive-behavioral Group Therapy in the Day Treatment
Background: Psychodynamic and cognitive-behavioral group therapies are frequently applied in day hospitals in the treatment of anxiety disorders, and comorbid depressive or personality disorders in Poland.
- Conditions
- Anxiety Disorders, Depressive Disorders, Personality Disorders
- Trial name
- NCT02126787
- Testing
- Intensive Group Analytic Psychotherapy, Intensive transdiagnostic cognitive-behavioral group therapy
- Where
- Poland
- Volunteers
- 123 people
- Sponsor
- Medical University of Warsaw
Social Anxiety Disorder, Major Depressive Disorder
Vortioxetine Versus Placebo in Major Depressive Disorder Comorbid With Social Anxiety Disorder
This placebo-controlled study is designed to determine the efficacy, safety, and tolerability of vortioxetine in the treatment of adults with Major Depressive Disorder (MDD) that is comorbid with Social Anxiety Disorder (SAD).
- Trial name
- NCT02294305
- Testing
- Vortioxetine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Medical Research Network
Obesity, Major Depressive Disorder
Comorbid Obesity and Depression With an Anti-inflammatory Medication
Research suggests that only a subset of individuals with major depressive disorder (MDD) may benefit from anti-inflammatory treatments: those who have C-reactive protein (CRP) ≥3 mg/L, a commonly used threshold for "low-grade"…
- Conditions
- Obesity, Major Depressive Disorder, Inflammation
- Trial name
- CODA (NCT06537921)
- Testing
- Minocycline 200mg
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- King's College London
Chronic Pain, Depression
The Impact of Comorbid Chronic Pain on Older Adults With Depression in Behavioral Activation
This qualitative nested sub-study will aim to explore how chronic pain (as defined as pain lasting for more than 3 months) impacts older adults' depression and treatment in a brief psychological therapy of behavioral activation…
- Trial name
- NCT05646628
- Testing
- Qualitative Interviews
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Teesside University
Depression; Psychoneurotic, Pain
Comprehensive Acupuncture for Depressive Disorder With Comorbid Psychogenic Pain
Experimental and clinical studies have indicated that acupuncture has a good effect for depression and comorbid pain. The purpose of this research is to compare the effect of comprehensive electro-acupuncture therapy and western…
- Trial name
- NCT03282110
- Testing
- ta-VNS, Electro-acupuncture, Citalopram
- Volunteers
- 60 people
- Sponsor
- China Academy of Chinese Medical Sciences
Epilepsy
A Prospective Cohort Study on the Comorbid Depression in Patients With Newly-diagnosed Epilepsy
Epilepsy is a chronic brain disease with recurrent seizures and the comorbidity of psychiatric diseases are very common. The prevalence of depression in patients with refractory epilepsy is about 60%.
- Trial name
- NCT04517058
- Testing
- psychology therapy
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai Zhongshan Hospital
Anxiety Depression, Sleep
Comparing Acupuncture With Medication to Reduce Depression, Anxiety and Comorbid Sleep Disorders in China
The main objective of this study is to compare medication (usual care; active comparator) with acupuncture (as experimental intervention) to identify the most (cost)effective and environmentally sustainable intervention to reduce…
- Trial name
- NCT07552246
- Testing
- Psychotropic Drugs, Acupuncture
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Duke Kunshan University
Major Depressive Disorder, Generalized Anxiety Disorder
Quetiapine Extended Release (XR) Treatment of Major Depressive Disorder With Comorbid Generalized Anxiety Disorder
The primary objective is to test the hypothesis that quetiapine XR (Extended Release) monotherapy or adjunctive therapy to antidepressant is superior to placebo monotherapy or placebo adjunctive therapy to antidepressant(s) in…
- Trial name
- MDD/GAD (NCT00868374)
- Testing
- Quetiapine XR
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Keming Gao
Depressive Disorder, Treatment-Resistant, Stress Disorders, Post-Traumatic
Ketamine Infusions for PTSD and Treatment-Resistant Depression
The relationship between depression and trauma is well established. Co-occuring depression and post-traumatic stress disorder (PTSD) are associated with more severe symptoms and lower levels of functioning.
- Trial name
- NCT02577250
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Posttraumatic Stress Disorder, Major Depressive Disorder
rTMS for PTSD Comorbid With Major Depressive Disorder
The purpose of this study is to see how well a treatment called "Repetitive Transcranial Magnetic Stimulation" works for patients who struggle with symptoms of both posttraumatic stress disorder and major depressive disorder.
- Conditions
- Posttraumatic Stress Disorder, Major Depressive Disorder, Transcranial Magnetic Stimulation, Repetitive
- Trial name
- NCT02273063
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Butler Hospital
Major Depression, Multiple Sclerosis
Escitalopram (Lexapro) for Depression MS or ALS
The purpose of this study is to see if escitalopram (Lexapro) improves symptoms of major depressive disorder in patients who have ALS or MS.
- Conditions
- Major Depression, Multiple Sclerosis, Amyotrophic Lateral Sclerosis
- Trial name
- NCT00965497
- Testing
- escitalopram
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of South Carolina
Type 2 Diabetes, Major Depressive Disorder
A Comprehensive Intervention for Diabetes and Comorbid Depression in Primary Care
The study involves a 32-week randomized controlled trial in primary care of a comprehensive diabetic and depression intervention in patients with type 2 diabetes and comorbid MDD, compared to a group treated with usual care for…
- Trial name
- NCT00939250
- Testing
- Diabetes and depression intervention, Diabetes intervention
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas Southwestern Medical Center