Clinical trials: Comorbidities and Coexisting Conditions
Cognitive Impairment, Dementia
Multidimensional Rehabilitation Programs for Cognitive Impairment in Comorbid Outpatients: a Randomized Controlled Trial
Dementias secondary to cerebrovascular diseases are of significant epidemiological and clinical relevance. As a result, the management of individuals with comorbid dementia should involve early diagnosis, effective treatment, and…
- Conditions
- Cognitive Impairment, Dementia, Comorbidities and Coexisting Conditions, Vascular Dementia
- Trial name
- RCTCogRehab (NCT05954741)
- Testing
- Motor rehabilitation alone, Motor rehabilitation and Cognitive rehabilitation (paper-based), Motor rehabilitation and cognitive rehabilitation (digital-based)
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Rare Diseases, Epidemiology
Verification of the Epidemiology and Mortality of Rare Diseases in Taiwan With Real-world Evidence
This study aims to explore the longitudinal incidence and prevalence trends of selected muscular and bone-related rare diseases, i.e., Familial Amyloidotic Polyneuropathy (FAP), Primary hyperoxaluria, Wilson's disease, Cystic…
- Conditions
- Rare Diseases, Epidemiology, Morbidity, Morality
- Trial name
- NCT05367115
- Testing
- longitudinal observational study
- Where
- Taiwan
- Volunteers
- 5,000 people
- Sponsor
- National Cheng-Kung University Hospital
Comorbidities and Coexisting Conditions, Cardiopulmonary Resuscitation
Charlson Comorbidity Index and Outcome of Cardiopulmonary Resuscitation in Geriatric Patients in Hong Kong
The goal of this observational study is to learn about the factors affecting the outcome (survival) of cardiopulmonary resuscitation in older persons in a hospital.
- Conditions
- Comorbidities and Coexisting Conditions, Cardiopulmonary Resuscitation, Geriatrics
- Trial name
- NCT06209944
- Testing
- Cardiopulmonary resuscitation
- Where
- China
- Volunteers
- 394 people
- Sponsor
- Jane Yidan Zhu
Helicobacter Pylori Infection, Comorbidities and Coexisting Conditions
Real-world Treatment of H. Pylori Eradication in Patients with Comorbidity
Most of the studies of H. pylori eradication were conducted in academic institutes and designed to enrolled patients who did not have comorbidities.
- Conditions
- Helicobacter Pylori Infection, Comorbidities and Coexisting Conditions, Real-world Outcome, Medication Adherence
- Trial name
- Real-world_Hp (NCT05475431)
- Testing
- The sequential therapy, The triple therapy, The hybrid therapy
- Where
- 2 sites in Taiwan
- Volunteers
- 1,053 people
- Sponsor
- National Cheng-Kung University Hospital
Comorbidities and Coexisting Conditions
Evaluation of a Personalized Care Management Program for High Hospital Utilizers
This randomized clinical trial intends to evaluate the effectiveness of enrollment in Atrium Health's Multiple Visit Patient (MVP) care management program compared to usual care on reducing 12-month total inpatient hospital…
- Trial name
- NCT04727567
- Where
- United States
- Volunteers
- 454 people
- Sponsor
- Wake Forest University Health Sciences
Cancer, Aging
Real-time Behavioral Interventions
The goal of this study is to adapt an evidence-based sedentary behavior reduction intervention for men and women living in Alabama and determine its feasibility, acceptance, and limited efficacy.
- Conditions
- Cancer, Aging, Comorbidities and Coexisting Conditions
- Trial name
- NCT04457128
- Testing
- Just-in-Time Adaptive Intervention
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa
Smoking Cessation, HIV
Evaluating Smoking Cessation Interventions for PWH in South Africa
The overall objective of the study is to optimize a smoking cessation treatment package for people with HIV (PWH) that can be integrated into existing HIV care in South Africa.
- Conditions
- Smoking Cessation, HIV, Comorbidities and Coexisting Conditions
- Trial name
- Tlogela (NCT05413122)
- Testing
- Varenicline, Nicotine patch, Nicotine gum
- Where
- South Africa
- Volunteers
- 660 people
- Sponsor
- Johns Hopkins University
Comorbidities and Coexisting Conditions, Old Age; Debility
Clinical and Biological Sample Database of Chinese Elderly Patients With Multiple Diseases
The investigators aim to establish a clinical database and biobank for elderly patients with multiple diseases. The collected data will include demographic information, comorbidity characteristic, FRAIL scale, age-adjusted…
- Trial name
- NCT05797402
- Where
- China
- Volunteers
- 10,000,000 people
- Sponsor
- Beijing Anzhen Hospital
Back Pain, Neck Pain
Exploring Multimorbidity in Patients With Spinal Pain
Spinal pain is frequently accompanied by other chronic conditions (multimorbidity) and the predicted rise in multimorbidity prevalence emphasizes the need for studies to understand its impact on patients with chronic pain…
- Conditions
- Back Pain, Neck Pain, Comorbidities and Coexisting Conditions
- Trial name
- NCT06402409
- Where
- Denmark
- Volunteers
- 2,000 people
- Sponsor
- Jacob Christiansen Gandløse
Substance Use Disorders, Comorbidities and Coexisting Conditions
Adaptation of Community Reinforcement Approach for the Treatment of Drug Addiction
Central idea of the study is to adapt a treatment program for drug addiction treatment indigenously and relapse prevention, and to establish its efficacy.
- Trial name
- NCT06559631
- Testing
- Indigenously Adapted CRA
- Where
- 2 sites in Pakistan
- Volunteers
- 59 people
- Sponsor
- Muhammad Saghir
HIV Infections, Drug Interaction
Variation in Drug Interactions in People With HIV (PLWH) Aged 60 Years and Older.
Several cohort studies have recently shown a significant increase in the mean age of PLWH ( People Living With HIV) and in the prevalence of people in advanced age in the various cohorts, as a result of the marked increase in the…
- Conditions
- HIV Infections, Drug Interaction, Elderly Infection, Comorbidities and Coexisting Conditions
- Trial name
- NCT06717581
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Severe Acute Malnutrition, HIV
An Adaptive Multi-arm Trial to Improve Clinical Outcomes Among Children Recovering From Complicated SAM
Malnutrition underlies 45% of child deaths, and has far-reaching educational, economic and health consequences. Severe acute malnutrition (SAM) affects 17 million children globally and is the most life-threatening form of…
- Conditions
- Severe Acute Malnutrition, HIV, Comorbidities and Coexisting Conditions, Child Malnutrition
- Trial name
- Co-SAM (NCT05994742)
- Testing
- Rifampicin, Azithromycin, Isoniazid
- Where
- 9 sites in Kenya, Zambia and 1 more
- Volunteers
- 674 people
- Sponsor
- Queen Mary University of London
Interdisciplinary Communication, Postoperative Complications
Effects of Preoperative Multidisciplinary Team Meetings for High-risk, Adult, Noncardiac Surgical Patients
The current multicenter stepped wedge randomized cluster trial study aims to assess whether implementation of preoperative multidisciplinary team (MDT) discussions is (cost)effective for high risk noncardiac surgical patients.
- Conditions
- Interdisciplinary Communication, Postoperative Complications, Noncardiac Surgery, Surgical Procedures, Operative
- Trial name
- PREPARATION (NCT05703230)
- Testing
- Structured preoperative multidisciplinary team meeting
- Where
- 14 sites in Netherlands
- Volunteers
- 1,200 people
- Sponsor
- Rijnstate Hospital
Insomnia, Comorbidities and Coexisting Conditions
A Mixed-method Pilot Investigation of Paradoxical Intention for Insomnia.
The investigators aim to test the preliminary efficacy as well as the acceptability and feasibility of paradoxical intention, which is a psychotherapeutic technique, for improving insomnia symptoms in adults.
- Trial name
- NCT06259682
- Testing
- Paradoxical Intention
- Where
- 3 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Örebro University, Sweden
Asthma Bronchiale, Breast Neoplasms
Digital Implementation of the German S3 Clinical Practice Guideline for Multimorbidity
The web application gp-multitool.de is a digital tool for implementing the German S3 clinical practice guideline for multimorbidity of the German Society of General Practitioners and Family Physicians in primary care.
- Conditions
- Asthma Bronchiale, Breast Neoplasms, Coronary Disease, Diabetes Mellitus, Type 2
- Trial name
- NCT06831994
- Testing
- gp-multitool.de
- Where
- Germany
- Volunteers
- 659 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD)
Ketamine-Enhanced Therapy for Individuals With Alcohol Use Disorder and Depression: A Pilot Study (KET-DUAL)
To assess the safety, feasibility and preliminary efficacy of ketamine-enhanced therapy (KET) for alcohol use disorder (AUD) and comorbid major depressive disorder (MDD) in an open-label, single arm, pilot clinical trial.
- Conditions
- Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD), Comorbidities and Coexisting Conditions
- Trial name
- KET-DUAL (NCT07247370)
- Testing
- Ketamine, Cognitive Behavioural Therapy
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- South West Sydney Local Health District
Comorbidities and Coexisting Conditions, Healthy
Immune Response of an Interchangeable Booster Vaccine Against COVID-19 Among Individuals With Risk Factors for Severity
Experimental, single-arm study in participants with comorbidities, previously immunized with 2 doses of CoronaVac, who will receive a booster vaccine with 1 dose of the Oxford/AstraZeneca vaccine.
- Trial name
- COVACManaus2 (NCT05289206)
- Testing
- Vaccine - ChAdOx1-S/nCoV-19 [recombinant]
- Where
- Brazil
- Volunteers
- 4,446 people, healthy volunteers welcome
- Sponsor
- Fundação de Medicina Tropical Dr. Heitor Vieira Dourado
Exercise, Sedentary Behavior
Association of a Digital Signature of Physical Activity and Sedentary Lifestyle With the Development of Multimorbidities in Chronic Diseases (eMOB)
Physical activity (PA) and sedentary lifestyle are determinants in the development of chronic diseases and associated quality of life alterations.
- Conditions
- Exercise, Sedentary Behavior, Non Communicable Diseases, Comorbidities and Coexisting Conditions
- Trial name
- eMOB (NCT05578495)
- Testing
- Accelerometer data
- Where
- France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Clermont-Ferrand