Clinical trials: Comorbidity
Obesity, Overweight
A Study of Enicepatide (CT-388) in Participants With Obesity or Overweight With at Least One Weight-Related Comorbidity
This is a multi-center, randomized, double-blind, placebo-controlled, parallel group dose-finding study to evaluate the efficacy and safety of enicepatide at low, middle, and high doses in participants with obesity or who are…
- Trial name
- NCT06525935
- Testing
- Enicepatide
- Where
- 34 sites in United States
- Volunteers
- 469 people
- Sponsor
- Carmot Therapeutics, Inc.
Covid19
Comorbidities And Complications Associated With Covid-19 Infection
To evaluate the spectrum of comorbidities and complications and its impact on the clinical outcome in hospitalized patients with coronavirus disease 2019 (COVID-19).
- Trial name
- NCT04563442
- Testing
- complication
- Volunteers
- 200 people
- Sponsor
- Assiut University
Parkinson's Disease, Insomnia
Effects of Lemborexant on Motor-sleep Comorbidity in Parkinson's Disease
The aim of this study is to explore the effects of the dual orexin receptor antagonist Lemborexant on improving motor and sleep comorbidity in patients with Parkinson's disease.
- Conditions
- Parkinson's Disease, Insomnia, Motor Disorder
- Trial name
- NCT07384429
- Testing
- Lemborexant
- Where
- China
- Volunteers
- 44 people
- Sponsor
- YangPan
Nicotine Dependence
Drug /Cue Interactions In Alcohol-Tobacco Comorbidity
The purpose of this study is to determine how people react to different combinations of alcohol and nicotine.
- Trial name
- NCT00816231
- Testing
- Tobacco, Alcoholic Beverage
- Where
- United States
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Mild Cognitive Impairment, Obesity
Caloric Restriction in Obese Patients With Mild Cognitive Impairment: Effects on Adiposity, Comorbidity and Cognition
Obesity has been associated with cognitive impairments, lower blood flow, metabolic activity and brain volume. Obesity in adulthood is a risk factor for Alzheimer's disease in the elderly.
- Trial name
- NCT01286389
- Testing
- medical care, caloric restriction
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Sao Paulo General Hospital
Atrial Fibrillation
Early Atrial Fibrillation Ablation for Stroke Prevention in Patients With High Comorbidity Burden (EASThigh-AFNET 11)
EASThigh-AFNET 11 is an international, prospective, randomized, open, blinded endpoint assessment, multicenter trial (Treatment Strategy trial).
- Trial name
- NCT06324188
- Testing
- Early atrial fibrillation ablation, Usual Care
- Where
- 7 sites in Australia, Canada and 5 more
- Volunteers
- 2,312 people
- Sponsor
- Atrial Fibrillation Network
Muscular Dystrophy, Facioscapulohumeral
Neurological and Psychiatric Comorbidities Patients With FSHD 1 and 2
The investigators propose to conduct a comparative pilot cognitive and psychiatric profiles of 10 patients Facio-Scapulo-Humeral Dystrophy (= FHSD) type 1 and 10 patients with type 2 FSHD study.
- Trial name
- NCT02032979
- Testing
- Psychiatric test
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Cataract
Visual Outcomes of Tecnis Symfony Opti-Blue EDOF Intraocular Lens (IOL)
Tecnis Symfony Optiblue EDOF IOL is the latest version of Tecnis Symfony IOL with a violet light filter (VLF), which blocks short-wavelength light and improves the quality of vision while minimizing visual disturbances.
- Trial name
- NCT06500416
- Testing
- Tecnis Symfony OptiBlue/ Tecnis Symfony OptiBlue toric IOL
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Coastal Eye Surgeons PLLC
Dengue Fever
A Study of Dengue Tetravalent Vaccine (TDV) in Adults (Age 45 to 60 and >60 to 79 Years)
Dengue fever is caused by an infection with the dengue virus. Vaccination with Dengue Tetravalent Vaccine (TDV) can help prevent dengue fever.
- Trial name
- NCT06579755
- Testing
- TDV
- Where
- 7 sites in Argentina, Brazil and 2 more
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Takeda
Depression, Opioid Dependence
Desvenlafaxine in Opioid-Dependent Patients
Background: Although substitution therapy has been shown to be highly effective to retain opioid-dependent patients in treatment and reduce drug use, this population is afflicted by numerous conditions including depression.
- Conditions
- Depression, Opioid Dependence, Methadone Treatment
- Trial name
- NCT02200406
- Testing
- Desvenlafaxine
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Metabolic Disorders in Children
Early Detection of Metabolic Syndrome and Obesity Comorbidities
To assess : Compare predictive value of waist to-height ratio and bio-electrical impedance analysis versus BMI in early detection of metabolic syndrome parameters and complication of obesity.
- Trial name
- NCT05681104
- Testing
- Waist-height ratio, body mass index, Bio-electrical impedance analysis
- Volunteers
- 275 people
- Sponsor
- Assiut University
Multimorbidity, Comorbidity
A Study on the Effectiveness of Comprehensive Intervention Based on Specialized Physical Education Courses in the Prevention of Comorbidity Among Junior Middle School Students
Junior high school students are in a critical period of physical and mental development, currently facing two major health challenges: first, persistently high rates of myopia with a noticeable trend toward younger onset; second…
- Conditions
- Multimorbidity, Comorbidity, Common Diseases in Children and Adolescents, Myopia
- Trial name
- NCT07237698
- Testing
- The intervention group participated in specialized physical education courses.
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xiaoyan Wu
Various Comorbidities
Pulse CO-Oximetry Noninvasive Monitoring and Laboratory Measurements of Subject Blood Samples
Characterize Masimo noninvasive technology in spot check reading on subjects and make comparison to invasive blood sampling tested on reference analyzers.
- Trial name
- NCT01638455
- Testing
- Noninvasive device
- Where
- United States
- Volunteers
- 2,776 people, healthy volunteers welcome
- Sponsor
- Masimo Corporation
Childhood Chronic Kidney Disease
Cardiovascular Comorbidity in Children With Chronic Kidney Disease
This 3-year study will systematically evaluate the prevalence, clinical symptoms, and progression of CV and kidney disease and assess the impact of potential genetic, pharmacological, behavior, and environmental risk factors in a…
- Trial name
- NCT03227055
- Where
- Taiwan
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Chronic Kidney Diease, Diabetes Mellitus
Chronic Kidney Disease and Metabolic Disorders in the Elderly
The goal of this observational study is to investigate the impact of metabolic comorbidities on outcomes in elderly Chinese adults, through two parallel sub-cohorts: one comprising elderly individuals without chronic kidney…
- Conditions
- Chronic Kidney Diease, Diabetes Mellitus, Hypertension, Hyperlipidemia
- Trial name
- NCT07494526
- Where
- 2 sites in China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Acute Leukemia, Myelodysplastic Syndromes
Clinical Registration Study of Haplo-HSCT for Elderly Patients With Acute Leukemia/ Myelodysplastic Syndrome
This study is an open, prospective, single-center, single-arm study expanded based on the study of NCT03412409.The primary objective of this study is to evaluate the transplantation efficacy of the RIC conditioning regimen in…
- Trial name
- NCT05902416
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University People's Hospital
Gambling, Alcohol Consumption
Web-based vs In-person Personalized Feedback Intervention for Comorbid Substance Use and Disordered Gambling
Rates of gambling and substance use behaviors are elevated among emerging adults (ages 18-24), and these behaviors are individually and jointly associated with a host of negative consequences.
- Conditions
- Gambling, Alcohol Consumption, Cannabis
- Trial name
- NCT01529047
- Testing
- Personalized Feedback Intervention
- Where
- United States
- Volunteers
- 361 people
- Sponsor
- University of Washington
Obese Adults
A Phase 1 Study of VK2735 in Obese Adults Without Comorbidities
The goal of this Phase 1, randomized, double-blind, placebo-controlled study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of VK2735 in adults who are obese (BMI ≥ 30 kg/m2) without comorbidities.
- Trial name
- NCT07838740
- Testing
- VK2735 Drug
- Where
- 2 sites in United States
- Volunteers
- 270 people
- Sponsor
- Viking Therapeutics, Inc.
End-Stage Renal Disease
Peroral Supplemental Nutrition in End-stage Renal Disease With and Without HIV Comorbidity
End-stage renal disease is often accompanied by malnutrition due to less appetite, metabolic changes or both. Human immunodeficiency virus-infection may exacerbate the state of malnutrition.
- Trial name
- NCT00687050
- Testing
- peroral high-caloric supplemental nutrition, peroral supplemental nutrition
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Mental Health Disorder, Substance Use Disorder
The IMPROV Project: Improving Mental Health and Substance Use Treatment Provision (IMPROV) Among People Living With HIV (Human Immunodeficiency Virus) in Atlanta
This project consists of a pilot trial to assess the preliminary impact of a stigma-reduction training to reduce clinic-level stigma and the You℞ Decision prescribing platform to increase HIV care providers' self-efficacy related…
- Conditions
- Mental Health Disorder, Substance Use Disorder, Stigmatization, Implementation Science
- Trial name
- IMPROV (NCT05415891)
- Testing
- Modified Health Policy Project (HPP) HIV-Stigma and Discrimination Reduction Training Curriculum, You℞ Decision prescribing platform
- Where
- 2 sites in United States
- Volunteers
- 333 people, healthy volunteers welcome
- Sponsor
- RTI International