Clinical trials: Comorbidity, open to volunteers
Obesity, Overweight
A Study of Orforglipron (LY3502970) in Chinese Participants With Obesity or Overweight and Weight-Related Health Problems
The purpose of this study is to learn how well orforglipron works and how safe it is in Chinese adults with obesity or overweight and related health problems. Participation in this study will last about 53 weeks (about 1 year).
- Trial name
- ATTAIN-CN (NCT07790861)
- Testing
- Orforglipron
- Where
- 13 sites in China
- Volunteers
- 192 people
- Sponsor
- Eli Lilly and Company
Persistent Atrial Fibrillation Longstanding
Multitarget Pulse Field Ablation Guided by Endocardial and Non-invasive Atrial Driver Mapping (PFA+ADM) Pilot Study. Development of an Ablation Strategy to Improve the Efficacy of Long Standing Atrial Fibrillation Ablation in Patients With High Comorbidity Burden or Heart Failure
To assess the efficacy and safety of a percutaneous ablation strategy that targets multiple extrapulmonary structures as the Cox-Maze IV.
- Trial name
- PFA+ADM (NCT07118488)
- Testing
- Multitarget PFA Ablation
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundacion para la Innovacion en Biomedicina (FIBMED)
ST-segment Elevation Myocardial Infarction (STEMI)
Systemic Organ Communication in STEMI
Despite progress in pre-hospital care, ambulance logistics, pharmacotherapy and PPCI techniques, ST-segment elevation myocardial infarction (STEMI) continues to confer a substantial burden of morbidity and mortality.
- Trial name
- SYSTEMI (NCT03539133)
- Testing
- collection of clinical data
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
HIV
Quality of Care in French HIV Infected Patients
The objective of the Dataids cohort is to continue a long-term, prospective collection of clinical, laboratory and therapeutic data on a large cohort of HIV infected patients seeking care in 15 HIV centers in France in order : 1.
- Trial name
- Dataids_PEC (NCT02898987)
- Where
- 39 sites in France, Guadeloupe and 1 more
- Volunteers
- 30,000 people
- Sponsor
- DatAids
Coronary Heart Disease
Unstable Angina Pectoris in Comorbidity With Anxiety-depressive Syndrome
Introduction: Today it is necessary to emphasize that coronary heart disease is often associated with anxiety disorders. Research over the years has shown several and sometimes surprising links between coronary heart disease and…
- Trial name
- NCT04599621
- Testing
- Collection of blood samples to determine the level of certain cytokines (TNF-α, IL-1β, IL-4 and IL-10),Collection of blood samples to determine the level of uric acid
- Where
- Uzbekistan
- Volunteers
- 3 people
- Sponsor
- Samarkand State Medical Institute
Obese Adults, MDD
NUTRIMOOD-Inflammation and Depressive Comorbidity in Obesity: Modulation by Omega-3 Polyunsaturated Fatty Acids Status
A 12-week, randomized, placebo-controlled trial testing the efficacy of n-3 PUFA treatment (EPA, 2 g/day) in alleviating depressive symptoms in a subgroup of obese subjects with comorbid depression and low n-3 PUFA status (n-3…
- Trial name
- NCT07439744
- Testing
- Eicosapentaenoic acid (omega-3 fatty acid)
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Science and Technology Council, Taiwan
Parkinson Disease
The Effects of 24-Weeks Community-based Brisk Walking in People With Parkinson's Disease
The goal of this clinical trial is to investigate if brisk walking can improve walking function in people with Parkinson's disease and what kind of brisk walking intervention that is most effective.
- Trial name
- We-Walk-PD (NCT06707402)
- Testing
- WALK, ACTIVE, CON
- Where
- Denmark
- Volunteers
- 129 people
- Sponsor
- University of Aarhus
Hypertension, Diabete Type 2
Comorbidity-Oriented Primary Care and Integrated Management for Hypertension and Diabetes Mellitus
The COMPACT-HTDM study is a parallel, two-arm cluster randomized controlled trial designed to evaluate a comorbidity-oriented integrated primary care management model for elderly patients with coexisting hypertension and type 2…
- Conditions
- Hypertension, Diabete Type 2, Comorbidities and Coexisting Conditions
- Trial name
- COMPACT-HTDM (NCT07528391)
- Testing
- Integrated Comorbidity Management Package, Usual Care intervention
- Volunteers
- 960 people
- Sponsor
- Nanchang University
Food Insecurities, Cardiometabolic Comorbidities
Human Immunodeficiency Virus (HIV) Food Insecurities
The objectives of this study are to better understand how FI (food insecurities) contributes to the development of cardiometabolic comorbidities among PWH (People with HIV) and to test a novel bilingual FI intervention designed…
- Conditions
- Food Insecurities, Cardiometabolic Comorbidities, HIV, PreDiabetes
- Trial name
- NCT04943861
- Testing
- weCare/Secure, Usual Care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Wake Forest University Health Sciences
Rheumatoid Arthritis, Comorbidities and Coexisting Conditions
Comorbidity Management in Rheumatic Disease.
Rheumatoid arthritis is a disease where the immune system attacks the body by mistake, causing inflammation of the joints and other body parts.
- Trial name
- NCT06579222
- Testing
- Primary Care Rheumatology Family Physician Consultation
- Where
- Canada
- Volunteers
- 199 people
- Sponsor
- Western University, Canada
NAFLD, NASH
The European NAFLD Registry
The European NAFLD Registry is a prospectively recruited, observational study supporting the study of the clinical phenotype, natural history, disease outcomes and pathophysiology of Non-Alcoholic Fatty Liver Disease and…
- Conditions
- NAFLD, NASH, NASH - Nonalcoholic Steatohepatitis, Fibrosis, Liver
- Trial name
- NCT04442334
- Where
- 37 sites in Belgium, Finland and 10 more
- Volunteers
- 10,000 people
- Sponsor
- Newcastle University
Obesity, Type 2 Diabetes Mellitus
Safety and Effectiveness of Tirzepatide in Patients With Obesity at Hospital de Clínicas, Paraguay
This is a Phase 4 observational study evaluating the safety and effectiveness of tirzepatide (T.G.) manufactured by INDUFAR S.A.
- Conditions
- Obesity, Type 2 Diabetes Mellitus, Overweight With Comorbidities
- Trial name
- NCT07492563
- Testing
- Tirzepatide (T.G.)
- Where
- Paraguay
- Volunteers
- 300 people
- Sponsor
- LABORATORIOS INDUFAR
Bronchial Asthma
Impact of Comorbidities, Some Biomarkers, Micro RNA in Childhood Asthma Phenotypes
Assess response to treatment in children with bronchial asthma attending Assiut university children hospital. Role of comorbidities in controlling symptoms of bronchial asthma.
- Trial name
- NCT07230912
- Testing
- Short Acting Beta 2 Agonist
- Volunteers
- 82 people
- Sponsor
- Assiut University
Back Pain, Neck Pain
Exploring Multimorbidity in Patients With Spinal Pain
Spinal pain is frequently accompanied by other chronic conditions (multimorbidity) and the predicted rise in multimorbidity prevalence emphasizes the need for studies to understand its impact on patients with chronic pain…
- Conditions
- Back Pain, Neck Pain, Comorbidities and Coexisting Conditions
- Trial name
- NCT06402409
- Where
- Denmark
- Volunteers
- 2,000 people
- Sponsor
- Jacob Christiansen Gandløse
Long Covid-19
LOng COvid COmorbidities: Endocrine,Metabolic,Neuropsychiatric,Muscle,Cardiovascular,Pulmonary,Dermatologic Dysfunctions
Considering the compelling amount of studies focused on patients in the active phase of COVID-19 disease and the scarcity of studies focused on patient cured from disease aimed at evaluating the sequelae of SARS-CoV-2 infection…
- Trial name
- LO-COCO (NCT05293366)
- Testing
- Assessments of endocrinological phenotypes of LO-COCO patients, Assessment of muscular phenotypes of LO-COCO patients, Assessment of neuropsychiatric phenotypes of LO-COCO patients
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Federico II University
Cutaneous Squamous Cell Carcinoma
Cemiplimab and Quad Shot Radiation for Cutaneous Squamous Cell Carcinoma in the Head and Neck
The goal of this clinical trial is to learn if the combination of the drug cemiplimab along with a short course of radiation therapy called Quad Shot can be successfully given in several rounds to elderly or frail patients with…
- Trial name
- NCT07869823
- Testing
- Cemiplimab, Radiation Therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Chronic Kidney Diease, Diabetes Mellitus
Chronic Kidney Disease and Metabolic Disorders in the Elderly
The goal of this observational study is to investigate the impact of metabolic comorbidities on outcomes in elderly Chinese adults, through two parallel sub-cohorts: one comprising elderly individuals without chronic kidney…
- Conditions
- Chronic Kidney Diease, Diabetes Mellitus, Hypertension, Hyperlipidemia
- Trial name
- NCT07494526
- Where
- 2 sites in China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Cerebral Palsy
Effects of Associated Impairments on Activity and Participation in Children With Cerebral Palsy
This study will investigate the effects of associated impairments on the activity levels and social participation of school-aged children with Cerebral Palsy (aged 6-12) and their impact on their families' quality of life and…
- Trial name
- NCT06944171
- Where
- Turkey (Türkiye)
- Volunteers
- 107 people
- Sponsor
- Hacettepe University
Adolescents With Obesity or Overweight With Weight-Related Comorbidities
A Study of IBI362 in Chinese Adolescents With Obesity or Overweight
The study is designed to assess the efficacy and safety of multiple doses of IBI362 in Chinese adolescent subjects with obesity or overweight.
- Trial name
- NCT07255209
- Testing
- IBI362
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Obesity
Effect of LY3437943 Versus Placebo in Participants Who Have Obesity or Are Overweight
Phase 2, multicenter, randomized, double-blind, placebo-controlled study evaluating once-weekly subcutaneous retatrutide (LY3437943) at multiple maintenance dose levels versus placebo in adults with obesity or overweight with…
- Trial name
- GZBF (NCT07467447)
- Testing
- Retatrutide (LY3437943), Standardized diet and physical activity counseling throughout the study.
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Hudson Biotech