Clinical trials: Comparative Study, open to volunteers
Abnormal Uterine Bleeding (AUB)
Pipelle Versus Manual Vacuum Aspiration Cannula for Endometrial Biopsy in Women With Abnormal Uterine Bleeding
women globally, often requiring endometrial tissue sampling for accurate evaluation and diagnosis. Traditional office-based sampling techniques like Pipelle are widely used, but the disposable instruments can be relatively…
- Trial name
- NCT07731581
- Testing
- Manual Vacuum Aspiration (MVA) Cannula, Pipelle Endometrial Suction Curette
- Volunteers
- 80 people
- Sponsor
- University of Health Sciences Lahore
Opioid Use Disorder
A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder
VA-BRAVE will determine whether a 28-day long-acting injectable sub-cutaneous formulation of buprenorphine at a target dose of 300 milligrams (mg) is superior in retaining Veterans in opioid treatment and in sustaining opioid…
- Trial name
- VA-BRAVE (NCT04375033)
- Testing
- Sublingual buprenorphine with naloxone, Injectable subcutaneous buprenorphine
- Where
- 25 sites in United States
- Volunteers
- 952 people
- Sponsor
- VA Office of Research and Development
Catheter-Associated Urinary Tract Infection, Catheter Related Complication
Comparative Study Between Foley and T-Control® Catheter in Patients With Long-term Catheterization
This is a comparative, randomized, controlled pilot study. The main objective of this study is to evaluate the efficacy, comfort, and patient experience in people with long-term bladder catheterization with T-Control® versus…
- Conditions
- Catheter-Associated Urinary Tract Infection, Catheter Related Complication, Quality of Life
- Trial name
- NCT05860231
- Testing
- Foley catheter, T-Control catheter
- Where
- 2 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Rethink Medical SL
Ankle Sprain
Computed Tomography With Stress Maneuvers for Evaluation of Distal Tibiofibular Syndesmosis Instability (CTMETS)
The main aim of this study was to investigate which strategy can diagnose more accurately syndesmotic instability among an existing index test (ankle CT in neutral position) and two new add-on index tests (ankle CT in a stress…
- Trial name
- CTMETS (NCT04095598)
- Testing
- Comparative Ankle Tomography with Stress Maneuvers
- Where
- Brazil
- Volunteers
- 133 people
- Sponsor
- Hospital Israelita Albert Einstein
Post Operative Pain, Acute
Effect of Preoperative Oral Pregabalin Versus Intraoperative Fentanyl on Postoperative Analgesia
Pregabalin is a structural analogue of gamma amino butyric acid (GABA). It binds to presynaptic alpha-2-delta subunit of voltage gated calcium channels in the brain and the spinal cord.
- Trial name
- NCT05150795
- Testing
- Pregabalin 150mg, Fentanyl 100 micrograms ampoule
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pseudoexfoliation Syndrome, Biomechanical Parameters
Corneal Biomechanics, Optical Properties and Anterior Segment Structural Features in Patients With Pseudoexfoliation
The purpose of this study is to assess the effect of pseudoexfoliation syndrome on corneal biomechanics, optical clarity of the cornea, and anterior segment structural features.
- Conditions
- Pseudoexfoliation Syndrome, Biomechanical Parameters, Corneal Densitometry
- Trial name
- CorPEX (NCT06731530)
- Testing
- Pentacam-AXL, HD Analyzer, Corvis ST
- Where
- Greece
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Ventilator Associated Bacterial Pneumonia (VABP), Hospital Acquired Bacterial Pneumonia (HABP)
Safety, Pharmacokinetics and Efficacy of BV100 Plus Low Dose Polymyxin B Plus Ceftazidime/Avibactam, or Plus Cefiderocol in Patients With Pulmonary and Extrapulmonary Infections Due to Carbapenem-resistant Acinetobacter Baumannii-calcoaceticus Complex
This Phase IIb study aims to evaluate the safety and efficacy of BV100 in combination with low dose polymyxin B plus ceftazidime/avibactam or cefiderocol in patients with suspected or confirmed CRABC infections.
- Conditions
- Ventilator Associated Bacterial Pneumonia (VABP), Hospital Acquired Bacterial Pneumonia (HABP), Blood Stream Infection, Meningitis, Bacterial
- Trial name
- RIV- CARE (NCT07431307)
- Testing
- BV100 with 50 mg polymyxin B plus ceftazidime/avibactam, BV100 with 50 mg polymyxin B plus cefiderocol, Best Available Therapy (BAT)
- Volunteers
- 120 people
- Sponsor
- BioVersys AG
Cushing Syndrome
Pharmacokinetic (PK), Pharmacodynamic (PD) and Tolerability of Osilodrostat in Pediatric Patients With Cushing's Syndrome
Multicenter, open-label, non-comparative study to evaluate the pharmacokinetics, pharmacodynamics, and tolerability of osilodrostat in children and adolescent patients with Cushing's syndrome.
- Trial name
- NCT03708900
- Testing
- LCI699
- Where
- 15 sites in United States, Belgium and 5 more
- Volunteers
- 12 people
- Sponsor
- RECORDATI GROUP
Neuroendocrine Tumors
Comparing DLL3 PET/CT to Standard Scans in Neuroendocrine Cancer
This study is testing a new PET/CT scan that uses a special tracer called [⁶⁸Ga]Ga-DLL3 nanobody to see if it can better detect cancer spread (metastases) in people with neuroendocrine tumors than the standard scans currently…
- Trial name
- DSC-NEC (NCT07733024)
- Testing
- 68Ga-PFD3
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Tingting Yuan
Back Pain Lower Back Chronic
A Comparative Study of Erector Spinae Fascia (ESF) Injection and Dry Needling Combined With Functional Rehabilitation (FR) in Patients With Chronic Low Back Pain Who Have Undergone Spinal Surgery (SPIN-NEED)
Chronic low back pain represents a major public health issue, with an estimated prevalence of up to 23% in the adult population and a significant impact on quality of life and functional capacity.
- Trial name
- SPIN-NEED (NCT07555496)
- Testing
- infiltration of the erector spinae fascia, Dry needling
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Clinique de la Côte d'Emeraude
Rosacea, Erythematotelangiectatic, Rosacea Subtype 1 (Erythematotelangiectatic)
Dermocosmetic Treatment for Facial Redness in Rosacea With or Without Laser Therapy
The aim of this clinical study is to evaluate the effectiveness and safety of a dermocosmetic product in reducing facial redness and visible blood vessels associated with erythematotelangiectatic rosacea.
- Trial name
- NCT07521462
- Testing
- Dermocosmetic tested product, Vascular laser treatment
- Where
- France
- Volunteers
- 50 people
- Sponsor
- ISISPHARMA
Hirschsprung Disease
Surgical Approach for the Treatment of Hirschsprung Disease Using the Swenson Technique (SMILES)
Hirschsprung disease (HD) is a rare congenital disorder of the enteric nervous system, affecting approximately 1 in 5,000 live births.
- Trial name
- SMILES (NCT07468565)
- Testing
- transanal or laparoscopy assisted Swenson coloanal pullthrough
- Volunteers
- 70 people
- Sponsor
- University Hospital, Angers
Coronary Artery Disease
Comparative Analysis of NTG-Pd/Pa and Saline-Pd/Pa (CANS)
The goal of this observational study is to compare the value of NTG-Pd/Pa and saline-Pd/Pa in participants with intermediate stenosis of the coronary artery.
- Trial name
- NCT07195968
- Testing
- NTG-Pd/Pa measurement, Saline-Pd/Pa measurement
- Where
- 3 sites in Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Congenital Inguinal Hernia
Needlescopic Versus Traditional Laparoscopic Inguinal Hernia Repair in Pediatrics
The aim of the study is to evaluate the results of Needlescopic inguinal hernia repair in comparison with traditional laparoscopic repair in children as regard operative time, cosmetic appearance, recurrence and other…
- Trial name
- NCT06660550
- Testing
- laparoscopic inguinal hernia repair, Needlescopic inguinal hernia repair
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Sohag University
Esophageal Diseases
Comparative Assessment of Esophagitis in Cases With and Without Esophageal Motility Disorders: A Prospective Study
Achalasia is a neuro-degenerative disorder marked by changes in the peristalsis of the esophagus and the lack of relaxation in the lower esophageal sphincter (LES), thought to be due to damage to the myenteric plexus with an…
- Trial name
- NCT06835374
- Testing
- Per oral endoscopy myotomy (Per oral endoscopy myotomy), Endoscopy procedure
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Asian Institute of Gastroenterology, India
Vascular Access Devices, Vascular Access
Impact of a Long Peripheral Venous Catheter Protocol in Pediatric and Neonatal Care
The purpose of this study is to evaluate the impact of a training intervention aimed at nursing personnel on the appropriateness of the indication of long peripheral venous catheters in candidate pediatric and neonatal patients…
- Conditions
- Vascular Access Devices, Vascular Access, Vascular Access Complication
- Trial name
- NCT07870876
- Testing
- Training program on long peripheral catheter insertion
- Volunteers
- 33 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Glaucoma
Comparative Study of the Tomey FT-1000, and Goldmann Applanation Tonometer (GAT)
This study is intended to evaluate the agreement between Intraocular pressure(IOP) measurements obtained with the FT-1000 non-contact tonometer and a GAT to confirm the feasibility of the measurement procedures.
- Trial name
- NCT07804277
- Testing
- Non Contact Tonometer and Applanation Tonometer
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tomey Corporation
Intubation Complications
Ramped Versus Supine Position for Emergent Endotracheal Intubation in Adult Patients; Prospective, Randomized, Comparative Study
Endotracheal intubation is a life saving procedure for critically unwell and injured patients presenting to the emergency department.
- Trial name
- NCT06924411
- Testing
- Direct Intubation
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Myopia
Comparative Study of SMILE, ICL, and Wavelight Plus Alcon Technologies in Myopia Correction
Myopia is a prevalent refractive error with significant lifestyle impact. While traditional SMILE (Small Incision Lenticule Extraction) and ICL (Implantable Collamer Lens) surgeries are standard options, the advent of the…
- Trial name
- NCT06788418
- Testing
- Wavelight Plus Alcon system, SMILE, ICL
- Where
- 2 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Visionly Plus Eye Hospital
Regional Anesthesia, Video-assisted Thoracoscopic Surgery (VATS)
Ultrasound-Guided Erector Spinae Plane Block Versus Thoracoscopically-Guided Intercostal Nerve Block in Video-Assisted Thoracoscopic Surgery
Effective postoperative pain management is essential after thoracic surgery. Insufficient pain control may impair breathing and coughing, increasing the risk of pulmonary complications such as collapsed lungs (atelectasis) or…
- Conditions
- Regional Anesthesia, Video-assisted Thoracoscopic Surgery (VATS), Erector Spinae Plane Block, Intercostal Nerve Block
- Trial name
- NCT07535697
- Testing
- Anesthesiological, Ultrasound-Guided "Erector Spine Plane Block" (ESPB), Surgical, Thoracoscopically-Guided "Intercostal Nerve Block" (ICNB)
- Where
- Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sana Klinikum Offenbach