Clinical trials: Comparative Study, open to volunteers
Systemic Lupus Erthematosus
Safety, Pharmacokinetics, Immunogenicity BCD-256-1 and Divozilimab in Subjects With Systemic Lupus Erythematosus
The goal of this clinical trial to investigate the safety, pharmacokinetics, pharmacodynamics, immunogenicity, and preliminary efficacy of BCD-256 alone and in combination with anti-CD20 therapy (divozilimab) as second- or…
- Trial name
- NCT07136389
- Testing
- BCD-256, Divozilimab
- Where
- Russia
- Volunteers
- 135 people
- Sponsor
- Biocad
Total Hip Arthroplasty (THA), Antibiotic Prophylaxis
Infection-related Revision Rates After Single-dose Versus Multiple-dose Antibiotic Prophylaxis in Primary Hip and Knee Arthroplasty: a Comparative Implementation Study.
Prosthetic Joint Infection (PJI) is a significant issue in joint replacement surgeries, causing additional surgeries and substantial healthcare costs.
- Conditions
- Total Hip Arthroplasty (THA), Antibiotic Prophylaxis, Revision Arthroplasty, Total Knee Arthroplasty
- Trial name
- REVISE (NCT07053943)
- Where
- Netherlands
- Volunteers
- 70,000 people
- Sponsor
- JointResearch
Effect of Ligamentum Teres in Hiatus Hernia
Ligamentum Teres Cardiopexy in Treatment of GERD After Sleeve Gastrectomy
The aim of this study is to evaluate the effectiveness and safety of surgical repair techniques with ligamentum teres cardiopexy on symptomatic relief of gastroesophageal reflux disease (GERD), recurrence rates of hiatus hernia…
- Trial name
- GERD (NCT07349732)
- Testing
- ligamentum teres cardiopexy
- Where
- Egypt
- Volunteers
- 35 people
- Sponsor
- Andrew Mokbel
Caries,Dental, Pain
Comparative Evaluation of SMART Hall Technique Vs. Conventional SS Crown in Primary Molars: a Randomized Clinical Trial
Dental caries, particularly in primary molars, significantly affects children's oral health and overall well-being. Traditional management with stainless steel crowns (SSCs) involves significant tooth reduction and advanced…
- Conditions
- Caries,Dental, Pain, Plaque, Dental, Gingival Bleeding
- Trial name
- RCT (NCT06453005)
- Testing
- SMART Hall Technique or procedure
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- C K S Teja Institute Of Dental Sciences & Research
Chronic Low Back Pain, Facet Joint Syndrome
MRgFUS and RFA for Treatment of Facet-joint Osteoarthritis Low Back Pain
This is a prospective, randomized, two-arm, phase II study. The purpose of this study is: To evaluate and compare the efficacy and safety of magnetic resonance-guided focused ultrasound (MRgFUS) and radiofrequency ablation (RFA)…
- Trial name
- NCT03168802
- Testing
- MRgFUS ablation, Radiofrequency ablation
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Medical University Hospital
Acne Vulgaris
Fractional CO2 Laser Delivery of Topical Insulin Versus Platelet Rich Plasma in Treatment of Atrophic Post Acne Scars
compare the efficacy and safety of treating atrophic post acne scars with topical insulin versus Platelet rich Plasma PRP combined with fractional ablative Co2 laser
- Trial name
- NCT06590909
- Testing
- Fractional CO2 laser assisted PDT
- Volunteers
- 22 people
- Sponsor
- Assiut University
Breast Cancer
Comparative Study of QL1209 and Perjeta® in Healthy Male Participants
The goal of this clinical trial is to evaluate the similarity of pharmacokinetic (PK) parameters following a single intravenous infusion of QL1209 (Perjeta® biosimilar candidate) and Perjeta® (Pertuzumab) in healthy male…
- Trial name
- NCT07861139
- Testing
- QL1209, US-Perjeta®
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Low Rectal Cancer, Rectal Neoplasms
Reinforced Versus Conventional Anastomosis in Laparoscopic Low Rectal Cancer Resection: A Comparative Study
Study Description This prospective, controlled clinical study aims to compare the clinical outcomes of reinforced anastomosis using 8-10 interrupted sutures versus the conventional Dixon procedure in patients undergoing…
- Conditions
- Low Rectal Cancer, Rectal Neoplasms, Colorectal Cancer
- Trial name
- NCT07346534
- Testing
- Reinforced Anastomotic Suturing (8-10 Interrupted Sutures), Conventional Laparoscopic Dixon Procedure
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai 10th People's Hospital
Macular Holes
Comparative Study of Decellularized Human Amniotic Membrane Hydrogel and Inverted Internal Limiting Membrane Flap in Idiopathic Large Macular Holes
The human amniotic membrane (hAM) patch, introduced by Rizzo et al. in 2018, showed a 100% anatomical success rate for large or failed macular holes over a 6-month follow-up.
- Trial name
- MACROHOLE (NCT06433284)
- Testing
- 25-gauge pars plana vitrectomy with inverted flap technique and SF6 tamponade, 25-gauge pars plana vitrectomy with complete internal limiting membrane peeling with amniotic membrane hydrogel filling and SF6 tamponade
- Where
- Thailand
- Volunteers
- 26 people
- Sponsor
- Walailak University
Coronary Artery Atherosclerosis
Radial vs Vena No-Touch Assessment
This study examines the outcomes of coronary artery bypass grafting (CABG) in women at 1 year after surgery. A randomized controlled trial is planned, including a comparative analysis of two observed groups depending on the…
- Trial name
- RAVENTA (NCT07552948)
- Testing
- radial artery graft, no-touch vein graft
- Where
- Russia
- Volunteers
- 110 people
- Sponsor
- Tomsk Cardiology Research Institute
Persistent Atrial Fibrillation
Pulmonary Vein Isolation Alone or in Combination With Substrate Modulation After Electric Cardioversion Failure
This study aims at assessing whether electric cardioversion can act as a discriminant factor between patients requiring Pulmonary Vein Isolation (PVI) procedure alone or PVI procedure combined with substrate modulation.
- Trial name
- PACIFIC (NCT05264831)
- Testing
- Pulmonary Vein Isolation (PVI) alone, PVI procedure associated with substrate modulation
- Where
- 13 sites in France
- Volunteers
- 450 people
- Sponsor
- Elsan
Polycystic Ovary Syndrome (PCOS), Female Infertility
Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS
This study aims to compare the outcomes of two ovarian stimulation protocols used in in vitro fertilization (IVF): the progestin-primed ovarian stimulation (PPOS) protocol and the GnRH antagonist protocol.
- Trial name
- PPOS-PCOS-IVF (NCT07394530)
- Testing
- Progestin-Primed Ovarian Stimulation (PPOS), GnRH Antagonist Protocol
- Where
- Vietnam
- Volunteers
- 400 people
- Sponsor
- Hanoi General Hospital (Vietnam)
Lice; Head Lice
Efficacy and Safetyof a Medical Device With a Physical Mode of Action (X92001919) Versus Paranix Anti-lice Shampoo.
Comparison of the efficacy of a new medical device with a physical mode of action to Paranix anti-lice shampoo in the treatment of head lice infestation.
- Trial name
- NCT07244523
- Testing
- Pulverize (X92001919)
- Volunteers
- 34 people
- Sponsor
- Oystershell NV
Rosacea, Erythematotelangiectatic, Rosacea Subtype 1 (Erythematotelangiectatic)
Dermocosmetic Treatment for Facial Redness in Rosacea With or Without Laser Therapy
The aim of this clinical study is to evaluate the effectiveness and safety of a dermocosmetic product in reducing facial redness and visible blood vessels associated with erythematotelangiectatic rosacea.
- Trial name
- NCT07521462
- Testing
- Dermocosmetic tested product, Vascular laser treatment
- Where
- France
- Volunteers
- 50 people
- Sponsor
- ISISPHARMA
Erectile Disfunction, Coronary Artery Disease (CAD)
"Erectile Function After PCI in MI and Non-MI Patients"
The goal of this observational study is to assess changes in patients' erectile function after percutaneous coronary intervention (PCI) using a standard IIEF (International Index of Erectile Function) questionnaire at 1, 3, and 6…
- Conditions
- Erectile Disfunction, Coronary Artery Disease (CAD), Diabete Mellitus, Anxiety
- Trial name
- ERECT-PCI (NCT07444697)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Oral Complication
A Comparative Study of Three Oral Care Methods in NIMV Patients in Intensive Care
This study aims to examine the effects of different oral care methods on oral health in patients receiving non-invasive mechanical ventilation (NIMV) in the intensive care unit.
- Trial name
- NCT07200297
- Testing
- Active Comparator: Control, Experimental: Electric Toothbrush, Experimental: Manual Toothbrush
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- SÜMEYYE BİLGİLİ TEKİN
Varicose Veins
Study on Treatment of Varicose Veins by Endovenous Laser (1940 nm vs 1470 nm)
The goal of this clinical trial is to compare efficacy of two wavelength for EndoVenous Laser Ablation (EVLA) in treatment of varicose veins of the lower limbs. The main questions it aims to answers are : 1.
- Trial name
- NEWWAVE (NCT05663359)
- Testing
- EVLA 1940 nm, EVLA 1470 nm
- Where
- France
- Volunteers
- 280 people
- Sponsor
- Clinique Pasteur
Gynecomastia
Modularities of Management of Severe Grades of Gynecomastia.
Gynecomastia is defined as a benign enlargement of the mammary glands, commonly diffused among men. The prevalence of gynecomastia ranges from 38 to 64 percent in the male population.
- Trial name
- NCT07257445
- Testing
- Group A: circumerolar skin excision, Group B: elliptical skin excision with pedicled flap +_ lateral roll excision., Group C: elliptical skin excision with free nipple areola complex +_ lateral roll excision.
- Volunteers
- 45 people
- Sponsor
- Assiut University
Patient Cataract
Propofol Versus Sevoflurane Anesthesia on the Intraocular Pressure and Hemodynamics in Patient Undergoing Cyclophotocoagulation
we use two different technique of anaesthesia for anaesthesia of patient undergoining CPC operation (20 each) were comparable with regard to demographic data and hemodynamic variables, IOP.
- Trial name
- cyclophotocoag (NCT07445672)
- Testing
- Propofol and Fentanyl administration, Sevoflurane and fentanyl administration
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Periodontal Regeneration, Wound Healing
Effects of Standard PRP and Extracellular Vesicle-Enriched PRP on Human Gingival Fibroblasts
The goal of this study is to compare the biological effects of two blood-derived products, standard platelet-rich plasma (PRP) and extracellular vesicle-enriched PRP (EV-enriched PRP), on human gingival (gum) fibroblasts, the…
- Conditions
- Periodontal Regeneration, Wound Healing, Fibroblast
- Trial name
- NCT07855822
- Where
- Turkey (Türkiye)
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Inonu University