Clinical trials: Comparison of the Efficacy
Chronic Obstructive Pulmonary Disease
Clinical Endpoint Bioequivalence Study of Test and Reference Inhalation Products in Patients With COPD With Device Robustness
The purpose of this study is to show bioequivalence of test product to reference product based on baseline-adjusted forced expiratory volume in one second (FEV1).
- Trial name
- NCT03137992
- Testing
- Test Product (tiotropium bromide inhalation powder), Reference Product (Spiriva®)
- Where
- 34 sites in United States
- Volunteers
- 377 people
- Sponsor
- Lupin, Inc.
Hypotension After Spinal Anesthesia, Hypotension During Cesarean Delivery
Comparison of the Efficacy of Continuous Metaraminol Infusion Versus Continuous Norepinephrine Infusion for the Prevention of Hypotension During Cesarean Section Under Spinal Anaesthesia. A Randomised Controlled Trial.
The aim of this double-blind randomised study will be to compare a fixed-rate prophylactic metaraminol infusion to a fixed-rate prophylactic norepinephrine infusion during elective cesarean section under combined spinal-epidural…
- Trial name
- NCT07363109
- Testing
- Metaraminol infusion, Norepinephrine infusion
- Volunteers
- 80 people
- Sponsor
- Aretaieion University Hospital
Neovascular Age-related Macular Degeneration, Age-Related Macular Degeneration
A 3-month Study to Assess the Safety and Effectiveness of ONS-5010 in Subjects With Neovascular Age-related Macular Degeneration (AMD)
Multicenter, randomized, masked, controlled study of the safety and effectiveness of intravitreally administered ONS-5010.
- Conditions
- Neovascular Age-related Macular Degeneration, Age-Related Macular Degeneration, Wet Macular Degeneration
- Trial name
- NCT06190093
- Testing
- bevacizumab, ranibizumab
- Where
- 61 sites in United States
- Volunteers
- 400 people
- Sponsor
- Outlook Therapeutics, Inc.
Shoulder Pain, Musculoskeletal Diseases
The Efficacy of PRP Injection in the Treatment of Rotator Cuff Syndrome
The aim of this study is to investigate the efficacy of single PRP injection compared with placebo and multiple PRP injections on pain, quality of life, shoulder function and muscle strength in the treatment of patients who have…
- Conditions
- Shoulder Pain, Musculoskeletal Diseases, Rotator Cuff Tendinopathy, Rotator Cuff Syndrome
- Trial name
- PRP (NCT05561452)
- Testing
- Single PRP Injection, Multiple PRP Injections
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Afyonkarahisar Health Sciences University
Clostridia Difficile Colitis, Clostridium; Sepsis
Comparing the Effectiveness of IV Bezlotoxumab Versus Placebo in Decreasing Morbidity and Mortality in Patients With Fulminant C. Diff Requiring Surgery.
A new medication, Bezlotoxumab, has been approved for treatment of recurrent Clostridium difficile diarrhea by the U.S. Food and Drug Administration. The way this new medication works, is by binding the toxin produced by C.
- Trial name
- NCT03756454
- Testing
- Bezlotoxumab, Normal Saline
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Ohio State University
Chronic Ulcer of Lower Extremity
Plasma On Chronic Wounds for Epidermal Regeneration
Every year, 5 million people throughout Germany suffer from extensive, often chronic wounds. Cold plasma is an innovative therapeutic approach in the treatment of these persistent tissue defects.
- Trial name
- POWER (NCT05855499)
- Testing
- CPtcube, CPTpatch
- Where
- 8 sites in Germany
- Volunteers
- 120 people
- Sponsor
- Coldplasmatech
Chronic Plaque Psoriasis, Moderate to Severe Chronic Plaque Psoriasis
A Study to Evaluate the Efficacy and Safety of Bimekizumab Compared to Placebo and an Active Comparator in Adult Subjects With Moderate to Severe Chronic Plaque Psoriasis
This is a study to compare the efficacy of bimekizumab versus placebo and an active comparator in the treatment of subjects with moderate to severe chronic plaque psoriasis (PSO).
- Conditions
- Chronic Plaque Psoriasis, Moderate to Severe Chronic Plaque Psoriasis, Psoriatic Arthritis
- Trial name
- BE VIVID (NCT03370133)
- Testing
- Bimekizumab, Ustekinumab
- Where
- 105 sites in United States, Australia and 9 more
- Volunteers
- 567 people
- Sponsor
- UCB Biopharma SRL
Metastatic, Uveal Melanoma
Selumetinib (AZD6244: ARRY-142886) (Hyd-Sulfate) in Metastatic Uveal Melanoma (SUMIT)
Selumetinib therapy in patients with metastatic uveal melanoma.
- Trial name
- SUMIT (NCT01974752)
- Testing
- 75mg selumetinib, Dacarbazine
- Where
- 31 sites in United States, Belgium and 9 more
- Volunteers
- 152 people
- Sponsor
- AstraZeneca
Treatment Resistant Depression (TRD)
Comparison of Different Acceleration Modes of Transcranial Magnetic Stimulation
To compare the efficacy and safety of 6 times a day, 10 times a day acceleration mode and sham stimulation intervention for TRD, and to explore the antidepressant mechanism of accelerated mode, so as to provide a more simple and…
- Trial name
- NCT06881030
- Testing
- Noninvasive transcranial magnetic stimulation was administered six times daily, Noninvasive transcranial magnetic stimulation was administered 10 times daily
- Volunteers
- 45 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Erosive Esophagitis
Efficacy of TAK-438 Compared to AG-1749 (Lansoprazole) in the Maintenance Treatment of Healed Erosive Esophagitis
The purpose of this study is to confirm the efficacy of TAK-438, once daily (QD), compared to lansoprazole for the maintenance treatment of healed erosive esophagitis and to determine the clinical dose.
- Trial name
- NCT01459367
- Testing
- TAK-438, Lansoprazole
- Where
- 37 sites in Japan
- Volunteers
- 607 people
- Sponsor
- Takeda
Status Epilepticus, Convulsions
Intranasal Lorazepam Versus Intramuscular Paraldehyde in Paediatric Convulsions
The purpose of this study is to evaluate intranasal lorazepam in paediatric status epilepticus. This is a potentially, more effective, safer and cheaper treatment for a common paediatric medical emergency compared to our present…
- Trial name
- NCT00116064
- Testing
- intranasal lorazepam, intramuscular paraldehyde
- Where
- Malawi
- Volunteers
- 156 people
- Sponsor
- Kamuzu University of Health Sciences
Diabetic Peripheral Neuropathic Pain
Efficacy and Safety of Gabapentin/B-complex Versus Pregabalin in Diabetic Peripheral Neuropathy Pain Management
This is a multicenter, randomized, open-label, parallel, Phase 4 clinical trial to compare efficacy and safety of gabapentin/B-complex versus pregabalin in diabetic peripheral neuropathy pain (DPNP) management.
- Trial name
- NCT01364298
- Testing
- Gabapentin/B-complex, Pregabalin
- Where
- Mexico
- Volunteers
- 353 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Leukoma
Safety and Effectiveness of the RHCIII-MPC Biosynthetic Cornea in Patients Requiring Anterior Lamellar Keratoplasty
In this study safety and effectiveness of bioengineered cornea comprising of interpenetrating networks of recombinant human type III collagen and synthetic phospholipid - phosphorylcholine - will be tested in patients with…
- Trial name
- NCT02424006
- Testing
- RHCIII-MPC cornea, Donor cornea
- Where
- India
- Volunteers
- 2 people
- Sponsor
- L.V. Prasad Eye Institute
Down Syndrome, Motor Performance
Bobath and Vojta Therapy for DS
Different physiotherapy approaches and education programs are applied to minimize motor and mental impairment in children with Down syndrome (DS).
- Conditions
- Down Syndrome, Motor Performance, Bobath Therapy, Vojta Technique
- Trial name
- NCT04536506
- Testing
- Bobath Therapy, Vojta technique
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people
- Sponsor
- Pamukkale University
HIV Infections
The Effectiveness of Nelfinavir and Efavirenz, Used Alone or Together, Combined With Other Anti-HIV Drugs in Patients Who Have Taken Anti-HIV Drugs
Steps I and II: The purpose of this study is the following: To look at how many patients achieve undetectable HIV blood levels at Week 16.
- Trial name
- NCT00001087
- Testing
- Ritonavir, Nelfinavir mesylate, Efavirenz
- Where
- 6 sites in United States, Puerto Rico
- Volunteers
- 300 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Uremic Pruritus, Chronic Kidney Disease-associated Pruritus
Fexofenadine Versus Gabapentin for Uremic Pruritus in Patients on Regular Hemodialysis
Several studies investigated the effectiveness of Gabapentin in Uremic Pruritus (UP). No previous studies investigated the use of fexofenadine in UP.
- Conditions
- Uremic Pruritus, Chronic Kidney Disease-associated Pruritus, Hemodialysis, End-stage Renal Disease
- Trial name
- NCT06466421
- Testing
- Fexofenadine, Gabapentin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Abdominal Pain, Gallstone; Colic
RELIEF-pathway in Patients With Upper Abdominal Pain
Upper abdominal pain (UAP) is a common symptom and frequently the reason to visit the hospital. The prevalence of epigastric pain in the Dutch population is estimated to be as high as 37%.
- Conditions
- Abdominal Pain, Gallstone; Colic, Dyspepsia, Irritable Bowel Syndrome
- Trial name
- RELIEF (NCT06002516)
- Testing
- RELIEF-pathway
- Where
- Netherlands
- Volunteers
- 471 people
- Sponsor
- Radboud University Medical Center
Plasmodium Falciparum Malaria (Uncomplicated)
A Trial to Compare the Efficacy, Safety and Tolerability of Combinations of 3 Anti-malarial Drugs Against Combinations of 2 Anti-malarial Drugs (Asia)
A partially blinded randomised controlled non-inferiority trial comparing the efficacy, tolerability and safety of Triple ACTs artemether-lumefantrine + amodiaquine (AL+AQ) and artesunate- mefloquine+piperaquine (AS-MQ+PPQ) with…
- Trial name
- DeTACT-ASIA (NCT03939104)
- Testing
- Artemether-lumefantrine+amodiaquine, Artesunate-mefloquine+piperaquine
- Where
- 3 sites in Bangladesh, Cambodia
- Volunteers
- 103 people
- Sponsor
- University of Oxford
Acne Vulgaris
To Compare the Efficacy and Safety of Clindamycin Phosphate 1.2% / Benzoyl Peroxide 5% Gel of CHL Versus DUAC® Gel
This is an Randomized, Double-blind, Multicentric, Parallel-group, Active and Placebo Controlled, Three Arm Clinical Study. The main objective is to evaluate bioequivalence of Test formulation (Clindamycin Phosphate 1.2%/Benzoyl…
- Trial name
- NCT02005666
- Testing
- Clindamycin Phosphate 1.2% / Benzoyl Peroxide 5% Gel, DUAC® Gel
- Where
- 36 sites in United States, India
- Volunteers
- 850 people
- Sponsor
- Zydus Lifesciences Limited
Endocarditis, Bacteremia
Efficacy and Safety of Dalbavancin Compared to Standard of Care Antibiotic Therapy for the Completion of Treatment of Patients With Complicated Bacteremia or Infective Endocarditis
This study will compare dalbavancin to standard of care (SOC) antibiotic therapy for the completion of therapy in patients with complicated bacteremia or infective endocarditis.
- Trial name
- NCT03148756
- Testing
- Dalbavancin, Standard of Care
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- AbbVie
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