Clinical trials: Comparison of the Efficacy
Spur, Heel
Radial or Focus Extracorporeal Shock Wave Therapy in Epin Calcanei
Objective: The aim of the study was to investigate the effectiveness of radial and focused ESWT treatment on pain, function, and size of the calcaneal spur in patients with a clinical and radiological diagnosis of epin calcanei.
- Trial name
- NCT06356064
- Testing
- Extracorporeal shock wave therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people
- Sponsor
- Ankara City Hospital Bilkent
Autism
Efficacy and Safety of Trichuris Suis Ova (TSO) as Compared to Placebo in Autism Spectrum Disorder
This is a randomized, double-blind, 2-arm, placebo-controlled crossover study in pediatric patients with autism spectrum disorder with all patients receiving 16-weeks of TSO treatment and 16 weeks of placebo.
- Trial name
- NCT02140112
- Testing
- Trichuris suis ova
- Where
- 5 sites in United States
- Volunteers
- 23 people
- Sponsor
- Coronado Biosciences, Inc.
PTSD
Effectiveness of Trauma Management Therapy and Prolonged Exposure Therapy
The purpose of this requirement is to identify an effective exposure psychotherapy paradigm for the treatment of Post-Traumatic Stress Disorder (PTSD) in active duty service members and veterans by comparing different exposure…
- Trial name
- NCT04549493
- Testing
- Exposure Therapy
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Atelectasis
Efficacy of Percussive Ventilation Therapy (MetaNeb ®) Compared With Mucolytic Agents for Atelectasis in the Mechanically Ventilated Pediatric Patient
The purpose of this study is to evaluate whether a therapy that uses a machine called a continuous high frequency oscillator (CHFO) is more successful at removing mucus than medications that thin out the mucus.
- Trial name
- NCT02168387
- Testing
- continuous high frequency oscillator (CHFO), Acetylcysteine, dornase alfa
- Volunteers
- 39 people
- Sponsor
- Duke University
Seasonal Allergic Rhinitis
Azelastine Allergen Chamber - Onset of Action Study
This study is to assess the Onset of Action and Efficacy of azelastine hydrochloride 0.15% in treating the nasal symptoms of seasonal allergic rhinitis (SAR) induced by an allergen challenge in an Environmental Exposure Unit…
- Trial name
- NCT06126952
- Testing
- Treatment A: Azelastine hydrochloride 0.15% nasal spray (Azelair), Treatment C: Ryaltris (Active Control) - mometasone furoate monohydrate and olopatadine hydrochloride nasal spray
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- MEDA Pharma GmbH & Co. KG
Acne Vulgaris
Clinical Study to Test the Efficacy and Safety of Adapalene, 0.1%
The purpose of this study is to determine whether Adapalene, 0.1% is safe and effective in the treatment of Acne Vulgaris.
- Trial name
- NCT00598832
- Testing
- Adapalene lotion 0.1%, Adapalene Lotion Vehicle
- Where
- 34 sites in United States, Canada
- Volunteers
- 1,075 people
- Sponsor
- Galderma R&D
Hypertension With Hyperlipidemia
Study to Evaluate the Safety and Efficacy of CJ-30060 in Hypertensive Patients With Hyperlipidemia
To evaluate the safety and efficacy of CJ-30060 compared with amlodipine/valsartan combination therapy and valsartan/rosuvastatin combination therapy in hypertensive patients with hyperlipidemia
- Trial name
- NCT03536598
- Testing
- Amlodipine 10 mg + Valsartan 160 mg + Rosuvastatin 20 mg, Amlodipine 10 mg + Valsartan 160 mg, Valsartan 160 mg + Rosuvastatin 20 mg
- Volunteers
- 203 people
- Sponsor
- HK inno.N Corporation
Labor, Pain
Intravenous Remifentanil Patient-controlled Analgesia (PCA) and Epidural Patient Controlled Epidural Analgesia (PCEA) for Labor Analgesia
Women requesting analgesia do not always wish to receive a potent analgesic method, and may fear the risks of epidural analgesia.
- Trial name
- NCT00801047
- Testing
- Bupivacaine epidural, Remifentanil
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hadassah Medical Organization
Osteosarcoma, Localised High Grade Osteosarcoma of the Limbs
Comparison of High-Dose Methotrexate (HDM) Plus Doxorubicin to HDM Plus Etoposide-Ifosfamide in Osteosarcoma Children
The purpose of this study is to compare two preoperative chemotherapy regimens based on high-dose methotrexate courses given alternately either with doxorubicin or with etoposide-ifosfamide.
- Trial name
- NCT00180908
- Testing
- Etoposide, Ifosfamide, Methotrexate, Doxorubicin, Methotrexate
- Where
- France
- Volunteers
- 226 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Bacterial Conjunctivitis
Clinical and Microbial Efficacy of ISV403 in Bacterial Conjunctivitis
To evaluate the clinical and microbial efficacy of ISV-403 administered three times a day (TID) for 5 days compared to vehicle three times a day for 5 days in the treatment of bacterial conjunctivitis
- Trial name
- NCT00622908
- Testing
- ISV-403, Vehicle
- Volunteers
- 270 people
- Sponsor
- Bausch & Lomb Incorporated
Hypertension
A Clinical Study to Evaluate the Safety and Efficacy of the Combination of Aliskiren and Amlodipine in Hypertensive Non Responders Patients
To evaluate the blood pressure lowering effect and safety of aliskiren 150 mg used in combination with amlodipine 5 mg in patients with essential hypertension not adequately responsive to amlodipine 5 mg.
- Trial name
- NCT00219076
- Testing
- aliskiren
- Where
- 2 sites in United States, Germany
- Volunteers
- 504 people
- Sponsor
- Novartis
Dyslipidemias
Phase 3 Trial to Evaluate the Efficacy and Safety of DKP21102_B Added on to DKP21102_A Compared With DKP21102_A
Phase 3 study to evaluate the efficacy and safety of DKP21102_B Added on to DKP21102_A Compared with DKP21102_A
- Trial name
- NCT05809687
- Testing
- DKP21102_C, DKP21102_B, DKP21102_A
- Sponsor
- Dongkwang Pharm. Co., Ltd.
Overweight, Obesity
A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide
The purpose of this study is to find out if zenagamtide is safe and effective for treating participants who have excess body weight compared to treatment with semaglutide.
- Trial name
- AMAZE 7 (NCT07668414)
- Testing
- Zenagamtide, Semaglutide
- Where
- 45 sites in United States
- Volunteers
- 650 people
- Sponsor
- Novo Nordisk A/S
Ulcerative Colitis
Efficacy, Safety and Immunogenicity of the Proposed Biosimilar Vedolizumab PB016 in Comparison With Entyvio®
This is a multi-center, randomized, parallel arm, double-blind study with approximately 750 participants with moderately to severely active Colitis Ulcerosa randomized to receive either PB016 or Entyvio®
- Trial name
- UCESIVE (NCT05771155)
- Testing
- Intravenous (IV) infusions
- Where
- Georgia
- Volunteers
- 750 people
- Sponsor
- Polpharma Biologics S.A.
Type 2 Diabetes Mellitus
Comparison of the Safety and Efficacy of HOE901-U300 With Lantus in Older Patients With Type2 Diabetes Insufficiently Controlled on Their Current Antidiabetic Medications
Primary Objective: To demonstrate the non-inferiority of H0E901-U300 to Lantus, in change of glycated hemoglobin A1c (HbA1c). Secondary Objectives: To demonstrate the superiority of H0E901-U300 in comparison with Lantus in…
- Trial name
- SENIOR (NCT02320721)
- Testing
- Insulin Glargine (HOE901 - U300), Insulin Glargine (HOE901 - U100), Background therapy
- Where
- 162 sites in United States, Argentina and 16 more
- Volunteers
- 1,014 people
- Sponsor
- Sanofi
Sleep
The Effectiveness of a Proprietary of a Botanical Extract on Sleep Quality
The purpose of this study is to evaluate the efficacy and superiority of a botanical based sleep product on sleep quality as compared to melatonin, among healthy female participants.
- Trial name
- NCT06894108
- Testing
- Proprietary Blend of Botanical Extracts, Melatonin
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Nutraceuticals Research Institute
Female Pattern Hair Loss
Efficacy of Therapy With the Spironolactone Pills Compared to Minoxidil Lotion in Female Pattern Hair Loss
This study evaluates the efficacy of therapy with the anti-androgen spironolactone compared to topical minoxidil in female pattern hair loss.
- Trial name
- NCT00175617
- Testing
- Spironolactone, Minoxidil
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Acne Vulgaris, Acne
Study of NVN1000 Topical Gel and Topical Gel Vehicle in the Treatment of Moderate to Severe Acne Vulgaris
The primary objective of this study is to compare the tolerability, safety and efficacy of NVN1000 Topical Gel and Topical Gel Vehicle in the treatment of subjects with moderate to severe acne vulgaris.
- Trial name
- NCT01556698
- Testing
- NVN1000, Vehicle
- Where
- Dominican Republic
- Volunteers
- 70 people
- Sponsor
- Novan, Inc.
Coronary Arterial Disease (CAD)
The Safety and Efficacy for In-segment Late Lumen Loss of the 'Genoss® SCB' Versus 'SeQuent® Please NEO' in Patients With Coronary ISR
The objective of this study is to evaluate the safety and effectiveness of Genoss® SCB by comparing in-segment late lumen loss (LLL) to the control group (SeQuent® Please NEO) at 6 months in patients with coronary stent-in-stent…
- Trial name
- NCT07159087
- Testing
- Sirolimus Coated PTCA Balloon Catheter(Genoss® SCB), Paclitaxel Coated PTCA Balloon Catheter(SeQuent® Please NEO)
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Genoss Co., Ltd.
Diabetes Mellitus, Type 2
Loose-dose Combination of Acarbose and Metformin for T2DM in Metformin-failure Patients
To demonstrate the efficacy and safety of acarbose and metformin loose-dose combination as compared to metformin monotherapy in the treatment of subjects with T2DM that is inadequately controlled by metformin alone
- Trial name
- NCT03349684
- Testing
- Acarbose, Metformin
- Where
- 29 sites in China
- Volunteers
- 287 people
- Sponsor
- Bayer
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