Clinical trials: Complete Spinal Cord Injury
Neurogenic Bladder, Spinal Cord Injuries (Complete and Incomplete)
Spinal COrd NeuromodulaTor by SpIneX and ScoNE to Treat NeurogeniC BladdEr - SCONE "CONTINENCE" Clinical Study
The purpose of this study is to evaluate the effectiveness and safety of SCONE neuromodulation therapy after 12 weeks of therapy in comparison to inactive sham control in improving symptoms of Neurogenic Lower Urinary Tract…
- Conditions
- Neurogenic Bladder, Spinal Cord Injuries (Complete and Incomplete), Stroke, Multiple Sclerosis
- Trial name
- CONTINENCE (NCT05301335)
- Testing
- SCONE
- Where
- 12 sites in United States, Canada and 1 more
- Volunteers
- 126 people
- Sponsor
- SpineX Inc.
Spinal Cord Injuries
Urodynamics of Suprasacral Spinal Cord Injury Patients
The medical records of 215 patients with spinal cord injury(SCI) at the Department of Rehabilitation Medicine of the 2nd Affiliated Hospital of Wenzhou Medical University, Wenzhou, China were evaluated between January 1, 2016 and…
- Trial name
- NCT04642170
- Volunteers
- 101 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Spinal Cord Injuries
Minocycline and Perfusion Pressure Augmentation in Acute Spinal Cord Injury
While research in animal models of spinal cord injury have provided many promising insights, human studies have failed to produce effective therapies.
- Trial name
- NCT00559494
- Testing
- Minocycline, SCPP augmentation, SCPP control
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- University of Calgary
Spine Injury, Cord Injury, Spinal
The Outcome of Injured Cervical Spinal Cord With Uncontrolled Swelling Under Duraplasty
Overall Objective: To assess whether incorporating duraplasty alongside bony decompression enhances motor function outcomes in individuals following Traumatic Spinal Cord Injury (TSCI).
- Conditions
- Spine Injury, Cord Injury, Spinal, Cord Infarction Spinal, Incomplete Spinal Cord Injury
- Trial name
- NCT06552507
- Testing
- Duroplasty
- Where
- Taiwan
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Brainstem Stroke, ALS
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01)
People with brainstem stroke, advanced amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), or other disorders can become unable to move or speak despite being awake and alert.
- Conditions
- Brainstem Stroke, ALS, Tetraplegia, Spinal Cord Injuries
- Trial name
- BG-Tablet-01 (NCT06511934)
- Testing
- BrainGate Neural Interface System
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Leigh R. Hochberg, MD, PhD.
Spinal Cord Injuries (Complete and Incomplete), Spinal Cord Injuries (SCI)
Feasibility of Transcutaneous Spinal Stimulation in Rehabilitation
Transcutaneous spinal stimulation (TSS) is a non-invasive neuromodulation approach that delivers electrical stimulation to spinal nerve roots through electrodes placed over the spinal cord.
- Conditions
- Spinal Cord Injuries (Complete and Incomplete), Spinal Cord Injuries (SCI), Spinal Cord Injuries and Disorders (SCI/D)
- Trial name
- NCT07898150
- Testing
- Transcutaneous Spinal Stimulation, Inpatient SCI Physiotherapy, Inpatient SCI Occupational Therapy
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Janelle Unger
Spinal Cord Injuries, Chronic
High Doses of 4-aminopyridine in Clinically Complete Chronic Spinal Cord Injury Patients.
150 patients with clinically complete chronic spinal cord Injury will be included in a randomized, parallel, placebo controlled, multi-centric, phase III trial.
- Trial name
- NCT03899584
- Testing
- 4-Aminopyridine
- Where
- Mexico
- Volunteers
- 150 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Motor Complete Spinal Cord Injury
The Effects of Passive Gait Training in Complete Motor Spinal Cord Injury (SCI)
The purpose of this study is to determine whether a three times per week, 2 month robotic assisted treadmill gait training program, will beneficially affect the fitness, physical and psychological well-being, and the vascular and…
- Trial name
- NCT01349478
- Testing
- LOKOMAT
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- Dr. Gabriel Zeilig
Injury, Spinal Cord
Study of Probable Benefit of the Neuro-Spinal Scaffold™ in Subjects With Complete Thoracic AIS A Spinal Cord Injury as Compared to Standard of Care
This is a randomized, controlled, single-blind, multicenter, two Arm (Treatment or "Scaffold" Arm; Standard of Care or "Comparator" Arm) of a Neuro-Spinal Scaffold to evaluate whether the Scaffold is safe and demonstrates…
- Trial name
- INSPIRE 2 (NCT03762655)
- Testing
- Neuro-Spinal Scaffold
- Where
- 16 sites in United States
- Volunteers
- 20 people
- Sponsor
- InVivo Therapeutics
Spinal Cord Injury
Autologous Incubated Macrophages for Patients With Complete Spinal Cord Injuries
Autologous Incubated Macrophages (ProCord) is being developed as a therapy for acute, complete spinal cord injury (SCI). The therapy is intended to reverse the loss of motor and sensory function.
- Trial name
- NCT00073853
- Testing
- Autologous Incubated Macrophages (cell therapy)
- Where
- 7 sites in United States, Israel
- Volunteers
- 61 people
- Sponsor
- Proneuron Biotechnologies
Neurogenic Bowel, Spinal Cord Injuries (SCI)
Transcutaneous Spinal Cord Stimulation for Bowel Management in Individuals with Motor Complete Spinal Cord Injury
The primary goals of this pilot trial are to understand the feasibility and safety of thoracolumbar transcutaneous spinal cord stimulation for neurogenic bowel management in individuals with new onset, traumatic, cervicothoracic…
- Trial name
- NCT06801431
- Testing
- Transcutaneous spinal cord stimulation
- Volunteers
- 5 people
- Sponsor
- Nova Scotia Health Authority
Traumatic Thoracic Acute Spinal Cord Injury
The INSPIRE Study: Probable Benefit of the Neuro-Spinal Scaffold for Treatment of AIS A Thoracic Acute Spinal Cord Injury
This is an HDE probable benefit, open-label, non- randomized, single-arm, multicenter study to evaluate the safety and probable benefit of the poly(lactic-co-glycolic acid)-b-poly(L-lysine) Scaffold ("Scaffold") in subjects with…
- Trial name
- NCT02138110
- Testing
- Neuro-Spinal Scaffold
- Where
- 8 sites in United States
- Volunteers
- 20 people
- Sponsor
- InVivo Therapeutics
Spinal Cord Injuries, Spinal Cord Injury at C5-C7 Level
Multi-functional Neuroprosthetic System for Restoration of Motor Function in Spinal Cord Injury
This study is to evaluate the use of a fully implanted device for providing hand function, reach, and trunk function to individuals with cervical spinal cord injury. Funding Sources: FDA OOPD NIH NINDS
- Conditions
- Spinal Cord Injuries, Spinal Cord Injury at C5-C7 Level, Spinal Cord Injury Cervical, Spinal Cord Injury at C5-C7 Level With Complete Lesion
- Trial name
- NNP-UE+T (NCT02329652)
- Testing
- Networked Neuroprosthetic System for Grasp and Trunk
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Anne Bryden
Spinal Cord Injury
Autologous Mesenchymal Stem Cells Transplantation in Thoracolumbar Chronic and Complete Spinal Cord Injury Spinal Cord Injury
The purpose of this study is to analyze the safety and efficacy of autologous bone marrow mesenchymal stem cell transplantation in patients with thoracolumbar chronic and complete spinal cord injury.
- Trial name
- NCT02574585
- Testing
- Autologous mesenchymal cells transplantation
- Volunteers
- 40 people
- Sponsor
- Hospital Sao Rafael
Spinal Cord Injury
Spinal Cord Injury Epidural Stimulation
This is a feasibility study to test the use of epidural stimulation to restore volitional function previously lost due to spinal cord injury.
- Trial name
- NCT02592668
- Testing
- Epidural Stimulator
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Spinal Cord Injuries (Complete and Incomplete)
Pilot Testing of Vagus Nerve Stimulation for Early Spinal Cord Injury Recovery
This study looks at a treatment called transcutaneous auricular vagus nerve stimulation, or taVNS. taVNS uses a small device worn on the ear to gently stimulate a nerve.
- Trial name
- PIVOTS-Rehab (NCT07562113)
- Testing
- Transauricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Alabama at Birmingham
Severe Mobility Impairment, Spinal Cord Injuries (Complete and Incomplete)
The Impact of 'Digital Strolling' on Depression and Quality of Life of People With Severe Mobility Impairment
This intervention aims to develop and test the feasibility, acceptability, and preliminary effects of a "Digital Strolling" intervention among people with SMI.
- Conditions
- Severe Mobility Impairment, Spinal Cord Injuries (Complete and Incomplete), Poliomyelitis
- Trial name
- NCT07073144
- Testing
- Virtual walking, Passive observing walking
- Where
- Hong Kong
- Volunteers
- 24 people
- Sponsor
- The Hong Kong Polytechnic University
Complete Spinal Cord Injuries
Transplantation of Autologous Olfactory Ensheathing Cells in Complete Human Spinal Cord Injury
The purpose of this experimental therapy is an assessment of the safety and feasibility of transplantation of autologous olfactory ensheathing glia and olfactory fibroblasts obtained from the olfactory mucosa in patients with…
- Trial name
- NCT01231893
- Testing
- olfactory mucosa ensheathing cell grafting, rehabilitation, rehabilitation
- Where
- Poland
- Volunteers
- 10 people
- Sponsor
- Wroclaw Medical University
Spinal Cord Injury
Autologous Mesenchymal Stem Cells Transplantation in Cervical Chronic and Complete Spinal Cord Injury
The purpose of this study is to analyze the safety and efficacy of autologous bone marrow mesenchymal stem cell transplantation in patients with cervical chronic and complete spinal cord injury.
- Trial name
- NCT02574572
- Testing
- Autologous mesenchymal cells transplantation
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Hospital Sao Rafael
Complete Spinal Cord Injury, Surgery
Anesthetic Requirement and Stress Hormone Response During Surgery in Spinal Cord-injured Patients
Spinal cord injury (SCI) reduces anesthetic requirements and stress hormonal responses. Anesthetic requirements and stress hormone response are compared in SCI patients undergoing anesthesia with sevoflurane supplemented with…
- Trial name
- NCT01683916
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Chonnam National University Hospital