Clinical trials: Complete Spinal Cord Injury
Spinal Cord Injuries, Paraplegia, Complete
Epidural Stimulation After Neurologic Damage
This study will evaluate a method to optimize parameter settings in epidural spinal cord stimulation used to recover lower extremity volitional movement.
- Trial name
- E-STAND (NCT03026816)
- Testing
- Epidural Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Minnesota
Spinal Cord Injury, Tetraplegia/Tetraparesis
Evaluation of Usability and Safety of the System Atalante in Patients With High Paraplegia and Tetraplegia
The objective of this clinical trial is to determine whether the Atalante X exoskeleton can be safely utilized by patients with tetraplegia and high paraplegia (at or above T4).
- Conditions
- Spinal Cord Injury, Tetraplegia/Tetraparesis, Paraplegia, Complete, Paraplegia, Incomplete
- Trial name
- QUATRO (NCT06939634)
- Testing
- Hands-free exoskeleton
- Where
- 3 sites in France
- Volunteers
- 35 people
- Sponsor
- Wandercraft
Spinal Cord Injuries
Spinal Stimulation for Chronic Complete Tetraplegia
The purpose of this study is investigate the acceptability and effectiveness of transcutaneous spinal cord stimulation in people with complete high level spinal cord injury.
- Trial name
- Complete TESCS (NCT05522920)
- Testing
- Therapy with and without spinal cord stimulation
- Volunteers
- 12 people
- Sponsor
- NHS Greater Glasgow and Clyde
Xerosis
Safety and Efficacy of SQIN™ on Xerosis in Adults With Mobility Problems and Paralysis
In the general population, xerosis is often caused by external factors such as seasonal changes. In that case, the best way to relieve dry skin is to use a standard moisturizer.
- Trial name
- NCT02429206
- Testing
- SQIN, standard moisturizing cream (Glaxal Base)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Nordic Life Science Pipeline Inc.
Acute Spinal Cord Injury
Transplantation of Autologous Adipose Derived Stem Cells (ADSCs) in Spinal Cord Injury Treatment
This study is designed to assess the safety and effect of autologous adipose derived stem cell (ADSCs) transplantation in acute spinal cord injury patients. 1.
- Trial name
- NCT02034669
- Testing
- Laminectomy, Intradural space, Intrathecal
- Where
- Vietnam
- Volunteers
- 48 people
- Sponsor
- Tri Phuoc Biotechnology., JSC
Spinal Cord Injury
Study to Assess Safety, Tolerability and MTD of a Central Pattern Generator-activating Tritherapy (SPINALON) in Patients With Chronic Spinal Cord Injury
As a first-in-class (Central Pattern Generator or CPG activator) approach, this tritherapy candidate called SPINALON has been identified and is currently under development for its capacity to temporarily induce episodes of…
- Trial name
- NCT01484184
- Testing
- SPINALON (buspirone + levodopa + cardidopa)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Nordic Life Science Pipeline Inc.
Spinal Cord Injuries
Early Surgical Intervention Combined With Weight-supported Walking Training
To determine the efficacy of a novel combinatorial treatment involving early surgical intervention and long-term weight-bearing walking training in spinal cord injury (SCI) patients clinically diagnosed as complete or American…
- Trial name
- NCT04034108
- Testing
- Surgical intervention combined with weight-supported ambulation training
- Where
- 2 sites in China
- Volunteers
- 339 people
- Sponsor
- Kunming Tongren Hospital
Spinal Cord Injuries
Training for Persons With Complete SCI for FES Cycling: a Case Series
The main objective of this study is to validate the effectivity of a simple home-based training for cycling with functional electrical stimulation (FES).
- Trial name
- NCT04412447
- Testing
- Functional Electrical Stimulation
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Centre de Rééducation et Réadaptation Fonctionnelle La Châtaigneraie
Spinal Cord Injury Thoracic
Electromyography-Triggered Electrical Stimulation on Trunk Balance and Muscle Thickness in SCI Patients
The aim of this study was to investigate the effect of electromyography (EMG) triggered electrical stimulation (ES) applied to multifidus and erector spinae muscles on trunk balance in patients with complete thoracic spinal cord…
- Trial name
- NCT06527417
- Testing
- Neuro Trac Myo Plus Pro, Trunk eccentric exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Ankara City Hospital Bilkent
Spinal Cord Injury Cervical, Spinal Cord Injuries (Complete and Incomplete)
Development of Optimal Sensory Feedback Strategies to Maximize Function After Tetraplegia
The goal of this clinical trial is to learn more about how stimulating the nerves involved in sensation (either in the limbs or in the brain) can be used to restore sensation in participants who have a spinal cord injury.
- Trial name
- NCT07225582
- Testing
- Brain Computer Interface (BCI) - Functional Electrical Stimulation (FES) system
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Case Western Reserve University
Spinal Cord Injury
Restoring Walking With a Powered Exoskeleton After Spinal Cord Injury
Powered exoskeletons have emerged recently, promising to offer walking to individuals with severe spinal cord injury who are unable to walk.
- Trial name
- NCT02322125
- Testing
- ReWalk
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Alberta
Spinal Cord Injury, Acute, Spinal Cord Injury at C4 Level With Complete Lesion
Safety and Exploratory Efficacy of Transplantation Therapy Using PSA-NCAM(+) NPC in AIS-A Level of Sub-acute SCI
This study intends to evaluate the safety and exploratory efficacy of transplantation therapy using neural precursor cells (PSA-NCAM(+) NPC) derived from the human embryonic stem cell line for the treatment of paralysis and other…
- Conditions
- Spinal Cord Injury, Acute, Spinal Cord Injury at C4 Level With Complete Lesion, Spinal Cord Injury at C5-C7 Level With Complete Lesion
- Trial name
- SB-SCI-001 (NCT04812431)
- Testing
- Neural precursor cells derived from human embryonic stem cell line
- Where
- 2 sites in South Korea
- Volunteers
- 5 people
- Sponsor
- S.Biomedics Co., Ltd.
Spinal Cord Injury, Spinal Cord Injury No Sensory/Motor in S4-S5
The Aim of This Research is to Better Understand How Complete Spinal Cord Injury May Change Erogenous Zones in Adult Males
A complete spinal cord injury (SCI) in men is characterized by the total loss of motor skills and sensations below the injury. The loss of penile sensation, the erogenous zone primarily involved in sexual response, is involved in…
- Trial name
- QualiEroSCI (NCT06908850)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Fondation Garches
Spinal Cord Injury Thoracic
The Effect of Superimposed Electrical Stimulation on Sitting Balance, Respiratory Functions, and Abdominal Muscle Thickness in Complete Spinal Cord Injury
The primary aim of the current study was to investigate the effects of SiFES (superimposed functional electrical stimulation) on sitting balance in patients with complete Spinal Cord Injury (SCI) compared to exercise alone.
- Trial name
- NCT06104982
- Testing
- NeuroTrac MyoPlus Pro single-channel electromyography biofeedback electrotherapy devices, Isometric strengthening exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Ankara City Hospital Bilkent
Complete Spinal Cord Injury, Incomplete Spinal Cord Injury
Algorithmic-Based Evaluation and Treatment Approach for Robotic Gait Training
The purpose of this study is to develop an algorithmic-based evaluation and treatment approach for wearable robotic exoskeleton (WRE) gait training for patients with neurological conditions.
- Conditions
- Complete Spinal Cord Injury, Incomplete Spinal Cord Injury, Acquired Brain Injury, Multiple Sclerosis
- Trial name
- NCT03057652
- Testing
- ReWalk, EKSO, REX
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Complete or Incomplete Paraplegia/quadriplegia, Spinal Cord Injury
Research on Wireless Brain Implant System for General Control of External Devices
The clinical trial aims to evaluate the safety and efficacy of the minimally invasive, wireless brain-machine interface system (WRS) in enabling general brain control of external devices, such as a cursor and other assistive…
- Conditions
- Complete or Incomplete Paraplegia/quadriplegia, Spinal Cord Injury, Brainstem Stroke, Amyotrophic Lateral Sclerosis
- Trial name
- RISE (NCT06829212)
- Testing
- WRS
- Where
- China
- Volunteers
- 4 people
- Sponsor
- Shanghai StairMed Technology Co., Ltd.
Acute Spinal Cord Injury
Functional Neural Regeneration Collagen Scaffold Transplantation in Acute Spinal Cord Injury Patients
The study is designed to assess the safety and efficacy of functional neural regeneration collagen scaffold transplanted into acute spinal cord injury patients.
- Trial name
- NCT02510365
- Testing
- Functional collagen scaffold
- Where
- 5 sites in China
- Volunteers
- 20 people
- Sponsor
- Chinese Academy of Sciences
Spinal Cord Injuries
Vibrotactile Feedback in Exoskeletons
This study aims to investigate the impact of providing discrete vibrotactile feedback related to weight shift and step initiation on exoskeleton use in individuals with motor-complete SCI.
- Trial name
- NCT06306352
- Testing
- Vibrotactile feedback
- Where
- Netherlands
- Volunteers
- 7 people
- Sponsor
- Sint Maartenskliniek
Spinal Cord Injuries (SCI), Spinal Cord Injury
mSCI: Mobile Health App for Veterans With SCI and Caregivers
Caregivers of persons with Spinal Cord Injury (SCI) face increased risk of psychological distress, health problems, reduced quality of life, relationship strain, and restrictions in social and work participation.
- Conditions
- Spinal Cord Injuries (SCI), Spinal Cord Injury, Spinal Cord Injuries (Complete and Incomplete), Family Caregivers
- Trial name
- NCT07269977
- Testing
- iMHERE 2.0. A mobile health App designed to support veterans with SCI manage their self care, and their caregivers
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh