Clinical trials: Complex Care, active
Health Care Quality, Access, and Evaluation
ICP for Patients With Complex Care Needs in Ontario and Alberta, Canada
The Integrated Care Pathway (ICP) model can reduce hospital readmissions and emergency department (ED) visits while improving continuity of care.
- Trial name
- NCT06679309
- Testing
- Integrated care plan
- Where
- Canada
- Volunteers
- 2,000 people
- Sponsor
- University of Calgary
Multi Drug Resistant Department, Multi Drug Resistant Bacteria
Testing Carriage of Resistant Bacteria Using Swabs on Surfaces and Staff in a Complex Nursing Unit for Patients with Resistant Bacteria
Impact of Care Team and Surfaces on the Spread of Resistant Bacteria in a Specialized Complex Nursing Unit for MDR Pathogen Carriers Background Multi-drug resistant (MDR) bacteria present a severe clinical and epidemiological…
- Trial name
- NCT06696144
- Testing
- Skin swabs for multi drug resistant bacteria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shmuel Harofeh Hospital, Geriatric Medical Center
Endometriosis
Developing a Complex ex Vivo Endometrial Tissue Model to Improve Endometriosis Care
Endometriosis is a chronic gynaecological disease characterised by the growth of endometrium outside the uterus. It affects 10% of childbearing age women. There is no cure for endometriosis.
- Trial name
- OTEndo (NCT06331676)
- Testing
- Tissue collection, Data collection
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- Hospices Civils de Lyon
Pediatric Medical Complexity Based on PMCA Score of 3
Comprehensive Assessment of Reactions to Pharmacogenetics in Complex Care Patients
The goal of this clinical trial is to determine the feasibility and acceptability of Pharmacogenetic Testing, and the attitudes towards the same in caregivers of complex care patients in Cincinnati, OH.
- Trial name
- CAREPICC (NCT07060300)
- Testing
- Agree to Pharmacogenetic Testing
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Aging, Functional Recovery
Supplemental Mobility
This pilot study will evaluate the feasibility of a supplemental mobility intervention, the Safe Transfers And Mobility Program (STAMP).
- Conditions
- Aging, Functional Recovery, Skilled Nursing Facility, Medically Complex
- Trial name
- NCT07872384
- Testing
- High Intensity Rehabilitation, Safe Transfers and Mobility Program, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 192 people
- Sponsor
- University of Colorado, Denver
Opioid Dependence, Substance Abuse Disorders
The MOUD Plus Pilot: Counseling and Peer Support to Support Retention for Medically Complex Patients With Opioid Use Disorder Seen In Primary Care
The goal of this pilot clinical trial is to learn if a community informed designed program of addiction counseling with coordinated community peer navigator for people with Opioid Use Disorder (OUD) and other medical conditions…
- Conditions
- Opioid Dependence, Substance Abuse Disorders, Complex Medical Patients, Primary Care Patients With Chronic Conditions
- Trial name
- MOUD+ (NCT06837662)
- Testing
- MOUD "Plus" Intervention (treatment as usual + coordinated counseling and referral to community based peer), Treatment As Usual (primary care with low threshold MOUD prescribing)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Oregon Health and Science University
Palliative Care
Complex Decisions Regarding Antithrombotic Therapy: the QUIET Study
"Complex decisions regarding antithrombotic therapy: the QUIET study" is a monocentric observational study without drug intervention, conducted through the administration of a questionnaire (survey).The aim of this study is to…
- Trial name
- QUIET (NCT07486154)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Admitted Multimorbid Patients
Poland Integrated Medicines Management (PL-IMM) - Study Assessing the Provision of Complex Clinical Pharmacy Services to Hospitalized Patients
The aim of the study is to assess whether the involvement of a clinical pharmacist in patient care at every stage of hospitalization, from admission to discharge, will improve the quality of healthcare services provided in…
- Trial name
- PL-IMM (NCT07159932)
- Testing
- multidisciplinary treatment
- Where
- Poland
- Volunteers
- 610 people
- Sponsor
- Wroclaw Medical University
Dementia, Alzheimer Disease
Learning Skills Together Family Caregiver Complex Intervention
Learning Skills Together (LST) is a 6-week psychoeducational intervention focused on complex care (nursing) tasks completed by family caregivers to persons living with Alzheimer's Disease and related dementias.
- Conditions
- Dementia, Alzheimer Disease, Caregiver Burden, Self Efficacy
- Trial name
- LST (NCT05846984)
- Testing
- Learning Skills Together Intervention, Caregiver Healthy Living Intervention
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Soft Tissue Sarcoma
Zemetostat With Anlotinib in Patients With Recurrent/Metastatic Head and Neck Soft Tissue Sarcoma
This is a single-center, single-arm, prospective, Phase II clinical study designed to evaluate the efficacy and safety of zemetostat combined with anlotinib in patients with head-and-neck soft-tissue sarcoma featuring SWI/SNF…
- Trial name
- NCT07917949
- Testing
- zemetostat combined with anlotinib
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Complex Patient, Multimorbidity
Pursuing the Triple Aim in Hotspotters: Identification and Integrated Care
Hotspotters are patients with complex care needs, defined by problems in multiple life domains and high acute care use. These patients often receive mismatched care, resulting in overuse of care and increased healthcare costs.
- Conditions
- Complex Patient, Multimorbidity, Psychosocial Problem, Chronic Disease
- Trial name
- NCT05878054
- Testing
- Proactive, integrated and personalised care
- Where
- Netherlands
- Volunteers
- 41 people
- Sponsor
- Leiden University Medical Center
Head and Neck Neoplasms
Feasibility Testing a Decision-support Intervention for Clinical Trials
A decision-support intervention are developed for a Danish nationwide randomised controlled trial (RCT) among patients with laryngeal and pharyngeal cancer referred to curative intended radiotherapy.
- Trial name
- NCT06291610
- Testing
- Clinical trial decision support intervention
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Alcohol Use Disorder
Coordinated Care for Alcohol Problems
Parallel group individually randomised controlled trial (RCT) with stratified (by severity of drinking problem) randomisation into intervention and control arms.
- Trial name
- CCAP (NCT07260149)
- Testing
- CCAP, Enhanced usual care
- Where
- India
- Volunteers
- 1,022 people
- Sponsor
- Sangath
Obesity
Intensive Weight Loss Intervention Versus Usual Care for Adults With Severe and Complex Obesity
In this trial, the aim is to assess the clinical benefits and harms, as well as cost-effectiveness of an intensive weight loss (IWL) intervention that includes total dietary replacements, behavioural support and weight-loss…
- Trial name
- LightWAY (NCT06321458)
- Testing
- Intensive weight loss intervention, Usual care
- Where
- 14 sites in Denmark, United Kingdom
- Volunteers
- 605 people
- Sponsor
- Carsten Dirksen
Cancer, Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Advancing Care Coordination Between Cancer and Primary Care Teams for Complex Cancer Survivors
The purpose of this randomized clinical trial is to learn if 'complex' cancer patients who receive care guided by a health system intervention, Primary Care Connect (PC2) have their risks of cardiovascular disease (CVD) managed…
- Conditions
- Cancer, Breast Cancer Early Stage Breast Cancer (Stage 1-3), Bladder Cancer, Prostate Cancer (Adenocarcinoma)
- Trial name
- ACCESS-PC (NCT06834204)
- Testing
- PC2: Primary Care Connect
- Where
- United States
- Volunteers
- 266 people
- Sponsor
- Rutgers, The State University of New Jersey
TBI (Traumatic Brain Injury), Status Epilepticus
Augmented Renal Clearance in Neurocritical Care
Stroke, severe brain injury, uncontrolled seizures and brain infections are the most common life-threatening neurological illnesses in the world with an estimated combined annual hospital management cost of up to 44 billion…
- Conditions
- TBI (Traumatic Brain Injury), Status Epilepticus, Bacterial Meningitis, Augmented Renal Clearance (ARC)
- Trial name
- Neuro-ARC (NCT07410624)
- Where
- 3 sites in United States, Canada
- Volunteers
- 512 people
- Sponsor
- University of Alberta
Longitudinal, Genomic Stability
Epidemiology and Overtime Genomic Evolution of Klebsiella Pneumoniae and Enterobacter Cloacae Complex (ECC) in Stools of ICU's Patients
Infections are one of the major threats for inpatients, even more for patients hospitalized in intensive care units (ICUs). They are responsible for an important increase of morbidity and mortality rates as well as a burst of…
- Conditions
- Longitudinal, Genomic Stability, Klebsiella Infections, Enterobacter Cloacae Infection
- Trial name
- NormandyKlebs (NCT07744321)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Postoperative Follow-up
PROMs-guided Perioperative Care in Patients With Complex Care Needs: An Open-label Randomized Controlled Trial
This research aims to identify, as early as the preoperative phase, groups of patients likely to experience maximum clinical improvement through structured paramedical follow-up based on PROMs.
- Trial name
- OPTICAIRE (NCT07338188)
- Testing
- Patient-Reported Outcomes-based perioperative follow-up (QoR-15 focus)
- Volunteers
- 276 people
- Sponsor
- University Hospital, Strasbourg, France
Complex Care, Post-Acute Care Utilization
Comprehensive Enhanced Care Management Under CalAIM for High-Risk Medi-Cal Members
This pragmatic, cluster-randomized trial will evaluate whether a comprehensive CalAIM-aligned care model consisting of Enhanced Care Management, selected Community Supports, Transitional Care Services, and residential care…
- Conditions
- Complex Care, Post-Acute Care Utilization, Housing Instability, Residential Care Transition
- Trial name
- COMPASS-CalAIM (NCT07587073)
- Testing
- Comprehensive CalAIM Care Bundle, Usual CalAIM Service Delivery
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- StratiHealth
Medical Complexity
ASKids! Inpatient Agenda-Setting Study for Hospitalized Children With Medical Complexity
The goal of this open pilot is to co-design and test a clinical agenda-setting intervention in the inpatient pediatric environment.
- Trial name
- ASKids (NCT07127666)
- Testing
- Structured Agenda-Setting Tool
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dartmouth-Hitchcock Medical Center