Clinical trials: Complex Symptom Disorders
Ventricular Premature Complexes
CBT for Premature Ventricular Contractions
The purpose of the present interdisciplinary research program is to develop and evaluate a disease-specific cognitive behavior therapy (CBT) protocol to increase quality of life (QoL) and reduce symptom burden in patients with…
- Trial name
- PVC-CBT (NCT05087238)
- Testing
- CBT
- Where
- Sweden
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Complex Regional Pain Syndromes, Distal Radius Fractures
Prednisone for CRPS in Distal Radius Fracture
Wrist fractures are the most prevalent adult fracture. Complex regional pain syndrome (CRPS) is a common complication that can occur, leading to permanent disability and is costly to the patient and healthcare system.
- Trial name
- NCT06453447
- Testing
- Prednisone
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Intracranial Hemorrhages
International Normalized Ratio (INR) Normalization in Coumadin Associated Intracerebral Haemorrhage
Intracerebral haemorrhage (ICH) is the most feared complication in patients on vitamin K antagonists (VKA). VKA related ICH occurs 8-10 times more frequently and the mortality is 2 times higher than in non-anticoagulated…
- Trial name
- INCH (NCT00928915)
- Testing
- Prothrombin complex concentrate (PCC); fresh frozen plasma (FFP)
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- Heidelberg University
Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria
Nonmyeloablative Allogeneic Transplant
Allogeneic transplant from a matched sibling for the treatment of a variety of illnesses including bone marrow failure states, leukemias, myelodysplastic or myeloproliferative syndromes, lymphoma, or myeloma using a…
- Conditions
- Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria, Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia
- Trial name
- Mini-allo (NCT01272817)
- Testing
- Nonmyeloablative Allogeneic Transplant
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Scripps Health
Atrial Fibrillation
Clinical Benefits of Additional Complex Fractionated Atrial Electrogram Targeted Catheter Ablation for Longstanding Persistent Atrial Fibrillation
1. Purpose of the study 1) To compare clinical outcome, procedure time, complication rate of persistent atrial fibrillation patients between conventional additional linear ablation and additional complex fractionated atrial…
- Trial name
- NCT02175043
- Testing
- atrial electrogram and liner ablation
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Gait, Drop Foot, Chemotherapy-induced Peripheral Neuropathy
Impact of an Orthotic Intervention in Children With Peripheral Neuropathy
This research study will investigate the effect of two orthotic (brace) devices for the ankle and foot on walking and ankle flexibility in children with cancer not involving the brain or spinal cord.
- Conditions
- Gait, Drop Foot, Chemotherapy-induced Peripheral Neuropathy, Acute Lymphocytic Leukemia, Pediatric, Rhabdomyosarcoma
- Trial name
- IOPN (NCT03655587)
- Testing
- Solid ankle foot orthotic, Resting night splint
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Childhood Obesity
Effect of Polysaccharide-based Complex Administration on the Gut Microbiome and Cardio-Metabolic Profile in Children With Obesity and Metabolic Syndrome.
Childhood obesity is a growing public health concern and is associated with long-term health issues. Changing lifestyle habits, especially improving diet and maintaining these changes over time, can be challenging for children…
- Trial name
- Polymets (NCT07321184)
- Testing
- Polysaccharide-based complex
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- University of Milan
Complex Regional Pain Syndrome Type I
Longitudinal Follow-up Study About Complex Regional Pain Syndrome (CRPS) Patients
Complex regional pain syndrome (CRPS) is a post-traumatic chronic pain condition characterized by pain and other symptoms typically affecting a distal limb.
- Trial name
- NCT04703647
- Testing
- Administration of questionnaires for prospective group, Blood samples for prospective group, Blood samples for control group
- Where
- Switzerland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Clinique Romande de Readaptation
Ventricular Premature Complexes, Outflow Tract
Effects of Carvedilol on Suppressing the Premature Ventricular Complex/Ventricular Tachycardia From Outflow Tract
Carvedilol is known to be effective in reducing ventricular arrhythmias and mortality in patients with heart failure. It is suggested that one of the mechanisms is its ability to block store overload-induced Calcium release which…
- Conditions
- Ventricular Premature Complexes, Outflow Tract, Carvedilol
- Trial name
- FOREVER (NCT03587558)
- Testing
- Carvedilol, Flecainide
- Where
- 11 sites in South Korea
- Volunteers
- 104 people
- Sponsor
- Keimyung University Dongsan Medical Center
Lymphedema, Lower Limb
Correlation Between Volume and Pain in Lower Limbs Lymphoedema
The vascular physiotherapy department of the UCL University Clinics of Mont-Godinne specializes in the physiotherapeutic management of lymphoedema.
- Trial name
- NCT06145204
- Testing
- questionnaire
- Where
- Belgium
- Volunteers
- 79 people
- Sponsor
- University Hospital of Mont-Godinne
Hepatitis C, Medication Adherence
Intensive Models of HCV Care for Injection Drug Users
Injection drug users (IDUs) constitute 60% of the approximately 5 million people in the U.S. infected with hepatitis C virus (HCV). HCV treatment leading to sustained viral response (SVR) is associated with increased survival.
- Trial name
- NCT01857245
- Testing
- Intensive Models (mDOT and CGT) of HCV Care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Prisma Health-Upstate
Obesity
Intermittent Hypoxia-hyperoxia Therapy in Obese Patients (IHHTOP)
Obesity represents the excessive or abnormal accumulation of adipose tissue in the body, which affects health through its association with the risk of developing diabetes mellitus, cardiovascular and pulmonary diseases and…
- Trial name
- (IHHTOP) (NCT06451601)
- Testing
- Intermittent hypoxia-hyperoxia therapy
- Where
- Romania
- Volunteers
- 70 people
- Sponsor
- Balnear and Rehabilitation Sanatorium Techirghiol
Coronary Artery Disease With Myocardial Infarction
Pragmatic Trial Comparing Symptom-Oriented Versus Routine Stress Testing in High-Risk Patients Undergoing Percutaneous Coronary Intervention
The primary objective of the POST-PCI trial is to compare the clinical outcomes of a post-percutaneous coronary intervention(PCI) aggressive management strategy of routine noninvasive functional testing to a usual-care strategy…
- Trial name
- POST PCI (NCT03217877)
- Testing
- routine stress testing, No Routine stress testing
- Where
- 11 sites in South Korea
- Volunteers
- 1,700 people
- Sponsor
- Seung-Jung Park
HBA1c, Body Weight
Simplification of Complex Insulin Regimens With Preserving Good Glycemic Control in Type 2 Diabetes
This study examines prospectively the safety and efficacy of switching from multiple daily insulin injections (MDI) to once daily IDegLira (insulin degludec and liraglutide fix ratio combination), a fixed-ratio combination of…
- Conditions
- HBA1c, Body Weight, Hypoglycemia
- Trial name
- NCT04020445
- Testing
- de-escalation of complex insulin regimens
- Where
- Hungary
- Volunteers
- 150 people
- Sponsor
- Bekes County Central Hospital
Mycobacterium Avium-intracellulare Infection, HIV Infections
A Study to Learn More About MAC Disease and the Use of Anti-HIV Drugs in Patients With Advanced HIV Infection
The purpose of this study is to determine if infection with Mycobacterium avium complex (MAC) occurs in other parts of the body before it is found in the blood.
- Trial name
- NCT00000895
- Testing
- Nelfinavir mesylate, Nevirapine, Azithromycin
- Where
- 26 sites in United States
- Volunteers
- 85 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Psychiatric Health
Complex Post-traumatic Stress Disorder: What Symptomatological Specificities
A better understanding of the Complex Post-Traumatic Stress Disorder would allow a management as close as possible to the specificities of this one, but also a better training of professionals and adapted therapeutic indications.
- Trial name
- StuCoTra (NCT05070962)
- Testing
- clinical population
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Raincy Montfermeil Hospital Group
Tuberous Sclerosis Complex
Potential EEG Biomarkers and Antiepileptogenic Strategies for Epilepsy in TSC
To determine whether EEGs during infancy is a reliable biomarker to identify TSC patients that will develop infantile spasms/epilepsy in the near future and thus are appropriate candidates for an antiepileptogenic drug trial.
- Trial name
- NCT01767779
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Cardiotoxicity, Pulmonary Toxicity
Study on Proton Radiotherapy of Thymic Malignancies
This is a multicentre non-randomized phase II study of proton beam radiotherapy in patients with thymic epithelial tumours (i.e.
- Conditions
- Cardiotoxicity, Pulmonary Toxicity, Thymus Neoplasms
- Trial name
- PROTHYM (NCT04822077)
- Testing
- Proton radiation
- Where
- 3 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Ass. Prof. Jan Nyman
Complex Regional Pain Syndrome, Chronic Pain
Low Dose Naltrexone Therapy for Complex Regional Pain Syndrome
Complex Regional Pain Syndrome (CRPS) is a rare and often debilitating chronic pain condition whereby individuals may experience extreme sensitivity, discoloration, and swelling of the affected area -- along with numerous other…
- Conditions
- Complex Regional Pain Syndrome, Chronic Pain, Causalgia, Complex Regional Pain Syndrome Type I
- Trial name
- LDN-CRPS (NCT06306157)
- Testing
- Low dose naltrexone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Hospital for Special Surgery, New York
Cough, Cerebellar Ataxia
Chronic Cough and CANVAS (Cerebellar Ataxia With Neuropathy and Bilateral Vestibular Areflexia Syndrome)
Chronic cough is a frequent cause of Pneumology consultations. CANVAS syndrome (Cerebellar Ataxia with Neuropathy and bilateral Vestibular Areflexia Syndrome) is a progressive and disabling neurological disease that very…
- Conditions
- Cough, Cerebellar Ataxia, Gastroesophageal Reflux
- Trial name
- CANVAS (NCT04703595)
- Testing
- To determine the presence of biallelic expansion of AAGGG in RFC1 in patients with chronic cough, regardless of the presence of neurological symptoms.
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau