Clinical trials: Complex Symptom Disorders
Cancer
Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment
RATIONALE: Caspofungin acetate or amphotericin B liposomal may be effective in preventing or controlling fever and neutropenia caused by chemotherapy, bone marrow transplantation, or peripheral stem cell transplantation.
- Trial name
- NCT00008359
- Testing
- caspofungin acetate, liposomal amphotericin B
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Atrial Fibrillation
Selective Complex Fractionated Atrial Electrograms (CFAE) Targeting for Atrial Fibrillation
This study will be a multicenter, open, prospective, randomized trial. Patients with either paroxysmal or persistent atrial fibrillation will be considered for the study.
- Trial name
- SELECT-AF (NCT00926783)
- Testing
- CFAE ablation
- Where
- 7 sites in United States, Australia and 1 more
- Volunteers
- 86 people
- Sponsor
- Biosense Webster, Inc.
COPD Asthma, Lung Neoplasm
Using Artificial Intelligence for the Detection of Respiratory Diseases Associated With Pollution
Generating a picture at the city level, through geospatial and temporal grouping a lung diseases associated or exacerbated by pollution (COPD, AB and neoplasm pulmonary or pleural) and correlating this data with pollution data.
- Conditions
- COPD Asthma, Lung Neoplasm, Emphysema
- Trial name
- SmartLungs (NCT06512142)
- Where
- Romania
- Volunteers
- 30,000 people
- Sponsor
- University of Medicine and Pharmacy "Victor Babes" Timisoara
Chronic Periodontitis
Effect of Pranayama on Periodontal Health
The objective of the study was to evaluate the levels of Peroxisome proliferator-activated receptor gamma (PPAR-γ), Nuclear factor-kappa B (NF-kB) and the presence of red complex microorganisms (RCM) such as Treponema denticola…
- Trial name
- NCT02967861
- Testing
- Pranayama, Scaling and root planing
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Peptic Ulcer
Efficacy and Safety Study of HZT-501 in Reducing the Risk of Ibuprofen-associated Ulcers
The purpose of this study is to evaluate whether HZT-501 is effective in reducing the rate of development of ibuprofen-associated ulcers in patients who require long-term daily use of ibuprofen.
- Trial name
- NCT00450658
- Testing
- HZT-501, Ibuprofen
- Volunteers
- 627 people
- Sponsor
- Amgen
Nephrolithiasis, Staghorn Calculus
Impact of Tranexamic Acid Use in Percutaneous Nephrolithotomy
This study is a double blinded randomized controlled trial evaluating the impact of tranexamic acid use on the transfusion rate in patients with complex kidney stones undergoing percutaneous nephrolithotomy.
- Trial name
- NCT02966236
- Testing
- Tranexamic Acid
- Where
- Brazil
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Premature Ventricular Complex, Ventricular Arrythmia
Non-Invasive 3D Mapping for Identifying Origin and Preferential Propagation of Ventricular Arrhythmias
This study will measure the diagnostic sensitivity and specificity of the Medtronic CardioInsight wearable 252 electrode vest in predicting the chamber of origin of premature ventricular complexes (PVCs) and compare its…
- Trial name
- NCT03831516
- Testing
- Non Invasive Electroanatomical Mapping
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
Neuroblastoma, Medulloblastoma
Accurate Diagnosis and Grading of Pediatric Solid Tumors Based on Pathological Large Models
Pediatric malignancies are the second leading cause of death in the pediatric population, with solid tumors accounting for approximately 60% of all pediatric malignancies.
- Conditions
- Neuroblastoma, Medulloblastoma, Wilms Tumor, Hepatoblastoma
- Trial name
- NCT06822842
- Where
- China
- Volunteers
- 1,229 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Stroke, Atrial Fibrillation
Atrial Fibrillation and Premature Atrial Complexes in Patients With Ischemic Stroke.
The purpose of this study is to improve secondary prevention of ischemic stroke patients by 1. Estimating prevalence and the prognostic significance of frequent premature atrial complexes in ischemic stroke patients in relation…
- Conditions
- Stroke, Atrial Fibrillation, Premature Atrial Complexes
- Trial name
- Pacific (NCT02180542)
- Where
- Denmark
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Cardiac Arrhythmia, Atrial Fibrillation
Vektor vMap™ Clinical Validation Study
This is a retrospective, multi center clinical study collecting existing, de-identified subject data from medical records to be analyzed using an independent core laboratory to validate performance of a computational ECG mapping…
- Conditions
- Cardiac Arrhythmia, Atrial Fibrillation, Ventricular Arrythmia, Premature Ventricular Complexes Multiple
- Trial name
- NCT04559061
- Testing
- Cardiac ablation procedure
- Where
- 4 sites in United States
- Volunteers
- 225 people
- Sponsor
- Vektor Medical
Survivorship, Breast Cancer
The LYSA (Linking You to Support and Advice) Trial
This study's aim is to evaluate the feasibility of introducing a women's malignancy survivorship clinic incorporating symptom management through ePRO collection (complex intervention) into routine follow up care in patients with…
- Conditions
- Survivorship, Breast Cancer, Cervical Cancer, Endometrial Cancer
- Trial name
- LYSA (NCT05035173)
- Testing
- Survivorship Clinic Assessments, Survivorship Clinic Nurse Resource, Survivorship Clinic Dietitian Resource
- Where
- Ireland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University College Cork
Non-muscle Invasive Bladder Cancer
A Study of ALT-801 in Patients With Bacillus Calmette-Guerin (BCG) Failure Non-Muscle Invasive Bladder Cancer
This is a Phase Ib/II, open-label, multi-center and competitive enrollment study of ALT-801 combined with gemcitabine for patients who have BCG failure (defined as refractory, relapsing or intolerant), non-muscle invasive bladder…
- Trial name
- NCT01625260
- Testing
- ALT-801, Gemcitabine
- Where
- 5 sites in United States
- Volunteers
- 12 people
- Sponsor
- Altor BioScience
Intracranial Hemorrhages
CPP Versus PFC to Correct Coagulation Disorders in Adult Neurosurgical Patients
This prospective, randomized, multicenter study is performed to determine whether prothrombin complex concentrates confers any benefits over fresh frozen plasma in adult neurological patients with coagulation disorders (PT value…
- Trial name
- CLOT-CRANE (NCT02777424)
- Testing
- Prothrombin Complex Concentrate, Fresh Frozen Plasma
- Where
- 4 sites in France
- Volunteers
- 18 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Childhood Burkitt Lymphoma, Childhood Central Nervous System Germ Cell Tumor
Oxaliplatin and Irinotecan in Treating Young Patients With Refractory Solid Tumors or Lymphomas
This phase I trial is studying the side effects and best dose of oxaliplatin when given together with irinotecan in treating young patients with refractory solid tumors or lymphomas.
- Conditions
- Childhood Burkitt Lymphoma, Childhood Central Nervous System Germ Cell Tumor, Childhood Diffuse Large Cell Lymphoma, Childhood Grade III Lymphomatoid Granulomatosis
- Trial name
- NCT00101270
- Testing
- irinotecan hydrochloride, oxaliplatin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
IgA Vasculitis
Evaluation of Glucocorticoids Plus Rituximab in Patients With Newly-Diagnosed or Relapsing IgA Vasculitis
Systemic vasculitis are inflammatory diseases of the blood vessels, responsible for systemic manifestations. Among the systemic vasculitis affecting small blood vessels, IgA vasculitis (IgAV) is one of the most common forms and…
- Trial name
- RIGA (NCT05329090)
- Testing
- Rituximab Injection
- Where
- 14 sites in France
- Volunteers
- 75 people
- Sponsor
- Hopital Foch
Scar-related Atrial Tachycardia, Persistent Atrial Fibrillation
A Study of Intracardiac Ultrasound With the NUVISION NAV Ultrasound Catheter
The purpose of this study is to assess the performance and safety of using the investigational catheter.
- Conditions
- Scar-related Atrial Tachycardia, Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Ventricular Tachycardia
- Trial name
- NCT05970120
- Testing
- NUVISION NAV Ultrasound Catheter
- Where
- 3 sites in Croatia, Israel and 1 more
- Volunteers
- 30 people
- Sponsor
- Biosense Webster, Inc.
Common Cold
Acetylsalicylic Acid Combined With Pseudoephedrine in Common Cold
The purpose of the study is to determine the effectiveness of an acetylsalicylic acid (aspirin) pseudoephedrine combination for the treatment of pain and congestion symptoms compared to the effectiveness of the individual…
- Trial name
- NCT00963443
- Testing
- Acetylsalicylic Acid (Aspirin, BAYE4465), Pseudoephedrine
- Where
- United Kingdom
- Volunteers
- 833 people
- Sponsor
- Bayer
Obstructive Sleep Apnea, Premature Ventricular Contraction (PVC)
Disrupted Sleep and Concurrent Ectopy or Atrial Fibrillation
Whereas the available evidence mostly supports chronic sleep disruption as a risk factor for incident AF, less is known about the near-term risk of a discrete atrial fibrillation (AF) episode following a night of disrupted or…
- Conditions
- Obstructive Sleep Apnea, Premature Ventricular Contraction (PVC), Atrial Fibrillation (AF), Premature Atrial Contraction
- Trial name
- DISCRETE AF (NCT07220525)
- Testing
- HGNS Use Randomized Instructions
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
Atrial Fibrillation (AF)
Augmented Reality Aided Remote Access and Technical Support for Complex Ablation Procedures
Prospective, randomized, controlled, single-center pilot study evaluating the feasibility and safety of augmented reality-based remote technical support using the Microsoft HoloLens and EnSite™ Connected Care compared with…
- Trial name
- HOLO-Remote (NCT07777042)
- Testing
- HoloLens supported catheter ablation, On-site supported catheter ablation
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Luebeck
Mycobacterium Avium Complex Pulmonary Disease
Prevention of Recurrence With Cordyceps Sinensis in Mycobacterium Avium Complex Pulmonary Disease
The goal of this clinical trial is to learn if cordyceps sinesis capsule (Bailiing Capsule) works to prevent the recurrence of microbiologically cured mycobacterium avium complex pulmonary disease in adults.
- Trial name
- NCT07174076
- Testing
- cordyceps sinesis capsule
- Where
- 6 sites in China
- Volunteers
- 300 people
- Sponsor
- Bin Cao