Clinical trials: Complex Symptom Disorders
Neuropathic Pain, Complex Regional Pain Syndromes (CRPS)
Sub-threshold DRG Stimulation vs Sham in Established Responders
The goal of this clinical trial is to learn if sub-threshold dorsal root ganglion (DRG) stimulation provides pain relief beyond placebo in adults with chronic neuropathic pain who already have an implanted DRG stimulator.
- Conditions
- Neuropathic Pain, Complex Regional Pain Syndromes (CRPS), Causalgia, Chronic Pain
- Trial name
- DRG-SHAM (NCT07170722)
- Testing
- Subtreshhold DRG-S
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Umeå University
Neuralgia
To Evaluate the Efficacy and Tolerability of the Use of Vitatonus Dexa Compared to Dexamethasone in Patients With Neuralgia of Various Origins
To evaluate the efficacy and tolerability of Vitatonus Dexa compared with dexamethasone in the signs and symptoms of neuralgia of various origins.
- Trial name
- NCT00944502
- Testing
- Dexamethasone
- Where
- Brazil
- Volunteers
- 104 people
- Sponsor
- Bunker Industria Farmaceutica Ltda.
Diabetes
Jump Start Shared Medical Appointments for Diabetes With Weight Management
The proposed research will test a novel program that combines intensive weight management with shared (group) medical appointments for patients with diabetes.
- Trial name
- Jump Start (NCT01973972)
- Testing
- Weight management, Shared medical appointments (SMA)
- Where
- United States
- Volunteers
- 263 people
- Sponsor
- VA Office of Research and Development
Coronary Disease, Myocardial Infarction
Half-Dose Intracoronary Abciximab Bolus Improves the Mortality Outcome Compared to Standard Intravenous Regimen
The aim of our study was to demonstrate that, during a percutaneous coronary intervention, even smaller amounts of abciximab than standard dose, injected locally, could achieve a rapid thrombus resolution and clinical improvement…
- Trial name
- NCT00320229
- Testing
- abciximab
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- Azienda Sanitaria Ospedaliera
Breast Cancer, Mastectomy
Kinesio Tex Tape in Reducing Edema and Seroma After Complex Reconstructive Breast Surgery
Over the last two decades in the field of oncology, the prevention, diagnosis, treatment and rehabilitation have reached a remarkable development, improving healing rates and reducing the number of deaths from cancer.
- Conditions
- Breast Cancer, Mastectomy, Breast Implantation, Edema
- Trial name
- BREASTAPE (NCT03477565)
- Testing
- Kinesio tape lymphatic drainage technique application
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS San Raffaele
Fibromyalgia, Chronic Fatigue Syndrome
Complex Chronic Diseases Program Data Registry
The purpose of this data registry is to prospectively collect data from patients referred to an Complex Chronic Diseases Program (CCDP) at BC Women's Hospital + Health Centre to assess the quality of life of the CCDP Patients…
- Conditions
- Fibromyalgia, Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Chronic Lyme-Like Syndrome
- Trial name
- NCT03409653
- Where
- Canada
- Volunteers
- 1,300 people
- Sponsor
- BC Women's Hospital & Health Centre
CPTSD, Compelx Post-traumatic Stress Disorder
The Effectiveness of Group Guided Written Exposure Therapy for CPTSD Symptoms Among Adolescents
This study aims to examine the effectiveness of group-delivered Guided Written Exposure Therapy for Complex Post-Traumatic Stress Disorder (GWE-C) among Chinese adolescents through a randomized controlled trial.
- Trial name
- NCT06931093
- Testing
- Group Guided Written Exposure Therapy for CPTSD (GWE-C), Supportive counselling
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University
Arrhythmias
Picasso NAV High-Density Mapping Catheter for Signal Analysis of Complex Arrhythmias - First-In-Man
The primary purpose of the First-In-Man clinical investigation is to assess the Picasso NAV Catheter's ability to collect intracardiac signals within the desired chambers (atrial and/or ventricle) in the heart for the analysis of…
- Trial name
- NCT02110004
- Testing
- Ablation procedure, Picasso NAV Catheter
- Volunteers
- 30 people
- Sponsor
- Biosense Webster, Inc.
Premature Ventricular Complexes, Ventricular Tachycardia (VT)
Transcutaneous Vagus Nerve Stimulation for Ventricular Arrhythmias
Ventricular arrhythmias are abnormal heart rhythms that arise from the bottom chambers of the heart. They can cause debilitating symptoms when they occur intermittently (these are called premature ventricular ectopics or PVCs)…
- Conditions
- Premature Ventricular Complexes, Ventricular Tachycardia (VT), Ventricular Arrhythmias
- Trial name
- TREAT-VT (NCT07026695)
- Testing
- transcutaenous vagal nerve stimulation
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- University College, London
Amplified Musculoskeletal Pain Syndrome, Reflex Sympathetic Dystrophy
Audio-Visual Relaxation Technology for Pediatric Amplified Musculoskeletal Pain Syndrome
A pilot randomized controlled trial to assess feasibility, acceptability and generate outcome domains for a future RCT testing the efficacy of immersive virtual reality on pain intensity in pediatric amplified musculoskeletal…
- Conditions
- Amplified Musculoskeletal Pain Syndrome, Reflex Sympathetic Dystrophy, Complex Regional Pain Syndromes
- Trial name
- NCT03762213
- Testing
- Oculus GO VR HMD, application Happy Place (© Mimerse), iPad, application Happy Place (© Mimerse)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Tufts Medical Center
Anaplastic Astrocytoma, Anaplastic Ependymoma
SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors
Approximately 90% of children with malignant brain tumors that have recurred or relapsed after receiving conventional therapy will die of disease.
- Conditions
- Anaplastic Astrocytoma, Anaplastic Ependymoma, Anaplastic Ganglioglioma, Anaplastic Meningioma
- Trial name
- NCT03434262
- Testing
- Gemcitabine, ribociclib, sonidegib
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- St. Jude Children's Research Hospital
Immune Senescence, Sarcopenia
Effects of PS-IPC Supplementation on Muscle Mass and Functional Outcomes in Older Adults
Sarcopenia, the age-associated loss of skeletal muscle mass and strength, is a frequent precursor to functional impairment, disability, falls, and loss of independence in the elderly.
- Trial name
- PS-IPC (NCT00926250)
- Testing
- Oral PS-IPC supplement
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Chronic Pain, Neuropathic Pain
Intraoperative Neuromonitoring Recording With a Novel SCS Paddle: Phase II
The purpose of this study is to demonstrate safety and efficacy of a new spinal cord stimulation paddle electrode which is able to target the dorsal horns, dorsal nerve roots, and dorsal columns.
- Conditions
- Chronic Pain, Neuropathic Pain, Failed Back Surgery Syndrome, Complex Regional Pain Syndromes
- Trial name
- NCT05459324
- Testing
- HD Study Electrode
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Albany Medical College
Sepsis, Coagulopathy
The Early Coagulopathy for the Prognosis in Sepsis
In this cohort study, the parameters (TM, TAT, PIC, tPAIC, et al.) associated with the hemostatic system will be collected in sepsis patients when admitted to the Intensive Critical Unit.
- Conditions
- Sepsis, Coagulopathy, Outcome, Fatal
- Trial name
- NCT04582188
- Volunteers
- 200 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Non-communicable Diseases (NCD), Cardiovascular Risk
Interdisciplinary Program to Improve Lifestyle in Chronic Pathology: Alt Pirineu Aran in Fit (APA-FIT)
Interdisciplinary Program to Improve the Lifestyle of Individuals with Chronic Conditions in the Alt Pirineu and Aran Region Sedentary behavior and lack of regular physical activity have been widely recognized as urgent global…
- Conditions
- Non-communicable Diseases (NCD), Cardiovascular Risk, Obesity Prevention
- Trial name
- APA-FIT (NCT07172490)
- Testing
- APA-FIT interdisciplinary program
- Where
- Spain
- Volunteers
- 520 people
- Sponsor
- University of Barcelona
Tachycardia, Paroxysmal Supraventricular Tachycardia
AI-Based Differential Diagnosis and Localization of Tachycardia Using ECG: Multicenter Registry (EP-AI ASSIST)
This multicenter retrospective study aims to develop, validate, and clinically apply an artificial intelligence (AI)-powered electrocardiography (ECG) algorithm for the diagnosis and prognostic prediction of cardiovascular…
- Conditions
- Tachycardia, Paroxysmal Supraventricular Tachycardia, Wolff-Parkinson-White Syndrome, Premature Ventricular Contractions
- Trial name
- EP-AI ASSIST (NCT07859020)
- Testing
- AI-based ECG Diagnostic and Localization Algorithm
- Where
- South Korea
- Volunteers
- 10,000 people
- Sponsor
- Inha University Hospital