Clinical trials: Complicated Appendicitis, open to volunteers
Appendicular Mass, Acute Appendicitis
Immediate Laparoscopic Appendectomy Versus Interval Laparoscopic Appendectomy for Early Appendicular Mass
This study compares two standard treatment approaches for patients presenting with an appendicular mass, an inflammatory lump that forms when the appendix becomes severely inflamed and walled off by surrounding abdominal tissues.
- Conditions
- Appendicular Mass, Acute Appendicitis, Appendiceal Phlegmon, Appendicitis With Periappendicular Abscess
- Trial name
- NCT07837531
- Testing
- Immediate Laparoscopic Appendectomy, Interval Laparoscopic Appendectomy
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute Appendicitis
Antibiotics vs. Placebo in Acute Uncomplicated Appendicitis
Appendicectomy has been the treatment of acute appendicitis for over a hundred years. Appendicectomy, however, includes operative and postoperative risks despite being a "routine" operation.
- Trial name
- APPACIII (NCT03234296)
- Testing
- Ertapenem
- Where
- Finland
- Volunteers
- 147 people
- Sponsor
- Turku University Hospital
Appendicitis, Surgical Wound Infection
Primary Versus Delayed Wound Closure in Complicated Appendectomy (The HIEDI-Yemen Trial)
The goal of this clinical trial is to compare primary wound closure (PC) versus delayed primary closure (DPC) after standardized wound decontamination using the High-Efficiency Incision and Drainage with Irrigation (HIEDI)…
- Conditions
- Appendicitis, Surgical Wound Infection, Postoperative Complications, Wound Healing
- Trial name
- HIEDI-Yemen (NCT07688109)
- Testing
- Primary Closure with HIEDI, Delayed Primary Closure with HIEDI
- Where
- 3 sites in Yemen
- Volunteers
- 200 people
- Sponsor
- Sana'a University
Complicated Appendicitis, Intra-Abdominal Abscess
Laparoscopic Antibiotic Lavage to Prevent Intra-abdominal Abscess Formation in Complicated Appendicitis
Appendicitis is one of the most common causes of acute surgical admission. Presently, two types of appendicitis are distinguished: complicated and uncomplicated (phlegmonous).
- Trial name
- ALPACA (NCT06841003)
- Testing
- Laparoscopic antibiotic peritoneal lavage with gentamicin / clindamycin
- Where
- 11 sites in Netherlands
- Volunteers
- 752 people
- Sponsor
- Spaarne Gasthuis
Laparoscopic Appendectomy, Complicated Appendicitis
Fast Track Therapeutic Model in Acute Complicated Appendicitis in Pediatrics
To evaluate whether a postoperative therapeutic strategy, Fast Track, aimed at shortening hospital stay in pediatric patients undergoing laparoscopic appendectomy for complicated acute appendicitis, yields outcomes that are not…
- Conditions
- Laparoscopic Appendectomy, Complicated Appendicitis, Periappendicular Abscess
- Trial name
- FTAA (NCT05761080)
- Testing
- Oral amoxicillin-clavulanic acid (40mg/kg in 3 times/day; maximum dose 3g/day), Inpatient postpoperative intravenous antibiotic treatment according to the established protocol in each center
- Where
- 12 sites in Spain
- Volunteers
- 772 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Acute Complicated Appendicitis With Abscess
Appendicoliths in Acute Complicated Appendicitis Patients With Abscess
Complicated appendicitis, characterized by the presence of an abscess or perforation, involves acute inflammation of the peritoneum secondary to an infection of the appendix, presenting additional challenges for management.
- Trial name
- NCT06469086
- Testing
- Clinical data collection
- Volunteers
- 100 people
- Sponsor
- Shanghai Zhongshan Hospital
Appendicitis Acute, Appendicitis Perforated
Enhanced Recovery After Surgery (ERAS) for Complicated Appendicitis
The exploratory objective of this pilot study is to evaluate the feasibility and safety of an enhanced recovery protocol that will allow adult patients to be discharged to home on an oral antibiotic regimen for three days…
- Conditions
- Appendicitis Acute, Appendicitis Perforated, Appendicitis With Perforation, Appendicitis Suppurative
- Trial name
- NCT06948071
- Testing
- Discharge on oral antibiotics
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Appendicitis, Perforated Appendicitis
Comparative Study Between Laparoscopic and Open Appendectomy of Complicated Appendicitis
Acute appendicitis is one of the most common surgical emergencies in children. In complicated cases, where the appendix has perforated, become gangrenous, or caused peritonitis and purulent contamination, determining the optimal…
- Conditions
- Appendicitis, Perforated Appendicitis, Gangrenous Appendicitis, Peritonitis
- Trial name
- NCT07879235
- Testing
- Laparoscopic Appendectomy, Open Appendectomy
- Volunteers
- 100 people
- Sponsor
- Assiut University
Conservative Management
Risk Factors of Failure of Conservative Treatment in Acute Non Complicated Appendicitis
From this study, it can be concluded that patients who meet the following criteria are more likely to fail expectant management and thus should not be considered for the NOM of uncomplicated acute appendicitis.
- Trial name
- appendicitis (NCT06828952)
- Testing
- ceftriaxone, ceftriaxone 1 gm/12 hourly and IV metronidazole 500 mg/8 hourly
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ahmed Mohammed Hussein Sayed
Acute Complicated Appendicitis With Peri-appendiceal Abscess or Phlegmon
Peri-appendiceal Abscess and Phlegmon in Acute Complicated Appendicitis Patients
This study aim to analyze the clinical data of patients who underwent emergency appendectomy for acute complicated appendicitis with peri-appendiceal abscess or phlegmon, identify factors influencing the post-operative length of…
- Trial name
- NCT06490185
- Testing
- Clinical data collection
- Volunteers
- 150 people
- Sponsor
- Shanghai Zhongshan Hospital
Acute Complicated Appendicitis With Diffuse Peritonitis
Laparoscopic Versus Open Appendectomy Plus Peritoneal Lavage for Acute Complicated Appendicitis Patients With Diffuse Peritonitis
This study aim to evaluate the efficacy and safety of laparoscopic versus open appendectomy in the treatment of acute complicated appendicitis with diffuse peritonitis.
- Trial name
- NCT06633744
- Volunteers
- 60 people
- Sponsor
- Shanghai Zhongshan Hospital
Ileus Postoperative, Gastrointestinal Function
Oral Lactulose for Gastrointestinal Recovery After Complex Appendectomy
This is a prospective, triple-blind, placebo-controlled, single-center randomized clinical trial to evaluate the efficacy and safety of early oral lactulose for promoting postoperative gastrointestinal functional recovery in…
- Conditions
- Ileus Postoperative, Gastrointestinal Function, Complicated Appendicitis
- Trial name
- NCT07589465
- Testing
- Lactulose oral solution
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Nanchong Central Hospital
Perforated Appendicitis
Perforated Appendicitis and Postoperative Antibiotics Pilot Trial
The goal of this clinical trial is to learn if not giving antibiotics is as effective as giving antibiotics after surgery for patients who have surgery for a perforated (burst) appendix.
- Trial name
- PAPA Pilot (NCT07656636)
- Testing
- Postoperative antibiotico-prophylaxis, No postoperative antibiotics
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's