Clinical trials: Complication, Postoperative
Nausea and Vomiting, Postoperative
Antiemetic Prophylaxis for Postdischarge Nausea and Vomiting After Hip Arthroscopy
The study is a randomized placebo controlled trial to determine whether repeated postoperative prophylactic ondansetron ("Zofran") administration will prevent postoperative and/or postdischarge nausea and vomiting in patients…
- Trial name
- PDNV (NCT00878228)
- Testing
- Ondansetron
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Hospital for Special Surgery, New York
Delayed Emergence From Anesthesia
Recovery Profile Comparison Between Remifentanil-propofol or Desflurane Anesthesia Monitored With Bispectral Index.
Bispectral monitoring anesthesia with remifentanil-desflurane has a better post-operative recovery than remifentanil-propofol.
- Trial name
- NCT02631525
- Testing
- Desflurane, Propofol
- Volunteers
- 40 people
- Sponsor
- Federal University of Minas Gerais
Colorectal Surgery, Surgical Wound Infection
A Study of an Antibiotic Implant in General Surgical Subjects at Higher Risk for Surgical Wound Infection
The purpose of this study is to determine whether the gentamicin-collagen sponge is safe and effective for preventing surgical wound infections in patients undergoing colorectal surgery.
- Trial name
- NCT00600925
- Testing
- gentamicin-collagen sponge dipped in saline
- Where
- 39 sites in United States
- Volunteers
- 602 people
- Sponsor
- Innocoll
Ischemia Reperfusion Injury
Purge Vs no Purge in Living Donor Liver Transplantation Recipients
The investigators tested the impact of purging the graft contents and mesenteric blood into the systemic circulation versus washing out this volume out of the circulation in living donor liver transplantation recipients.
- Trial name
- PNP (NCT02540447)
- Testing
- Purge
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Ovarian Cancer, Hysterectomy
Implementing Enhanced Recovery After Surgery (ERAS) Pathways In Major Gynecologic Oncology Operations In Greece
The Enhanced Recovery After Surgery (ERAS) program includes preoperative counseling, fasting avoidance, non-opioid analgesia, fluid balance, normothermia and early mobilization.
- Conditions
- Ovarian Cancer, Hysterectomy, Endometrial Cancer, Gynecologic Cancer
- Trial name
- ERAS (NCT04696276)
- Testing
- ERAS protocol
- Where
- Greece
- Volunteers
- 101 people
- Sponsor
- University of West Attica
Failed Back Surgery Syndrome, Back Pain
Spinal Cord Stimulation for Predominant Low Back Pain
The purpose of this study is to compare the effectiveness of spinal cord stimulation (SCS) using the Medtronic Specify® 5-6-5 multicolumn surgical lead plus optimal medical management (OMM) versus OMM alone in patients suffering…
- Conditions
- Failed Back Surgery Syndrome, Back Pain, Pain in Leg, Unspecified
- Trial name
- PROMISE (NCT01697358)
- Testing
- Spinal Cord Stimulation (SCS), Optimal Medical Management (OMM)
- Where
- 28 sites in United States, Belgium and 7 more
- Volunteers
- 278 people
- Sponsor
- MedtronicNeuro
Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants
Effect of Photodynamic Treatment on Skin Microbiome. Single Center Study
The overarching aim of this research project is to prevent orthopedic implant-associated infections. This study aims to investigate if photodynamic therapy has an effect on bacterial skin colonization and decrease number of…
- Conditions
- Postoperative Wound Infection Deep Incisional Surgical Site, Prosthesis and Implants, Surgical Site Infection, Prosthetic Joint Infection
- Trial name
- PHOMIC (NCT04067843)
- Testing
- Photodynamic treatment
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Postoperative Nausea and Vomiting
Study of APD421 as PONV Treatment (no Prior Prophylaxis)
Double-blind, randomised, parallel-group, placebo-controlled, adaptive, seamless, dose-selecting study to compare the efficacy of APD421 to placebo as treatment of established PONV, in patients who have not had prior PONV…
- Trial name
- NCT02449291
- Testing
- APD421
- Where
- 4 sites in United States, France and 1 more
- Volunteers
- 568 people
- Sponsor
- Acacia Pharma Ltd
Pain, Postoperative, Anesthesia
Transversus Abdominal Plane Block at Total Laparoscopic Hysterectomy: Effect on Quality of Recovery
The Transversus Abdominal Plane (TAP) block has been used with good success to decrease postoperative pain following laparatomy.
- Trial name
- TAP (NCT01479270)
- Testing
- TAP Block
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Urinary Retention
The Effect of Tamsulosin on Postoperative Urinary Retention
This is a double-blinded randomized controlled trial of perioperative use of tamsulosin to prevent postoperative urinary retention in female pelvic reconstructive surgery undergoing same-day discharge with an enhanced recovery…
- Trial name
- NCT04682366
- Testing
- Tamsulosin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Wake Forest University Health Sciences
POSTOPERATIVE DELIRIUM, POSTOPERATIVE COGNITIVE DECLINE
Daridorexant to Prevent Delirium After Heart Surgery
The goal of this phase 2 clinical trial is to demonstrate the feasibility of the current study methods and obtain preliminary data for an adequately powered trial of daridorexant with the aim of preventing delirium after heart…
- Trial name
- NCT06630390
- Testing
- Daridorexant 50 mg
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Rochester
Post-operative Pain
Uniport and Multiport Epidural Catheters in Post-surgical Patients
The investigators hypothesize that multi-port thoracic epidural catheters will provide superior pain relief when compared to uniport catheters for post-surgical patients.
- Trial name
- NCT02159560
- Testing
- Epidural catheter
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Beth Israel Deaconess Medical Center
Surgical Site Infection
Prevena™ Incisional Negative Pressure Wound Therapy in Re-operative Colorectal Surgery
Many strategies have been attempted to reduce SSI rates. The Centers for Medicare and Medicaid Services introduced the Surgical Care Improvement Project infection project with the aim of reducing SSI incidence and morbidity.
- Trial name
- NCT02509260
- Testing
- Prevena wound management system, Standard wound dressings
- Where
- United States
- Volunteers
- 298 people
- Sponsor
- The Cleveland Clinic
Pressure Ulcer, Ankle, Prosthesis User
Limb Health and Socket Pressure in Response to Powered Ankle Protheses
this project seeks to understand and quantify the effects of powered transtibial prostheses on socket loading and direct measures of residual limb health so as to inform the optimization of prosthesis fit.
- Conditions
- Pressure Ulcer, Ankle, Prosthesis User, Prosthesis Durability, Mobility Limitation
- Trial name
- OPORP (NCT05112679)
- Testing
- PROPRIO FOOT® by Ossur & Empower ankle by Ottobock
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Indiana University
Surgical Site Infection
Checklist to Prevent MRSA Surgical Site Infections
The goals of this project are 1) to assess the effectiveness and cost-effectiveness of the checklist to prevent MRSA SSIs among Veterans undergoing TJA or cardiac surgery, and 2) to assess barriers and facilitators to checklist…
- Trial name
- NCT02216227
- Testing
- Mupirocin, Chlorhexidine gluconate, Cefazolin
- Where
- 11 sites in United States
- Volunteers
- 23,005 people
- Sponsor
- VA Office of Research and Development
Peritoneal Surface Malignancy, Postoperative Adhesion
SurgiPerito Trial: High-Purity Type-I Collagen for Peritoneal Reconstruction After Cytoreductive Surgery
This dual-centre, randomized controlled trial evaluates the safety and efficacy of high-purity Type-I collagen-based biomaterial, as a peritoneal substitute following peritonectomy in patients undergoing cytoreductive surgery…
- Conditions
- Peritoneal Surface Malignancy, Postoperative Adhesion, Bowel Obstruction, Wound Complications
- Trial name
- NCT07241091
- Testing
- High-Purity Type-I Collagen Scaffold, Standard Peritonectomy Closure
- Where
- 2 sites in India
- Volunteers
- 60 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Failed Back Surgery Syndrome, Post-laminectomy Syndrome
Subcutaneous Nerve Stimulation for Failed Back Surgery Syndrome (FBSS) Patients
The purpose of this study is to assess the safety and efficacy of Subcutaneous Nerve Stimulation (SQS) (also known as Peripheral Nerve Stimulation [PNS]) in the reduction of chronic, intractable post-surgical back pain in adults.
- Trial name
- SubQStim (NCT01818297)
- Testing
- PrimeAdvanced® neurostimulator system
- Where
- 27 sites in United States
- Volunteers
- 137 people
- Sponsor
- MedtronicNeuro
Pain, Postoperative
Continuous Erector Spinae Block Versus Continuous Paravertebral Block
Overall Aim: To evaluate the efficacy of continuous erector spinae block (ESB) versus continuous paravertebral block (PVB) for postoperative analgesia in children and adolescents undergoing surgical procedures via unilateral…
- Trial name
- NCT03768440
- Testing
- continuous erector spinae block (ESB), continuous paravertebral block (PVB), Ropivacaine
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Analgesia
Study of Post-Herniorrhaphy Non-opioid MMA Regimens
This is a Phase 3b, open-label study to assess postoperative opioid use in subjects undergoing unilateral open inguinal herniorrhaphy with intraoperative administration of HTX-011 and a postoperative non-opioid multimodal…
- Trial name
- NCT03907176
- Testing
- HTX-011, Luer lock applicator, Ibuprofen
- Where
- 30 sites in United States
- Volunteers
- 209 people
- Sponsor
- Heron Therapeutics
Complication, Postoperative
Preoperative High Dose Steroids for Liver Resection- Effect on Complications in the Immediate Postoperative Period
Background: Several randomized clinical trials have shown beneficial effects of pre-operative glucocorticoids on post-operative complications.
- Trial name
- STEREO (NCT03403517)
- Testing
- Methylprednisolone, Dexamethasone
- Where
- Denmark
- Volunteers
- 174 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
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