Clinical trials: Complication of Delivery
Brain Injuries, Infant, Premature
SafeBoosC - a Phase II Trial
Background 25,000 infants are born extremely preterm every year in Europe. This group of infants carries a high risk of death and subsequent cerebral impairment for the infant, especially in the first 72 hours of life.
- Trial name
- SafeBoosC (NCT01590316)
- Testing
- Cerebral NIRS oximetry
- Where
- Denmark
- Volunteers
- 165 people
- Sponsor
- Gorm Greisen
Premature Birth of Newborn
Kangaroo Care and Premature Infant Sleep
90 preterm infants were randomly assigned to kangaroo care (skin-to-=skin, chest-to-chest) group (n=50) or control (remained in incubator, prone (n=40) for a pretest period of 2- 3 hours, then fed, then KC group was placed in KC…
- Trial name
- NCT02473055
- Testing
- Kangaroo Care
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Case Western Reserve University
Surgical Site Infection in Obese Women Undergoing C-section
Use of 48 Hour Course of Antibiotics to Prevent Surgical Site Infection in Obese Patients Undergoing Cesarean Delivery
The purpose of this study is to evaluate if preoperative antibiotics, followed by 48 hour course of broad spectrum antibiotics prevents wound infection complications in patients that are obese who undergo cesarean section.
- Trial name
- SSI (NCT01194115)
- Testing
- cephalexin & metronidazole
- Where
- United States
- Volunteers
- 475 people
- Sponsor
- University of Cincinnati
Apnea of Prematurity, Prematurity
Nasal Olfactory Stimulation and Its Effect on Respiratory Drive in Preterm Infants
This trial analyzes the effect of an olfactory stimulation with vanilla or strawberry aroma compared to placebo on desaturations and bradycardia in preterm infants with apnea of prematurity.
- Conditions
- Apnea of Prematurity, Prematurity, Infant, Premature, Diseases
- Trial name
- NOSE (NCT05878925)
- Testing
- Aroma
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Zurich
Preterm Labor, Preterm Birth
Biomarkers Associated With Spontaneous Preterm Birth Less Than 32 Wks Gestation
Preterm delivery (PTD) is a leading cause of neonatal mortality and continues to be a major public health concern, reaching 12.9% in 2006, despite intense research to reverse this trend.
- Trial name
- NCT02317315
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ranjith Kamity, MD
Premature Birth
Plasticity of Neonatal Neuronal Networks Temporal Theta Activity, the First Endogenous
Temporal theta slow-wave activity (TTA-SW) in premature infants is a specific signature of the early development of temporal networks, as it is observed at the turning point between non-sensory driven spontaneous local processing…
- Trial name
- NEURONAUX (NCT03677908)
- Testing
- ElectroEncephaloGraphy
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Infection, Candida
Early Diagnosis of Candidiasis in Premature Infants
This observational study evaluated the performance of new lab tests in detecting candida species fungal infections in extremely low birth weight (ELBW) infants quickly and accurately.
- Conditions
- Infection, Candida, Candidiasis, Infant, Newborn
- Trial name
- Candida (NCT00109525)
- Where
- 20 sites in United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Neonatal Infection
Impact of a Multi-infusion Strategy in Neonatology on the Rate of Central Line-associated Bloodstream Infections
The management of premature infants hospitalized in neonatal units requires the simultaneous intravenous (IV) infusion of several drugs and parenteral nutrition solutions, when oral administration is impossible or unsuitable.
- Trial name
- EDELVAISS (NCT06656104)
- Testing
- Reference strategy, Experimental strategy
- Where
- 3 sites in France
- Volunteers
- 569 people
- Sponsor
- Hospices Civils de Lyon
Preeclampsia, Hypertensive Disorder of Pregnancy
Cardiovascular Protection After Preeclampsia With Enalapril
The purpose of this study is to learn if postpartum women are willing to be randomized to different blood pressure medicines after delivery and how that affects blood pressure in women with hypertensive disorders of pregnancy.
- Conditions
- Preeclampsia, Hypertensive Disorder of Pregnancy, Hypertension, Gestational Hypertension
- Trial name
- CAPP-E (NCT07222852)
- Testing
- Enalapril, Standard treatment
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Premature Infant Disease
A Randomized Controlled Trial to Evaluate the Effect of White Noises and Parental Voices As Protectors Against Noise Damage in a Neonatal Intensive Care Unit
The goal of this Randomized Controlled Trial is to test the efficacy of listening to white noises and parental voices against environmental noise damage in premature babies admitted to the Newborn Intensive Care Unit.
- Trial name
- NCT06150404
- Testing
- White Noises and Maternal and/or Paternal voices
- Where
- Italy
- Volunteers
- 11 people
- Sponsor
- Istituto Giannina Gaslini
Bronchopulmonary Dysplasia
Follow-up Safety and Efficacy Evaluation on Subjects Who Completed PNEUMOSTEM® Phase-II Clinical Trial
This is a follow-up study to investigate the long-term safety and efficacy of PNEUMOSTEM® versus placebo, for the treatment of BPD in premature infants.
- Trial name
- NCT01897987
- Testing
- Pneumostem®, normal saline
- Where
- 2 sites in South Korea
- Volunteers
- 62 people
- Sponsor
- Medipost Co Ltd.
Prematurity, Necrotizing Enterocolitis
Prediction of NEC With Urinary iFABP
During the first four days of life, intestinal fatty acid binding protein (iFABP) is elevated in the urine of premature babies who go on to develop necrotizing enterocolitis (NEC) days to weeks later.
- Trial name
- NCT01805206
- Testing
- Assessment of urinary iFABP, Administration of enteral feedings
- Where
- United States
- Sponsor
- Loma Linda University
Low Birth Weight Babies, Preterm Babies
Use of a Foot Length Card to Improve Careseeking Practices of Vulnerable Newborns in Sarlahi District, Nepal
This study will evaluate whether or not provision of a simple card ("footlength card") that allows identification of low birth weight and/or preterm babies through measurement of the length of a baby's foot, can improve basic…
- Trial name
- NCT02802332
- Testing
- Footlength Card
- Where
- Nepal
- Volunteers
- 4,574 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Bronchopulmonary Dysplasia
The Role of Volatile Organic Compounds (VOCs), Airway Mucins and the Microbiome in the Early Prediction of Bronchopulmonary Dysplasia (BPD)
Bronchopulmonary dysplasia (BPD), the most common respiratory complication of extremely preterm birth, significantly impacts healthcare with high morbidity and mortality rates.
- Trial name
- INFANCY (NCT06342752)
- Testing
- Breath test, Throat swabs, Placental samples
- Where
- Belgium
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Oocyte Donation, Infertility, Female
Transfer Strategy in an Oocyte Donation Programme
It has been previously shown that although the activation of the embryonic genome can begin as early as two days of initiation of the embryonic development (D2), it is expressed on day 3 (D3).
- Conditions
- Oocyte Donation, Infertility, Female, Embryo Transfer
- Trial name
- NCT03088735
- Testing
- Blastocyst-stage embryo transfer strategy, Cleavage-stage embryo transfer strategy
- Where
- Spain
- Volunteers
- 134 people
- Sponsor
- Fundacion Dexeus
Preterm Birth, Pregnancy
An Electronic Medical Record Alert of Progesterone
Progesterone can be given to women at risk for preterm birth, and is advocated by many guidelines as progesterone has been shown to markedly decrease preterm birth, death in newborns, and disability.
- Trial name
- NCT03219489
- Testing
- Electronic medical record alert
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- McMaster University
Preterm Birth Complication
Serial Brain MRI in Hospitalized Preterm Infants
The purpose of this research study is to use serial magnetic resonance imaging (MRI) to define the timing and factors associated with brain injury as well as the pattern of brain growth of very preterm infants during…
- Trial name
- NCT06052865
- Testing
- SENSE-plus: The Supporting and Enhancing NICU Sensory Experiences 2nd Edition (SENSE II) program, SENSE: The Supporting and Enhancing NICU Sensory Experiences 2nd Edition (SENSE II) program, Reference/ Standard of care
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Brigham and Women's Hospital
Prolonged Second Stage of Labor, Prolonged Second Stage of Labor Due to Poor Maternal Effort
Vacuum Delivery in All-fours Position vs Traditional Position
The aim of the study is to investigate the safety, clinical efficacy and the maternal/neonatal outcomes of vacuum application in all-fours position compared with supine traditional position, in women undergoing vacuum-assisted…
- Trial name
- VaDe-4 (NCT05612321)
- Testing
- Vacuum application
- Volunteers
- 250 people
- Sponsor
- Ospedale degli Infermi di Biella
Fluid Loss, Dehydration
The Application of Sterile Water to the Skin of Extremely Low Birth Weight (ELBW) Infants
Extremely low birth weight infants have significant water loss through their skin immediately after birth. This significant fluid loss is because they have large amounts of fluids, have immature skin and large surface area.
- Conditions
- Fluid Loss, Dehydration, Extreme Immaturity
- Trial name
- NCT02052284
- Testing
- Sterile water application
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- George Washington University
Hypotension, Cesarean Section Complications
Norepinephrine to Prevent Hypotension in Ceasrean Delivery
This study will be conducted on 40 healthy women having spinal anesthesia for elective cesarean delivery in the operating rooms at Menoufia university hospital.
- Trial name
- NCT05248932
- Testing
- Norepinephrine bolus, cardiometry, Norepinephrine infusion
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Menoufia University