Clinical trials: Complication of Dialysis
End Stage Renal Disease, Hemodialysis Patients
Association Between Dose Dialysis by Kt and Mortality
The aim of this study is to assess whether patients receiving current recommendations of an adequate dialysis dose by Kt adjusted for body surface area improved survival at 24 months compared to those who do not get it, as well…
- Trial name
- NCT01932853
- Where
- Spain
- Volunteers
- 6,129 people
- Sponsor
- NephroCare Spain
ESRD
Effects of Postdilution Online Hemodiafiltration With AcEtate-free Citrate dialySis Fluid on Inflammation Markers
The aim of this study was to evaluate the effect and timing of action on the inflammatory state of a acetate-free containing citrate concentrate (Cit-, 1 mM Citrate) in online postidultion HDF with high volumes compared to…
- Trial name
- HEPHAESTUS (NCT02863016)
- Testing
- SelectBag One
- Where
- 3 sites in Italy
- Volunteers
- 66 people
- Sponsor
- Ospedale Santa Maria Annunziata
End Stage Renal Disease
The Effect of Probiotic Supplementation
This is a double-blind randomised controlled trial where participants will be randomised to either twice daily 65ml of Lactobacillus casei Shirota for six months or a matched placebo.
- Trial name
- NCT04390347
- Testing
- Yakult
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Leicester
Stage 5 Chronic Kidney Disease, Hemodialysis
Comparison of Outcomes Between Hemodialysis and Peritoneal Dialysis Patients in a Multi-Ethnic Asian Population
End-stage renal disease (ESRD) presents a heavy burden on a patient's psychological and social life, as well as overall quality of life (QoL).
- Conditions
- Stage 5 Chronic Kidney Disease, Hemodialysis, Peritoneal Dialysis
- Trial name
- NCT01587443
- Where
- Singapore
- Volunteers
- 200 people
- Sponsor
- National University of Singapore
End Stage Renal Disease
The Benefit of Оn-Line High Convection Volume Hemodiafiltration Treatment Versus High Flow Dialysis on Reduction of Oxidative Stress and Health Related Quality of Life in Dialysis Patients
Introduction: Patients with end stage renal disease are exposed to metabolic and hemodynamic complications due to the disease itself and as a result of the dialysis treatment related complications.
- Trial name
- NCT02673099
- Testing
- HDF online
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- Western Galilee Hospital-Nahariya
End Stage Renal Disease
The Measurement of Insulin Resistance in Peritoneal Dialysis Patients
The goal of this study is to examine the relevance of insulin resistance in peritoneal dialysis (PD) patients as well as the means to improve this metabolic derangement.
- Trial name
- NCT01119196
- Testing
- Icodextrin dialysate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University
Chronic Kidney Disease Requiring Chronic Dialysis
Activation of the Contact System and the Immune System in Patients With Chronic Kidney Disease.
Patients with end-stage renal disease undergoing hemodialysis (HD) are burdened with extremely high mortality rates (15% per year) and during the early stage (≤120days) the mortality rate is even higher (27% per year).
- Trial name
- AKIM-CKD (NCT05266092)
- Testing
- Observational study
- Where
- Denmark
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Chronic Kidney Diseases
The Danish Symptomburden Study Among Patients With Advanced Kidney Disease
Patients with chronic kidney disease stage five have a high symptom burden regardless of whether they are treated with dialysis or without dialysis, a conservative kidney management pathway (CKM).
- Trial name
- NCT06019871
- Testing
- Dialysis
- Where
- Denmark
- Volunteers
- 341 people
- Sponsor
- University of Aarhus
Moderate-severe Chronic Kidney Disease Not Treated With Dialysis, Diabetic Kidney Disease, HgbA1c Less Than 8.5
Exercise Study Testing Enhanced Energetics of Mitochondria Video Integrated Delivery of Activity Training in CKD
Skeletal muscle dysfunction (sarcopenia) is an under-recognized target organ complication of CKD with substantial adverse clinical consequences of disability, hospitalization, and death.
- Trial name
- ESTEEM-VIDA (NCT02923063)
- Testing
- Combined Aerobic and Resistance Exercise via videoconferencing
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, Davis
Acute Kidney Injury, Intensive Care
The Cost-effectiveness of Artificial Intelligence Acute Kidney Injury Prediction Auxiliary Software (Acura AKI)
"Huede" AI Aided AKI Prediction Software, Acura AKI, uses machine learning algorithms to predict the risk of AKI within the next 24 hours and provide a ranking of feature importance.
- Conditions
- Acute Kidney Injury, Intensive Care, Renal Replacement Therapy
- Trial name
- NCT06685367
- Testing
- Acura AKI
- Where
- Taiwan
- Volunteers
- 3,600 people
- Sponsor
- Huede Healthtech Co., Ltd.
Anaemia
4 Week Correction Study in Subjects With Anemia Associated With Chronic Kidney Disease Who Are Not Undergoing Dialysis
This is a four-week Phase IIa, randomized, double-blind, placebo-controlled, parallel-group, multi-center study to evaluate the safety, efficacy and pharmacokinetics of GSK1278863 in approximately 68 subjects with anemia…
- Trial name
- NCT01587898
- Testing
- GSK1278863
- Where
- 55 sites in United States, Canada and 1 more
- Volunteers
- 72 people
- Sponsor
- GlaxoSmithKline
Chronic Hepatitis C
Pegylated Interferon and Ribavirin to Treat Chronic Hepatitis C With and Without Kidney Disease
This study will examine the effectiveness of pegylated interferon, or peginterferon (a long-acting form of alpha interferon) plus ribavirin in treating hepatitis C (genotype 1) infection with and without kidney disease.
- Trial name
- NCT00028093
- Testing
- Peginterferon alfa-2a with Ribavirin, Peginterferon alfa-2a
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ESRD, Cardiovascular Diseases
The Impact of Statin Holiday in Dialysis Patients Over 70 Years Old on Mental Function, Physical Function and Frailty
Patients who are on chronic dialysis and 70 and older are frequently on multiple medications including statins. However, the benefit of statins in dialysis patient population is uncertain.
- Trial name
- NCT03663049
- Testing
- discontinue statin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Loyola University
Pulmonary Hypertension, End-Stage Renal Disease
Impact of Hemo-dialysis Therapy on Blood Levels of Treprostenil in End Stage Renal Disease Patients With Pulmonary Hypertension
Remodulin (Treprostenil sodium) is synthetic prostacyclin analog available as a solution for administration in the intravenous route.
- Conditions
- Pulmonary Hypertension, End-Stage Renal Disease, Hemo-dialysis Therapy
- Trial name
- NCT01234571
- Volunteers
- 5 people
- Sponsor
- Rambam Health Care Campus
Calciphylaxis, Calcific Uremic Arteriolopathy
Phase 2 Study With SNF472 in Calciphylaxis Patients
To evaluate the effect of SNF472 on top of standard of care on promoting wound healing and other parameters of therapeutic response in haemodialysis patients with calciphylaxis (calcific uraemic arteriolopathy, CUA).
- Trial name
- NCT02790073
- Testing
- SNF472
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 14 people
- Sponsor
- Sanifit Therapeutics S. A.
Kidney Failure, Secondary Hyperparathyroidism
Cinacalcet Versus Parathyroidectomy in Peritoneal Dialysis Patients
This is a pilot, prospective randomized controlled study with the primary objective to evaluate and compare medical treatment of severe SHPT, namely oral cinacalcet versus surgical treatment, that is, parathyroidectomy with…
- Conditions
- Kidney Failure, Secondary Hyperparathyroidism, Vascular Diseases
- Trial name
- PROCEED (NCT01447368)
- Testing
- Cinacalcet, Surgical total parathyroidectomy with forearm autografting
- Where
- Hong Kong
- Volunteers
- 67 people
- Sponsor
- The University of Hong Kong
Chronic Kidney Disease
Skin Autofluorescence as a Risk Marker in People Receiving Dialysis.
The purpose of the present study is to investigate the association between the accumulation of advanced glycation end-products (AGE) and adverse outcomes (e.g.
- Trial name
- AGED (NCT02878317)
- Where
- United Kingdom
- Volunteers
- 81 people
- Sponsor
- University of Nottingham
Chronic Kidney Diseases
Feasibility Study of a mHealth Platform for Remote Patient Monitoring of CKD and Peritoneal Dialysis Patients
The best treatment of Chronic Kidney Disease (CKD) is facilitated by early detection, when the progression of the disease can be slowed down or stopped.
- Trial name
- NCT05012020
- Testing
- mHealth Remote Monitoring platform
- Where
- Singapore
- Volunteers
- 35 people
- Sponsor
- AWAK Technologies Pte Ltd
End Stage Renal Disease
Dialysis Catheter Comparative Clinical Trial
The purpose of this clinical trial is to compare the longevity of two dialysis catheters.
- Trial name
- NCT00526123
- Testing
- Symmetric Tip Catheter, Conventional Split-tip Catheter
- Where
- 14 sites in United States
- Volunteers
- 599 people
- Sponsor
- Tyco Healthcare Group
Normal Renal Function, Impaired Renal Function
A Phase 1 Study of Roxadustat in Subjects With Different Degrees of Renal Function
For subjects with normal renal function or severely impaired renal function, this study will evaluate the pharmacokinetics of roxadustat and its main metabolites in plasma and urine.
- Trial name
- NCT02965040
- Testing
- Roxadustat
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Europe B.V.
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