Clinical trials: Complication of Dialysis
Renal Disease, Peripheral Arterial Disease
The Effects of INP on Peripheral Circulation in Dialysis Patients and Patients With PAD and Leg Ulcers
This experimental study will look at the effects of INP therapy for two patient groups: 1) patients with reduced peripheral circulation and chronic wounds in patients with renal disease (dialysis patients); 2) and peripheral…
- Conditions
- Renal Disease, Peripheral Arterial Disease, Arterial Leg Ulcers
- Trial name
- NCT02622308
- Testing
- FlowOx™
- Where
- Norway
- Volunteers
- 4 people
- Sponsor
- Oslo University Hospital
Renal Failure, Chronic Kidney Diseases
Influence of Variable Inflow Volume, Dwell Duration and Glucose Concentration on Ultrafiltration Volume in APD Patients
The purpose of the current investigation is to provide proof of concept for a future approach to improve UF prediction accuracy.
- Trial name
- pPD (NCT06443021)
- Testing
- PD cycler
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Anaemia
Anemia Studies in CKD: Erythropoiesis Via a Novel PHI Daprodustat - Pediatric (ASCEND-P)
This is an international, multicenter trial, evaluating pharmacokinetics (PK) (4 weeks), safety (52 weeks), and hemoglobin (Hgb) response (52 weeks) to daprodustat in children and adolescent participants with anemia associated…
- Trial name
- ASCEND-P (NCT05682326)
- Testing
- Daprodustat
- Where
- 4 sites in Japan, South Korea
- Volunteers
- 4 people
- Sponsor
- GlaxoSmithKline
Anemia, Renal Insufficiency, Chronic
A Study of Molidustat for Maintenance Treatment of Renal Anemia in Non-dialysis Subjects
The purpose of this study is to evaluate the efficacy and safety of molidustat in non-dialysis subjects previously treated with Erythropoiesis-Stimulating Agents (ESAs)
- Trial name
- MIYABI ND-M (NCT03350347)
- Testing
- Molidustat (BAY85-3934), Darbepoetin alfa
- Where
- 59 sites in Japan
- Volunteers
- 164 people
- Sponsor
- Bayer
Kidney Failure, Chronic
Influence of Amlodipine on the Mortality of Patients With End-Stage Renal Failure
Patients with end-stage renal failure have a markedly higher mortality because of cardiovascular events in comparison with the normal population.
- Trial name
- NCT00124969
- Testing
- Amlodipine
- Where
- Germany
- Volunteers
- 356 people
- Sponsor
- Charite University, Berlin, Germany
Vascular Access Complication, Restenosis, Vascular Graft
Drug-eluting Balloon vs. Conventional Balloon in the Treatment of (re)Stenosis (Dialysis Fistulae)
The purpose of this study is to determine whether the use of drug-eluting balloons is effective in the treatment of (re)stenosis in dialysis fistulae.
- Conditions
- Vascular Access Complication, Restenosis, Vascular Graft, Dialysis Related Complications
- Trial name
- DRECOREST2 (NCT03036241)
- Testing
- Conventional angioplasty, Angioplasty with drug-eluting balloon
- Volunteers
- 39 people
- Sponsor
- Helsinki University Central Hospital
End-Stage Renal Disease, Hemodialysis
Comparison of Four and Eight Hours Dialysis Sessions in Thrice Weekly Hemodialysis
The investigators hypothesize that an increase in the duration of dialysis session in thrice weekly center hemodialysis may provide better outcome, less morbidity, higher quality of life, lesser requirement of medications, and…
- Trial name
- NCT00413803
- Testing
- 4-hour thrice weekly in center hemodialysis, 8-hour thrice weekly in center hemodialysis
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 410 people
- Sponsor
- Ege University
Peritonitis
Effect of Icodextrin on the Treatment Outcome of Peritoneal Dialysis Patients During Acute Peritonitis
The objective of the present study is to evaluate the a prior hypothesis that treatment with icodextrin during acute peritonitis would improve the treatment outcomes of peritonitis complicating peritoneal dialysis.
- Trial name
- NCT01044446
- Testing
- Icodextrin, glucose-based peritoneal dialysate
- Where
- Hong Kong
- Volunteers
- 56 people
- Sponsor
- Chinese University of Hong Kong
End Stage Renal Disease, Dialysis
Peritoneal Membrane Dysfunction in Peritoneal Dialysis Using Metabolomics
Ability and sensitivity of metabolomics analysis to highlight biomarkers or a score of biomarkers that will be able to identify those pediatric patients on peritoneal dialysis at high risk for possible peritoneal dialysis…
- Trial name
- NCT03964701
- Testing
- no intervention
- Where
- Greece
- Volunteers
- 18 people
- Sponsor
- Baxter (Hellas) Ltd
Renal Dialysis, Renal Failure, Chronic
Tobramycin Administered at the Beginning of Dialysis
The purpose of the study is to evaluate whether the administration of a full tobramycin dose (5 mg/kg) during the first 30 minutes of a hemodialysis session provides favorable pharmacokinetic parameters in subjects with end-stage…
- Trial name
- ESRD (NCT03904836)
- Testing
- Tobramycin
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- Maisonneuve-Rosemont Hospital
End-stage Renal Disease, Dialysis
Economic Evaluation of an Education Platform for Patients With End-stage Renal Disease
1600 patients with severe, end stage renal disease or post transplant will be randomised 1:1:1 to either standard therapeutic education; or education using a specific app; or the enhanced interactive app using feedback messages.
- Conditions
- End-stage Renal Disease, Dialysis, Kidney Transplantation
- Trial name
- PIC-R (NCT03090828)
- Testing
- app-based therapeutic education, enhanced app-based therapeutic education
- Volunteers
- 1,600 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atherosclerosis of Artery, Inflammation
The Impact of Selected Factors on the Cardiovascular System in Chronic Kidney Disease
Chronic kidney disease (CKD), is characterized by accelerated development of atherosclerosis and advanced remodelling of vessels and the heart.
- Conditions
- Atherosclerosis of Artery, Inflammation, Chronic Kidney Diseases, Dialysis; Complications
- Trial name
- NCT05214872
- Testing
- laboratory parameters - complete blood count, body mass index (BMI) [kg/m^2] calculation, selected parameters of oxidative stress (1)
- Where
- Poland
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Anaemia
Anemia Studies in Chronic Kidney Disease (CKD): Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat in Non-Dialysis Subjects Evaluating Hemoglobin (Hgb) and Quality of Life (ASCEND-NHQ)
The purpose of this multi-center study in non-dialysis participants with anemia associated with CKD is to evaluate safety, efficacy and quality of life of daprodustat compared to placebo.
- Trial name
- NCT03409107
- Testing
- Daprodustat (GSK1278863), Iron therapy
- Where
- 168 sites in United States, Argentina and 12 more
- Volunteers
- 614 people
- Sponsor
- GlaxoSmithKline
Renal Failure Acute Chronic
Efficacy and Tolerability of the APD Treatment in PAED Patients
The Silencia PD (peritoneal dialysis) cycler offers a pediatric (PAED) mode with advanced features such as Time and Volume Optimization (TAVO), supporting precise and individualized treatment.
- Trial name
- SilenciaPAED (NCT07004907)
- Testing
- Treatment with the pedriatic mode of the APD cycler
- Volunteers
- 13 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Anemia of Chronic Kidney Disease
Study to Evaluate the Safety and Efficacy of Oral Vadadustat in Pediatric Participants With Anemia of Chronic Kidney Disease
This study will assess the safety and efficacy of once daily dosing of vadadustat for the treatment of pediatric participants with anemia of Chronic Kidney Disease (CKD) after conversion from an Erythropoiesis Stimulating Agent…
- Trial name
- CONVERSION (NCT05082571)
- Testing
- vadadustat
- Where
- United States
- Sponsor
- Akebia Therapeutics
Anaemia
Anemia Studies in Chronic Kidney Disease: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Non-Dialysis (ASCEND-ND)
The purpose of this multi-center event-driven study in non-dialysis (ND) participants with anemia associated with chronic kidney disease (CKD) is to evaluate the safety and efficacy of daprodustat compared to darbepoetin alfa.
- Trial name
- NCT02876835
- Testing
- Daprodustat, Darbepoetin alfa, Iron Therapy
- Where
- 574 sites in United States, Argentina and 37 more
- Volunteers
- 3,872 people
- Sponsor
- GlaxoSmithKline
Renal Dialysis
Pain Perception by the Chronic Renal Patient at the Time of Vascular Access Cannulation.
Pain in patients under hemodialysis affects chronic renal patients' quality of life. Distraction has been effective in controlling pain induced by the insertion of needles.
- Trial name
- NCT05729113
- Testing
- Distraction technique
- Where
- Portugal
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Joana Sofia Dias Pereira de Sousa
End Stage Renal Disease
Investigating the Effectiveness of Intradialytic Massage on Cramping in Dialysis Patients
Primary Aim. The primary aim is to determine the effectiveness of intradialytic massage on the frequency and severity of cramping among hemodialysis patients prone to lower extremity cramping during treatment.
- Trial name
- NCT01944280
- Testing
- massage
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Catherine Sullivan
End-Stage Renal Disease, Hemodialysis
Hemocontrol and Blood Pressure Control in Dialysis Patients
Volume overload contributes significantly to the pathogenesis of hypertension in hemodialysis patients. The Hemocontrol(HC)system (Gambro), which automatically adjusts ultrafiltration rate and dialysate conductivity according to…
- Trial name
- NCT00319774
- Testing
- Hemocontrol Biofeedback System
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Université de Montréal
Hepatitis C Virus Infection, Response to Therapy of
Clinical Trial to eLiminate HCV-infection in Treatment-naïve, Renally Impaired EgyptiAn Patients on Renal Dialysis, With Chronic Hepatitis C Genotype 4
Primary Efficacy Objective -To assess whether a 12-week treatment course with oral 50 mg elbasvir plus 100 mg grazoprevir given in a single daily dose to treatment-naïve patients with end-stage renal disease (ESRD) and infected…
- Trial name
- CLEAR-C4 (NCT03381859)
- Testing
- Elbasvir/Grazoprevir 50 MG-100 MG Oral Tablet [ZEPATIER]
- Where
- Egypt
- Sponsor
- University of Maryland, Baltimore
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