Clinical trials: Complication of Dialysis
Anemia in Incident Dialysis Patients
Safety and Efficacy Study of Roxadustat (FG-4592) for the Treatment of Anemia in End-Stage Renal Disease (ESRD) Newly Initiated Dialysis Participants
The purpose of this study is to determine whether roxadustat is safe and effective in the treatment of anemia in participants who have just begun dialysis treatment for ESRD.
- Trial name
- Himalayas (NCT02052310)
- Testing
- Roxadustat, Epoetin Alfa
- Where
- 113 sites in United States, Argentina and 13 more
- Volunteers
- 1,043 people
- Sponsor
- Kyntra Bio
Pediatric Continuous Renal Replacement Therapy, Dialysis
Safety and TDM of Continuous Infusion Vancomycin Through Continuous Renal Replacement Therapy Solution
The purpose of this investigation is to evaluate the safety of delivering continuous infusion (CI) vancomycin in pediatric CRRT by utilizing CI via by mixing the vancomycin into the CRRT solution(s).
- Conditions
- Pediatric Continuous Renal Replacement Therapy, Dialysis, Renal Failure
- Trial name
- NCT02663596
- Testing
- Vancomycin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Drexel University
Renal Disease, Chronic, Renal Disease, End-Stage
Non-invasive Testing for End-Stage Chronic Kidney Disease
This study evaluates the clinical performance of a non-invasive digital diagnostic test (KF4+, developed and manufactured by Gisens Biotech) for the measurement of urea and potassium in capillary blood in patients with end-stage…
- Conditions
- Renal Disease, Chronic, Renal Disease, End-Stage, Dialysis Patients, Urea in Blood; High
- Trial name
- NiTED (NCT07777523)
- Testing
- KF4+ Noninvasive Test
- Where
- Argentina
- Volunteers
- 55 people
- Sponsor
- Gisens Biotech
Hemodialysis Complication
Comparison of the Effectiveness of Intradialytic Core Stabilization and Aerobic Exercise in Hemodialysis Patients
Purpose: To examine the effects of core stabilization and aerobic exercises on dialysis adequacy, functionality level, and quality of life in hemodialysis (HD) patients.
- Trial name
- NCT05534542
- Testing
- exercıse
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Muş Alparslan University
Fluid Overload, Dialysis; Complications
ULtrafiltration-Rate Induced CArdiac Strain (ULRICA) - Study
Patients performing chronic hemodialysis (HD) retain more or less water between dialyses. The water is removed by ultrafiltration and usually during the cleansing of waste products - the HD.
- Trial name
- ULRICA (NCT06153888)
- Testing
- Ultrafiltration rate
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Umeå University
Renal Insufficiency, Chronic, Kidney Failure, Chronic
First-in-human Study to Examine Safety of a New Peritoneal Dialysis Device (WEAKID) in End-stage Kidney Disease Patients
The goal of this first-in-human clinical trial is to examine the safety and efficacy of treatment with a new peritoneal dialysis (PD) device called WEAKID (WEarable Artificial KIDney for peritoneal dialysis).
- Conditions
- Renal Insufficiency, Chronic, Kidney Failure, Chronic, Chronic Kidney Diseases
- Trial name
- CORDIAL (NCT06314503)
- Testing
- WEAKID
- Where
- 3 sites in Italy, Netherlands and 1 more
- Volunteers
- 12 people
- Sponsor
- UMC Utrecht
Cardiovascular Disease, Chronic Kidney Disease Patients
A Study Using L5 as a Risk Factor of Cardiovascular (CV) Disease in Chronic Renal and Dialytic Patients
The purpose of this study is to determine whether L5, one of the Low Density Lipoproteins, is an effective predicting factor for cardiovascular disease in chronic renal and hemodialytic patients.
- Conditions
- Cardiovascular Disease, Chronic Kidney Disease Patients, Hemodialytic Patients, High LDL Level
- Trial name
- L5 (NCT01236820)
- Where
- Taiwan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Fatigue, End Stage Renal Disease (ESRD)
Lipid Infusion in Dialysis Patients With Endotoxemia
The purpose of this study is to determine whether a phospholipid emulsion is effective in the treatment of chronic endotoxemia in hemodialysis patients.
- Trial name
- LIPIDOSE (NCT00506454)
- Testing
- Lipidose
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Sepsicure
Kidney Disease
Zemplar® Capsule in Reducing Serum Intact Parathyroid Hormone Levels in Chronic Kidney Disease Stage 5 Subjects on Hemodialysis or Peritoneal Dialysis
The objective of this study is to determine the safety and efficacy of Zemplar® Capsule versus placebo, in decreasing elevated intact parathyroid hormone levels in chronic kidney disease stage 5 subjects with secondary…
- Trial name
- NCT00091975
- Testing
- Zemplar Capsule
- Where
- 16 sites in United States
- Volunteers
- 78 people
- Sponsor
- Abbott
Acute Kidney Injury, Acute Kidney Failure Stage 3
The Performance of Renal Doppler Ultrasound in Predicting Outcome of Dialysis Weaning
Acute kidney injury (AKI) is a frequent problem in the intensive care unit (ICU) affecting more than 50 % of patients. AKI is associated with several adverse outcomes, including increased mortality and increased length of ICU…
- Trial name
- NCT04622384
- Testing
- Dialysis weaning
- Where
- Denmark
- Volunteers
- 33 people
- Sponsor
- Johan Fridolf Hermansen
Chronic Kidney Disease (CKD)
Pilot Study for the Early Detection of Chronic Kidney Disease, Non-Dialysis Objective (NDO).
Chronic kidney disease (CKD) is a significant public health problem worldwide, affecting more than 10% of the Spanish population.
- Trial name
- NDO (NCT06447038)
- Testing
- albumin creatinine ratio
- Where
- Spain
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario de Burgos
Intradialytic Hypertension, End Stage Kidney Disease
Effect of Low Versus Standard Dialysate Sodium on 48h Ambulatory BP in Patients With Intradialytic Hypertension
Intradialytic hypertension (IDH) is a well-recognized and established complication of hemodialysis that affects an estimated 10-15% of the dialysis population and is associated with an increased risk for cardiovascular adverse…
- Trial name
- NCT05430438
- Testing
- dialysis with low dialysate sodium concentration, dialysis with standard dialysate sodium concentration
- Where
- 4 sites in Greece, Slovenia
- Volunteers
- 30 people
- Sponsor
- Aristotle University Of Thessaloniki
Liver Failure as A Complication of Care
Early Liver Support With MARS in Post-hepatectomy Liver Failure
This is a prospective, randomized, open-label, multicentre study involving European centers with experience in the management of PHLF to assess the impact of early liver support with MARS on survival in patients with…
- Trial name
- ELISH (NCT03761238)
- Testing
- Molecular Adsorbent Recirculating System, Standard medical treatment (SMT)
- Volunteers
- 44 people
- Sponsor
- Stefan Gilg, MD, PhD
End Stage Renal Disease, Chronic Kidney Diseases
Shared Decision Making in Dialysis
Older patients ≥65 years with chronic kidney disease (CKD) face challenges in decision making about dialysis. These patients report little effort by physicians to elicit treatment preferences, discuss prognoses, or explain the…
- Trial name
- DIAL-SDM (NCT04392440)
- Testing
- DIAL-SDM, usual care
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Rochester
Dialysis; Complications, Vascular Access Complication
Access Cannulation Trial II
This is a pivotal, interventional, prospective, single-arm, open-label, multi-site clinical investigation intended to support FDA clearance of the study device based on the safety and efficacy of the device in cannulating…
- Trial name
- ACT II (NCT05490225)
- Testing
- VenaSure
- Where
- 8 sites in United States
- Volunteers
- 100 people
- Sponsor
- Voyager Biomedical
Autosomal Recessive Polycystic Kidney Disease (ARPKD)
A Study to See if Tolvaptan Can Delay Dialysis in Infants and Children Who at Enrollment Are 28 Days to Less Than 12 Weeks Old With Autosomal Recessive Polycystic Kidney Disease (ARPKD)
The primary objective of this study is to evaluate the effect of tolvaptan on the need for renal replacement therapy in pediatric subjects with autosomal recessive polycystic kidney disease (ARPKD)
- Trial name
- NCT04786574
- Testing
- Tolvaptan (OPC-41061)
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Cirrhosis, Acute on Chronic Hepatic Failure
Single Pass Albumin Dialysis in Patients With Cirrhosis
The aim of this study is to determine whether a simplified device of albumin dialysis also has beneficial effects.
- Conditions
- Cirrhosis, Acute on Chronic Hepatic Failure, Hepatorenal Syndrome, Encephalopathy
- Trial name
- DACAR (NCT00764049)
- Testing
- Single pass albumin dialysis
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Kidney Diseases
Intradialisis Physical Exercise in Quality of Life and Health
Evaluate the effectiveness of different modalities of physical exercise about clinical health indicators and quality of life of patients with chronic kidney disease undergoing hemodialysis.
- Trial name
- EJERINTRA (NCT05207527)
- Testing
- cardiovascular exercise, Muscle strength, Mixed
- Volunteers
- 120 people
- Sponsor
- Universidad del Rosario
Chronic Kidney Disease(CKD), Chronic Kidney Disease Requiring Chronic Dialysis
Investigation of the Validity, Reliability, and Responsiveness of BETY-BQ in Chronic Kidney Disease, on Dialysis, and Kidney Transplantation
A review of the literature has shown that Chronic Kidney Disease (CKD) is strongly associated with an increasing degree of psychosocial impact, such as depression and anxiety and a decrease in quality of life.
- Conditions
- Chronic Kidney Disease(CKD), Chronic Kidney Disease Requiring Chronic Dialysis, Kidney Transplantation
- Trial name
- NCT06591702
- Testing
- Questionnaire study
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Hacettepe University
End-Stage Renal Disease
Safety and Cardiovascular Efficacy of Spironolactone in Dialysis-Dependent ESRD Trial
The SPin-D Trial is a phase II randomized, double-blind, placebo-controlled, multi-center study of spironolactone (SPL) for patients with hemodialysis-dependent end-stage renal disease.
- Trial name
- SPin-D (NCT02285920)
- Testing
- Spironolactone
- Where
- 4 sites in United States
- Volunteers
- 129 people
- Sponsor
- University of Pennsylvania
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