Clinical trials: Complication of Dialysis
End Stage Renal Disease, Inflammation
Evaluation of Biocompatibility and Performances of 4 Dialyzers in Different Mode Treatments
Prospective multicenter randomized cross-over study Number of patients : 32 (8 patients per group) Obtain objectives data to advise each hemodialyzer according to dialysis treatment and patient profile.
- Trial name
- BIOMODAL (NCT03262272)
- Testing
- VIE A Hemodialyzer, Rexsys 27H hemodialyzer, Leoceed 21HX hemodialyzer
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Hemotech
Anemia, Chronic Kidney Disease
Evaluation of Monthly Darbepoetin Alfa Dosing for Correction of Anemia in Non-dialysis Chronic Kidney Disease
The purpose of this study is to determine whether once monthly (QM) dosing of darbepoetin alfa is non-inferior to that of once every 2 week (Q2W) dosing of darbepoetin alfa for the correction of anemia in patients with Chronic…
- Trial name
- NCT00925587
- Testing
- darbepoetin alfa
- Where
- 157 sites in Australia, Belgium and 21 more
- Volunteers
- 358 people
- Sponsor
- Amgen
End-stage Kidney Disease, End-stage Renal Disease
The Prevalence of Sarcopenia in a Cohort of Haemodialysis Patients and Its Correlation With Mortality
The study aims to explore the correlation between the prevalence of sarcopenia and one year mortality amongst patients on maintenance hemodialysis
- Conditions
- End-stage Kidney Disease, End-stage Renal Disease, Dialysis Dependent Chronic Kidney Disease, Sarcopenia
- Trial name
- NCT06477978
- Testing
- Hand grip function testing
- Where
- Egypt
- Volunteers
- 274 people
- Sponsor
- Kasr El Aini Hospital
Anemia, Chronic Kidney Disease
A Study of MK2578 in Patients With Chronic Kidney Disease Who Are Not on Dialysis (2578-002)
This study will define an effective starting dose for subcutaneous administration of MK2578 to correct anemia in erythropoiesis-stimulating agent (ESA)-naive patients with chronic kidney disease (CKD) who are not on dialysis…
- Trial name
- NCT00968617
- Testing
- MK2578, Comparator: darbepoetin alfa
- Volunteers
- 7 people
- Sponsor
- Merck Sharp & Dohme LLC
End-Stage Kidney Disease
Randomised Evaluation of Sodium Dialysate Levels on Vascular Events
This global study will assess the effect of randomising dialysis sites to one of two default dialysate sodium concentrations in current practice, 140mmol/l and 137mmol/l, on major cardiovascular events and death in patients…
- Trial name
- RESOLVE (NCT02823821)
- Testing
- Default dialysate sodium concentration of 137mmol/l, Default dialysate sodium concentration of 140mmol/l
- Where
- 264 sites in Australia, Canada and 4 more
- Volunteers
- 50,000 people
- Sponsor
- University of Sydney
Chronic Kidney Disease
Effect of Dietary Fiber on Non-dialysis Patients With Chronic Kidney Disease
The main objective of this study was to investigate the effect of dietary fiber on anemia and glomerular filtration rate in non-dialysis patients with chronic kidney disease.
- Trial name
- NCT05835648
- Testing
- Nutrasumma
- Volunteers
- 56 people
- Sponsor
- Qianfoshan Hospital
Anemia
Long Term Safety Study of (VIT45) Extension Study: Treatment of Anemia in Non-Dialysis Dependent Chronic Kidney Disease
The primary objective of this study is to evaluate the long term safety and tolerability of an iron maintenance dosing strategy utilizing VIT45 in the treatment of anemia of non-dialysis dependent chronic kidney disease…
- Trial name
- NCT00317226
- Testing
- Ferric Carboxymaltose (FCM)
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- American Regent, Inc.
Anemia, Kidney Failure
Levocarnitine for Reducing ESA Requirements in Hemodialysis Patients With Renal Anemia
Renal anemia is common in people receiving long-term hemodialysis and is usually treated with erythropoiesis-stimulating agents (ESAs).
- Conditions
- Anemia, Kidney Failure, End-Stage Renal Disease, Renal Dialysis
- Trial name
- L-CAR-ESA (NCT07160452)
- Testing
- Levocarnitine Injection, Usual ESA-Based Anemia Care
- Volunteers
- 94 people
- Sponsor
- Shaikh Zayed Hospital, Lahore
Chronic Disease, Kidney Diseases
A Study to Evaluate Whether Correction of Anemia Using Recombinant Human Erythropoietin Reduces the Progression of Atherosclerosis and Cardiac Hypertrophy in Pre-dialysis Chronic Kidney Disease Patients
The primary aim of the study is to evaluate the effects of correction of anemia using erythropoietin on the progression of atherosclerosis and cardiac muscle thickening in patients with chronic kidney disease
- Conditions
- Chronic Disease, Kidney Diseases, Cardiovascular Diseases
- Trial name
- NCT00563355
- Testing
- erythropoietin
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Hospital Authority, Hong Kong
Chronic Kidney Failure
Clinical Evaluation of Low Sodium Peritoneal Dialysis (PD) Solution on Hypertensive Patients Treated With PD
The aim of this study is to assess the superiority of the new low sodium peritoneal dialysis (PD) solution PDsol 12 in comparison with a conventional, already marketed solution, Gambrosol trio 40, in the treatment of the…
- Trial name
- PDOne (NCT00794326)
- Testing
- Solution for Peritoneal Dialysis
- Where
- 29 sites in Denmark, France and 3 more
- Volunteers
- 140 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
End Stage Renal Disease, Hemodialysis Complication
The Effect of Home-Based Tele-Exercise on Dialysis Patients
The objective of the trial is to assess key areas of uncertainty regarding the use of synchronous home-based tele-exercise in future practice and research, including issues relating to feasibility, safety and potential for…
- Trial name
- NCT06313892
- Testing
- Home-based Exercise
- Where
- Iran
- Volunteers
- 26 people
- Sponsor
- Pardis Specialized Wellness Institute
Quality of Life, End Stage Renal Disease
Improved Selection of Elderly (> 65 Years) for Kidney Transplantation
Kidney transplantation has been shown to provide improved survival even in patients older than 70 years of age. The purpose of the study is to determine whether kidney transplantation provides any improvement of health related…
- Conditions
- Quality of Life, End Stage Renal Disease, End Stage Renal Failure on Dialysis
- Trial name
- QUESTION65 (NCT01760733)
- Where
- Norway
- Volunteers
- 289 people
- Sponsor
- Sykehuset Telemark
CKD Anemia in Stable Dialysis Patients
Study to Evaluate the Efficacy and Safety of Roxadustat in the Treatment of Anemia in Participants With ESRD on Stable Dialysis
The primary objective of this study is to evaluate the efficacy and safety of roxadustat compared with active control (epoetin alfa) for the maintenance treatment of anemia in participants with ESRD on dialysis.
- Trial name
- NCT02273726
- Testing
- Epoetin Alfa, Roxadustat
- Where
- 76 sites in United States, Puerto Rico
- Volunteers
- 741 people
- Sponsor
- Kyntra Bio
Covid19
PROphylaxis for paTiEnts at Risk of COVID-19 infecTion -V
COVID-19 (SARS-CoV2 virus) was declared a global pandemic by the WHO on 11th March 2020. Currently there are no drugs proven to prevent COVID-19 or to reduce the severity of illness if given as prophylaxis.
- Trial name
- PROTECT-V (NCT04870333)
- Testing
- Niclosamide, Ciclesonide, Sotrovimab
- Where
- 45 sites in United Kingdom
- Volunteers
- 2,240 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
End-stage Renal Disease
Impact of Dialysis Modality on Hepcidin and Iron Metabolism
Dialysis modality may influence the oxidative stress and proinflammatory cytokines in ESRD patients. Dialysis modality may affect hepcidin Dialysis modality may influence iron and ESA requirements.
- Trial name
- HERMES (NCT01723111)
- Where
- 4 sites in South Korea
- Volunteers
- 120 people
- Sponsor
- Kyungpook National University Hospital
Influenza, End Stage Renal Failure
Immunogenicity of a Trivalent Influenza Vaccine in Chronic Kidney Disease Patients Undergoing Hemodialysis
During the 2013-2014 influenza season, CKD patients undergoing HD participated in the study. The patients were randomized into two groups (MF59-adjuvanted vaccine group or non-adjuvanted vaccine group) and were immunized with the…
- Conditions
- Influenza, End Stage Renal Failure, Chronic Kidney Disease
- Trial name
- NCT02686398
- Testing
- Fluad, Agrippal
- Volunteers
- 174 people
- Sponsor
- Korea University Guro Hospital
End-Stage Renal Disease (ESRD)
Improvement of EPO-resistance in Hemodialysis Patients With Chronic Inflammation by High Cut-off Hemodialysis
Chronic inflammation in dialysis patients is linked to cardiovascular mortality and clinical signs and symptoms, like the impaired response to erythropoiesis-stimulating agents (ESAs).
- Trial name
- CIEPO-PILOT (NCT01526798)
- Testing
- Theralite (high cut-off hemodialysis), Conventional high-flux dialyzer
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Vantive Health LLC
Renal Insufficiency, Kidney Disease
A Study to Evaluate the Pharmacokinetics Of Sativex® in Subjects With Severe Renal Impairment or End Stage Renal Disease, Compared to Matched Subjects With Normal Renal Function.
The study aims to determine the pharmacokinetic (PK) profile of a single oromucosal dose of Sativex® (i.e. how the body absorbs, distributes, metabolises and excretes the drug) when subjects have severe renal impairment or end…
- Trial name
- NCT02325024
- Testing
- Sativex
- Volunteers
- healthy volunteers welcome
- Sponsor
- GW Pharmaceuticals Ltd
Chronic Kidney Disease
A Study of PRT-201 Administered Immediately After Arteriovenous Fistula Creation in Patients With Chronic Kidney Disease
The purpose of this study is to determine if PRT-201 when applied to a limited segment of your blood vessel (about 2 inches) immediately after surgery to create an arteriovenous fistula is safe and improves the patency of your…
- Trial name
- NCT01305824
- Testing
- PRT-201
- Where
- 23 sites in United States
- Volunteers
- 151 people
- Sponsor
- Proteon Therapeutics
End Stage Renal Disease
Impact of Hemodialysis on Exhaled Volatile Organic Compounds in End Stage Renal Disease
End stage renal disease (ESRD) is a severe clinical state of irreversible loss of endogenous kidney function, shortening life expectancy, if left untreated.
- Trial name
- NCT01684228
- Where
- Israel
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
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