Clinical trials: Complication of Hemodialysis
End-Stage Renal Disease
Anti-Cytokine Therapy for Hemodialysis InflammatION
Anti-Cytokine Therapy for Hemodialysis InflammatION (ACTION) is a phase II multi-center study to evaluate the safety and tolerability of anakinra, an IL-1 receptor antagonist, for patients treated with maintenance hemodialysis.
- Trial name
- ACTION (NCT03141983)
- Testing
- Anakinra
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Kidney Failure, Chronic, Dietary Modification
Dietary Sodium-Restriction (DIS) and Renal Meals (RM) for Hemodialysis (HD)(DISaRM-HD)
Chronic volume overload (VO) is a primary factor responsible for the excessive cardiovascular morbidity and mortality in hemodialysis (HD) patients.
- Trial name
- DISaRM-HD (NCT04991441)
- Testing
- Controlled Dietary Sodium Restriction, Control Diet & Controlled Dietary Sodium Restriction
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Illinois at Urbana-Champaign
End Stage Kidney Disease (ESRD), Hemodialysis
Hand Reflexology for Fatigue and Anxiety in Hemodialysis Patients
This randomized controlled trial evaluates the efficacy of hand reflexology massage (HRM) in reducing fatigue and anxiety among adult patients receiving maintenance hemodialysis.
- Conditions
- End Stage Kidney Disease (ESRD), Hemodialysis, Anxiety, Fatigue
- Trial name
- NCT07253831
- Testing
- Hand Reflexology Massage, Standard
- Where
- Iraq
- Volunteers
- 70 people
- Sponsor
- Kufa University
Chronic Kidney Disease, Secondary Hyperparathyroidism
A Single-dose Study in Paediatric Patients Aged 2 to Less Than 18 Years With Secondary Hyperparathyroidism (sHPT) Receiving Haemodialysis
This is a study to evaluate the safety and pharmacokinetics in pediatric patients with secondary hyperparathyroidism receiving a single dose of etelcalcetide at the end of hemodialysis.
- Trial name
- NCT02833857
- Testing
- Etelcalcetide
- Where
- 13 sites in United States, Belgium and 4 more
- Volunteers
- 11 people
- Sponsor
- Amgen
Renal Failure, End Stage Renal Disease
Comparison of Clinical Performance and Hemocompatibility of Dialyzers Applied During Post-dilution Online Hemodiafiltration
Comparison of the clinical performance and the hemocompatibility profile of different high-flux dialyzers, all applied during post-dilution online hemodiafiltration
- Trial name
- eMPORAIII (NCT04714281)
- Testing
- Dialyser
- Where
- 8 sites in Czechia, Germany and 1 more
- Volunteers
- 82 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Renal Failure, End Stage Renal Disease
Comparison of the Human Acellular Vessel (HAV) With Fistulas as Conduits for Hemodialysis
The main purpose of this study is to compare the Human Acellular Vessel (HAV) with arteriovenous fistula (AVF) when used for hemodialysis access
- Conditions
- Renal Failure, End Stage Renal Disease, Hemodialysis, Vascular Access
- Trial name
- NCT03183245
- Testing
- Human Acellular Vessel (HAV), Arteriovenous fistula (AVF), Hemodialysis
- Where
- 31 sites in United States
- Volunteers
- 242 people
- Sponsor
- Humacyte, Inc.
Hemodialysis Complication
Effect of Intradialytic Resistance Versus Aerobic Exercise on Cardiovascular System in Patients on Regular Hemodialysis
The purpose of the study is to compare the effect of resistance exercise and aerobic exercise on intradialytic hypotension in patients undergoing hemodialysis.
- Trial name
- NCT07054827
- Testing
- Hemodialysis, Intradialytic resistive exercise, Intradialytic aerobic exercise
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Cairo University
End Stage Renal Disease
Preliminary Safety of The TRUE Vascular Graft for Hemodialysis Access (TRUE HD I Study)
Prospective, nonrandomized, single-arm, single-center, open-label, first-in-human clinical study in subjects with end-stage renal disease (ESRD) and not candidates for an autogenous fistula creation.
- Trial name
- NCT04905511
- Testing
- natural human collagen arteriovenous graft for hemodialysis access
- Where
- Paraguay
- Volunteers
- 10 people
- Sponsor
- Vascudyne, Inc.
Hyperphosphatemia, Chronic Kidney Disease
Placebo Versus SBR759 in Lowering Phosphate in Dialysis Patients
This study will compare placebo to 4 different doses of SBR759 to assess the phosphate lowering efficacy in dialysis patients.
- Trial name
- SBR759 (NCT01069692)
- Testing
- SBR759A
- Where
- 9 sites in Belgium, Italy
- Volunteers
- 115 people
- Sponsor
- Novartis
Physical Activity, End Stage Kidney Disease
The "Step4Life" Randomized Control Trial in Hemodialysis
Persons with end-stage kidney disease (ESKD) have very low physical activity, and among ESKD patients, the level of inactivity is strongly associated with morbidity and mortality.
- Conditions
- Physical Activity, End Stage Kidney Disease, Hemodialysis
- Trial name
- NCT05241171
- Testing
- Fitbit
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of California, San Diego
End Stage Renal Disease, Hypotension During Dialysis
Effect of Protein Intake During Hemodialysis on Blood Pressure and Arterial Stiffness Indices
Open label, randomized, cross-over clinical study comparing the acute effect of high versus low protein meals during dialysis on intradialytic blood pressure, 24-hour ambulatory blood pressure and arterial stiffness indices on…
- Conditions
- End Stage Renal Disease, Hypotension During Dialysis, Protein Malnutrition, Arterial Sclerosis
- Trial name
- NCT03947710
- Testing
- High-protein meals, Low- protein meals, No meals
- Where
- Greece
- Volunteers
- 45 people
- Sponsor
- Aristotle University Of Thessaloniki
Chronic Kidney Disease Stage 5
Study to Assess Pegloticase (KRYSTEXXA®) in Patients on Hemodialysis
This is a Phase 1 single dose study conducted to evaluate the PK and PD of pegloticase administered to hemodialysis patients. A single dose of pegloticase will be administered intravenously to male or female hemodialysis patients…
- Trial name
- NCT01739660
- Testing
- Pegloticase
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Savient Pharmaceuticals
End Stage Renal Disease on Dialysis (Diagnosis)
Targeted Deprescribing in Patients on Hemodialysis
Hemodialysis (HD) patients take more pills per day on average than any other chronically ill patient population. On average, an HD patient takes 19 medications per day, of which 70% may not be appropriate.
- Trial name
- NCT03733262
- Testing
- De-prescribing Trial
- Where
- 4 sites in Canada
- Volunteers
- 480 people
- Sponsor
- University Health Network, Toronto
Chronic Kidney Disease, Renal Failure Chronic Requiring Hemodialysis
Specific Enteral Nutrition in Malnourished, Dialysis Patients With Chronic Kidney Disease. Efficacy, Safety, Quality of Life
The objective of this unblinded study is to assess the nutritional effects of a 12 weeks administration of the specific enteral nutrition (SEN) RealDiet®Renal pockets, as well as the impact on the patients' quality of life.
- Conditions
- Chronic Kidney Disease, Renal Failure Chronic Requiring Hemodialysis, Severe Malnutrition, Tolerance
- Trial name
- AL-EN-PHED (NCT01946841)
- Testing
- RealDiet®Renal
- Where
- France
- Sponsor
- Lactalis
Renal Failure, End Stage Renal Disease
Comparison of the Human Acellular Vessel (HAV) With ePTFE Grafts as Conduits for Hemodialysis
The main purpose of this study is to compare the Human Acellular Vessel (HAV) with ePTFE grafts when used for hemodialysis access.
- Conditions
- Renal Failure, End Stage Renal Disease, Hemodialysis, Vascular Access
- Trial name
- NCT02644941
- Testing
- Human Acellular Vessel (HAV), ePTFE graft
- Where
- 38 sites in United States, Germany and 4 more
- Volunteers
- 355 people
- Sponsor
- Humacyte, Inc.
Complication of Hemodialysis, Hyperthyroidism Treated or Under Control
Early Administration of L-carnitine in Hemodialysis Patients
Hemodialysis is a cause of carnitine deficiency. The deficiency of carnitine induces an anemia by an increase fragility of the red blood cells, a muscular fatigue and a cardiac dysfunction.
- Trial name
- NCT00322322
- Testing
- L-Carnitine
- Where
- 2 sites in France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
End Stage Renal Disease
Effect of Expanded Dialysis on Patient Reported Symptoms Using LEVIL
Investigators know that many patients who are on dialysis suffer from the burden of unwanted symptoms, which can affect quality of life.
- Trial name
- NCT03640858
- Testing
- Theranova Dialyzer
- Where
- 2 sites in Canada
- Volunteers
- 82 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cardiovascular Diseases, Chronic Kidney Disease Stage 3
Vitamin K to Slow Progression of Cardiovascular Disease Risk in Hemodialysis Patients
The life span of adults with end-stage renal disease is reduced, and cardiovascular disease (CVD) accounts for approximately half the deaths among those undergoing hemodialysis (HD).
- Conditions
- Cardiovascular Diseases, Chronic Kidney Disease Stage 3, Chronic Kidney Disease Stage 4, Chronic Kidney Disease Stage 5
- Trial name
- NCT03311321
- Testing
- Vitamin K2 (menaquinone-7; 360-mcg/d)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Augusta University
Renal Failure
Pharmacokinetic Assessment of Ceftazidime in Intermittent Hemodialysis Patients
Ceftazidime is a broad spectrum cephalosporin with high activity against a variety of Gram-negative pathogens, including Pseudomonas aeruginosa.
- Trial name
- NCT01507532
- Testing
- pharmacokinetic monitoring
- Where
- United States
- Sponsor
- Midwestern University
End Stage Renal Disease
Clinical Evaluation of a Vascular Venous Anastomotic Connector [InterGraft VIG-only Study]
The InterGraft™ Venous Anastomotic Connector provides an endovascular, minimally invasive means for attachment of an arteriovenous graft to a vein in the upper extremity.
- Trial name
- NCT02532621
- Testing
- Venous InterGraft Connector, sutured arterial anastomosis of an implanted vascular graft for hemodialysis, hemodialysis
- Where
- 10 sites in United States
- Volunteers
- 158 people
- Sponsor
- Phraxis, Inc.
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