Clinical trials: Complication of Hemodialysis
Chronic Kidney Diseases, Chronic Kidney Disease 5D
The Discrepancy in Radiologists' Practice of Intravenous Contrast Imaging Studies Among Chronic Kidney Disease Patients
There is a discrepancy between protocols used for intravenous imaging for chronic kidney disease including hemodialysis patients among different hospitals and even, among radiologists same selves.
- Trial name
- NCT05729126
- Testing
- Questionnare
- Where
- Egypt
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Benha University
Anemia
A Phase 2a Study To Evaluate The Pharmacokinetics, Safety, Efficacy, Tolerability, And Pharmacodynamics of Sotatercept (ACE-011) for the Correction of Anemia in Subjects With End-stage Renal Disease on Hemodialysis.
This is the first study in hemodialysis subjects with anemia to evaluate the pharmacokinetics, safety, efficacy, tolerability, and pharmacodynamics of sotatercept (ACE-011)
- Trial name
- NCT01146574
- Testing
- Sotatercept
- Where
- 24 sites in United States
- Volunteers
- 50 people
- Sponsor
- Celgene
Anemia Associated With Chronic Kidney Disease (CKD)
Study Evaluating the Efficacy and Safety of Dose Conversion From a Long-acting Erythropoiesis-stimulating Agent (Mircera®) to Three Times Weekly Oral Vadadustat for the Maintenance Treatment of Anemia in Hemodialysis Subjects
This study will be conducted to demonstrate the efficacy and safety of vadadustat administered three times weekly (TIW) compared to a long-acting erythropoiesis-stimulating agent (ESA) (Mircera®) for the maintenance treatment of…
- Trial name
- NCT04707768
- Testing
- Vadadustat, Mircera®
- Where
- 58 sites in United States
- Volunteers
- 456 people
- Sponsor
- Akebia Therapeutics
Anemia in End-Stage Renal Disease
Comparing Efficacy and Safety of CinnaGen Beta Erythropoietin (CinnaPoietin®) Versus Eprex® on the Treatment of Anemia in ESRD Hemodialysis Patients
This Phase III, randomized, two-armed, parallel, double-blind, active-controlled clinical trial is designed to compare efficacy and safety of CinnaPoietin® (Beta erythropoietin) and Eprex® (epoetin alpha) on the treatment of…
- Trial name
- NCT03408639
- Testing
- CinnaPoietin®, Eprex®, Nephrovit
- Where
- 8 sites in Iran
- Volunteers
- 156 people
- Sponsor
- Cinnagen
Hemodialysis, Chronic Kidney Disease
The Effect of Mindfulness-Based Nursing Interventions Applied to Hemodialysis Patients on Psychological Well-Being and Treatment Adherence
Chronic kidney disease (CKD) and its treatment with hemodialysis pose significant challenges to patients' psychological well-being and adherence to complex treatment regimens.
- Trial name
- Mindfulness (NCT07471828)
- Testing
- The intervention group received mindfulness-based nursing interventions for six weeks
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Baskent University
End Stage Kidney Disease
Symptom Monitoring in Hemodialysis
The SMaRRT-HD trial is a cluster randomized trial of symptom monitoring with supported clinician follow-up using the SMaRRT-HD electronic patient reported outcome measure (ePROM) system versus Usual Care.
- Trial name
- SMaRRT-HD (NCT05738330)
- Testing
- Symptom Monitoring on Renal Replacement Therapy - Hemodialysis (SMaRRT-HD), Usual Care
- Where
- United States
- Volunteers
- 2,400 people
- Sponsor
- University of Pennsylvania
End-Stage Renal Disease (ESRD)
Dose Ranging Study of Dialysate Containing Soluble Iron to Treat Subjects With End Stage Renal Disease (ESRD) Receiving Chronic Hemodialysis
The purpose of this study is to determine whether Dialysate containing soluble iron (Soluble Ferric Pyrophosphate) is safe and effective in maintaining physiological iron levels during chronic hemodialysis.
- Trial name
- NCT00548249
- Testing
- Standard Bicarbonate Solution, Soluble Ferric Pyrophosphate
- Where
- 28 sites in United States, Canada
- Volunteers
- 131 people
- Sponsor
- Rockwell Medical Technologies, Inc.
Kidney Failure
Mobilising Lower Limb Fluid for Hemodynamic Stability in Haemodialysis
Cardiovascular disease is the leading cause of death of dialysis patients and poor fluid management is associated with the increased risk.
- Trial name
- NCT02450474
- Testing
- Intermittent pneumatic compression device, Neuromuscular electrical stimulation
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
ESRD, Sleep Apnea
Identification of Desaturation Episodes by Means of Continuous Measurement of Oxygen Saturation During Hemodialysis
The clinical diagnosis of sleep apnea is difficult among ESRD patients since the characteristic clinical features of sleep apnea may be absent and since sleep-related symptoms, such as fatigue and sleepiness, may be attributed to…
- Conditions
- ESRD, Sleep Apnea, Oxygen Deficiency
- Trial name
- NCT02987179
- Testing
- Observational
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Renal Research Institute
Chronic Kidney Disease-Mineral and Bone Disorder
Neutrophil Gelatinase-associated Lipocalin VS Vascular Calcification in Maintenance Hemodialysis Patients
The goal of this observational study or clinical trial is to learn about the effect of neutrophil gelatinase-associated lipocalin (NGAL) on vascular calcification in maintenance hemodialysis patients with secondary…
- Trial name
- NGAL (NCT05720273)
- Testing
- palicalcitol
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xiaoyan Jia
Chronic Renal Failure, Hemodialysis
Effect of Homocysteine and Asymmetric Dimethylarginine on Cardiovascular Events in Hemodialysis Patients
Homocysteine (Hcy) and asymmetric dimethylarginine (ADMA) have recently been recognized as potential risk factors for atherosclerosis in the general population, and the metabolism of each of these substances seems to be closely…
- Conditions
- Chronic Renal Failure, Hemodialysis, Atherosclerosis
- Trial name
- NCT00161369
- Where
- Japan
- Volunteers
- 200 people
- Sponsor
- University of Shizuoka
End Stage Kidney Disease (ESKD), Hemodialysis
Randomized Cross-Over Comparison of Medium Cut-Off and High-Flux Hemodialysis Membranes
Patients receiving maintenance hemodialysis are at increased risk of cardiovascular disease, chronic inflammation, endothelial dysfunction, and impaired quality of life.
- Conditions
- End Stage Kidney Disease (ESKD), Hemodialysis, Cardiovascular Diseases (CVD), Inflammation
- Trial name
- MCO-HD (NCT07679763)
- Testing
- Medium Cut-Off Hemodialysis Membrane, High-Flux Hemodialysis Membrane
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gazi University
End Stage Renal Disease (ESRD), Hemodialysis
Effect of Dialysis Techniques on Blood Pressure and Cardiac Function During Dialysis
Online hemodiafiltration confers a reduced mortality risk. However, it is not clear why HDF improved survival. To gain more insight in this issue, the effect of 4 dialysis techniques (differing in dialysate temperature and the…
- Conditions
- End Stage Renal Disease (ESRD), Hemodialysis, Hemodiafiltration, Intradialytic Hypotension
- Trial name
- HOLLANT (NCT03249532)
- Testing
- standard hemodialysis, cool hemodialysis, low volume hemodiafiltration
- Where
- 3 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Amsterdam UMC, location VUmc
Fabry Disease
A Study to Evaluate Migalastat in Fabry Subjects With Amenable GLA Variant and Renal Disease
An Open-label Study to Evaluate the Safety and Pharmacokinetics of Migalastat HCl in Subjects with Fabry Disease and Amenable GLA Variants and Severe Renal Impairment (SRI) or End Stage Renal Disease (ESRD)
- Trial name
- NCT04020055
- Testing
- migalastat HCl 150 mg
- Where
- 12 sites in United States, Australia and 4 more
- Volunteers
- 14 people
- Sponsor
- Amicus Therapeutics
Chronic Kidney Diseases, Hemodialysis
Must Cannulation Technique of Vascular Access in Patients Undergoing Haemodialysis: Contributions for a Safe Nursing Intervention
The aims of this study are to: Determine the AVF (arteriovenous fistula) survival of patients submitted to MuST compared to those submitted to RL (rope-ladder).
- Conditions
- Chronic Kidney Diseases, Hemodialysis, Vascular Access Complication, Hemodialysis Access Failure
- Trial name
- MuST (NCT05081648)
- Testing
- CT MuST, Rope-ladder cannulation technique
- Where
- 3 sites in Portugal
- Volunteers
- 101 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
End Stage Renal Disease, Coronary Heart Disease
T Wave Alternans in Hemodialysis
The purpose of this study is to determine if the hemodialysis procedure changes the risk for cardiac arrest in patients.
- Conditions
- End Stage Renal Disease, Coronary Heart Disease, Congestive Heart Failure
- Trial name
- NCT00296543
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
End Stage Renal Disease
Events Before Death
Previous studies of the patients treated in RRI clinics suggest that hemodialysis patients undergo a certain consistent predictable pattern at the initiation of dialysis and before death.
- Trial name
- NCT01329055
- Where
- United States
- Volunteers
- 50,000 people
- Sponsor
- Renal Research Institute
ESRD, Hemodialysis
Evaluation of the Optimal Transition Program
This is an evaluation of a program developed by a team of nephrologists, operations experts and researchers. The goal is to provide CKD patients with a better way to transition to life on dialysis - one that emphasizes even more…
- Trial name
- NCT04263233
- Testing
- Analysis using descriptive statistics of patient clinical outcomes., Surveys with participants using validated survey tools., Evaluation of the program process including time, costs, referral rates, admission to the program and length of stay.
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Satellite Healthcare
Secondary Hyperparathyroidism
Observational Program of Zemplar in Patients With End Stage Chronic Kidney Disease and Parathyroid Disorder on Hemodialysis in the Russian Federation
Eighty-six eligible participants with secondary hyperparathyroidism will be enrolled at thirteen sites in Russia. Planned therapy will be six months.
- Trial name
- NCT01401478
- Where
- 13 sites in Russia
- Volunteers
- 86 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Myocardial Stunning, End-stage Renal Disease
Myocardial Stunning During Hemodialysis: Role of Dialyste Calcium Concentration
Chronic kidney disease (CKD) is linked to elevated mortality rate, and cardiovascular disease is the main cause related to this outcome.
- Trial name
- NCT02545426
- Testing
- Change the dialysate calcium concentration
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- University of Sao Paulo General Hospital
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