Clinical trials: Complication of Hemodialysis
Kidney Diseases, End-Stage Kidney Disease
Outcomes of a Higher vs. Lower Hemodialysate Magnesium Concentration (Dial-Mag)
Many patients on hemodialysis have low levels of magnesium. Magnesium is needed to keep the heart, kidneys, and other organs working properly.
- Conditions
- Kidney Diseases, End-Stage Kidney Disease, Hemodialysis
- Trial name
- NCT04079582
- Testing
- Dialysate magnesium formulation of 1.5 mEq/L (0.75 mmol/L)., Dialysate magnesium formulation of ≤1.0 mEq/L (≤0.5 mmol/L).
- Where
- Canada
- Volunteers
- 25,000 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Chronic Kidney Disease on Hemodialysis, Secondary Hyperparathyroidism
Dose-response Study of Paricalcitol Injection in Chronic Kidney Disease Patients Receiving Hemodialysis
The purpose of this study was to investigate the initial dose and dose adjustment range for paricalcitol injection in patients with chronic kidney disease on hemodialysis who have secondary hyperparathyroidism.
- Trial name
- NCT00667576
- Testing
- Maxacalcitol, Paricalcitol
- Where
- 12 sites in Japan
- Volunteers
- 153 people
- Sponsor
- Abbott
End Stage Renal Disease, Haemodialysis
Comparison of Citrate and Heparin Anticoagulation During Hemodialysis With MCO PES-PVP (Theranova) Membrane
The purpose of the study is to compare the efficiency and biocompatibility of citrate and heparin anticoagulation during hemodialysis with medium cut-off polyarylethersulphone-polyvinylpirrolidone membrane (Theranova®).
- Conditions
- End Stage Renal Disease, Haemodialysis, Anticoagulation
- Trial name
- NCT04139525
- Testing
- unfractionated heparin, 8% trisodium citrate
- Where
- Slovenia
- Volunteers
- 32 people
- Sponsor
- Marija Malgaj Vrečko
End Stage Renal Disease
Cost Utility Analysis of HD and CAPD in Ministry of Health Dialysis Centres, Malaysia
End-stage renal disease represents a major problem for public health, and is a severe disease affecting hundreds of millions of people in the world and increasing rapidly.
- Trial name
- NCT02862717
- Where
- 5 sites in Malaysia
- Volunteers
- 173 people
- Sponsor
- National University of Malaysia
Renal Insufficiency, Chronic
Effects of Resistance Training on Physical Activity in Daily Life and Functional Capacity in Hemodialysis Patients
The purpose of this study is to determine whether a supervised resistance exercise training during hemodialysis is effective to increase physical activity in daily life in patients with end stage renal disease.
- Trial name
- NCT02651025
- Testing
- Resistance Exercise Program
- Where
- Brazil
- Volunteers
- 29 people
- Sponsor
- Federal University of Juiz de Fora
Kidney Failure, Chronic
Low-frequency Electrical Muscle Stimulation vs Cycle Training During Haemodialysis
The purpose of the trial is to compare the effects of intra-dialytic low-frequency electrical muscle stimulation and intra-dialytic cycling, with usual care haemodialysis without exercise training.
- Trial name
- NCT02874521
- Testing
- Intra-dialytic LF-EMS, Intra-dialytic cycle training
- Where
- United Kingdom
- Volunteers
- 63 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
End Stage Renal Failure, Hemodialysis, Vascular Access
Comparison of Tunneled Cuffed Dialysis Catheters Versus Arteriovenous Fistulae in Elderly or Multimorbid Patients
Patients are randomly assigned to a study group. Depending on the study group, either an arteriovenous fistula or tunneled cuffed catheter (TCC) will be implanted, followed by continuous evaluation of the patients during the…
- Conditions
- End Stage Renal Failure, Hemodialysis, Vascular Access, Fistulas Arteriovenous, Haemodialysis Complication
- Trial name
- NCT07649083
- Testing
- Tunneled cuffed catheter (TCC) will be implanted for chronic haemodialysis treatment, Arteriovenous fistula creation for chronic haemodialysis treatment
- Volunteers
- 220 people
- Sponsor
- Medical University of Vienna
Hemodialysis, Chronic Kidney Disease
Comparison of Body Hydration State in Hemodialysis Patients
Estimation of hydration state in dialysis patients is a major challenge in clinical practice. Although many methods have been studied, none have been established yet for clinical routine practice.
- Trial name
- NCT01814254
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Renal Research Institute
ESRD
Experience of Patients Starting Hemodialysis
Patients starting dialysis have significant and often daunting changes to their lifestyle, and investigators have only little information from the patient perspective on patient experiences during dialysis initiation.
- Trial name
- NCT04988568
- Testing
- None. This is a qualitative interview study.
- Where
- 17 sites in United States
- Volunteers
- 20 people
- Sponsor
- Satellite Healthcare
End-stage Renal Disease
Effects of Oral Sodium Bicarbonate Supplementation in Haemodialysis Patients (BicHD)
The purpose of the study is to investigate whether oral sodium bicarbonate supplementation to ensure a constant bicarbonate profile in haemodialysis patients will primarily lower predialysis potassium levels and secondary lead to…
- Trial name
- BicHD (NCT02692378)
- Testing
- sodium bicarbonate 500mg capsules
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- Imperial College Healthcare NHS Trust
End Stage Renal Disease, End Stage Renal Disease on Dialysis
First Evaluation of the Moda-Flx Hemodialysis System™ in Real World Clinical Settings
This is a non-significant risk study utilizing a device cleared for use by the FDA under its 510(k) clearance. Consented patients will complete their usual dialysis treatment under professional care in an ICHD (In-Center…
- Conditions
- End Stage Renal Disease, End Stage Renal Disease on Dialysis, End Stage Kidney Disease
- Trial name
- NCT06581393
- Testing
- Moda-flx Hemodialysis System
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Diality Inc.
Secondary Hyperparathyroidism
Etelcalcetide to Treat Secondary Hyperparathyroidism in Hemodialysis Patients With Chronic Kidney Disease-Mineral and Bone Disorder
The purpose of this study is to evaluate the effect of thrice weekly intravenous (IV) administration of etelcalcetide in the treatment of secondary hyperparathyroidism (SHPT) in hemodialysis patients with chronic kidney…
- Trial name
- NCT01414114
- Testing
- Etelcalcetide
- Volunteers
- 37 people
- Sponsor
- KAI Pharmaceuticals
End-stage Renal Disease, Chronic Kidney Disease
Acupuncture for Pain Management of Hemodialysis Patients
The purpose of this study is to determine the feasibility, effectiveness and safety of acupuncture for pain management in hemodialysis patients.
- Trial name
- NCT01102816
- Testing
- Individualized acupuncture treatment, Routine care
- Where
- 2 sites in South Korea
- Volunteers
- 1 people
- Sponsor
- Korea Institute of Oriental Medicine
Chronic Kidney Diseases, Uremia
12 Weeks of Hemodialysis With Medium Cut-Off Filter Compared to Hemodiafiltration With Standard High-flux Filter.
The medium cut-off dialysis (MCO) membrane has been developed to improve middle molecule removal compared to standard high-flux dialysis filters.
- Trial name
- NCT03416192
- Testing
- MCO-HD, high-flux HDF
- Sponsor
- Region Skane
End-Stage Renal Disease (ESRD)
Improvement of EPO-resistance in Hemodialysis Patients With Chronic Inflammation by High Cut-off Hemodialysis
Chronic inflammation in dialysis patients is linked to cardiovascular mortality and clinical signs and symptoms, like the impaired response to erythropoiesis-stimulating agents (ESAs).
- Trial name
- CIEPO-PILOT (NCT01526798)
- Testing
- Theralite (high cut-off hemodialysis), Conventional high-flux dialyzer
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Vantive Health LLC
End Stage Renal Disease
A Model of Computer-assisted Prescription of Erythropoiesis-stimulating Agents (ESA) in Patients Under Hemodialysis
This is a randomized, double-blind controlled trial to compare AI (model) with the physician on prescribing ESA dose to maintain hemoglobin near the therapeutic target, 11g/dl.
- Trial name
- NCT04185519
- Testing
- AI (model)
- Where
- Taiwan
- Volunteers
- 126 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Renal Failure
Pharmacokinetic Assessment of Ceftazidime in Intermittent Hemodialysis Patients
Ceftazidime is a broad spectrum cephalosporin with high activity against a variety of Gram-negative pathogens, including Pseudomonas aeruginosa.
- Trial name
- NCT01507532
- Testing
- pharmacokinetic monitoring
- Where
- United States
- Sponsor
- Midwestern University
Hemodialysis, End Stage Renal Disease (ESRD)
Exploring the Modulatory Effect of the Dialyzer Membrane Choice on Hemodialysisassociated Thromboinflammation: a Prospective Randomized Cross-over Trial
This clinical trial investigates whether the dialyzer membrane influences hemodialysis-associated thromboinflammation. Specifically, it evaluates the effects of 3 commercially available dialyzer membrane types on immune cell…
- Conditions
- Hemodialysis, End Stage Renal Disease (ESRD), Hemodialysis Treatment, Thromboinflammation
- Trial name
- CELL-ACT-MEMBR (NCT07682701)
- Testing
- Use of a polysulfone membrane, Use of an asymmetric triacetate membrane, Use of a polymethyl methacrylate membrane
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitair Ziekenhuis Brussel
Hemodialysis, Restless Legs Syndrome
Exercise Training Versus Ropinirole in Treating Restless Legs Syndrome Among Hemodialysis Patients
This research aims to compare the efficacy of these two interventions, thereby addressing a critical gap in current therapeutic approaches.
- Conditions
- Hemodialysis, Restless Legs Syndrome, ESRD (End Stage Renal Disease), Diabetes Complications
- Trial name
- NCT06468371
- Testing
- Dopamine Agonist (Ropinirole), Excercise training
- Where
- Pakistan
- Volunteers
- 84 people
- Sponsor
- Lahore General Hospital
Secondary Hyperparathyroidism, Chronic Kidney Disease
Head-to-Head Study of Etelcalcetide and Cinacalcet in Asian Hemodialysis Patients With Secondary Hyperparathyroidism (SHPT)
The primary objective is to demonstrate that treatment with etelcalcetide (AMG 416) is not inferior to treatment with cinacalcet for lowering serum intact parathyroid hormone (PTH) levels by > 30% from baseline among participants…
- Trial name
- NCT03299244
- Testing
- Etelcalcetide, Cinacalcet
- Where
- 90 sites in China, Hong Kong and 4 more
- Volunteers
- 637 people
- Sponsor
- Amgen
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