Clinical trials: Complication of Transplanted Liver
Hepatoblastoma, Hepatocellular Carcinoma
Yttrium-90 (TARE-Y90) in Children, Adolescents, and Young Adults With Liver Tumors
This study will be performed to evaluate the Clinical Outcomes and Quality of Life after Transarterial Radioembolization with Yttrium-90 (TARE-Y90) in Children, Adolescents, and Young Adults with Liver Tumors.
- Conditions
- Hepatoblastoma, Hepatocellular Carcinoma, Rhabdoid Tumor of Liver, Undifferentiated (Embryonal) Sarcoma of the Liver
- Trial name
- NCT04315883
- Testing
- Quality of Life Assessment, Transarterial Radioembolization
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Nemours Children's Clinic
Veno Occlusive Disease, Hepatic, Sinusoidal Obstruction Syndrome
Liver Stiffness Measurement Predicts VOD/SOS Development (ELASTOVOD ITALIAN MULTICENTRIC STUDY)
ELASTOVOD is a prospective multicenter study, involving several centers of Onco-haematology in Italy. Investigators perform hepatic elastographic measurements (with Transient Elastography, ARFI or 2D-SWE) on patients undergoing…
- Conditions
- Veno Occlusive Disease, Hepatic, Sinusoidal Obstruction Syndrome, Stem Cell Transplant Complications
- Trial name
- ELASTOVOD (NCT03426358)
- Testing
- LSM assessed by Elastographic Techniques
- Where
- 37 sites in Italy
- Volunteers
- 1,101 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
COVID-19, Vaccine Adverse Reaction
COVID19 Vaccine in SOT Adult Recipients
Background: ISHLT and AASLD guidelines recommend SARS-CoV2 vaccination in all individuals undergoing lung and liver transplantation, but there are currently scarce data on the safety and efficacy of these vaccines in this…
- Conditions
- COVID-19, Vaccine Adverse Reaction, Vaccine Response Impaired, Vaccine Reaction
- Trial name
- COVID19_VaxSOT (NCT05116748)
- Testing
- COVID19 mRNA vaccine
- Where
- Italy
- Volunteers
- 364 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Noradrenaline
Prophylactic Norepinephrine for Prevention of Acute Kidney Injury in Living-Donor Liver Transplantation
goal-directed fluid therapy has demonstrated benefits on postoperative organ function, vasopressor support with norepinephrine is commonly employed to maintain perfusion pressure, though its renal impact in this setting remains…
- Trial name
- NE AKI in LDLT (NCT07885657)
- Testing
- Norepinephrine started prophylactically immediately post induction of general anesthesia, Norepinephrine infusion will only initiated if mean arterial pressure <65 mmHg despite preload optimization (stroke volume variation <12%) or if systemic vascular resistance <800 dynes•s/cm⁵
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Mansoura University
Liver Diseases, Liver Cancer
Liver Transplantation for Unresectable GIST Liver Metastases
Liver Transplantation for Unresectable GIST Liver Metastases
- Conditions
- Liver Diseases, Liver Cancer, Liver Metastases, Liver Neoplasms
- Trial name
- TRANSGIST (NCT04825470)
- Testing
- Liver Transplantation
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Universitario Virgen de la Arrixaca
Renal Insufficiency
Safety Use of ATeGe in Liver Transplant Recipients With Pre-transplant Renal Dysfunction
Renal dysfunction in the context of liver transplantation is a major issue, with difficult patients' management and determining a worsened prognosis.
- Trial name
- ATG_HVH (NCT01453218)
- Testing
- ATeGe-Fresenius
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Vall d'Hebron
Liver Transplantation, Hyperspectral Imaging
The Clinical Study Aims to Assess the Quality of Donor Livers Using Hyperspectral Imaging.
Based on hyperspectral imaging equipment, this project collected hyperspectral imaging data of donor livers, analyzed various parameters, investigated the detection capability of hyperspectral imaging for assessing donor liver…
- Trial name
- NCT06608667
- Testing
- The study was retrospective and did not involve the application of interventions
- Where
- China
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Liver Transplantation, Postoperative Renal Complication
Postoperative Complications After Liver Transplantation
Incidence and risk factors for renal, cardiovascular and pulmonary complications after liver transplantation are not well defined.
- Conditions
- Liver Transplantation, Postoperative Renal Complication, Postoperative Pulmonary Complication, Postoperative Cardiovascular Complication
- Trial name
- NCT02761109
- Where
- Italy
- Volunteers
- 1,600 people
- Sponsor
- Azienda Ospedaliera S. Maria della Misericordia
Liver Transplantation
Impact of the Procurement Technique on Outcomes After Liver Transplantation
Liver transplantation (LT) is the standard treatment for hepatocellular carcinoma (HCC) and end-stage liver disease, with excellent long-term outcomes despite the increasing use of extended criteria donors due to organ shortage.
- Trial name
- PLVT_TH (NCT07582978)
- Volunteers
- 1,810 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Transplant; Complications, Renal Insufficiency
Extended-Release Tacrolimus Following Liver Transplantation
Medications used after transplant to prevent rejection are associated with many side effects. Tacrolimus side effects include kidney dysfunction; tremor, headaches, difficulty sleeping, change in sensation (legs), seizure, or…
- Conditions
- Liver Transplant; Complications, Renal Insufficiency, Immunosuppressant Adverse Reaction, Metabolic Syndrome
- Trial name
- NCT05242315
- Testing
- Envarsus Oral Product, Prograf (SOC)
- Where
- Canada
- Volunteers
- 94 people
- Sponsor
- University of Alberta
Solid Organ Transplantation, Pregnancy
Long-term Follow-up of the Offspring Born to Mothers With a Solid Organ Transplant, Transplantlines Next Generation
Background Pregnancy after all types of solid organ transplantation (SOT) is possible, although these have higher risk of pregnancy complications for mother and child, such as preeclampsia and preterm birth.
- Conditions
- Solid Organ Transplantation, Pregnancy, Long-term Follow-up, Kidney Transplant
- Trial name
- NCT07291258
- Where
- Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Complication of Transplanted Organ, Nos
Glucose/Insulin Clamp on Solid Organ Transplant (Liver, Kidney, Pancreas and Heart) on Cadaveric Donors
Our objective in this study will be to determine if implementing the glucose/insulin clamp (GICT) on cadaveric organ donors can: Prevent hyperglycaemia Drop in the inflammatory cytokine response after brain death after a minimum…
- Trial name
- NCT01304290
- Testing
- Hyperinsulinemic/normoglycemic clamp
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Liver Transplant Disorder, Liver Transplant; Complications
Effects of Aerobic and Resistance Exercises on Inpatients Liver Transplantation Recipients
The prevalence of chronic liver disease and primary liver cancer is still increasing on a global scale, and so are their associated deaths.
- Conditions
- Liver Transplant Disorder, Liver Transplant; Complications, End-stage Liver Disease
- Trial name
- NCT06615934
- Testing
- Aerobic and resistance exercise, Respiratory physiotherapy
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Tehran University of Medical Sciences
Liver Transplantation, Acute Kidney Injury
Influence of Human Albumin Supplementation on Kidney Dysfunction After Liver Transplantation
To verify whether albumin administration to achieve serum concentration above 30g/L (treated group) and its maintenance within plasmatic physiologic range (above 30 g/L) for five days diminishes rate of AKI at Day 7 after liver…
- Trial name
- HALT (NCT06535945)
- Testing
- Albumin administration
- Where
- 8 sites in France
- Volunteers
- 400 people
- Sponsor
- Rennes University Hospital
Renal Impairment, Liver Transplantation
CNI-free "Bottom"-up Immunosuppression in Patients Undergoing Liver Transplantation
The primary objective of the trial is to evaluate efficacy and safety of delayed introduction (up to 30 days post-transplantation in patients without signs of acute rejection that had received an aIL-2 induction and MMF) of…
- Conditions
- Renal Impairment, Liver Transplantation, Everolimus
- Trial name
- BUILT_01 (NCT01023542)
- Testing
- delayed, low-dose CNI, BU-CNI, BU-Everolimus
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- University of Regensburg
Liver Transplant; Complications
Immune Function Following Liver Transplantation
Post-operative care following liver transplantation is characterized by a high incidence of infective and immunological complications.
- Trial name
- SEPTIFOIE (NCT04302246)
- Testing
- Biological testing on sequential blood sample
- Volunteers
- 61 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fatty Liver, Liver Transplant; Complications
Single-Cell and Spatial Transcriptomics Analysis of Steatotic Donor Liver Susceptibility to Post-Transplant Injury
The goal of this observational study is to understand why liver transplants from donors with fatty liver disease (steatotic donor livers) are more vulnerable to post-transplant injury, analyzing historical clinical data and…
- Conditions
- Fatty Liver, Liver Transplant; Complications, Ischaemia Reperfusion Injury of Liver, End Stage Liver Disease
- Trial name
- NCT07362745
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xijing Hospital
Liver Transplant; Complications
Outcome Analysis of Aspirin in Liver Transplantation
In the experimental setting inhibition of platelet activation was able to reduce immune-mediated necroinflammatory liver disease and consecutively hepatocellular carcinoma development.
- Trial name
- NCT04327427
- Testing
- Aspirin
- Where
- Switzerland
- Volunteers
- 3,000 people
- Sponsor
- University of Zurich
Liver Transplant; Complications
Effect of N_Acetylcysteine on Liver Functions in Donors in Living Liver Transplantation
our practice for the past 10 years we have noticed a transitional impairment of liver function (elevated liver enzymes, total and direct bilirubin, and elevated serum lactate levels) following donors' liver resection.
- Trial name
- NCT03634566
- Testing
- N-Acetylecysteine
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Intraoperative Bleeding
The Efficacy of the Administration of Fibrinogen in Liver Transplantation
Objective: To evaluate the efficacy of preoperative administration of fibrinogen in liver transplantation by maintaining a preoperative plasma level equal to 2.9 g / L compared with placebo, reflecting a reduction in the number…
- Trial name
- FibstudLT (NCT01539057)
- Testing
- Fibrinogen, Saline
- Where
- 4 sites in Spain
- Volunteers
- 132 people
- Sponsor
- Hospital Universitari de Bellvitge