Clinical trials: Complication of Ventilation Therapy
Rib Fractures, Blunt Chest Trauma
Effectiveness of an Innovative Chest Stabilizer in Rib Fracture Treatment: Impact on Respiratory Function, Complications, and Clinical Outcomes
This study aims to evaluate the effectiveness of an innovative, non-invasive chest stabilizer in patients with multiple rib fractures caused by blunt chest trauma.
- Conditions
- Rib Fractures, Blunt Chest Trauma, Thoracic Injuries, Pulmonary Complications
- Trial name
- NCT07238582
- Testing
- Standard Analgesic Therapy, Innovative Chest Stabilizer
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Caner İşevi, MD
Bronchopulmonary Dysplasia, Respiratory Distress Syndrome
Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE)
This multicenter clinical trial tested whether minimal ventilation decreases death or BPD. Infants with birth weight 501g to 1000g and mechanically ventilated before 12 hours were randomly assigned to minimal ventilation (partial…
- Conditions
- Bronchopulmonary Dysplasia, Respiratory Distress Syndrome, Infant, Newborn, Infant, Low Birth Weight
- Trial name
- SAVE (NCT00005777)
- Testing
- Minimal mechanical ventilation management, Routine mechanical ventilation management, Dexamethasone
- Where
- 13 sites in United States
- Volunteers
- 220 people
- Sponsor
- NICHD Neonatal Research Network
Ventilation Therapy; Complications
Correlation Between Muscle Thickness and Inflammation With Ventilator Use in Critically Ill Patients
Decrease thickness of diaphragm muscle, cross-sectional area of rectus femoris and biceps brachii muscle, and increase in CRP would affect ventilator length of use in critically ill patients in ICU
- Trial name
- NCT03933332
- Testing
- Diaphragm thickness, Cross-sectional area of rectus femoris muscle, Cross-sectional area of biceps brachii
- Where
- Indonesia
- Volunteers
- 52 people
- Sponsor
- Universitas Indonesia
Sleep Apnea, Cardiovascular Diseases
Oxidative Stress and Cardiovascular Morbidity in Sleep Apnea-Hypopnea Syndrome (SAHS)
The purpose of this study is to compare the levels of 8-isoprostane and other oxidative stress biomarkers in plasma and condensed exhaled air between patients with SAHS and cardiovascular complications, patients with SAHS without…
- Trial name
- OSCAMSA (NCT00487929)
- Testing
- nasal CPAP
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario La Paz
Ventilation Therapy; Complications
Comparison of Effectiveness of Mask Ventilation and Endotracheal Tube in Pharynx (TTIP) in Patients With Potential Difficult Airway
The purpose of this study is to determine the efficacy of TTIP-first ventilation and to compare the efficacy of TTIP first ventilation with the current practice of mask-first ventilation
- Trial name
- NCT05005390
- Testing
- TTIP ventilation, Mask Ventilation
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- The University of Texas Health Science Center, Houston
COVID-19, Mechanical Ventilation
Risk Factors for Prolonged Invasive Mechanical Ventilation in COVID-19 Acute Respiratory Distress Syndrome
This multicentric prospective clinical practice study aims at evaluating clinical factors associated with a prolonged invasive mechanical ventilation and other outcomes such as mortality and ICU length of stay in patients…
- Conditions
- COVID-19, Mechanical Ventilation, Quality of Life, Radiologic Increased Density of Lung
- Trial name
- NCT04411459
- Testing
- Invasive mechanical ventilation
- Where
- 20 sites in Italy
- Volunteers
- 470 people
- Sponsor
- Azienda Usl di Bologna
Ventilation Therapy; Complications
Amflow-device Can Help Proper Ambu-bag Ventilation
This is a simulation study with a prospective randomized cross-over design. The aim of this study is to evaluate whether Amflow-assisted ambu-bag can delivery the accurate tidal volume compare to ordinary ambu-bag
- Trial name
- NCT03119935
- Testing
- Amflow, Ambu bag
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Complication of Ventilation Therapy, Observation of Neuromuscular Block
Influence of the Neuromuscular Blockade on Mask Ventilation
Mask ventilation during induction of anesthesia can be improved by administration of neuromuscular blocking agents (NMBAs). NMBAs are usually administered after testing mask ventilation; however, muscle relaxants may improve mask…
- Trial name
- NCT02318810
- Testing
- Rocuronium 0.3 mg/kg, Rocuronium 0.6 mg/kg, Rocuronium 0.9 mg/kg
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University of Rostock
Apnea
Prophylactic Versus Therapeutic Caffeine for Apnea of Prematurity
Investigators hypothesized that the timing of caffeine administration in either prophylaxis or treatment of apnea of prematurity will affect the apnea response to caffeine
- Trial name
- NCT02677584
- Testing
- Prophylactic caffeine citrate, Therapeutic caffeine citrate
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Mansoura University Children Hospital
Obstructive Sleep Apnea, Postoperative Pain
Effect of Sleep Apnea on Pain After Dental Treatment
This observational study aims to investigate the effects of sleep quality and systemic health status on pain levels following endodontic treatment in adult patients.
- Conditions
- Obstructive Sleep Apnea, Postoperative Pain, Hypertension Complicated With Type 2 Diabetes
- Trial name
- OSA-EndoPain (NCT07581964)
- Testing
- Standard Endodontic Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Harran University
Apnea of Prematurity
Apnea of Prematurity Results in Respiratory Distress and Cyanosis. Caffeine Citrate Can Treat It.
High-dose caffeine citrate is more effective than low-dose caffeine citrate in the treatment of apnea of prematurity (AOP). The high-dose group showed fewer apnea episodes, higher extubation success rate, lower extubation failure…
- Trial name
- AOP (NCT06905496)
- Testing
- High-Dose, Low Dose
- Where
- Pakistan
- Volunteers
- 114 people
- Sponsor
- Nishtar Medical University
Postoperative Complications, Rehabilitation
Pulmonary Expansion Device in Tracheostomized Patients Therapies in Tracheostomized Patients
The goal of this clinical trial is to evaluate the safety and efficacy of using PED (Pulmonary Expansion Device) in tracheostomized patients requiring lung reexpansion therapy within a single institution.
- Conditions
- Postoperative Complications, Rehabilitation, Postoperative Care
- Trial name
- PEDTRAQ (NCT06075381)
- Testing
- Pulmonary Expansion Device (PED), Conventional management
- Volunteers
- 50 people
- Sponsor
- Fundacion Clinica Valle del Lili
Sleep Apnea, Obstructive, Pre-Eclampsia
Screening and Treatment of Obstructive Sleep Apnea in High-risk Pregnancy
This is an open-label multicenter randomized-controlled trial in 3 tertiary care hospitals including Ramathibodi Hospital, Phramongkutklao Hospital and Rajavithi Hospital.
- Conditions
- Sleep Apnea, Obstructive, Pre-Eclampsia, Hypertension, Pregnancy-Induced
- Trial name
- NCT03356106
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- 3 sites in Thailand
- Volunteers
- 340 people
- Sponsor
- Ramathibodi Hospital
Hypocalcemia, Vitamin D Deficiency
The Effect of Preoperative Oral Dexamethasone Supplementation on the Outcome of Thyroidectomised Patients.
Glucocorticoids are well known for their analgesic, anti-inflammatory, immunomodulatory and anti-emetic effects. Recovery time after thyroid surgery may depend on several factors, such as postoperative pain, nausea and vomiting…
- Conditions
- Hypocalcemia, Vitamin D Deficiency, Postoperative Complications, Postoperative Nausea
- Trial name
- Dexa (NCT04412694)
- Testing
- Dexamethasone oral tablet 8mg (Dexamethasone Krka tablets(8mg), Warsaw, Poland)., Preoparative blood laboratory tests, Postoperative laboratory blood tests at 6 hour
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Lodz
Respiratory Distress Syndrome
Pilot Trial of Surfactant Therapy For Preterm Neonates 5-21 Days Old With Respiratory Decompensation
The purpose of the study is to determine whether additional surfactant(Infasurf) doses at 7 to 10 days of life time will improve lung function in premature infants, allowing a decrease in required oxygen concentration and…
- Trial name
- NCT00165074
- Testing
- Infasurf (drug)
- Volunteers
- 11 people
- Sponsor
- Children's Hospital of Philadelphia
Cardiac Arrest, Post Cardiac Arrest Syndrome
Lung-cOnservative Liquid VEntilation for the Induction of Ultra-Rapid COOLing After Cardiac Arrest
Out-of-hospital cardiac arrest (OHCA) affects over 356,000 individuals annually in the United States, with fewer than 10% surviving to hospital discharge, mirroring statistics from Europe.
- Trial name
- OverCool (NCT06798818)
- Testing
- Ultra-rapid therapeutic hypothermia induction by total liquid ventilation
- Where
- France
- Volunteers
- 24 people
- Sponsor
- ORIXHA
Neonatology, Perinatal Distress Syndrome
Evaluation of Semi-rigid and Flexible Catheters for Less Invasive Surfactant Administration in Preterm Infants
The overall aim of this study is to determine the differences between two surfactant administration catheters in preterm infants.
- Trial name
- NCT05024435
- Testing
- Surfactant Administration
- Where
- Austria
- Volunteers
- 31 people
- Sponsor
- Salzburger Landeskliniken
Anemia, Neonatal, Intracranial Hemorrhages
Autologous Cord Blood Infusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates
The purpose of this study is to test the safety and effectiveness of a whole own (autologous) umbilical cord blood transfusion in the first 5 days after birth if the baby is born premature <34 weeks and developed anemia of…
- Conditions
- Anemia, Neonatal, Intracranial Hemorrhages, Necrotizing Enterocolitis, Respiratory Distress Syndrome, Newborn
- Trial name
- NCT02050971
- Testing
- Umbilical Cord Blood Infusion, Intravenous Infusion of Peripheral Blood or its Components
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Pomeranian Medical University Szczecin
Sleep Apnea, Chronic Kidney Diseases
Impact of Obstructive Sleep Apnea (OSA) Treatment on Blood Pressure Control in Chronic Kidney Disease
The role of obstructive sleep apnea (OSA) on chronic kidney disease (CKD) is not clear. This randomized clinical trial will test the impact of OSA treatment on blood pressure (BP) and on the estimated glomerular filtration rate…
- Trial name
- NCT05846490
- Testing
- CPAP, Usual care
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- University of Sao Paulo
Complication of Ventilation Therapy
Effect of Mode of Transport Ventilation on Respiratory Parameters After Cardiac Surgery
After cardiac surgery patients are transported from the operating room (OR) to the intensive care unit (ICU) while intubated. Two principal methods of oxygenation and ventilation are used: (1) a transport ventilator or (2) a…
- Trial name
- NCT02740075
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego