Clinical trials: Complications, Postoperative
Pulpitis - Irreversible
Effect of Preoperative Diclofenac Potassium on Postoperative Endodontic Pain
The purpose of this study is to assess the effect of preoperative a single-dose of 50 mg diclofenac potassium on postoperative endodontic pain in mandibular molars with symptomatic irreversible pulpitis.
- Trial name
- NCT03341260
- Testing
- Diclofenac Potassium 50mg Tab.
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Postoperative Pain
OFA - Opioid Free Anesthesia
Opioids have been used for analgesia since many years, but despite potent analgesia they are also associated to side effects, including opioid induced Hyperalgesia (OIH).
- Trial name
- OFA (NCT03124082)
- Testing
- Remifentanil, Ketamine, Lidocaine
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- University of Parma
Hemorrhage, Postoperative Blood Loss
Desmopressin as Treatment for Postoperative Bleeding After Cardiac Surgery
Some patients undergoing cardiac surgery develop excessive postoperative bleeding. Cardiopulmonary bypass causes platelet dysfunction.
- Trial name
- NCT00885924
- Testing
- Desmopressin
- Where
- Norway
- Volunteers
- 17 people
- Sponsor
- St. Olavs Hospital
Postoperative Residual Curarization, Airway Obstruction on Anaesthetic Emergence
Measuring Upper Airway Cross Sectional Areas During Residual Neuromuscular Blockade and After Reserval
In our study, the investigators sought to answer the question of how the retroglossal pharyngeal areas measured after extubation of patients compare to baseline (before muscle relaxation) values.
- Trial name
- NCT06544980
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- Tamas Vegh, MD
Postoperative Cognitive Dysfunction
Effects of Brain Beta-Amyloid on Postoperative Cognition
Postoperative cognitive decline (POCD) affects up to 50% of non-cardiac surgical patients greater than or equal to 65 years of age.
- Trial name
- NCT01606488
- Testing
- Florbetapir F 18 (18F-AV-45), no intervention
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of California, San Francisco
Short Bowel Syndrome
Study of Teduglutide in Japanese Participants With Short Bowel Syndrome
The objectives of this clinical study are to evaluate the safety, efficacy, and pharmacokinetics (PK) of teduglutide in Japanese participants with short bowel syndrome (SBS) who are dependent on parenteral nutrition/intravenous…
- Trial name
- NCT03663582
- Testing
- Teduglutide, Syringe, Needle
- Where
- 5 sites in Japan
- Volunteers
- 7 people
- Sponsor
- Shire
Delirium, Postoperative Cognitive Dysfunction
Rivastigmine in the Treatment of Postoperative Delirium: a Pilot Clinical Trial
The purpose of this study is to determine whether preoperative administration of Rivastigmine prevents the incidence of postoperative delirium in patients undergoing major surgery as well as postoperative cognitive dysfunction.
- Trial name
- NCT00835159
- Testing
- Rivastigmine Patch
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Postoperative Pain
Efficacy of Ultrasound Guided Rectus Sheath Block on Post Operative Quality of Recovery
Effective Postoperative pain management following laparotomy represents a cornerstone in the care of surgical patients. With the growing utilization of Enhanced recovery after surgery protocols (ERAS), a paradigm shift in…
- Trial name
- NCT05244746
- Testing
- rectus sheath block
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Kasr El Aini Hospital
Scheduled Cardiac Surgery, Sternotomy
Postoperative Rehabilitation After Cardiac Surgery in Patients at Risk of Respiratory Complications. Effects of a Continuous Bi-laterosternal Infusion of Ropivacaine Through Multihole Catheters
Postoperative pain after cardiac surgery is a risk factor for postoperative complications. In cardiac surgery, pain is more intense during the first 48 hours and disturbs the patient's capacity of coughing, deep breathing, and…
- Conditions
- Scheduled Cardiac Surgery, Sternotomy, Elderly Patients, Obesity
- Trial name
- BLS-Sterno (NCT01828788)
- Testing
- Ropivacaine
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Clermont-Ferrand
High-grade Partial or Full Thickness Rotator Cuff Tears
Cold and Compression After Rotator Cuff Repair (RCR)
The purpose of this study is to compare pain score (Patient-Reported Outcomes Measurement Information System: PROMIS NRS Pain Subscale) between the control and cold/compression groups pre-surgically, daily after surgery for 14…
- Trial name
- NCT07516327
- Testing
- SOC (Standard of care), Cold and Compression
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ochsner Health System
Postoperative Pain
Postoperative Pain Management for Hip Surgeries: UltrasoundGuided Suprainguinal Fascia Iliaca Compartment Block Versus Suprainguinal Fascia Iliaca Compartment Block in Combination With Sciatic Nerve Block
The aim of the Study is to compare the analgesic efficacy and clinical outcomes of suprainguinal fascia iliaca block (SIFIB) alone versus SIFIB combined with sciatic nerve block (SNB) in patients undergoing hip surgery.
- Trial name
- NCT07787442
- Testing
- Bupivacaine injection
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Intraabdominal Abscess After Procedure, Leakage
Outcome After Laparoscopic Surgery for Peptic Ulcer Perforation
Despite advances in laparoscopic surgery for perforated peptic ulcer (PPU), intra-abdominal abscess (IAA) is recognized as one of the commonly reported complications with relation to the extent of infectious abdominal…
- Conditions
- Intraabdominal Abscess After Procedure, Leakage, Pneumonia, Operation Wound; Infection
- Trial name
- NCT05147870
- Testing
- Peritoneal irrigation, Suction only
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Chang Wei-Jung
Surgical Injury
Prophylactic Effects of Esketamine in Surgical Patients
Evidences have showing that esketamine has anti-inflammatory and therapeutic effects on depression and cardiac surgery. The investigators' preliminary results suggest that combined prophylactic and therapeutic use of esketamine…
- Trial name
- NCT05180318
- Testing
- Esketamine Hydrochloride 28 Mg in 0.2 mL NASAL SOLUTION [Spravato], 0.9% saline
- Where
- China
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Infection Control, Surgical Site Infection
Early Recognition and Response to Increases in Surgical Site Infections Using Optimized Statistical Process Control Charts: The Early 2RIS Study
The purpose of this quality improvement study is to measure the effectiveness of surveillance using optimized statistical process control (SPC) methods and feedback on rates of surgical site infection (SSI) compared to…
- Trial name
- Early 2RIS (NCT03075813)
- Testing
- Intervention Cluster
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Duke University
Acute Pain, Post Operative Pain
Pharmacogenetic-guided Choice of Post-surgery Analgesics
Pharmacogenomics (PGx) is the study of how genes affect a person's response to drugs. PGx testing for certain genes can help predict the risk of side effects or therapeutic failure from analgesics.
- Trial name
- PRECISE (NCT05548660)
- Testing
- Pharmacogenetic testing, Pharmacist note with genotype-guided analgesic recommendations, Pharmacist detailed note with genotype-guided recommendations per CPIC guidelines
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of Pennsylvania
Postoperative Complications
Impact of Oral Diets on Postoperative Fluid Collection
Patients after the surgical removal of axillary lymphnodes suffers from prolonged fluid collections. The aim of the study is to assess the impact of oral immunonutrition and high-protein diets on the reduction of fluid collection.
- Trial name
- BC1 (NCT05068882)
- Testing
- Immunonutrition, High-protein nutrition, Standard nutrition
- Where
- 2 sites in Poland
- Volunteers
- 400 people
- Sponsor
- Stanley Dudrick's Memorial Hospital
Pain, Postoperative
The Effect of Gabapentin, Ketamine and Dexamethasone on Pain and Opioid Requirements After Hip Surgery
Patients scheduled for primary hip replacement needs postoperative pain treatment, i.e. morphine. Morphine has side-effects: nausea, vomiting, sedation and dizziness.
- Trial name
- NCT00236223
- Testing
- Gabapentin + dexamethasone + ketamine
- Where
- 2 sites in Denmark
- Volunteers
- 48 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Lower Abdominal Surgery
Transversus Abdominis Plane Versus Caudal Block for Pediatrics
The transversus abdominis plane (TAP) block is a relatively simple technique that provides myocutaneous anesthesia that, as part of a multimodal analgesic treatment, may be useful in the prevention and treatment of parietal…
- Trial name
- NCT02398123
- Testing
- Transversus abdominis plane block, Caudal block, Bupivacaine
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Mansoura University
Colorectal Disorders, Anorectal Disorder
A Multimodal Enhanced Recovery Program in Anorectal Surgery
The goal of this study is to establish whether an opioid-sparing Enhanced Recovery After Surgery (ERAS) program in ambulatory anorectal surgery can be safely introduced at a single tertiary referral center without an increase in…
- Conditions
- Colorectal Disorders, Anorectal Disorder, Patient Satisfaction, Pain, Postoperative
- Trial name
- ARSE (NCT03992079)
- Testing
- ReCOVER Enhanced Recovery Protocol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Columbia University
Blood Loss, Postoperative, Liver Transplant
Individualized Multimodal Hemostasis Evaluation Pyramid (IMHOTEP)
This study evaluates the hemostatic changes defined as hemostasis reserve capacity (HRC) in the first perioperative 48 hours of bloodless liver transplanted patients.
- Conditions
- Blood Loss, Postoperative, Liver Transplant, Hemostatic Disorder
- Trial name
- NCT03555383
- Testing
- Coagulation factor levels
- Where
- Hungary
- Volunteers
- 59 people
- Sponsor
- Semmelweis University
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