Clinical trials: Complications, Postoperative
Emergence Delirium
AGItated Patients Management: intraNASAL Midazolam vs Intramuscular Loxapine
This study is a non-inferiority phase III randomized trial evaluating the effect of intranasal midazolam versus intramuscular loxapine on the rapid tranquilization of agitated patient in emergency department.
- Trial name
- AGINASAL (NCT05324852)
- Testing
- Intranasal midazolam, Intramuscular loxapine
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postoperative Pain, Acute
Effect of Dexmedetomidine Versus Dexamethasone as Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Plane Block on Postoperative Analgesia in Myasthenic Patients Undergoing Thoracoscopic Thymectomy
This current comparative study involved 54 patients undergoing thoracoscopic thymectomy who were distributed randomly into three equal groups to receive ultrasound (US)-guided ESPB using 20 ml bupivacaine 0.25% (group B) , 20 ml…
- Trial name
- NCT07424599
- Testing
- Erector Spinae Plane Block
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Postoperative Pain
Epidural Versus Wound Infusion Plus Morphine Bolus in Open Abdominal Aortic Aneurysm Repair
The aim of the study is to determine wether continuous wound infusion with local anaesthetic plus a single dose intravenous morphine is non-inferior to postoperative analgesia provided with continuous thoracic epidural infusion…
- Trial name
- APERIVIP (NCT02677532)
- Testing
- Paracetamol, Levobupivacaine wound infiltration, Levobupivacaine epidural bolus
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- University of Genova
Bladder Neoplasm, Prostate Neoplasm
Pre-Operative Single Shot Rectus Sheath Block
Objectives The primary objective is to demonstrate that in patients undergoing major urologic surgery, Patient Controlled Analgesia (PCA) opioid consumption in the first 24 hours after surgery will be significantly less in…
- Conditions
- Bladder Neoplasm, Prostate Neoplasm, Pelvic Neoplasm, Urologic Neoplasms
- Trial name
- NCT03458598
- Testing
- Rectus sheath block, Bilateral rectus sheath catheter, Patient controlled opioid analgesia (PCA)
- Where
- Canada
- Volunteers
- 49 people
- Sponsor
- University of Alberta
Fractures, Open, Fractures, Closed
LOQTEQ® Antibacterial Pre-Market Study
aap001 is a randomized, controlled, subject-blinded, multi-center study to show the safety of the LOQTEQ® antibacterial silver-coated system is non-inferior in comparison with the uncoated LOQTEQ® system
- Conditions
- Fractures, Open, Fractures, Closed, Surgical Site Infection, Fracture of Fibula
- Trial name
- NCT05260463
- Testing
- Implantation
- Where
- 13 sites in Germany
- Volunteers
- 203 people
- Sponsor
- aap Implantate AG
Post Operative Pain, Acute, Bariatric Surgery Candidate
ZYNRELEF® for Postoperative Analgesia After Laparoscopic Sleeve Gastrectomy
Approximately 120 subjects will be randomized into 1 of the following 2 treatment groups in a 1:1 ratio: Group 1: ZYNRELEF® up to 200 mg/ 6mg ( 7ml vial) via instillation at all incision sites in addition to 30 ml of 0.5%…
- Conditions
- Post Operative Pain, Acute, Bariatric Surgery Candidate, Postoperative Pain
- Trial name
- HeronBariatric (NCT05863221)
- Testing
- ZYNRELEF 200Mg-6Mg Extended-Release Solution
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Dr. Yannis Raftopoulos
Esophageal Cancer
Tissue Oxygenation Are Associated With Anastomotic Leak Rates After an Ivor Lewis Esophagectomy
The purpose of this study is to test whether after an Ivor Lewis esophagectomy (the removal of a portion of the stomach and esophagus with re-attachment) there is an association between the intraoperative level of oxygen at the…
- Trial name
- NCT01551433
- Testing
- wireless pulse oximeter (Wipox)
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Post Operative Pain
Effect of Ascorbic Acid Final Flush on Post-operative Pain in Mandibular Molars.
The study is conducted to evaluate the effect of Ascorbic acid as a final flush on post operative pain after single visit root canal treatment in cases with symptomatic irreversible pulpits.
- Trial name
- NCT05478044
- Testing
- Ascorbic acid, saline
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Kidney Calculi
Paravertebral Block Versus Epidural Anesthesia for Percutaneous Nephrolithotomy
This prospective, randomized study is aimed to assess the efficacy and safety of paravertebral block compared to epidural anesthesia for percutaneous nephrolithotomy.
- Trial name
- PVB (NCT03018899)
- Testing
- paravertebral block, epidural anesthesia
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Huazhong University of Science and Technology
Strabismus
Comparison of Propofol 1mg/kg and Propofol 0.5mg/kg for Prevention of Emergence Agitation in Children Undergoing Strabismus Surgery During Sevoflurane Anesthesia
The occurrence of emergence agitation (EA) in pediatric patients who have received sevoflurane anesthesia is a common postoperative problem.
- Trial name
- NCT02152787
- Testing
- Injection of propofol 1.0mg/kg, propofol 0.5mg/kg, normal saline
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Yonsei University
Morbid Obesity
VAS Correlation With BMI
The aim of the study is to observe if any correlation between Body mass index and VAS values exists in patients who has gone under abdominal surgery.
- Trial name
- NCT02017314
- Testing
- Morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul University
Urinary Retention, Rectal Cancer
Effect of ICCAUT Strategy on Postoperative Urinary Retention After Radical Rectal Cancer Surgery (ICCAUT-2)
The objective of this trial is to investigate the effect of bladder training on the incidence of re-catheterization after proctectomy.
- Conditions
- Urinary Retention, Rectal Cancer, Urinary Catheterization
- Trial name
- NCT06217016
- Testing
- ICCAUT, Free drainage
- Where
- China
- Sponsor
- The First Hospital of Jilin University
Hip Fractures
Hip Fracture and Patent Foramen Ovale
Ereth et al. showed in 1992, using transesophageal echocardiography, that the implantation of a hip prosthesis may be complicated by intracardiac embolization of various origin.
- Trial name
- COL-FOP (NCT02564133)
- Testing
- Transthoracic echocardiography
- Where
- 2 sites in France
- Volunteers
- 41 people
- Sponsor
- Hopital Foch
Postoperative Cognitive Dysfunction
Post Cardiac Surgery Neurocognitive Decline: Correlations Between Neuropsychological Tests and Functional MRI Techniques
Postoperative cognitive decline (POCD) is a frequent complication after cardiac surgery. It is estimated that 40-70% of all cardiac patients show cognitive dysfunction during the first post-surgical week.
- Trial name
- CardChNeuroMRI (NCT01622452)
- Volunteers
- 50 people
- Sponsor
- Fondazione Toscana Gabriele Monasterio
Liver Transplantation and Antithrombin
Antithrombin III and Post-liver Transplantation Acute Kidney Injury
The reno-protective effect of Antithrombin III (ATIII) has been well-studied in various animal studies; however, little is known about the effect of ATIII on kidney function in patients undergoing liver transplantation (LT).
- Trial name
- NCT04912193
- Testing
- Antithrombin III
- Where
- South Korea
- Volunteers
- 2,395 people
- Sponsor
- Asan Medical Center
Tonsillitis Chronic, Tonsillectomy
Tonsillectomy Using BiZact™ - a Randomized Side-controlled Clinical Trial
Tonsillectomies are frequently followed by severe postoperative pain, hence high analgetics consumption and prolonged hospitalization. Also, postoperative hemorrhages can be hazardous.
- Conditions
- Tonsillitis Chronic, Tonsillectomy, Hemorrhage, Postoperative Pain
- Trial name
- NCT03793816
- Testing
- BiZactTM Open Sealer/Divider
- Where
- Austria
- Volunteers
- 48 people
- Sponsor
- Medical University of Vienna
Postoperative Pain, Opioid Consumption
Erector Spinalis Plane Block in Bariatric Surgery
Background/objective: Bariatric surgery is often associated with moderate to severe pain. In obese individuals, opioids have the potential to induce ventilatory impairment; thus, opioid use needs to be limited.
- Trial name
- NCT04915521
- Testing
- erector spina plane block (ESPB) group
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Meliha Orhon
Spinal Vascular Disorder Nos, Overactive Bladder
Efficacy Comparison Between Different Management Strategies for Consistent OAB in Patients With SVMs After Surgery
The investigators' goal is to compare the efficacy of three different management strategies (sacral neuromodulation, botulinum toxin, M receptor antagonist) in treating consistent OAB in patients with SVMs after surgery.
- Trial name
- NCT03280316
- Testing
- surgery, sacral neuromodulation, botulinum toxin A injection
- Volunteers
- 100 people
- Sponsor
- Xuanwu Hospital, Beijing
Reperfusion Injury After Pulmonary Thromboendarterektomy
High PEEP Application Following Pulmonary Thromboendarterectomy; Does it Have Any Impact on Outcome?
Investigation of the effect of intraoperative lung protection high PEEP maneuver on ischemic reperfusion injury in patients undergoing pulmonary endarterectomy.
- Trial name
- NCT03806504
- Testing
- PEEP, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Pain, Postoperative
Low Dose Caudal VS Dorsal Penile Nerve Block for Postoperative Analgesia After Circumcision
in order to eliminate fear and anxiety. Regional techniques are more effective than systemic opioids, non steroidal anti-inflammatory drugs, and acetaminophen for postoperative analgesia in circumcision, The most preferred…
- Trial name
- NCT05342259
- Testing
- Caudal nerve block /neuroaxial, Dorsal penile nerve block, Combined caudal and dorsal penile nerve block
- Where
- Egypt
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
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