Clinical trials: Complications; Cesarean Section
Uterine Prolapse, Urinary Incontinence
Delivery Method and Risk for Urogenital Prolapse 15-20 Years Later
The lifetime risk for a woman to undergo surgery for either vaginal prolapse or urinary incontinence is high. Previous studies have shown that pregnancy and childbirth are risk factors for developing prolapse.
- Conditions
- Uterine Prolapse, Urinary Incontinence, Fecal Incontinence
- Trial name
- uropro (NCT01766193)
- Testing
- vaginal delivery, forceps extraction, vacuum extraction
- Where
- Norway
- Volunteers
- 1,641 people
- Sponsor
- Norwegian University of Science and Technology
Post Partum Hemorrhage
Efficacy of Tranexamic Acid in Preventing Postpartum Haemorrhage After Elective Caesarean Section
Background Postpartum haemorrhage (PPH) is a major cause of maternal mortality worldwide accounting for 25% of maternal deaths. In Zimbabwe PPH is the second most common cause of death.
- Trial name
- NCT03463993
- Testing
- Tranexamic Acid, Oxytocin
- Where
- 2 sites in Zimbabwe
- Volunteers
- 506 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Post Partum Hemorrhage, Fibrinolysis; Hemorrhage
Tranexamic Acid for Prevention of Hemorrhage in Cesarean Delivery
The investigators prepared a novel study of tranexamic acid (TXA) designed to estimate the quantity of blood loss in women undergoing elective repeat cesarean deliveries.
- Conditions
- Post Partum Hemorrhage, Fibrinolysis; Hemorrhage, Blood Loss
- Trial name
- TXA (NCT03856164)
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Postoperative Pain, Cesarean Section Surgery
Analysis of the Incidence and Risk Factors of Chronic Pain After Cesarean Section
Persistent postoperative pain is a globally recognized issue that deserves attention. Cesarean section is one of the surgeries that may cause persistent postoperative pain.
- Trial name
- NCT06704490
- Testing
- Cesarean section
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Huazhong University of Science and Technology
Blood Loss, Surgical, Blood Loss, Postoperative
Comparative Study Between Preoperative and Postoperative Rectal Misoprostol
Cesarean delivery (CD) is the most common major surgical procedure undergone by women around the world. Over the past two decades, there has been a witnessed increase in rates of caesarean deliveries, which continues to rise…
- Trial name
- NCT06049160
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 128 people
- Sponsor
- Egymedicalpedia
Postoperative Pain
Effect of Mu-opioid Receptor Genetics on 3 Doses of Spinal Morphine for Postoperative Analgesia After Cesarean Section
HYPOTHESIS: The response to a given dose of morphine given via a spinal anesthetic for cesarean section will be affected by the genetics of the woman's mu-opioid receptor Most women undergoing elective cesarean section (CS)…
- Trial name
- NCT01465191
- Testing
- Morphine
- Where
- 2 sites in United States
- Volunteers
- 169 people
- Sponsor
- Columbia University
Complications; Cesarean Section, Anesthesia; Adverse Effect, Spinal and Epidural
Non-invasive Cardiac Output Monitoring in Obstetric Patients
The investigators hypothesize that continuously measuring stroke volume (SV) and cardiac output (CO) will 1) reveal hemodynamic instability in a timely manner and alert the physician promptly, 2) provide information for the…
- Trial name
- NCT01516697
- Testing
- experimental, Control
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Cardiac Output,Low, Hemodynamic Instability
Cardiac Output Changes in Cesarean Section
Since 2011, phenylephrine was recommended as the preferred drug to maintain blood pressure in obstetric anesthesia.Phenylephrine, an α adrenoceptor agonist, can induce peripheral vasoconstriction to maintain blood pressure, while…
- Conditions
- Cardiac Output,Low, Hemodynamic Instability, Obstetrical Complication of Anesthesia
- Trial name
- NCT02759510
- Testing
- Norepinephrine, Phenylephrine
- Volunteers
- 106 people
- Sponsor
- RenJi Hospital
Cesarean Wound; Dehiscence, Cesarean Section Complications
Lower Uterine Segment Following a Cesarean Section With Barbed Suture
This aim of this study is to investigate the LUS in the pregnancy following a previous cesarean section with the use of barbed or conventional smooth suture.
- Trial name
- BARB-LOWSEGM (NCT05166174)
- Testing
- Transvaginal ultrasound in the third trimester pregnancy
- Where
- Italy
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Piazza della Vittoria 14 Studio Medico - Ginecologia e Ostetricia
Postoperative Pain
Intrathecal Morphine for Cesarean Delivery
This is a randomized double blinded non-inferiority study comparing the duration of pain relief when patients receive one of three doses of spinal morphine.
- Trial name
- NCT05069012
- Testing
- Morphine Sulfate
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Beth Israel Deaconess Medical Center
Cesarean Section Complications, Cesarean Section Pain
Insufficient Regional Anesthesia and Conversion to General Anesthesia for Cesarean Section A Qualitative Multicenter Study
Background In Denmark, approximately 20% of all children are born via cesarean section (C-section), making it the most common surgical procedure (also internationally).
- Conditions
- Cesarean Section Complications, Cesarean Section Pain, Regional Anesthesia
- Trial name
- NCT06669156
- Where
- 7 sites in Denmark
- Volunteers
- 21 people
- Sponsor
- Sygehus Lillebaelt
Postpartum Hemorrhage
Comparison Between Preoperative Vaginal and Postoperative Sublingual Misoprostol for Prevention of Postpartum Hemorrhage During Cesarean Section
Cesarean section (CS) is one of the most frequently performed operative interventions worldwide [1]. Cesarean section rates increase each year throughout the world.
- Trial name
- NCT06765473
- Testing
- Misoprostol
- Volunteers
- 400 people
- Sponsor
- Assiut University
Postpartum Hemorrhage
Carbetocin at Elective Cesarean Delivery
Post-partum hemorrhage (PPH) is a major cause of maternal death worldwide. Oxytocin is the most commonly uterotonic drug used to prevent and treat PPH in North America, however, there are some limitations to its use.
- Trial name
- NCT01262742
- Testing
- Carbetocin
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Post-operative Complications, Surgical Site Infection
The Use of the Prevena™ Incision Management System on Post-Surgical Cesarean Section Incisions
The purpose of this study is to compare the post-surgical standard-of-care dressing to the Prevena™ Incision Management System in women undergoing Cesarean section surgery.
- Conditions
- Post-operative Complications, Surgical Site Infection, Surgical Wound Infection
- Trial name
- NCT01450631
- Testing
- Prevena™ Incision Management System (PIMS), Standard-of-care Dressing
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- KCI USA, Inc
Preeclampsia, Hypotension
Phenylephrine in Spinal Anesthesia in Preeclamptic Patients
Hypotension remains a common clinical problem after induction of spinal anesthesia for cesarean delivery. Maternal hypotension has been associated with considerable morbidity (maternal nausea and vomiting and fetal/neonatal…
- Trial name
- NCT00458003
- Testing
- Ephedrine, Phenylephrine
- Where
- 2 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Pain, Postpartum Depression
Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery
The purpose of this study is to identify pharmacokinetics of postpartum ketamine infusion. This study will assess ketamine kinetics and metabolism in this setting.
- Trial name
- PREPARE-2 (NCT06767566)
- Testing
- Ketamine (Ketalar)
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Utah
Caesarean Section, Postoperative Pain
Efficacy and Safety of Intrathecal Morphine for Postoperative Pain Management Following Planned Caesarean Section
The goal of this clinical trial is to learn if morphine added to the spinal anaesthesia can improve postoperative pain treatment for patients undergoing caesarean section, without increasing the risk of serious adverse events in…
- Trial name
- MOTHER (NCT06797973)
- Testing
- Intrathecal Morphine
- Where
- 9 sites in Denmark
- Volunteers
- 1,312 people
- Sponsor
- Anne Juul Wikkelsø
Analgesia Obstetrical, Analgesia
Intrathecal Versus Epidural Morphine for Post-Cesarean Analgesia
Cesarean section is one of the most commonly performed surgical procedures worldwide, making effective management of acute postoperative pain a key issue in obstetric anesthesiology.
- Conditions
- Analgesia Obstetrical, Analgesia, Post Operative Pain, Patient Satisfaction
- Trial name
- NCT07386353
- Testing
- Intrathecal Morphine, Epidural Morphine
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospital Central do Funchal
IUD (Intrauterine Device) Malposition, IUD; Complications, Infection or Inflammation
Clinical Outcomes of Post-placental Insertion of Cupper T380A and Multiload 375 Contraceptive Devices During Cesarean Section
Clinical outcomes of post-placental insertion of Cupper T380A and Multiload 375 contraceptive devices during cesarean section
- Trial name
- NCT05624411
- Testing
- CU T380A IUD, multiload 375 IUD
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Sohag University
Cesarean Section Complications, Hypotension
Prediction of Hypotension Using Perfusion Index and Pleth Variability Index After Spinal Anesthesia for C/S
Spinal anesthesia for caesarean section is associated with a decrease in systemic vascular resistance and cardiac output and may cause hypotension in a significant portion of the parturients.
- Conditions
- Cesarean Section Complications, Hypotension, Spinal Anesthesia, Perfusion Index
- Trial name
- NCT03864692
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Kahramanmaras Sutcu Imam University
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