Clinical trials: Complications of Perfusion
Kidney Injury, Acute, Perfusion Imaging
Validation of Renal Perfusion CEUS Against MRI, and Its Application in Acute Kidney Injury
The purposes of this study is 1. To establish the validity of CEUS to measure renal perfusion by comparing it against ASL-MRI in young and older healthy volunteers, and generate a normative dataset of CEUS measures of renal…
- Conditions
- Kidney Injury, Acute, Perfusion Imaging, Ultrasonography, Kidney Diseases
- Trial name
- NCT04181281
- Testing
- Contrast enhanced ultrasound, Arterial Spin Labelling -Magnetic Resonance Imaging
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Fluid Retention Tissue, Perfusion; Complications
Weightlessness Associated Cephalad Fluid Shifts; The Potential to Evaluate Venous and Lymphatic Dysfunction
In the weightlessness of space and significant alterations of terrestrial 1 g (1 gravity equivalent) head-to-foot hydrostatic pressure gradients, astronauts experience a dramatic fluid redistribution of ~ 2 liters from the legs…
- Trial name
- NIID (NCT06405282)
- Testing
- Manual Lymphatic Drainage, Near infrared spectroscopy, Temperature
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Wound Heal, Diabetic Foot Ulcer
Effect of New High Ankle Block on Wound Healing After the Operation of Debridement of Diabetes Foot
The goal of this clinical trial is to compare high ankle block and general anesthesia on wound recovery and ankle blood flow perfusion after diabetes foot surgery in diabetics.
- Trial name
- NCT06395961
- Testing
- high ankle block, general anesthesia
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Xuzhou Central Hospital
Lung Diseases, Lung Inflammation
Impact of Lidocaine Administration on Postoperative Complications During Lung Resection Surgery
The purpose of this study is to analyze the impact of the intravenous (IV) or paravertebral (PV) lidocaine administration during the intraoperative period of lung resection surgery on the appearance of postoperative…
- Conditions
- Lung Diseases, Lung Inflammation, Lung Injury, Acute, Postoperative Complications
- Trial name
- NCT03905837
- Testing
- Lidocaine, Remifentanil
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Francisco Andres de la Gala
Breast Reconstruction, Flap Necrosis
a Prospective Study of Surgical Results, Complications and Predictive Values in Chinese Women Breast Reconstruction
This study prospectively evaluates and compares the effectiveness of ICG fluorescence imaging and LSCI in predicting the risk of necrosis following direct-to-implant breast reconstruction.
- Trial name
- BEST (NCT06779019)
- Testing
- LSCI, ICG (Indocyanine Green)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital
Complication of Extracorporeal Circulation, Renal Impairment
Renal Perfusion, Filtration and Oxygenation During Cardiopulmonary Bypass (CPB)
Acute kidney injury is a common complication after cardiac surgery with cardiopulmonary bypass (CPB). This study aims to investigate the effects of CPB on renal perfusion, filtration and oxygenation.
- Trial name
- ECCSTUD (NCT02405195)
- Testing
- cardiopulmonary bypass
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- Sahlgrenska University Hospital
Stage I Renal Cell Cancer, Stage II Renal Cell Cancer
Perfusion Magnetic Resonance Imaging in Diagnosing Patients With Kidney Tumors
This pilot clinical trial studies perfusion magnetic resonance imaging in diagnosing patients with kidney tumors. Diagnostic procedures, such as perfusion magnetic resonance imaging, may help find and diagnose kidney tumors and…
- Conditions
- Stage I Renal Cell Cancer, Stage II Renal Cell Cancer, Stage III Renal Cell Cancer, Stage IV Renal Cell Cancer
- Trial name
- NCT02526511
- Testing
- Arterial Spin Labeling Magnetic Resonance Imaging, Dynamic Contrast-Enhanced Magnetic Resonance Imaging, Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Rutgers, The State University of New Jersey
Uremia, Uremic Osteodystrophy
Multi-center Clinical Study on Hemoperfusion of KHA80
To evaluate the decreasing rate of blood IL-6, β2-MG and PTH in maintenance hemodialysis patients in the 52nd week compared with routine hemodialysis.
- Conditions
- Uremia, Uremic Osteodystrophy, Dialysis Related Complication
- Trial name
- NCT06233838
- Testing
- KHA80 hemoperfusion treatment
- Where
- China
- Volunteers
- 394 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Diabetic Foot
Wound Bed Preparation for Diabetic Foot Ulcers
The study objective was to compare the efficacy of NPWT versus alginates dressings on the wound bed preparation prior to STSG surgery, as well as investigating the underlying mechanisms.
- Trial name
- NCT05577104
- Testing
- Negative pressure wound therapy (NPWT), conventional moist dressings
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
End Stage Renal Disease, Hemodialysis
L-Arginine and Spironolactone Trial in Dialysis-Dependent ESRD
Cardiovascular disease is the primary cause of death in patients with end stage renal disease (ESRD). New research suggests that the high risk of death may be partly due to high levels of fibrosis and a loss of small blood…
- Trial name
- LAST-D (NCT01855334)
- Testing
- Spironolactone, L-arginine
- Where
- 3 sites in United States
- Sponsor
- Brigham and Women's Hospital
Liver Transplant, Organ Perfusion
NRP vs DHOPE vs COR-NMP in ECD-DCD Donation
There is still a discrepancy between the number of liver transplant candidates and the availability of liver grafts, resulting in waiting list mortality.
- Conditions
- Liver Transplant, Organ Perfusion, Complication of Surgical Procedure
- Trial name
- NCT05327478
- Testing
- NRP, DHOPE, COR-NMP
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Erasmus Medical Center
Kidney Transplant; Complications
Kidney Transplant Monitoring Using Near Infra-red Spectroscopy
Kidney transplant thrombosis (loss of blood flow) is responsible for up to 35% transplant failures in children. Detection of kidney transplant thrombosis currently relies on recognition of deterioration in parameters such as…
- Trial name
- NCT02956018
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Diabetic Ketoacidosis
Perfusion Index for Predicting Diabetic Ketoacidosis Severity in the Emergency Department
This prospective observational cohort study will evaluate whether the perfusion index measured at emergency department admission is associated with the severity of diabetic ketoacidosis in adults.
- Trial name
- NCT07820371
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Ankara Etlik City Hospital
Perfusion; Complications
The Effect of Nitroglycerin Ointment, Fluorescent Angiography, and Incisional Negative Pressure Wound Therapy on Mastectomy Skin Flap Perfusion-Related Problems
This is a randomized study using a variety of techniques to compare and examine blood flow to the remaining skin after mastectomy. All treatments being used are considered standard of care and are not experimental.
- Trial name
- NCT03716050
- Testing
- Nitroglycerin, Negative Pressure Wound Therapy/ Wound VAC, Fluorescent Angiography with indocyanine-green (not to exceed 5mg/kg)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Wake Forest University Health Sciences
Cerebral Autoregulation Impairment, Postoperative Cognitive Dysfunction
BrainProtect-guided, Real-time Cerebral Autoregulation Monitoring and Protection of Brain During Cardiac Surgery With Cardiopulmonary Bypass Requiring Heart-lung Machine
The purpose of this clinical investigation is to evaluate the clinical performance, safety, and clinical benefit of the BrainProtect System in reducing early postoperative neurological complications in adult participants…
- Conditions
- Cerebral Autoregulation Impairment, Postoperative Cognitive Dysfunction, Postoperative Delirium
- Trial name
- BrainProtect (NCT07872982)
- Testing
- BrainProtect System, Standard perioperative management
- Where
- 4 sites in United States, Austria and 2 more
- Volunteers
- 304 people
- Sponsor
- Scienceforbrain, UAB
Intracranial Pressure, Circulation System
The Effect of Arterial Carbon Dioxide Levels on Cerebral Blood Flow and Cerebral Autoregulation in the Steep Trendelenburg Position During Robot-assisted Prostatectomy, and Its Effect on Postoperative Cognition
Patients scheduled for robot-assisted prostatectomy will be randomized to either high or low concentrations of carbon dioxide in the blood.
- Conditions
- Intracranial Pressure, Circulation System, Cerebral Perfusion Pressure, Cognitive Function
- Trial name
- TILTDOWN-3 (NCT06865027)
- Testing
- Ventilation strategy
- Where
- Norway
- Volunteers
- 46 people
- Sponsor
- University Hospital, Akershus
Acute Kidney Injury
Perfusion - Pressure - Creatinine Trial
In Denmark around 3500 procedures are conducted involving a heart-lung-machine per year. An increase in the prevalence of postoperative kidney insufficiency have been observed following these procedures, during the last years.
- Trial name
- PPC (NCT01408420)
- Testing
- MAP > 60 mmHg
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Microvascular Disease, Microvascular Complications
Comparison of Differencens in VO2-max, Perfusion of the Heart and Brain and Cognitive Performance Between Patients with Type 2 Diabetes and Healthy Age Matched Controls.
In the aging population, ischemic heart disease, stroke and dementia are increasingly prevalent. Diagnosis and treatment of the former two i.e., large-vessel coronary heart disease and endovascular thrombectomy of the brain in…
- Conditions
- Microvascular Disease, Microvascular Complications, Dementia, Diabetes Mellitus Type 2
- Trial name
- SVAT (NCT06628297)
- Testing
- PET
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Surgical Wound Infection
Skin Perfusion After Abdominal Surgery
The purpose of this study is to evaluate the consequences of 3 selected surgical procedures on abdominal wall perfusion in order to help to reduce postoperative complication related to inadequate tissue perfusion.
- Trial name
- DIRTSURGERY (NCT03057249)
- Testing
- Dynamic infrared thermography (DIRT)
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- University Hospital of North Norway
Breast Cancer, Mastectomy
Post-Operative Outcomes of Low Thermal Dissection vs. Traditional Electrosurgery
Low thermal dissection devices have been introduced as a tool to improve surgical outcomes. PlasmaBlade, a low thermal dissection device, has shown to be associated with effective cutting, and significantly lower temperature than…
- Conditions
- Breast Cancer, Mastectomy, Perfusion; Complications, Hemostasis
- Trial name
- NCT03711916
- Testing
- PlasmaBlade 3.0S
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins