Clinical trials: Concentration
Diabetes Type 2
Effect of Dialysis Glucose Bath on Glycemic Control in Hemodialysis (HD)
Background: Type II diabetes is a disease that affects more than 246 million people worldwide. Most importantly, one of the complications of type II diabetes is kidney damage and this has lead to many patients seeking…
- Trial name
- NCT01359904
- Testing
- High Dialysate bath
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Seborrheic Keratosis
A Randomized, Vehicle-Controlled Study of 2 Concentrations of A-101 for the Treatment of Seborrheic Keratosis
The primary objective of this study is to evaluate the safety and effectiveness of 2 concentrations of A-101 compared to Vehicle for the treatment of 4 seborrheic keratosis (SK) Target Lesions on the trunk, extremities and face.
- Trial name
- NCT03148691
- Testing
- A-101
- Where
- 9 sites in United States
- Volunteers
- 253 people
- Sponsor
- Aclaris Therapeutics, Inc.
Health Behavior
Effects of Electronic Cigarettes on Nicotine Concentrations
This study will examine whether nicotine levels increase with electronic cigarettes. It will also examine whether electronic cigarettes alter lung function tests.
- Trial name
- ECIG (NCT01775787)
- Testing
- Nicotine with Tobacco Flavor and Tobacco & Menthol Flavor
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- UConn Health
Liver Iron Overload
Safety and Efficacy of Deferasirox in Patients With Transfusion Dependent Iron Overload - a Non-comparative Extension Study
The purpose of this study is to assess the safety and the effects on liver iron of Deferasirox when given for a long treatment period in patients with transfusion dependent iron overload.
- Trial name
- NCT01033747
- Testing
- Deferasirox
- Where
- 4 sites in Italy
- Volunteers
- 70 people
- Sponsor
- Novartis Pharmaceuticals
Septic Shock
Treatment of Patients With Early Septic Shock and Bio-Adrenomedullin(ADM) Concentration > 70 pg/ml With ADRECIZUMAB
This is a double-blind, placebo-controlled, randomized, multicenter proof of concept and dose-finding phase II study using two doses of ADRECIZUMAB in patients with early septic shock and a bio-ADM plasma concentration at…
- Trial name
- AdrenOSS-2 (NCT03085758)
- Testing
- Adrecizumab
- Where
- 30 sites in Belgium, France and 2 more
- Volunteers
- 301 people
- Sponsor
- Adrenomed AG
Attention-Deficit/Hyperactivity Disorder
Double-Blind 2-Site Randomized Clinical Trial of Neurofeedback for ADHD
Additional treatments with long-term benefit for attention-deficit/hyperactivity disorder (ADHD) are needed; one of the more promising is neurofeedback (EEG biofeedback), which has several randomized controlled trials showing…
- Trial name
- NCT02251743
- Testing
- Neurofeedback treatment
- Where
- 2 sites in United States
- Volunteers
- 144 people
- Sponsor
- Ohio State University
Adult Attention Deficit Hyperactivity Disorder (ADHD)
Evaluating the Methylphenidate Patch to Treat Former Stimulant Users With ADHD
The purpose of this study is to evaluate the effectiveness and safety of Daytrana® in the treatment of attention deficit hyperactivity disorder (ADHD) in adults who have abused stimulants in the past.
- Trial name
- NCT00780208
- Testing
- Daytrana (methylphenidate patch)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Medical University of South Carolina
Neurofibromatosis 1
Antioxidant Therapy With N-acetylcysteine for Children With Neurofibromatosis Type 1
Children with neurofibromatosis type 1 (NF1) commonly suffer from the effects of cognitive, behavioral, and motor impairments. At present, there is no specific treatment for this NF1 complication.
- Trial name
- DoDNAC (NCT04481048)
- Testing
- N-Acetyl cysteine
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Attention-Deficit/Hyperactivity Disorder (ADHD)
A Study to Test the Safety and Efficacy of MK0249 in Patients With ADHD (0249-018)(COMPLETED)
The purpose of this study is to investigate the safety and efficacy of an investigational treatment for Attention Deficit Hyperactivity Disorder (ADHD) when compared to placebo.
- Trial name
- NCT00475735
- Testing
- MK0249, Concerta (methylphenidate)
- Volunteers
- 72 people
- Sponsor
- Merck Sharp & Dohme LLC
Pregnancy
PIEB vs CEI for Labor Analgesia: An MLAC Study
Utilizing a 'minimal local analgesic concentration (MLAC) study' design to first determine the relative potency of Programmed Intermittent Epidural Bolus (PIEB) compared to Continuous Epidural Infusion (CEI) and secondly to…
- Trial name
- NCT02573597
- Testing
- Bupivacaine, Sufentanil
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Stanford University
Surgical Anesthesia
Minimum Effective Concentration of Ropivacaine for Brachial Plexus Block Via the Supraclavicular and Infraclavicular Approach, Femoral Nerve Block, Sciatic Nerve Block Via the Popliteal and Parasacral Approach
This is a dose finding study to identify the minimum effective anesthetic concentration (MEAC) of ropivacaine to produce insensate body parts sufficient for surgery in supraclavicular and infraclavicular approaches to the…
- Trial name
- MEAC (NCT01452126)
- Testing
- Ropivacaine concentration
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of New Mexico
Attention Deficit Hyperactivity Disorder
Long Acting Stimulant Treatment of Attention Deficit Hyperactivity Disorder (ADHD) in Young Children
This is a pilot study evaluating the effectiveness, safety, and tolerability of Ritalin LA in treating Attention Deficit Hyperactivity Disorder (ADHD) in 4 and 5 year old children.
- Trial name
- NCT00754208
- Testing
- methylphenidate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Nebraska
Mild Cognitive Impairment
Rehabilitation of Attention in Patients With MCI and Brain Subcortical Vascular Changes Using the APT-II
Background: Subcortical Vascular Dementia (VaD), consequent to deep brain small vessel disease (SVD), is the most frequent form of VaD.
- Trial name
- RehAtt (NCT02033850)
- Testing
- Attention Process Training-II
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Attention Deficit Hyperactivity Disorder
Methylphenidate Transdermal System (MTS) in the Treatment of Adult ADHD
This study will look at the effectiveness of Methylphenidate Transdermal System (MTS) in treating adult ADHD. MTS has received FDA approval for childhood ADHD but this is the first trial for adult ADHD.
- Trial name
- NCT00506285
- Testing
- Methylphenidate Transdermal System (MTS)
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Utah
Anaesthesia
General Anesthesia With Xenon in Inspiratory Concentrations of 50% and 70% and Total I.V. Anaesthesia.
The purpose of this study is to evaluate the quantity of propofol administered with Xenon in two inspiratory concentrations, to maintain comparable depth of anaesthesia during the maintenance period of general anaesthesia.
- Trial name
- NCT00919126
- Testing
- Xenon, Medical Air in Oxygen
- Where
- 6 sites in France, Germany and 1 more
- Volunteers
- 102 people
- Sponsor
- Air Liquide SA
Cancer-related Problem/Condition, Cognitive Impairment
Memory and Attention Adaptation Training-Geriatrics (MAAT-G) Phase II
Cancer-related cognitive dysfunction (CRCD) affects up to 75% of patients receiving chemotherapy and older adults are at greater risk of developing CRCD, which can negatively affect their functional independence and quality of…
- Trial name
- NCT04669301
- Testing
- MAAT-G, Supportive therapy (time and attention control)
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Rochester
ADHD, Smoking
Smoking Cessation for Adults With Attention Deficit Hyperactivity Disorder (ADHD)
The objective of this study is to evaluate whether Osmotic-Release Methylphenidate (OROS MPH), relative to placebo, increases the effectiveness of standard smoking treatment (i.e., nicotine patch and individual smoking cessation…
- Trial name
- NCT00253747
- Testing
- Osmotic-Release Methylphenidate
- Where
- 6 sites in United States
- Volunteers
- 255 people
- Sponsor
- University of Cincinnati
Chronic Insomnia
Brief Behavioral Treatment for Insomnia in Cancer Survivors
The purpose is to determine whether brief behavioral treatment is effective for insomnia in cancer survivors.
- Trial name
- NCT03810365
- Testing
- Brief behavioral treatment for insomnia, Healthy Eating Control
- Where
- 2 sites in United States
- Volunteers
- 132 people
- Sponsor
- State University of New York at Buffalo
Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder
Impact of Combined Medication and Behavioral Treatment for ASD & ADHD
Children with comorbid autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) have significantly worse outcomes than those with either ASD alone or ADHD alone.
- Trial name
- NCT03242772
- Testing
- Amphetamine, ESDM informed parent coaching
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Psoriasis Vulgaris
A 12-Day Randomized, Blinded, Vehicle and Active Comparator-Controlled Study to Determine the Efficacy and Safety of Six Concentrations of Topical E6201 Gel in Subjects With Psoriasis Vulgaris
The purpose of this study is to investigate the efficacy, safety, tolerability and the concentration/response relationship of E6201 in subjects with psoriasis vulgaris.
- Trial name
- NCT01268527
- Testing
- 0.03% E6201, 0.1% E6201, 0.2% E6201
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Eisai Limited