Clinical trials: Concentration
Hemodialysis, Thromboinflammation
Effect of Modifying Magnesium Concentration in Citrate-enriched Dialysate on Hemodialysis-associated Thromboinflammation
This clinical trial investigates whether the composition of dialysate influences hemodialysis-associated thromboinflammation. Specifically, it evaluates the effects of magnesium concentration and acid type in dialysate on immune…
- Conditions
- Hemodialysis, Thromboinflammation, Hemodialysis Complication, End Stage Renal Disease (ESRD)
- Trial name
- pilot OMAGOD + (NCT07206524)
- Testing
- Hemodialysis using dialysate containing citric acid and magnesium at a concentration of 1.0 mmol/L, Hemodialysis using acetic acid dialysate with magnesium 0.5 mmol/L, Hemodialysis using citric acid dialysate with magnesium 0.75 mmol/L
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Universitair Ziekenhuis Brussel
Attention-Deficit/Hyperactivity Disorder
Communication to Improve Shared Decision-Making in ADHD
The purpose of this study was to explore whether using an online patient portal plus a Care Manager is more effective than using an online portal alone in managing care for children with ADHD.
- Trial name
- ADHD-Link (NCT02716324)
- Testing
- Care Manager CM), ADHD Portal
- Where
- United States
- Volunteers
- 303 people
- Sponsor
- Children's Hospital of Philadelphia
Pain, Fatigue
Fatigue in Chronic Pain - Cognition, Emotional Aspects, Biomarkers, and Neuronal Correlates
The investigators will examine mental/cognitive as well as cognitive functions (executive functions, attention functions, processing speed, learning and memory) in 200 patients with chronic pain and 36 healthy controls.
- Conditions
- Pain, Fatigue, Cognitive Impairment
- Trial name
- NCT05452915
- Testing
- Neuropsychological (NPA), Imaging, Inflammatory biomarkers
- Where
- 3 sites in Sweden
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Danderyd Hospital
Dialysis; Complications
Effect of Modifying Magnesium Concentration in Citrate-enriched Dialysate on Serum Magnesium Levels
Individuals with ESKD and treated with hemodialysis have a high mortality risk. Associative studies suggest a relationship between serum magnesium concentration and mortality risk.
- Trial name
- OMAGOD-1 (NCT07565779)
- Testing
- A - Dialysate magnesium 0.75, B - Dialysate magnesium 1.00 mmol/L
- Where
- 4 sites in Belgium
- Volunteers
- 54 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Pain
A Study To Observe The Performance Of A Tablet Form Of PF-04531083 As Evidenced By The Concentration Of PF-04531083 In The Blood With Time Following Oral Administration To Healthy Volunteers.
A new tablet form of PF-04531083 has been manufactured. Previously the compound was administered as a solution/suspension to healthy volunteers.
- Trial name
- NCT01119235
- Testing
- PF-04531083
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Breast Cancer
Natriuretic Peptide Concentrations of B-type (BNP) During Anesthesia in Patients Previously Sensitized to Anthracyclines
The cardiotoxicity of anthracyclines chemotherapy remains a major problem, despite clinical and echocardiographic monitoring. In the case of treatment for breast cancer, surgery requiring general anesthesia may follow…
- Trial name
- PEP-NAT-B (NCT01754597)
- Testing
- Dosage of B-type natriuretic peptide (NT-proBNP)
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Institut Bergonié
Systemic Availability, Intestinal Absorption
The Systemic Concentration of Short-Chain Fatty Acids After Delivery in the Small and Large Intestine of Healthy Volunteers
The goal of this crossover study is to evaluate the systemic availability of short-chain fatty acids (SCFA) that are either administered in the small intestine or the colon in healthy volunteers.
- Conditions
- Systemic Availability, Intestinal Absorption, Metabolism, Short-chain Fatty Acids
- Trial name
- Sistine (NCT06082726)
- Testing
- SCFA
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Dry Eye
A Study Evaluating the Efficacy of SAR 1118 (0.1%, 1.0%, 5.0%) Ophthalmic Solution in Subjects With Dry Eye Conducted in a Controlled Adverse Environment (CAE)
The purpose of this study is to evaluate the efficacy of three different concentrations (0.1%, 1.0%, 5.0%) of SAR 1118 Ophthalmic Solution compared to placebo in the treatment of dry eye.
- Trial name
- NCT00926185
- Testing
- Lifitegrast
- Where
- 5 sites in United States
- Volunteers
- 230 people
- Sponsor
- Shire
Acute Effects of EMWs Emitted by Cell Phones
Acute Effects of Cell Phone Exposure on Immediate Attention Levels and Concentration of Emergency Physicians
To investigate the acute effects of cell phone exposure on immediate attention levels and concentration of emergency department physicians
- Trial name
- NCT03239925
- Testing
- Electromagnetic field of cell phone in ''on'' mode., Electromagnetic field of cell phone in 'off' mode.
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Vitamin A Deficiency
Effect of Daily Consumption of Orange Maize on Breast Milk Retinol in Lactating Zambian Women
The purpose of the study is to determine whether daily consumption of beta-carotene biofortified maize will increase breast milk retinol concentration in lactating Zambian women.
- Trial name
- NCT01922713
- Testing
- white maize and a corn oil capsule, orange maize and a corn oil capsule, white maize and a vitamin A capsule
- Where
- Zambia
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Cancer
A Study to Assess the Safety and Efficacy of UNO - Ultra High Concentration Nitric Oxide Injection in Combination With PD-1 Inhibitors Into Unresectable Solid Primary or Metastatic Tumors
This is a Phase 1, open-label, dose-escalation and dose-expansion study comprised of 2 parts: Phase 1a - a single treatment session, an evaluation period of 21±3 days, and safety and survival follow-up period of up to 12 weeks…
- Trial name
- NCT05351502
- Testing
- Nitric Oxide 25,000 ppm, Nitric Oxide 50,000 ppm
- Where
- 4 sites in Israel
- Volunteers
- 38 people
- Sponsor
- Beyond Air Inc.
Critical Illness, Infections
A Model for Drug Concentration Prediction of Vancomycin
Objective: This study aims to use machine learning methods to establish an optimal model for predicting serum vancomycin trough concentrations in critically ill patients. Methods: This is a single-center, retrospective study.
- Conditions
- Critical Illness, Infections, Drug Use
- Trial name
- NCT06431412
- Testing
- no intervention
- Where
- China
- Volunteers
- 401 people
- Sponsor
- Peking Union Medical College Hospital
Breast Cancer, Renal Cell Carcinoma
Everolimus TDM to Predict Long Term Toxicity
Metastatic (HR-positive, HER2-negative) breast cancer (BC), advanced or unresectable neuroendocrine tumours of pancreatic (pNET), gastrointestinal or lung origin and metastatic renal cell carcinoma (mRCC) are diseases with poor…
- Conditions
- Breast Cancer, Renal Cell Carcinoma, Pancreatic Neuroendocrine Tumour, Gastrointestinal Neuroendocrine Tumour
- Trial name
- Foresight (NCT03033186)
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Maastricht University Medical Center
Attention Deficit Disorder With Hyperactivity
Improving Attention Deficit Hyperactivity Disorder Treatment Adherence and Outcome in Primary Care Settings
This study will determine the effectiveness of educating pediatricians about attention deficit hyperactivity disorder treatment guidelines in improving child behavior and pediatricians' adherence to medication guidelines.
- Trial name
- NCT00179894
- Testing
- Physician training
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Coronary Artery Disease, Atherosclerosis
Neutrophil Gelatinase-associated Lipocalin Concentration in Coronary Artery Disease
Serum NGAL has been described as a biomarker of neutrophil activation and an inflammatory marker which correlates to obesity and its metabolic complications.
- Trial name
- NCT00749281
- Where
- Greece
- Volunteers
- 73 people
- Sponsor
- Cardiovascular Research Society, Greece
Healthy
Effects of Vortioxetine (Lu AA21004) on the Concentrations of Selected Neurotransmitters in Healthy Male Adults
The purpose of this study is to evaluate the pharmacodynamics (the drug's effect on the body), the pharmacokinetics (the body's handling of the drug), and the safety and tolerability of vortioxetine, once daily (QD) in healthy…
- Trial name
- NCT01299805
- Testing
- Vortioxetine
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Takeda
Traumatic Brain Injury
Improving Executive Functions After Traumatic Brain Injury (TBI): A Clinical Trial of the "Executive Plus" Program
This is a randomized clinical trial which compares a standard day treatment program for individuals with TBI with the "Executive Plus" program; the latter emphasizes training of attention, emotional self-regulation and problem…
- Trial name
- NCT00233129
- Testing
- Top Down, cognitive rehabilitation day treatment program
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
ADHD
Assessing a Wearable Digital Therapy for Youth With ADHD
The purpose of this study is to evaluate and compare three different investigational wearable digital interventions to determine if they are helpful for improving symptoms and functioning in children diagnosed with…
- Trial name
- NCT05710965
- Testing
- FRx-001, FRx-003, FRx-004
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Revibe Technologies
Invasive Pulmonary Aspergillosis
CYP 2C19 Polymorphism and Voriconazole Trough Concentration in Chinese Adult Patients
To investigate the relationship between cytochrome P450 (CYP) 2C19 genetic polymorphism and the steady-state blood concentration of voriconazole in Chinese patients with invasive pulmonary aspergillosis (IPA), and to assess the…
- Trial name
- NCT02100761
- Testing
- Voriconazole
- Where
- China
- Volunteers
- 200 people
- Sponsor
- dingshifang
Neck Pain
Effects of Cervical Manipulation and Mobilization on Salivary Cortisol Concentrations
Currently, there are many studies about the effects of manual therapy on pain, but there are not enough studies to know what are the mechanisms that cause these effects.
- Trial name
- NCT02628470
- Testing
- cervical manipulation, cervical control exercises, Oscillatory mobilization technique
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- University of Alcala
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