Clinical trials: Concentration
Crohn's Disease
Adalimumab Trough Concentrations in Crohn's Disease: A Pilot Pharmacokinetic Study
Observational pharmacokinetics study of adalimumab in patients with active refractory Crohn's disease who are naïve to TNF antagonist therapy.
- Trial name
- NCT02450513
- Testing
- Adalimumab
- Where
- 2 sites in Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Polycystic Ovary Syndrome
Effects of Flutamide on Insulin and Glucose Metabolism in Women With Polycystic Ovary Syndrome
Polycystic Ovary Syndrome (PCOS) is the major cause of infertility in the United States. Many women with PCOS demonstrate insulin resistance and a compensatory hyperinsulinemia.This is due to both an intrinsic form of insulin…
- Trial name
- PCOS (NCT00729560)
- Testing
- Flutamide
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Virginia Commonwealth University
Oppositional-Defiant Disorder
Comparison of Two Psychosocial Therapies for Treating Children With Oppositional-Defiant Disorder
This study will evaluate the effectiveness of two different psychosocial therapies, parent management training and collaborative problem solving, in treating children with oppositional-defiant disorder.
- Trial name
- NCT00510120
- Testing
- Parent management training (PMT), Collaborative problem solving (CPS), Waitlist control
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Virginia Polytechnic Institute and State University
Anxiety Disorders
Developing a Low-Intensity Primary Care Intervention for Anxiety Disorders
The purpose of the study is to develop a personalized, user-friendly computerized treatment for anxiety disorders linked to primary care.
- Trial name
- AIM-PC (NCT02266446)
- Testing
- Attention & Interpretation Modification
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Brown University
Heart Failure, Myocardial Ischemia
PK and Tolerability of IV and Oral CK-1827452 in Patients With Ischemic Cardiomyopathy and Angina
This study investigates whether symptom-limited exercise capacity in ischemic cardiomyopathy patients with angina is deleteriously affected by treatment with CK-1827452.
- Conditions
- Heart Failure, Myocardial Ischemia, Angina Pectoris
- Trial name
- NCT00682565
- Testing
- CK-1827452 24mg and 6 mg iv infusion, CK-1827452 12.5mg capsule, CK-1827452 48 mg and 11 mg iv infusion
- Where
- 14 sites in Georgia, Russia
- Volunteers
- 94 people
- Sponsor
- Cytokinetics
Chronic Kidney Disease (Stages 3b-5)
Pistachio Consumption in Patients With Chronic Kidney Disease
Standard chronic kidney disease (CKD) guidelines frequently restrict nut intake due to concerns regarding their phosphorus and potassium content.
- Trial name
- NCT07815600
- Testing
- Pistachio, Control
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
ADHD, Depression
Does Cultivating Self-compassion Improve Resilience to Criticism and Improve Mental Health in Adults With ADHD?
This study aims to investigate the effect that increasing levels of self-compassion may have on levels of perceived criticism, self-criticism, and mental health of adults with ADHD.
- Conditions
- ADHD, Depression, Stress, Self-Criticism
- Trial name
- NCT04978792
- Testing
- Online self-compassion intervention, Active Control
- Where
- United Kingdom
- Volunteers
- 114 people
- Sponsor
- University of Sheffield
Cognitive Interference and Selective Attention
Effect of Instrumental Lo-Fi Music on Stroop Interference Performance in University Students
This study aims to examine the effects of instrumental lo-fi background music compared to silence on cognitive interference performance among university students.
- Trial name
- LOFI (NCT07598877)
- Testing
- Instrumental Lo-Fi Music
- Where
- United Arab Emirates
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Canadian University Dubai
PTSD
Attention Control Treatment for Post Traumatic Stress Disorder ׂ(PTSD)
The purpose of this study is to explore the efficacy of Attention Control Training for Post Traumatic Stress Disorder (PTSD). ACT was found to be effective in decreasing attention bias variability and PTSD symptoms in combat…
- Trial name
- NCT02945709
- Testing
- Personalized Attention control training (ACT), Non-personalized Attention control training (ACT), Control training.
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Tel Aviv University
ADHD - Attention Deficit Disorder With Hyperactivity, Irritability
Predictors of Improvements in Irritability and Aggression in Children With ADHD Treated With CNS Stimulants
Impulsive Aggression and chronic irritability (IACI) often occur together and are one of the most common reasons children present for behavioral health (BH) care.
- Conditions
- ADHD - Attention Deficit Disorder With Hyperactivity, Irritability, Aggression Childhood
- Trial name
- NCT06871488
- Testing
- CNS Stimulant, CNS Stimulant open label first phase
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Milton S. Hershey Medical Center
Healthy Subjects
Measurement of HTL0016878 in Cerebrospinal Fluid
A Phase 1, open-label, randomised, single oral dose study to determine the concentration of HTL0016878 in CSF and plasma in healthy male subjects following dosing with HTL0016878 10 mg or 20 mg oral solution
- Trial name
- NCT04849286
- Testing
- HTL0016878
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Nxera Pharma UK Limited
Cushing Disease
Hair Cortisol and Cushing's Disease
The biochemical tools usable to assess the control of hypercortisolism in patients with Cushing's disease receiving medical treatments are debatable.
- Trial name
- HAIRCUSH (NCT04201444)
- Testing
- Patient group, Remission control group, Bilateral surrenalectomy control group
- Where
- 7 sites in France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Bordeaux
Schizophrenia, Schizoaffective Disorder
Guanfacine Adjunctive Treatment to Atypical Antipsychotics for Cognitive Dysfunction in Schizophrenia
Our overall aim is to determine if the administration of guanfacine in combination with aripiprazole, olanzapine, quetiapine, and/or risperidone is significantly more effective than any of those medications alone in treating some…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Cognitive Impairment
- Trial name
- Guanfacine (NCT00469664)
- Testing
- Guanfacine/Tenex
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Stroke
Repetitive Transcranial Magnetic Stimulation in Spatial Attention After Stroke
Randomized Controlled Trial (RCT) aiming at assessing the efficacy of a novel rehabilitation protocol, based on repetitive transcranial magnetic stimulation (r- TMS) in combination with a conventional cognitive treatment (CCT).
- Trial name
- r-TMS (NCT04080999)
- Testing
- r-TMS
- Where
- 2 sites in Italy
- Volunteers
- 56 people
- Sponsor
- Azienda Usl di Bologna
Autism Spectrum Disorder
Sensory and Behavioral Aspects With Particular Attention to Food Selectivity in Children With Autism
Brief Summary: Eating problems and in particular food selectivity is a condition that worsens a long-life disorder such as Autism Spectrum Disorder (ASD) , both on an individual level, both on family and social ones .
- Trial name
- NCT06335030
- Where
- 3 sites in Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Fondazione Stella Maris
Metformin Response, Fasting Glucose
Dietary Intake of Tryptophan and Metformin Response
This study will examine the influence of dietary intake of tryptophan on response to metformin. The investigators hypothesize that dietary tryptophan alteration will influence metformin response.
- Conditions
- Metformin Response, Fasting Glucose, Tryptophan Concentration, Metformin Concentration
- Trial name
- NCT02184832
- Testing
- Metformin, Low tryptophan diet, High tryptophan diet
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder
The Effect of Playful Physiotherapy Intervention
The goal of this quasi-experimental study is to evaluate the changes in emotional, behavioral, and psychosocial functioning of children aged 7-12 following a playful physiotherapy intervention.
- Trial name
- NCT07466147
- Testing
- Playful physiotherapy programme
- Where
- Estonia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Tartu
Hypertension
The Effect of Beetroot Juice on Plasma Trimethylamine N-oxide Concentration
The primary aim of the current study is to determine the effect of beetroot juice consumption on plasma trimethylamine N-oxide concentration.
- Trial name
- BRJ_TMAO (NCT05004935)
- Testing
- beetroot juice, nitrate
- Where
- Poland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Diabetes Mellitus, Type 2, Healthy Participants
A Research Trial Looking at the Comparability of 2 Different Concentrations of Semaglutide for the 0.5 Milligram (mg) Dose
In this study, a known investigational medicine called 'semaglutide' will be tested in 2 drug concentrations of 0.68 milligram per milliliter (mg/mL) and 1.34 mg/mL.
- Trial name
- NCT05689099
- Testing
- Semaglutide B, 1.34 mg/mL, Semaglutide B, 0.68 mg/mL
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Attention Deficit Hyperactivity Disorder
Endophenotype, Molecular Genetic Study on Attention-Deficit/Hyperactivity Disorder
The ultimate goals of this study are to identify patterns of familial aggregation with regards to categorical and dimensional approaches of ADHD and neuropsychological measures, to validate the phenotypes and endophenotypes that…
- Trial name
- NCT00529906
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
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