Clinical trials: Concentration
Critical Illness, Respiratory Failure
Targeted OXYgen Therapy in Critical Illness
The investigators propose to conduct a feasibility, multi-centre, randomised controlled trial of targeted oxygen therapy in adult critically ill patients receiving mechanical ventilation via an endotracheal tube as part of their…
- Trial name
- TOXYC (NCT03287466)
- Testing
- Oxygen
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University College, London
Psychosis
Psychosis TMS Study
The main goal of this study is to investigate the neural mechanisms of working memory function in patients with early psychosis using Transcranial Magnetic Stimulation (TMS) in conjunction with functional MRI.
- Trial name
- NCT05857137
- Testing
- Active TMS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Healthy
Study to Assess the Influence of Three Different α-antagonists and Placebo on the Extent of Weekly Phenylephrine-induced Mydriasis at Three Different Concentrations of Phenylephrine in Healthy Male Volunteers
The study was aimed to evaluate the pharmacological effect of different α-antagonists on phenylephrine induced pupil size in healthy male volunteers as pharmacological basis for Intraoperative floppy iris syndrome (IFIS)
- Trial name
- NCT02266537
- Testing
- Tamsulosin, Alfuzosin, Doxazosin
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Neurofeedback
Toward a Generalizable Closed-loop Neurofeedback-based BCI for Attention Training
The proposed study accelerates the translational aspect of neurofeedback-based attention training using novel technologies, algorithms, and neuromarkers.
- Trial name
- NCT05908253
- Testing
- nonadaptive neurofeedback, adaptive neurofeedback
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Attention Deficit Disorder With Hyperactivity
Safety, Tolerability and Efficacy of SPD503 in Treating ADHD in Children Aged 6-17
The purpose of this study is to determine the effects of SPD503 compared to placebo on tasks of sustained attention in children and adolescents aged 6-17 diagnosed with ADHD.
- Trial name
- NCT00150592
- Testing
- SPD503 (Guanfacine HCl)
- Volunteers
- 182 people
- Sponsor
- Shire
Type 2 Diabetes
A Guided Self-determination Intervention Versus Attention Control for People With Type 2 Diabetes in Outpatient Clinics
Background In management of type 2 diabetes, autonomy supporting interventions may be a prerequisite to achieve 'real life' patient engagement and more long-term improvement.
- Trial name
- OVERCOME (NCT04601311)
- Testing
- Guided self-determination, Personal support in goal-pursuing
- Where
- Denmark
- Volunteers
- 224 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cognitive Change, Memory; Disturbance, Mild
The Influence of Food for Special Dietary Use - Spread Enriched With 5-hydroxytryptophan, Theanine and Gamma-aminobutyric Acid on Psychophysiological Functions of Subjects Without Meaningful Organic and Cognitive Pathology
This is a single-centre, single-blind, two-arms, controlled study to assess the efficacy and safety of food for special dietary use enriched with 5-hydroxytryptophan, L-theanine and Gamma-aminobutyric acid in generally healthy…
- Conditions
- Cognitive Change, Memory; Disturbance, Mild, Emotional Regulation, Concentration Ability Impaired
- Trial name
- Spread Bogatyr (NCT05543811)
- Testing
- Food for special dietary use
- Where
- Russia
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Scientific Institution
Acute Ischemic Stroke, Intracranial Artery Occlusion
Intra-arterial TNK Following Endovascular Thrombectomy in Patients With Large Vessel Occlusion of Posterior Circulation
Rationale: Recently, one prospective multicenter RCT reported a potential beneficial effect of intra-arterial alteplase following successful endovascular thrombectomy (EVT) in patients with an acute intracranial large vessel…
- Conditions
- Acute Ischemic Stroke, Intracranial Artery Occlusion, Endovascular Thrombectomy
- Trial name
- NCT05684172
- Testing
- Tenecteplase, endovascular thrombectomy alone
- Where
- China
- Volunteers
- 208 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Adverse Effects in the Therapeutic Use of Other and Unspecified Agents Affecting Blood Constituents
Antibiotic Concentrations After MassivE Transfusion Study
Combat and civilian trauma frequently result in open wounds that are at risk for infection. Data from the Department of Defense Trauma Registry demonstrate that 74% of combat trauma casualties have an open wound.
- Trial name
- ACME (NCT06699901)
- Testing
- Massive Transfusion Group, Control Group
- Where
- 2 sites in United States
- Volunteers
- 417 people
- Sponsor
- Brooke Army Medical Center
Preeclampsia
A Trial Comparing Treatment With the Springfusor Infusion Pump to the IV Magnesium Sulfate Regimen
The trial will test the equivalence of a repeat bolus protocol of magnesium sulfate administered by the Springfusor® controlled pump to a continuous intravenous regimen.
- Trial name
- NCT02091401
- Testing
- Springfusor infusion pump, IV administration, Magnesium Sulfate
- Where
- 2 sites in Egypt
- Volunteers
- 200 people
- Sponsor
- Gynuity Health Projects
Body Dissatisfaction, Eating Disorder Symptoms
Attention Training and Its Effects on Body Image Disturbance
Research has consistently found attentional biases towards negative weight-related stimuli in individuals with eating disorders.
- Trial name
- NCT01110265
- Testing
- attention training
- Where
- Australia
- Volunteers
- 32 people
- Sponsor
- University of Sydney
Healthy Volunteers
Study to Assess the Intrapulmonary Pharmacokinetics of SPR859 by Comparing the Plasma, Epithelial Lining Fluid (ELF), and Alveolar Macrophages (AM) Concentrations Following the Oral Administration of Five Doses of SPR994 in Healthy, Nonsmoking Volunteers
To evaluate the intrapulmonary pharmacokinetics (PK), including ELF and AM concentrations, of SPR859 (tebipenem) compared to plasma concentrations of SPR859 (tebipenem) (the active moiety in plasma of the prodrug SPR994) in…
- Trial name
- NCT04710407
- Testing
- TBPM-PI-HBr
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Spero Therapeutics
Chronic Kidney Diseases, Osteodystrophy
Effect of Allopurinol on Markers of Mineral and Bone Metabolism
Hyperuricemia is a common condition in patients with chronic kidney disease (CKD) in the glomerular filtration rate. Recently, it has been suggested that uric acid is related to a mineral and bone disease of CKD (CKD-MBD) since…
- Conditions
- Chronic Kidney Diseases, Osteodystrophy, Uric Acid Concentration, Serum, Quantitative Trait Locus 7
- Trial name
- NCT05601271
- Testing
- Allopurinol
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital
Gastric Bypass
Mechanistic Investigation Of Intestinal Cytochrome p450 3A4 Following Roux-en-Y Surgery And Its Effect on Plasma Concentrations of Buspirone
This study is to compare intestinal Cytochrome P450 3A4 (CYP3A4) activity in 9-18 month post weight loss surgery Roux-en-Y Gastric Bypass (RYGB) versus control subjects who have not had a weight loss surgery and are of similar…
- Trial name
- NCT02483598
- Testing
- Buspirone, Buspirone and Grapefruit Juice
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- North Dakota State University
HIV, Physical Abuse of Adult (If Focus of Attention is on Victim)
Assessing the Impact of an Intervention to Prevent Intimate Partner Violence and HIV in Uganda
Intimate partner violence (IPV) is a precursor to and consequence of HIV infection. Few interventions combining HIV and IPV prevention have been evaluated and none has significantly decreased both outcomes.
- Conditions
- HIV, Physical Abuse of Adult (If Focus of Attention is on Victim), Sexual Abuse of Adult (If Focus of Attention is on Victim), Risk Reduction Behavior
- Trial name
- SHARE (NCT02050763)
- Testing
- The SHARE Project
- Where
- Uganda
- Volunteers
- 11,451 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
ADHD, Stimulant-Induced Euphoria
Prevention of Stimulant-Induced Euphoria With an Opioid Receptor Antagonist
The purpose of this study is to a) assess the efficacy of naltrexone in preventing stimulant-induced euphoria in adults with ADHD, b) assess whether naltrexone will interfere with the clinical efficacy of stimulants in treating…
- Trial name
- NCT01673594
- Testing
- SODAS MPH, Naltrexone
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Massachusetts General Hospital
Gastrointestinal Stromal Tumors
The Correlation Between Ripretinib Exposure and the Efficacy and Safety in Patients with Advanced GISTs
This is a prospective, single-center, observational study to explore the correlation between ripretinib exposure and the efficacy and safety in patients with advanced gastrointestinal stromal tumors
- Trial name
- NCT06431451
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Attention Deficit Hyperactivity Disorder
Improving Sleep and Daytime Functioning Among Children Diagnosed With Attention Deficit Hyperactivity Disorder (ADHD)
This study will test the efficacy of a systematic, multi-modal intervention protocol designed to improve sleep functioning and subsequent alleviation of daytime cognitive and behavioral difficulties among children diagnosed with…
- Trial name
- NCT00867451
- Testing
- Sleep Intervention, Melatonin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Methylene Blue, Chloroquine
BlueCQ Bioavailability
Bioavailability of methylene blue (MB) - comparison of an i.v. and two oral MB formulations - and influence of sustained release MB on chloroquine (CQ) concentrations in whole blood, plasma and urine.
- Conditions
- Methylene Blue, Chloroquine, Pharmacokinetics, Bioavailability
- Trial name
- NCT00176072
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Bypass Complications
Sustained-release Morphine Pharmacokinetics in Roux-en-Y Gastric Bypass Subjects
The purpose of this study is to determine whether sustained release morphine pharmacokinetics parameters in patients undergone roux-en-y gastric bypass (RYGB) differ from subjects who did not.
- Trial name
- OBEMO2 (NCT02641301)
- Testing
- Sustained release morphine sulfate, 30 mg
- Where
- 2 sites in France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hopital Lariboisière
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