Clinical trials: Conception
Pediatric Leukemia, Other Pediatric Cancers
Follow-up Study of Late Effects of Periconceptional Folic Acid in Mothers and Offspring in the Community Intervention Program Population: The Chinese Children and Families Study
Periconceptional folic acid supplements of 400 (Micro) daily prevent neural tube defects (NTD) in offspring. Some data suggest that periconceptional folic acid supplements, folate levels during pregnancy, and/or certain variants…
- Trial name
- NCT01365975
- Where
- United States
- Volunteers
- 1,382 people
- Sponsor
- National Cancer Institute (NCI)
Adenomyosis
Modified Downregulation for Women With Adenomyosis of the Uterus Prior to Frozen-thawed Embryo Transfer.
1 in 7 couples experience difficulty in conceiving. Many will require in vitro fertilization (IVF). IVF involves an initial period of downregulation to suppress the ovaries and prevent premature ovulation.
- Trial name
- MODA (NCT03946722)
- Testing
- GnRH analogue downregulation, Participant questionnaire
- Where
- United Kingdom
- Volunteers
- 162 people
- Sponsor
- University College, London
Uterine Polyp, Retained Products of Conception
Predictive Factors for Successful Operative Hysteroscopy Using Tissue Removal Device (TruClear System) Without Anesthesia
Background: Small-diameter operative hysteroscopes may allow to perform operative hysteroscopy without general anesthesia in selected patients.
- Trial name
- NCT05722028
- Testing
- hysteroscopy
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Assaf-Harofeh Medical Center
Asherman Syndrome
Efficiency of Intercoat (Oxiplex/AP Gel)in Decreasing Intrauterine Adhesions
This is a prospective single blind randomized controlled pilot study was designed to investigate whether the biological barrier Intercoat (Oxiplex/AP gel) reduces formation of intrauterine adhesions following hysteroscopic…
- Trial name
- NCT01377779
- Testing
- Oxiplex/AP gel, Normal Saline
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Assaf-Harofeh Medical Center
Prevenetion of Intrauterine Adhesions by Hyaluronic Acid Gel
Intrauterine Hyaluronic Acid Gel for Prevention of Intrauterine Adhesions
Women undergoing operative hysteroscopy for removal of retained placenta after delivery will be randomized into two groups. 1. study group - immediately after operative hysteroscopy 5 ml hyaluronic acid gel will be injected into…
- Trial name
- NCT04975373
- Testing
- Intrauterine injection of hyaluronic acid
- Where
- Israel
- Volunteers
- 160 people
- Sponsor
- Barzilai Medical Center
Substance Use, Sexual Behavior
Telling Our Daughters Our Story
The objective of this research study is to evaluate a culturally grounded program among American Indian (AI) female children and the children's female caregivers.
- Trial name
- TODOS (NCT06276595)
- Testing
- Nowhi Isdza bit Nadagoldi: Telling Our Daughters Our Story (TODOS), Control condition - 3 Monthly Group Activities in the Community
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Laparoskopic Cholecystectomy, Transversus Abdominis Plane (TAP) Block
Comparison of Postoperative Analgesic Efficacy of Transversus Abdominis Plane Block (TAP) and Modified Thoracoabdominal Nerve Block (M-TAPA)
Laparoscopic cholecystectomy is a frequently performed surgical procedure and is considered the gold standard for treating symptomatic gallstone disease.
- Conditions
- Laparoskopic Cholecystectomy, Transversus Abdominis Plane (TAP) Block, Modified Thoracoabdominal Nerve Block (M-TAPA)
- Trial name
- NCT06932835
- Testing
- Transversus Abdominis Plane (TAP) Block, Modified Thoracoabdominal Nerve Block (M-TAPA)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara Etlik City Hospital
Congenital Heart Disease
Peri-conception Key Nutritional Factors and Congenital Heart Disease
The study is a nested case-control study and the purpose is to describe the status of key nutrients(eg.folic acid and vitamins) supplementation among pregnant women in Shanghai, to find out the association between the level of…
- Trial name
- PKNFCHD (NCT02737644)
- Testing
- observation
- Where
- China
- Volunteers
- 37,000 people
- Sponsor
- Children's Hospital of Fudan University
Abortion Induced Complicated
Management of RPOC After Induced Abortion
Randomized trial comparing expectant management and medical management in women diagnosed with retained products of conception after first trimester induced abortion
- Trial name
- RPOC (NCT04685694)
- Testing
- Misoprostol
- Where
- Israel
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Shoulder Arthroscopy, İnterscalene Brachial Plexus Block
Comparison of Postoperative Analgesic Efficacy of SPSIPB and Combination of IBPB and SCPB
Shoulder arthroscopy is one of the frequently performed surgical procedures today. After shoulder surgery, ensuring sufficent analgesia is necessary for both the patient's comfort and for the early and regular performance of the…
- Conditions
- Shoulder Arthroscopy, İnterscalene Brachial Plexus Block, Superficial Cervical Plexus Block, Serratus Posterior Superior Intercostal Plane Block
- Trial name
- NCT06660875
- Testing
- Serratus posterior superior intercostal plane block, Interscalene brachial plexus block and superficial cervical plexus block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara Etlik City Hospital
Chronic Myeloid Leukemia, Pregnancy
Observational Study of Conception/Pregnancy in Adult Patients With CML Treated With Tyrosine Kinase Inhibitors
The objective of this study is to acquire more information about what we are doing during pregnancy in CML patients, in order to possibly establish in the future a consensus on the management of patients receiving TKIs who wants…
- Trial name
- CML1012 (NCT01752062)
- Where
- 52 sites in Italy
- Volunteers
- 148 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Pregnancy Related
Conception of a Decisional Tool Using a Pre-Anesthesic Numerical Evaluation (PANE) During the 8th Month of Pregnancy
In France, all pregnant women benefit from an pre-anesthesic consultation (PAC) to evaluate their physical and biological conditions.
- Trial name
- PANE (NCT04214223)
- Testing
- Pre-Anesthesic Consultation, Pre-Anesthesic Numerical Evaluation
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Rheumatoid Arthritis, Spondyloarthritis
Pregnancy and Medically Assisted Conception in Rare Diseases
Rare diseases frequently affect women of childbearing age. Pregnancy in these women has become less rare, but remains associated with high levels of complications.
- Conditions
- Rheumatoid Arthritis, Spondyloarthritis, Psoriatic Arthritis, Systemic Lupus Erythematosus
- Trial name
- EGR2 (NCT02450396)
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Overweight or Obesity
NDPP-NextGen: A Clinical Trial to Reduce Intergenerational Obesity and Diabetes Risks
The goal of this clinical trial is to test an enhanced version of the National Diabetes Prevention Program (NDPP-NextGen) that is tailored to young women in childbearing years.
- Trial name
- NCT05674799
- Testing
- NDPP-NextGen
- Where
- United States
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Retained Products After Miscarriage
The HYsteroscopic Miscarriage MaNagement Trial: A Pilot RCT Investigating a Novel Management Pathway for RPOC
Pregnancy tissue can be found remaining in the womb in up to 20% of women following a miscarriage. These "retained products of conception" (RPOC), which are diagnosed by transvaginal ultrasound, can cause prolonged bleeding…
- Trial name
- HYMMN (NCT04751500)
- Testing
- Outpatient hysteroscopy, Expectant management, Medical management
- Where
- United Kingdom
- Volunteers
- 149 people
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust
HIV Infections
The Impact and Cost-effectiveness of Safer Conception Strategies for HIV-discordant Couples (SAFER)
This is a prospective, non-randomized, open-label study to look at the uptake, adherence to, and impact of pre-exposure prophylaxis (PrEP), antiretroviral therapy (ART), semen washing, and vaginal insemination to prevent HIV…
- Trial name
- SAFER (NCT03049176)
- Testing
- PrEP (Truvada), Antiretrovirals, Semen washing
- Where
- Zimbabwe
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Infant, Premature
Preliminary Study to the Conception of a Non-invasive Neonatal Monitoring System With Development of a Database
Each year, 300 000 new borns are hospitalised in neonatology units in Europe. This period is very sensitive as newborns are exposed to a high risk of morbidity and mortality, with severe impact on neuro-developmental prognostic.
- Trial name
- Digi-NewB (NCT02863978)
- Testing
- Multimodal signal acquisitions
- Where
- 6 sites in France
- Volunteers
- 746 people
- Sponsor
- Rennes University Hospital
Retained Products of Conception Post Abortion
Oral Contraceptive Pills Versus Expectant Management for Retained Pregnancy Products
We speculate that the use of combined oral contraceptives may be a possible solution to promote the management of retained pregnancy products versus expectant management.
- Trial name
- NCT03230825
- Testing
- Oral contraceptive, Expectant management
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Retained Products of Conception, RPOC
A Prospective Multicenter Observational Real-world Study of Retained Products of Conception
The purpose of this study is to explore the optimal treatment strategy for retained products of pregnancy. Compared with surgical treatment, prospectively observe whether drug-assisted expectant management until the right time…
- Trial name
- NCT07421895
- Testing
- Uterine curettage, Expectant care
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
IVM, IVF
Children Born From IVM-CAPA vs IVF or Natural Conception
CAPA-IVM is a new promising IVM technique involving the use of a new compound to facilitate the oocyte and embryo competence. CAPA-IVM preserved the maintenance of trans-zonal projections and significantly improved maturation…
- Trial name
- NCT04048486
- Testing
- Developmental score according to The Ages & Stages Questionnaires®, Third Edition - ASQ®-3, Physical development and General Health, Developmental Red flags
- Where
- Vietnam
- Volunteers
- 66 people
- Sponsor
- Mỹ Đức Hospital