Clinical trials: Concussion, Brain
Brain Injury, Chronic
Hyperbaric Oxygen for Traumatic and Non-traumatic Brain Injury
The purpose of this study is to examine whether 40 hyperbaric oxygen sessions has effect on long-term symptoms after brain injury.
- Trial name
- HYBOBI2 (NCT01986205)
- Testing
- Hyperbaric Oxygen, Minimal pressure air
- Where
- 2 sites in United States
- Volunteers
- 49 people
- Sponsor
- Lindell Weaver
Mild Traumatic Brain Injury, Intracranial Lesions
TES HT100 Clinical Validation for Brain Injury Screening in Patients With Mild Head Trauma or Neurological Symptoms
The goal of this clinical study is to evaluate how accurately and safely the TES HT100 device can identify intracranial abnormalities in adult emergency department patients with mild head trauma or neurological symptoms that are…
- Conditions
- Mild Traumatic Brain Injury, Intracranial Lesions, Neurological Symptoms Not Related to Head Trauma
- Trial name
- TESCO (NCT07490418)
- Testing
- Temnographic Brain Screening Examination
- Where
- 3 sites in Italy, Poland
- Volunteers
- 850 people
- Sponsor
- B&B srl
Vestibular Rehabilitation
Vestibular Rehabilitation Exercise in Mild Traumatic Brain Injury
Traumatic brain injury (TBI) is a leading cause of long-term disability and mortality. The costs associated with hospitalization, rehabilitation, and productivity losses after injury impose a significant socioeconomic and…
- Trial name
- NCT06118541
- Testing
- Vestibular Rehabilitation therapy
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taiwan University Hospital
Brain Concussion, Brain Injuries
An Evaluation of HS-1000 Device Capabilities in the Diagnosis and Assessment of Patients After Concussion
The HeadSense (HS) HS-1000 device, a new non-invasive brain monitor is expected to safely and accurately monitor concussed patients with minimal discomfort, potentially providing a new modality for concussion measurement.
- Trial name
- NCT02699346
- Testing
- HS-1000 recording
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- HeadSense Medical
REM Sleep Behavior Disorder, Concussion, Brain
The COSP-RBD Study: Concussions and Contact Sports in RBD vs Controls
The goal of this observational study is to investigate concussions and contact sports practices in REM sleep behaviour disorder (RBD).
- Trial name
- COSP-RBD (NCT06270290)
- Testing
- Exposure to contact sports or history of concussions
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Post Concussion Syndrome
GyroStim for Post Concussion Syndrome
The goal of this study is to evaluate the efficacy of using sensorimotor multi-axis automated rotational therapy (SMART) to help treat post concussion syndrome (PCS) in adults.
- Trial name
- NCT07527663
- Testing
- Sensorimotor Multi-axis Automated Rotational Therapy (SMART) utilizing GyroStim device, Physical therapy and speech therapy/cognitive rehabilitation therapy
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Neuroscience Group
Acute Concussion Syndrome
Pilot Clinical Investigation Evaluating the Safety and Performance of RGn550 in Treating Sportspeople Suffering From Acute Concussion Syndrome
This is a controlled investigation, with randomization of the patients, which aims at evaluating the safety and performance of device RGn550 in treating sportspeople suffering from acute concussion syndrome.
- Trial name
- RECOVERY (NCT05647304)
- Testing
- RGn550 5 Hz-PWM, RGn550 10 Hz-PWM
- Where
- France
- Volunteers
- 50 people
- Sponsor
- REGEnLIFE SAS
Mild Traumatic Brain Injury, Alexithymia
Clinical Trial Comparing the Efficacy of Two Teletherapy Programs at Improving Psychological Health in People With Brain Injury
The purpose of the study is to test two different training programs to find out which is better at helping people with a concussion or mild TBI (mTBI) improve their emotional health and well-being.
- Trial name
- NCT07436754
- Testing
- Program 1, Program 2
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Hackensack Meridian Health
Tbi, Intracranial Edema
Comparative Effectiveness of Family Problem-Solving Therapy (F-PST) for Adolescent TBI
Traumatic brain injury (TBI) is the most common cause of acquired disability in youth and a source of significant morbidity and family burden.
- Conditions
- Tbi, Intracranial Edema, Brain Edema, Craniocerebral Trauma
- Trial name
- NCT02368366
- Testing
- Therapist Guided Face to Face Family Problem Solving, Therapist Guided Online Family Problem Solving, Self-Guided Online Family Problem Solving
- Where
- 5 sites in United States
- Volunteers
- 151 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Brain Injuries, Concussion, Mild
Evaluation and Validation of a Multimodal Brain Function Biomarker With NPC
This study is designed to collect data which will be used to associate changes in EEG, neurocognitive performance, eNPC and clinical symptoms in concussion subtypes.
- Conditions
- Brain Injuries, Concussion, Mild, Concussion, Brain, Near Point Convergence
- Trial name
- BSC-CI-NPC (NCT04074486)
- Testing
- BrainScope Ahead 300iP-O, SCAT5, Near Point Convergence
- Where
- 6 sites in United States
- Volunteers
- 1,318 people, healthy volunteers welcome
- Sponsor
- BrainScope Company, Inc.
Concussion, Brain
One Team: Changing the Culture of Youth Sport With Pregame Safety Huddles
Randomized controlled trial of a behavioral intervention (Pre-Game Safety Huddles) designed to study the impact of huddles on concussion safety in youth sport, primarily regarding intention to report concussive symptoms.
- Trial name
- NCT04099329
- Testing
- Pre-game Safety Huddles
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Seattle Children's Hospital
Persistent Post Traumatic Headache, Mild Traumatic Brain Injury
Remotely Supervised tDCS for Persistent Post-traumatic Headache
This pilot study is designed to provide preliminary data for a large scale, randomized clinical trial to evaluate the efficacy of remotely administrated at home transcranial Direct Current Stimulation (tDCS) with real-time…
- Trial name
- tDCS for PTH (NCT04012853)
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
Biomarkers in Prehospital Rule-out of Intracranial Lesions in TBI Patients
The PreTBI I study will investigate whether prehospital blood samples drawn already in the ambulance can rule-out intracranial lesions in patients suffering head trauma.
- Trial name
- PreTBI I (NCT02867137)
- Testing
- Blood sampling
- Where
- Denmark
- Volunteers
- 595 people
- Sponsor
- University of Aarhus
Traumatic Brain Injury
Growth Hormone or Sildenafil as Therapies for Fatigue in Mild- Traumatic-brain-injury (MTBI)
The overall goal is to determine whether perceptual or performance fatigue can be reduced in MTBI patients with and without growth hormone (GH) deficiency by treating them in a crossover fashion based upon GH status.
- Trial name
- NCT02114775
- Testing
- Growth Hormone, Sildenafil
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Brain Health Retired Elite Athletes
Long-term Brain Health of Retired Professional Rugby Players, With a History of Concussion/Head Impact Exposure
There has been significant recent interest on the issue of brain health in athletes. Participation in sports is generally viewed as extremely positive.
- Trial name
- NCT03544346
- Testing
- Exploratory brain and general health assessment
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Concussion Mild
Yoga and Female Concussion
Most research on the impact of mild Traumatic Brain Injury/Concussions have been deficit-based and focused on the impairments induced by the injury. Research shows that trauma doesn't always have negative effects.
- Trial name
- NCT07170488
- Testing
- Yoga, Yoga for wait list control
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Pittsburgh
Head Injury
The "Concussion or Brain Bleed" Trial
Researchers are trying to understand the effect of educating patients and encouraging shared decision making on rates of CT scanning in head injured patients by using an already developed app and observing the effect on the…
- Trial name
- NCT04002505
- Testing
- Concussion and Brain Bleed App (CBB)
- Where
- United States
- Volunteers
- 370 people
- Sponsor
- Mayo Clinic
Post-Concussion Syndrome, COVID Long-Haul
Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS)
The purpose of this study is to test the effect of Auricular Percutaneous Electrical Nerve Field Stimulation (a Neurostim device) on children with pain and Post Concussion symptoms.
- Conditions
- Post-Concussion Syndrome, COVID Long-Haul, COVID-19
- Trial name
- NCT04978571
- Testing
- percutaneous electrical nerve-field stimulation, PENFS, percutaneous electrical nerve-field stimulation, PENFS (COVID active device)
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Children's Hospital of Orange County
Concussion
Pathology in the Brain After mTBI - A Multimodal MRI Study
The purpose is to use Diffusion Kurtosis Imaging (DKI), Diffusion Tensor Imaging (DTI) and resting state functional MRI to examine tissue damage in the brains of people who have had a concussion, both acute and 3 months after the…
- Trial name
- NCT01936792
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Concussion
EEG Diagnostic for Repetitive Sub-concussive Head Impacts
The purpose of this study is to develop a diagnostic algorithm to help with the detection, diagnosis, and monitoring of sub-concussive head impacts.
- Trial name
- NCT05562544
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic