Clinical trials: Concussion; Syndrome
Concussion, Mild, Post-Concussion Symptoms
Bright Light Therapy for Treatment of Sleep Problems Following Mild Traumatic Brain Injury
The purpose of the research study is to understand the effectiveness of a six-week course of light exposure on cognitive functioning, mood, activity, and sleep in people that have suffered a head injury leading to a concussion.
- Conditions
- Concussion, Mild, Post-Concussion Symptoms, Sleep Problems
- Trial name
- NCT02374918
- Testing
- mTBI wavelength-1 bright light, mTBI wavelength-2 bright light, HC wavelength-1 bright light
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Vascular System Injuries, Concussion, Brain
Sildenafil Treatment for Mild TBI
About 300,000 people are hospitalized for traumatic brain injury (TBI) each year. After TBI, secondary brain injury escalates due in part to heightened levels of oxidant injury, inflammation, and vascular injury.
- Conditions
- Vascular System Injuries, Concussion, Brain, Post-Concussion Syndrome
- Trial name
- NCT03598140
- Testing
- Sildenafil Citrate
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Persistent Post-concussive Syndrome, Concussion Post Syndrome
Hyperbaric Oxygen Effects on Persistent Post-concussive Symptoms
Persistent post-concussive symptoms (PPCS) are a source of significant burden among a subset of patients with concussion with prevalence rates previously reported between 11 - 82% based on timing of assessment, diagnostic…
- Trial name
- HOINPCS (NCT05173818)
- Testing
- Hyperbaric oxygen at 1.5 ATA
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Essentia Health
Traumatic Brain Injury, Fatigue
Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy
Patients with a history of mild traumatic brain injury (mTBI) or post acute sequelae of SARS-CoV-2 (PASC) and abnormal growth hormone secretion, as measured by glucagon stimulation test, will be treated with replacement growth…
- Conditions
- Traumatic Brain Injury, Fatigue, Cognitive Impairment, COVID-19
- Trial name
- NCT03554265
- Testing
- Somatropin
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Post-Concussion Syndrome
The Effectiveness of Biofeedback for Individuals With Long-term Post-concussive Symptoms
Most concussions resolve within 7-10 days, but approximately 40% of individuals do not fully recover and suffer from persistent post-concussive symptoms.
- Trial name
- NCT03338036
- Testing
- Heart Rate Variability Biofeedback, Neurofeedback
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- Western University, Canada
Posttraumatic Headache, Combat Disorders
Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin
The purpose of this study is to determine if prazosin is more effective than placebo in decreasing frequency, severity, disability, and other negative effects of headaches related to mild traumatic brain injury in Service Members…
- Conditions
- Posttraumatic Headache, Combat Disorders, Post Concussion Syndrome, Headache
- Trial name
- NCT02266329
- Testing
- prazosin hydrochloride
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- VA Office of Research and Development
Sleep Initiation and Maintenance Disorders, Anxiety
HIRREM Developmental Study
The purpose of this study is to explore the functional and physiological effects associated with the use of High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM), as supplemental care, for symptoms of…
- Conditions
- Sleep Initiation and Maintenance Disorders, Anxiety, Post-Traumatic Stress Disorder, Hot Flashes
- Trial name
- NCT02709369
- Testing
- HIRREM
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Wake Forest University Health Sciences
Acute Concussion Syndrome
Pilot Clinical Investigation Evaluating the Safety and Performance of RGn550 in Treating Sportspeople Suffering From Acute Concussion Syndrome
This is a controlled investigation, with randomization of the patients, which aims at evaluating the safety and performance of device RGn550 in treating sportspeople suffering from acute concussion syndrome.
- Trial name
- RECOVERY (NCT05647304)
- Testing
- RGn550 5 Hz-PWM, RGn550 10 Hz-PWM
- Where
- France
- Volunteers
- 50 people
- Sponsor
- REGEnLIFE SAS
Traumatic Brain Injury, Post-traumatic Stress Disorder
Mission Connect Mild Traumatic Brain Injury (TBI) Integrated Clinical Protocol
The purpose of this study is to improve the ability to diagnose problems after mild traumatic brain injury (MTBI) and to test a drug that may improve the outcome from these injuries.
- Trial name
- NCT01013870
- Testing
- Atorvastatin
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- Baylor College of Medicine
Traumatic Brain Injury With Brief Loss of Consciousness, Post-Concussion Syndrome
mTBI Mechanisms of Action of HBO2 for Persistent Post-Concussive Symptoms
Purpose of this study is to investigate the mechanisms of action of hyperbaric oxygen therapy for persistent post-concussive symptoms after mild tramatic brain injury
- Trial name
- BIMA (NCT01611194)
- Testing
- Hyperbaric oxygen (HBO2) at 1.5 atms
- Where
- 5 sites in United States
- Volunteers
- 71 people
- Sponsor
- U.S. Army Medical Research and Development Command
Headache, Post-Concussion Syndrome
The Effectiveness of Osteopathic Manipulative Medicine in the Management of Headaches Associated With Post Concussion Syndrome
Pilot study looking at the Osteopathic Manipulative Treatment (OMT) for various headache types in patients with post-concussion syndrome (PCS).
- Trial name
- NCT04732338
- Testing
- Osteopathic Manipulative Therapy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Hackensack Meridian Health
Concussion Post Syndrome, Headaches Posttraumatic
Pediatric Concussion Outcomes
This is a randomized, placebo-controlled, double-blinded trial in which subjects with a post concussive headache meeting inclusion criterion will be assigned to one of two treatment groups: placebo or nortriptyline.
- Conditions
- Concussion Post Syndrome, Headaches Posttraumatic, Mild Traumatic Brain Injury
- Trial name
- PeCon (NCT04226365)
- Testing
- Nortriptyline
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Lancaster General Hospital
Concussion, mTBI
Neurofeedback Impact on Veterans With mTBI
This study will evaluate neurofeedback (NFB) training as a low risk, non-invasive, effective treatment for Veterans diagnosed with mild traumatic brain injury (mTBI) and experiencing chronic post-concussive symptoms (PCSs).
- Conditions
- Concussion, mTBI, Post-Concussive Symptoms, Chronic Headache
- Trial name
- NFBVETmTBI (NCT04195685)
- Testing
- Neurofeedback (NFB)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Post Concussive Symptoms
Transcranial Direct Current Stimulation for the Treatment of Deficits After Traumatic Brain Injury
Patients with mild-moderate traumatic brain injury (TBI) sustained between 3 months and 5 years ago with prolonged postconcussive symptoms will be recruited.
- Conditions
- Traumatic Brain Injury, Post Concussive Symptoms, Depression, Executive Dysfunction
- Trial name
- NCT02613936
- Testing
- Anodal tDCS, Cognitive training
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of New Mexico
Post-concussive Symptoms, Traumatic Brain Injury
Hyperbaric Oxygen Therapy (HBO2) for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (mTBI)
This is a Phase II randomized trial designed to describe the magnitude of change between baseline and follow-up outcomes for symptom surveys and a battery of neuropsychological tests administered at time points corresponding…
- Trial name
- HOPPS (NCT01306968)
- Testing
- hyperbaric oxygen
- Where
- 5 sites in United States
- Volunteers
- 79 people
- Sponsor
- U.S. Army Medical Research and Development Command
Concussion, Mild, Post-Concussion Symptoms
Effects of Bright Light Therapy in Mild Traumatic Brain Injury
Mild traumatic brain injuries (mTBI) or "concussions" are an increasingly prevalent injury in our society. Patients with post-concussion syndrome have been shown to have deficits on tests of short term memory, divided attention…
- Conditions
- Concussion, Mild, Post-Concussion Symptoms, Sleep Problems
- Trial name
- NCT01747811
- Testing
- wavelength-1 bright light, wavelength-2 bright light
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Vestibular Diseases, Labyrinth Diseases
Evaluation of a Sensory Enrichment Multimodal Device (SEMD) on Physical Therapy Patients With Disequilibrium
Purpose of this study is to determine the efficiency and safety of a Sensory Enrichment Multimodal Device (SEMD) when applied in conjunction with usual care vestibular-balance physical therapy for rehabilitation of patients who…
- Conditions
- Vestibular Diseases, Labyrinth Diseases, Ear Diseases, Otorhinolaryngologic Diseases
- Trial name
- SEMD (NCT01483937)
- Testing
- Usual care physical therapy plus SEMD, Usual care physical therapy only
- Where
- 4 sites in United States
- Volunteers
- 32 people
- Sponsor
- Karen L Atkins