Clinical trials: Condition
Kidney Diseases, Heart Transplantation
Safe Renal Function In Long Term Heart Transplanted Patients
The purpose of this study is to verify whether the reduction of cyclosporine dosages associated with Everolimus administration may improve renal function as compared to patients maintained on standard immunosuppressive therapy
- Trial name
- SAREFU (NCT00505102)
- Testing
- Everolimus
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Long COVID Symptoms
Using Enhanced External Counterpulsation to Recover Cardiovascular Function for Patient of Chronic Diseases
The goal of this clinical trial is to learn whether enhanced external counterpulsation (EECP) therapy can improve cardiopulmonary function and symptoms in adults with long COVID.
- Trial name
- NCT07492953
- Testing
- enhanced external counterpulsation
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Defense Medical Center, Taiwan
Active Breast Cancer Treatment
Involving Family to Improve Communication in Breast Cancer Care
This study evaluates a multi-component communication intervention in the outpatient setting to strengthen communication among patients being actively treated for breast cancer and their support network of family members and…
- Trial name
- NCT03283553
- Testing
- Checklist, MyChart, OpenNotes, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 132 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Spinal Muscular Atrophy, Neuromuscular Diseases
A Study to Evaluate the Efficacy and Safety of Taldefgrobep Alfa in Participants With Spinal Muscular Atrophy
This trial will study the efficacy and safety of taldefgrobep alfa as an adjunctive therapy for participants who are already taking a stable dose of nusinersen and/or risdiplam and/or have a history of onasemnogene abeparvovec…
- Conditions
- Spinal Muscular Atrophy, Neuromuscular Diseases, SMA
- Trial name
- RESILIENT (NCT05337553)
- Testing
- taldefgrobep alfa
- Where
- 53 sites in United States, Belgium and 7 more
- Volunteers
- 269 people
- Sponsor
- Biohaven Pharmaceuticals, Inc.
Colorectal Cancer
Evaluation of Serum Tumor Endothelial Marker1 as a Potential Biomarker for Colorectal Cancer Diagnosis and Cancer Progression
Aim of work 1. measurement level of serumTEM1 in CRC patients by ng/ml using ELISA kits . 2. find relation between serum TEM1 level and staging of CRC patients . 3.
- Trial name
- NCT05779553
- Testing
- Tumor Endothelial Marker 1 ( TEM1 ) by ELISA kits
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Colonic Neoplasms, Ileostomy - Stoma
Early Closure Versus Conventional Closure in Postoperative Patients With Low Anteriresection for Rectal Cancer
Colorectal cancer worldwide is the third most common in men and the second in female, although mortality is not as high as its incidence, there is less survival in developing countries.
- Conditions
- Colonic Neoplasms, Ileostomy - Stoma, Colorectal Surgery
- Trial name
- NCT03746353
- Testing
- early ileostomy closure
- Where
- 3 sites in Colombia
- Volunteers
- 52 people
- Sponsor
- Instituto Nacional de Cancerologia, Columbia
Transient Tachypnea Newborn, Cesarean Delivery Affecting Fetus
Misoprostol Before Elective Caesarean Section for Decreasing the Neonatal Respiratory Morbidity
Neonatal respiratory distress may occur in either term or preterm newborns with a higher relative risk in preterm, and whether born vaginally or through caesarean section, but in a higher percentage after elective caesarean…
- Trial name
- NCT03031353
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Ain Shams University
Hemorrhoids
EnSeal Device Versus Ferguson Technique in Hemorrhoidectomy
This study will compare hemorrhoid surgery by comparing a sutureless heating device with the old standard hemorrhoid surgery. Patients will be followed closely for wound healing and satisfaction.
- Trial name
- NCT00853853
- Testing
- EnSeal Device, Ferguson Hemorrhoidectomy technique
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Steven Schechter, M.D.
Endometriosis, Dyspareunia
Transvaginal Low-level Laser Therapy to Improve Pelvic Pain and Sexual Function in Patients with Endometriosis.
Dyspareunia is defined as pain with penetrative sexual intercourse. Women with endometriosis have a nine-fold increased risk of dyspareunia, when compared to the general female population.
- Conditions
- Endometriosis, Dyspareunia, Pelvic Pain
- Trial name
- NCT05540353
- Testing
- Transvaginal photobiomodulation
- Where
- 6 sites in United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Mitral Valve Regurgitation
Safety and Efficacy Study of the Sorin 3D Annuloplasty Ring For Mitral Repair
The purpose of this study is to collect data on the effectiveness and clinical outcomes of the MEMO 3D Annuloplasty ring as used for mitral valve repair.
- Trial name
- MEMO3D (NCT00567853)
- Testing
- Implantation of the MEMO 3D Annuloplasty Ring
- Where
- 6 sites in United States, Canada
- Volunteers
- 278 people
- Sponsor
- Sorin Group USA, Inc.
Conjunctival Diseases, Pterygium
The Use of Natural Latex Biomembrane in Ocular Surface Reconstruction
The main problem of ocular surface reconstruction is the lack of viable conjunctival tissue. The use of a biocompatible latex biomembrane in ocular surface healing, like post pterygium surgery, could be an alternative therapeutic…
- Trial name
- NCT01250353
- Testing
- pterygium surgery
- Where
- Brazil
- Volunteers
- 127 people
- Sponsor
- University of Sao Paulo
Psychological
Testing the Feasibility of an Online Guided-writing Intervention Designed for Informal Caregivers of People With Parkinson's Disease
When informal caregivers of people with Parkinson's disease treat themselves harshly, they can experience psychological distress.
- Trial name
- NCT07804953
- Testing
- An online guided-writing intervention that uses guidance based on self-compassion principles
- Where
- United Kingdom
- Volunteers
- 47 people
- Sponsor
- University of Reading
Laryngeal Cancer, Hypopharynx Cancer
SBRT Followed by Chemoimmunotherapy of Toripalimab Plus Docetaxel and Cisplatin for Larynx Preservation in Patients with Locally Regionally Advanced Squamous Cell Carcinoma of the Larynx and Hypopharynx
This trial aims to evaluate the safety and efficiency of SBRT followed by Chemoimmunotherapy of Toripalimab Plus Docetaxel and Cisplatin for Patients with Locally Regionally Advanced Squamous Cell Carcinoma of the Larynx and…
- Trial name
- NCT06611137
- Testing
- SBRT+Toripalimab Plus Docetaxel and Cisplatin
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Sun Yat-sen University
Immune Thrombocytopenia
Eltrombopag vs Standard Front Line Management for Newly Diagnosed Immune Thrombocytopenia (ITP) in Children
This is an investigator initiated, multicenter, open label, randomized phase 3 study for subjects with newly diagnosed ITP from ages 1 to less than 18 years old.
- Trial name
- NCT03939637
- Testing
- Eltrombopag, Steroids, IVIG
- Where
- 27 sites in United States
- Volunteers
- 122 people
- Sponsor
- Baylor College of Medicine
Chronic Peridontitis Patients, Chronic Gingivitis
Effect of Non-surgical Periodontal Therapy on Gingival Crevicular Fluid Interleukin-21 Levels
Human IL-21 is present in gingival crevicular fluid in periodontal health, gingivitis and chronic periodontitis. A significant increase in the concentration of IL-21 in gingival crevicular fluid is observed with an increase in…
- Conditions
- Chronic Peridontitis Patients, Chronic Gingivitis, Healthy
- Trial name
- NCT02861937
- Testing
- non surgical periodontal therapy
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Refractory Reflux Esophagitis
Double-blind Comparative Study of E3810 Tablets (10 or 20 mg b.i.d.) to Evaluate Efficacy and Safety in Patients With Refractory Reflux Esophagitis
The purpose of this study is to evaluate the efficacy and safety of E3810 tablets in patients with Proton Pump Inhibitor-resistant reflux esophagitis.
- Trial name
- NCT00770913
- Testing
- E3810
- Where
- 54 sites in Japan
- Volunteers
- 337 people
- Sponsor
- Eisai Co., Ltd.
Premature Birth, Psychological Stress
Parental Stress and Attachment in Preterm Infants
Introduction: Advances in neonatology mean a significant reduction in mortality in premature infants as well as an increase in the risk of morbidity in the medium, short and long term.
- Conditions
- Premature Birth, Psychological Stress, Physiological Stress
- Trial name
- NCT06813560
- Testing
- hair cortisol, salivary cortisol, salivary Oxytocin
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University
Dental Plaque
Efficacy of a Triclosan Formulation to Control the Initial Subgingival Biofilm Formation
The aim of the study is to compare the effect of a suspension containing Triclosan in dynamic of the subgingival biofilm formation versus a Placebo suspension.
- Trial name
- NCT02192060
- Testing
- Test - Using of a suspension containing Triclosan, Control - Using of a suspension without Triclosan
- Where
- Brazil
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Neurology, Immunology
Clinical Relationship Between Vitamin D-mediated Th17 and Treg Cells and Parkinson's Disease
The aim of this study is to detect the expression levels of vitamin D, Treg, and Th17 in the peripheral blood of patients with Parkinson\'s disease (PD), investigate the impact of Treg/Th17 imbalance on PD patients, and…
- Trial name
- NCT06539260
- Testing
- Vitamin D
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Suzhou Municipal Hospital of Anhui Province
Teledentistry
Accuracy of Teledentistry for Diagnosis and Treatment Need in Dental Caries Detection Versus Clinical Examination on a Group of Egyptian Children: A Diagnostic Accuracy Study
The aim of this study is to assess the accuracy of teledentistry for diagnosis and treatment need in dental caries detection versus clinical examination on a group of Egyptian children.
- Trial name
- NCT06600360
- Testing
- Teledentistry
- Volunteers
- 102 people
- Sponsor
- Cairo University
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