Clinical trials: Condition
Intrapartum Fetal Distress, Neonatal Asphyxia
Oral Sildenafil Citrate to Improve Maternal and Neonatal Outcomes in Low-resource Settings
The goal of this feasibility pilot clinical trial is to determine if sildenafil citrate 50mg orally, up to three times during labor, can: 1) reduce perinatal mortality and/or bag and mask ventilation at birth in planned vaginal…
- Conditions
- Intrapartum Fetal Distress, Neonatal Asphyxia, Intrapartum Asphyxia, Instrumental Delivery; Affecting Fetus
- Trial name
- NCT06522854
- Testing
- Sildenafil 50 mg Oral Tablet
- Where
- 4 sites in Nigeria
- Sponsor
- University of Alabama at Birmingham
Critical Limb Ischemia, Arteriosclerosis Obliterans
Effectiveness and Safety of Adipose-Derived Regenerative Cells for the Treatment of Critical Lower Limb Ischemia
Adipose-derived regenerative cells (ADRC) will be extracted from lipoaspirate by enzymatic digestion. 10 mL of autologous ADRC suspension injected intramuscularly, close to the site of muscle injury.
- Conditions
- Critical Limb Ischemia, Arteriosclerosis Obliterans, Peripheral Arterial Disease, Thromboangiitis Obliterans
- Trial name
- NCT02864654
- Testing
- ADRC injection, ADRC isolation, Liposuction
- Where
- Russia
- Volunteers
- 9 people
- Sponsor
- Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation
Healthy People, Benign Prostatic Hyperplasia
The Application of Multimodal Artificial Intelligence Systems in Prostate Cancer Diagnosis and Prognosis Analysis
Prostate-specific antigen (PSA) testing has limited specificity for prostate cancer diagnosis, leading to a high rate of unnecessary biopsies.
- Conditions
- Healthy People, Benign Prostatic Hyperplasia, Prostate Cancer
- Trial name
- NCT06589154
- Testing
- Multi-modal artificial intelligence model (BEAM)
- Where
- 10 sites in China
- Volunteers
- 1,651 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Breast Cancer, HER-2 Positive Breast Cancer
Gut Microbiome Changes During Abemaciclib Therapy in Breast Cancer
Abemaciclib (Verzenio) is a commonly used treatment for hormone receptor-positive breast cancer, but it can cause gastrointestinal side effects such as diarrhea, which may affect quality of life and treatment tolerance.
- Trial name
- MICRO-VERZ (NCT07406594)
- Testing
- Resistant Potato Starch
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Vermont Medical Center
Depression, Cognitive Decline
Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)
Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer's disease and related dementias (ADRD).
- Trial name
- ADEPT-ICU (NCT06627894)
- Testing
- Therapist-Assisted Internet Cognitive-Behavioral Therapy for Depression, Active Control
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Indiana University
Childhood Obesity
Proactve Assessment of Overweight Risk During Infancy
Children who are above healthy weight are more likely to be ill and to miss time off school. Being overweight in childhood can also sow the seeds for health problems in later life such as heart disease and diabetes.
- Trial name
- ProAsk (NCT02314494)
- Testing
- ProAsk
- Where
- 2 sites in United Kingdom
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Anglia Ruskin University
Schizophrenia, Quality of Life
Milestones of Adjustment Post-Psychosis
This nested design clinical outcome study of psychiatric case manager education on disease state, psychopharmacology of schizophrenia, relapse, motivational interviewing, and the process of psychological adjustment post-psychosis…
- Conditions
- Schizophrenia, Quality of Life, Adjustment, Psychological, Medication Adherence
- Trial name
- MAPP (NCT01192594)
- Testing
- Training in all modules including MAPP Recovery Model, Training in all modules except MAPP Recovery Model
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Yale University
Chronic Obstructive Pulmonary Disease
Improving Patient-Centered Care Delivery Among Patients With Chronic Obstructive Pulmonary Disease
This study involves development and testing of a patient and family-centered transitional care program for patients who are hospitalized with Chronic Obstructive Pulmonary Disease (COPD) exacerbations.
- Trial name
- BREATHE (NCT02036294)
- Testing
- BREATHE program, Usual Care
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Johns Hopkins University
Esophageal Squamous Cell Carcinoma
Study To Investigate the Efficacy and Safety of Sitravatinib in Combination With Tislelizumab in Participants With Esophageal Squamous Cell Carcinoma
The study aimed to evaluate the efficacy and safety of sitravatinib in combination with tislelizumab as a second- or third-line treatment for participants with locally advanced, unresectable, or metastatic esophageal squamous…
- Trial name
- NCT05461794
- Testing
- Sitravatinib, Tislelizumab, Docetaxel
- Where
- 31 sites in China
- Volunteers
- 96 people
- Sponsor
- BeiGene
Osteoarthritis, Knee, Osteoarthritis, Hip
Study Evaluating the Efficacy of Joint Replacement
Patient-related outcomes were originally designed to measure outcomes in clinical studies. They were not developed to predict outcomes, however, different studies showed close association between values achieved preoperatively…
- Trial name
- SEVERE (NCT04691466)
- Testing
- Joint replacement
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- Nicolaus Copernicus University
Anxiety, Child, Only
The Effect of "Quantum Touch" Application on Transfer Anxiety in Pediatric Patients and Their Parents Planned to Be Hospitalized in the Emergency Department
Anxiety, which is a subjective experience in which many emotions such as worry, uncertainty, restlessness, and sadness are experienced together, is defined as "a state of tension that arises as a result of the internal conflict…
- Conditions
- Anxiety, Child, Only, Emergencies
- Trial name
- NCT05380466
- Testing
- Quantum Touch
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Medeniyet University
Leber Congenital Amaurosis
Genetic Decryption of Leber Congenital Amaurosis (LCA) in a Large Cohort of Independent Families.
The main objectives of this study are: 1. Improve genetic counseling by establishment of prevalences of each of genetic subtypes within a expanded population of patients with LCA taking into account ethnicity of families. 2.
- Trial name
- GENPHENACL (NCT02970266)
- Where
- France
- Volunteers
- 659 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Insulin Sensitivity, Glucose Metabolism Disorders
Bisphenol A and Muscle Insulin Sensitivity
This study examine oral bisphenol A consumption on muscle insulin sensitivity and hepatic glucose suppression. Half of the participants will receive a diet plus BPA and the other half will receive a diet plus no bisphenol A.
- Conditions
- Insulin Sensitivity, Glucose Metabolism Disorders, Microtia
- Trial name
- NCT03771066
- Testing
- bisphenol A
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- California Polytechnic State University-San Luis Obispo
COPD
Effects of Eccentric Exercise Training in Patients With COPD
The goal of this study is to design eccentric exercise strategies for COPD patients to comprehensively improve their cardiopulmonary/muscular fitness, immune and hemorheological functions, and quality of life, thereby improving…
- Trial name
- NCT06168266
- Testing
- Eccentric bike, conventional group
- Where
- Taiwan
- Volunteers
- 170 people
- Sponsor
- Fu Jen Catholic University
Rheumatoid Arthritis
Study of the Efficacy and Safety of BCD-089 in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis
BCD-089 is the original therapeutic monoclonal antibody binding the alpha subunit of the IL-6 receptor. The aim of the study is to demonstrate the efficacy and safety of BCD-089 in combination with methotrexate in patients with…
- Trial name
- SOLAR (NCT04227366)
- Testing
- BCD-089, Methotrexat
- Where
- Russia
- Volunteers
- 154 people
- Sponsor
- Biocad
Colonic Adenoma, Adenoma
Assessing the Additional Neoplasia Yield of Computer-aided Colonoscopy in Follow-up Patients in a Screening Setting
The goal of this clinical trial is to evaluate the diagnostic yield of CADe in a consecutive population undergoing colonoscopy. The main question it aims to answer is the Adenoma Detection Rate (ADR).
- Conditions
- Colonic Adenoma, Adenoma, Polyp of Colon
- Trial name
- GENIAL-CO FU (NCT06160466)
- Testing
- CADe colonoscopy using GI Genius device, White light
- Where
- Italy
- Volunteers
- 1,156 people
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero
Hypercholesterolemia and Hyperlipidemia, Supplementation
Evaluation of the Effects of Two Dietary Supplement Formulations on the Lipid Profile in Mild Hypercholesterolemia
A single-center, randomized, parallel-group, double-blind, placebo-controlled clinical study followed by an open-label phase to evaluate the effects of a new formulation of a supplement on lipid profile in subjects with mild…
- Trial name
- NCT06810466
- Testing
- Test Product A, Test Product B
- Where
- Italy
- Volunteers
- 99 people
- Sponsor
- IBSA Farmaceutici Italia Srl
Recession, Gingival
Palatal Volumetric Change Analysis Following Connective Tissue Graft With and Without Donor Site Augmentation
The goal of this randomized clinical trial is to compare whether soft tissue augmentation placed in the donor site following a gum graft harvesting leads to volumetric changes compared to non-augmented sites in the palate.
- Trial name
- NCT05961566
- Testing
- Use of collagen matrix after subepithelial connective tissue graft harvest
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hailey Bivens
Degenerative Joint Disease of the Hip
A Prospective, Multicenter, Single Arm Feasibility Study of the Safety and Performance of GRADION™ Hip Total Cartilage Replacement (TCR)™ in the Treatment of Degenerative Joint Disease of the Hip
This is a prospective, multicenter, single arm feasibility study of the safety and performance of the GRADION™ Hip Total Cartilage Replacement (TCR)™ in patients who require cartilage replacement.
- Trial name
- NCT01982266
- Testing
- GRADION™ Hip Total Cartilage Replacement (TCR)™
- Where
- Netherlands
- Volunteers
- 4 people
- Sponsor
- Biomimedica, Inc
Chronic Cough (CC), Gastroesophageal Reflux (GER)
Impact of Gastroesophageal Reflux and Aspiration on Airway Inflammation and Microbiome in Children With Chronic Cough
Using an active cohort of children in whom Airway and gastrointestinal endoscopy will be performed, investigators will conduct a chart review to obtain relevant clinical data and the investigators will use an aliquot of airway…
- Trial name
- NCT02797756
- Testing
- Esophago-gastro-duodenoscopy (EGD) with biopsy, Esophageal Impedance Monitoring (EIM)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- NYU Langone Health
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