Clinical trials: Condition
Lung Cancer
Combination Chemotherapy Followed by Radiation Therapy in Patients With Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug is a way to kill more tumor cells.
- Trial name
- NCT00002822
- Testing
- carboplatin, cisplatin, cyclophosphamide
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- Medical Research Council
Jaw, Edentulous
Study on ASTRA TECH Implant System, OsseoSpeed™ Implants in Patients Missing All Teeth in the Upper Jaw, Restored With Provisional Teeth Within 24 Hours
The purpose of the study is to evaluate ASTRA TECH Implant System, OsseoSpeed™ implants, in patients with totally edentulous upper jaws and poor bone quality and quantity, when provisional artificial teeth are attached within 24…
- Trial name
- NCT00711022
- Testing
- ASTRA TECH Implant System, OsseoSpeed™, all dimensions.
- Where
- 2 sites in United States, Sweden
- Volunteers
- 51 people
- Sponsor
- Dentsply Sirona Implants and Consumables
Long Covid
Validation of Biomarkers for Long COVID in the LIINC Viral Immunopathogenesis and Persistence Repeat Donor Cohort (VIPER)
The purpose of this study is to better understand the biological changes associated with Long COVID and to identify laboratory tests (biomarkers) that may help diagnose the condition and measure how it changes over time.
- Trial name
- VIPER (NCT07770022)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy, Obese
A Drug-Drug Interaction Study of Orforglipron (LY3502970) in Healthy Overweight and Obese Participants
The main purpose of this study is to determine effect of orforglipron capsule formulation on the amount of digoxin, rosuvastatin, acetaminophen, midazolam, and simvastatin (each given alone and together with orforglipron) that…
- Conditions
- Healthy, Obese, Overweight
- Trial name
- NCT06186622
- Testing
- Orforglipron, Simvastatin, Digoxin
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Hepatocellular Carcinoma, Programmed Cell Death 1
Real-world Study of Efficacy and Safety of ICIs and TKIs Therapy for HCC
China is a high-risk area of Hepatocellular Carcinoma (HCC). Although Chinese population accounts for 18.4% of the global population, the number of new HCC patients accounting for about half of the global, which seriously…
- Conditions
- Hepatocellular Carcinoma, Programmed Cell Death 1, Effects of Immunotherapy
- Trial name
- NCT05420922
- Testing
- Lenvatinib Oral Product, PD-1 inhibitor, Local treatment
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Tongji Hospital
Agitation in Patients With Dementia of the Alzheimer's Type, Alzheimer Disease
Addressing Dementia Via Agitation-Centered Evaluation
This is a multi-center, randomized, double-blind, placebo-controlled study, to assess the efficacy and safety of AXS-05 in the treatment of agitation in patients with Alzheimer's disease.
- Conditions
- Agitation in Patients With Dementia of the Alzheimer's Type, Alzheimer Disease, Agitation,Psychomotor
- Trial name
- ADVANCE (NCT03226522)
- Testing
- AXS-05, Bupropion
- Where
- 78 sites in United States, Australia
- Volunteers
- 366 people
- Sponsor
- Axsome Therapeutics, Inc.
Schizophrenia
Effectiveness of Aripiprazole Long-acting Injection in Recent Onset and Chronic Schizophrenia Patients
The aim of the study is to investigate the effectiveness of Aripiprazole long-acting injection in recent onset and chronic schizophrenia patients
- Trial name
- NCT03839251
- Testing
- abilify maintena
- Where
- 5 sites in South Korea
- Volunteers
- 82 people
- Sponsor
- Chonbuk National University Hospital
Cerebral Infarction, Stroke, Acute
Medication Intake of Solid Dosage Forms: A Risk Factor for Patients With Stroke-induced Dysphagia?
In a prospective, quantitative explorative study, the risk of aspiration and penetration when swallowing solid pills (placebo) compared to a crushed placebo pill will be evaluated during a routine Fiberoptic Endoscopic Evaluation…
- Conditions
- Cerebral Infarction, Stroke, Acute, Stroke, Dysphagia
- Trial name
- MedISID (NCT05173051)
- Testing
- Solid Medication intake vs. crushed medication intake
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Karl Landsteiner University of Health Sciences
Fluid Overload
Ultrasound Lung Fluid Responsiveness During Hysterectomy
Bedside lung ultrasound can detect pulmonary congestion by detecting the appearance of B-lines. Pulmonary edema may occur even without cardiomyopathy or heart failure, especially after excessive fluid administration.
- Trial name
- NCT03429751
- Testing
- 30 ml/Kg/h crystalloid, 10 ml/Kg/h crystalloid
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Alaa Mazy
High Utilization / Heavy Use, Psychiatric Hospitalization
Integrated Care After Repeated Psychiatric Hospital Stays - Evaluation of an Interdisciplinary Treatment Program
The study aims to evaluate the treatment effects as well as inhibiting and promoting factors in the implementation of the new INTUK care offer in a sample of "heavy users", i.e.
- Conditions
- High Utilization / Heavy Use, Psychiatric Hospitalization, Rehospitalization, Intensive Care Psychiatric Disorder
- Trial name
- INTUK (NCT06411951)
- Testing
- Participation in the INTUK care offer at Klinik Zugersee
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- Michael Rufer
Thin Endometrium
Hysteroscopic Injections of Autologous Endometrial Cells and Platelet-rich Plasma in Patients With Thin Endometrium
The investigation is devoted to the study of the effect of the introduction of autologous platelet-rich plasma (PRP) on the thickness of the endometrium.
- Trial name
- NCT05455151
- Testing
- Conservative therapy, PRP injection, Injection of PRP after conservative therapy
- Where
- Russia
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare
Vagus Nerve Stimulation
Transauricular Vagus Nerve Stimulation Improves Postoperative Sleep Disorders in Elderly Patients.
Postoperative sleep disorder is one of the common complications after general anesthesia. Compared to patients of various ages, elderly patients have a much higher incidence of postoperative sleep disturbance.
- Trial name
- Vnstep (NCT06421051)
- Testing
- Transauricular Vagal Nerve Stimulation
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Beijing Tiantan Hospital
Bile Duct Diseases
Impact of Pinaverium Bromide on Bile Duct and Pancreatic Duct Cannulation During Endoscopic Retrograde Cholangiopancreatography
Pinaverium bromide can be used to treat symptoms related to irritable bowel syndrome (IBS) and functional disorders of the biliary tract.
- Trial name
- NCT02882451
- Testing
- pinaverium bromide, Vitamin C
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Carcinoma, Non-Small-Cell Lung, Mesothelioma
Pharmacokinetic, Safety, and Efficacy Effects of Oral LBH589 on Dextromethorphan in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer or Malignant Pleural Mesothelioma
This study will investigate the effect of oral LBH589 on dextromethorphan, a CYP2D6 substrate, and to assess safety and efficacy of oral LBH589 when used with this co-medication in advanced stage NSCLC or malignant pleural…
- Trial name
- NCT00535951
- Testing
- LBH589
- Where
- 5 sites in United States, Canada
- Volunteers
- 18 people
- Sponsor
- Novartis Pharmaceuticals
Medically Unexplained Chronic Fatigue, Chronic Fatigue Syndrome
Fatigue Self-Management in Primary Care
This study will evaluate, in a primary care setting, the effectiveness of a brief self-management behavioral treatment in patients with medically unexplained chronic fatigue.
- Trial name
- NCT00997451
- Testing
- Cognitive-behavioral self-management, Symptom monitoring
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Stony Brook University
Atopic Dermatitis, Pediatric ALL
TRacking Atopic Dermatitis Infants and Their Microbiome (TRAM)
TRacking Atopic dermatitis Infants and their Microbiome: A study to primarily assess the user experience of parents of infants with early onset eczema and parents of healthy infants on OneBiome real-world evidence research…
- Trial name
- TRAM (NCT06578351)
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
Sepsis
Single-dose/Multiple-doses Incremental Intravenous Injection of SY-005 （Recombinant Human Annexin A5）in Healthy Subjects
This is a single-dose/multiple-doses incremental, randomized, double-blind, parallel, placebo-controlled study on safety, tolerance and pharmacokinetics healthy subjects.
- Trial name
- NCT04217629
- Testing
- SY-005
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Suzhou Yabao Pharmaceutical R&D Co., Ltd.
Deafness; Perception
Auditory Midbrain Implant Study
The objectives of the clinical study are to implant five deaf patients (those with Neurofibromatosis Type II, NF2) with a new two-shank auditory midbrain implant array (AMI; developed by Cochlear Limited) into the central nucleus…
- Trial name
- NCT02984202
- Testing
- auditory midbrain implant (AMI)
- Where
- Germany
- Volunteers
- 5 people
- Sponsor
- Hannover Medical School
Keratocysts of the Jaw
Adjunctive Methods In Treatment Of Odontogenic Keratocyst
The purpose of this study was to compare both clinically and radiographically the effect of using 5- fluorouracil cream (5-FU) versus modified carnoy's solution (MCS) as adjunctive methods in treatment of odontogenic keratocyst…
- Trial name
- NCT06820229
- Testing
- Enucleation, cyst enucleation
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tanta University
End Stage Renal Disease, Renal Anemia
Assessment of an Anemia Model Predictive Controller for Anemia Management in Hemodialysis Patients
The purpose of this randomized, controlled pilot study is to evaluate the performance of this novel Anemia Controller (vis-à-vis standard of care) for anemia management in hemodialysis patients.
- Conditions
- End Stage Renal Disease, Renal Anemia, Chronic Kidney Diseases
- Trial name
- NCT04360902
- Testing
- Anemia Controller
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Renal Research Institute
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