Clinical trials: Condition
Depression, Anxiety
HIV Engagement and Adolescent Depression Support (HEADS-UP)
This pilot study will individually randomize 105 adolescents living with HIV 1:1:1 to standard of care, adapted intervention, or enhanced intervention.
- Conditions
- Depression, Anxiety, Adolescent Behavior, HIV Infections
- Trial name
- HEADS-UP (NCT06173544)
- Testing
- Standard of Care (SOC), Adapted Friendship Bench (AFB), Enhanced Friendship Bench (EFB)
- Where
- 5 sites in Malawi
- Volunteers
- 106 people
- Sponsor
- University of North Carolina, Chapel Hill
Posttraumatic Stress Disorder, Substance Abuse
Cognitive Behavioral Treatment of Posttraumatic Stress Disorder Enhanced by Virtual Reality for Individuals With PTSD and Substance Abuse
This study is exploring the use of an intervention designed to treat PTSD in individuals with comorbid PTSD and substance abuse resulting from the attacks of September 11 or from military service in Iraq.
- Trial name
- NCT00656344
- Testing
- Cognitive behavioral treatment enhanced by virtual reality
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Weill Medical College of Cornell University
MELAS Syndrome, Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS)
A Study to Assess TTI-0102 vs Placebo in MELAS Patients
This is a randomized, double-blind, placebo-controlled study. Prior to treatment, patients will undergo a screening visit. If eligible, each subject will return for a Day 1 visit and will receive their first dose of…
- Trial name
- NCT06644534
- Testing
- TTI-0102
- Where
- 2 sites in France, Netherlands
- Volunteers
- 9 people
- Sponsor
- Thiogenesis Therapeutics, Inc.
Breast Cancer
Decisional Aid Intervention for Women Considering Breast Reconstruction
This is an intervention development and pilot study whose purpose is to determine the feasibility and acceptability of the breast reconstruction decisional aid (BRDA) and provide preliminary data on its impact on decisional…
- Trial name
- BRDA (NCT01951534)
- Testing
- Breast Reconstruction Decisional Aid (BRDA), Usual Care
- Where
- 9 sites in United States
- Volunteers
- 56 people
- Sponsor
- Rutgers, The State University of New Jersey
Cervical Cancer
International Validation Study of Sentinel Node Biopsy in Early Cervical Cancer
SENTICOL III is large prospective multicenter international randomized study designed to validate the Sentinel Lymph Node (SLN) mapping technique in early cervical cancer.
- Trial name
- SENTICOLIII (NCT03386734)
- Testing
- SLN biopsy only, SLN biopsy + PLN dissection
- Where
- 106 sites in Belgium, Brazil and 12 more
- Volunteers
- 989 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Diabetic Retinopathy
Correlation Between Macular Ischemia and Peripheral Ischemia in Patients With Diabetes
The contribution of OCT- angiography (OCT-A) allows to consider, in a more or less long term, a drastic reduction in the use of fluorescein angiographies in diabetic retinopathy.
- Trial name
- CORISMAP (NCT02876744)
- Testing
- ophthalmologic examination
- Where
- France
- Volunteers
- 101 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Glaucoma
Metformin as a Neuroprotective Therapy for Glaucoma
Glaucoma, a chronic degenerative disease of the optic nerve, is the leading cause of irreversible blindness worldwide. Although lowering the intraocular pressure (IOP) has been shown to be effective to slow optic nerve…
- Trial name
- NCT05426044
- Testing
- Metformin
- Where
- Hong Kong
- Volunteers
- 125 people
- Sponsor
- Christopher Kai Shun Leung
Cardiac Surgery, Surgical Stress Response
Guided Visualization Meditation for Reducing Surgical Stress Response in Cardiac Surgery Patients
This study aims to evaluate whether guided visualization meditation can reduce the surgical stress response in patients undergoing open-heart surgery.
- Conditions
- Cardiac Surgery, Surgical Stress Response, Coronary Artery Disease, Postoperative Stress
- Trial name
- GVM-CARDIO (NCT07379944)
- Testing
- Guided Visualization Meditation
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- University of Gaziantep
COPD, Pneumonia
Burden of Hospitalized Pneumonia in Korea COPD Population
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. By 2030, COPD is expected to be the fourth main cause of death.
- Conditions
- COPD, Pneumonia, Pneumococcal Vaccine
- Trial name
- COPDCAP (NCT03046134)
- Testing
- PCV13
- Where
- 4 sites in South Korea
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Chung-Ang University Hospital
Weight Change, Body
Healthy Homes/Healthy Families (HH/HF) Intervention in 2-1-1 Callers
This trial will evaluate a healthy eating and weight gain prevention intervention for delivery through calls to the 2-1-1 number.
- Trial name
- NCT04373434
- Testing
- Health Homes/Healthy Families (HH/HF) Intervention, Control
- Where
- United States
- Volunteers
- 512 people
- Sponsor
- Emory University
CNLDO - Congenital Nasolacrimal Duct Obstruction, Amblyopia
Improving the Follow up Rate for Pediatric Patients
Follow-up of pediatric patients is important for their regular ocular morbidity monitoring, especially for amblyopia management.
- Conditions
- CNLDO - Congenital Nasolacrimal Duct Obstruction, Amblyopia, Conjunctivitis, Eye Injuries
- Trial name
- NCT04837534
- Testing
- Counseling group, SMS and phone call reminder group
- Where
- Nepal
- Volunteers
- 264 people
- Sponsor
- Seva Foundation
Club Foot
Low Dye Taping Technique Versus Robert Debre Method On Foot Posture And Range Of Motion In Children With Club Foot.
To Check the effects of the low dye taping technique versus the Robert Debre method on foot posture and range of motion in children with club feet.
- Trial name
- NCT05794334
- Testing
- Low Dye Taping
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Hyperlipidemia
A Comparison Study to Evaluate the Pharmacokinetics and Safety of NK-104-CR in Healthy Adult Volunteers
The purpose of this study is to compare the pharmacokinetics and safety of a controlled release (CR) version of pitavastatin (also referred to as NK-104) to immediate release (IR) pitavastatin in healthy adult volunteers.
- Trial name
- NCT02634034
- Testing
- A: NK-104-CR 8 mg, B: Pitavastatin IR 4 mg, C: Pitavastatin IR 8 mg
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Kowa Research Institute, Inc.
Multiple Sclerosis
Spinal Cord Monitoring in Multiple Sclerosis
Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system and the most common cause of non-traumatic neurological disability in young adults.
- Trial name
- MSpine (NCT06827834)
- Where
- 5 sites in Netherlands
- Volunteers
- 155 people
- Sponsor
- Zuyderland Medisch Centrum
Parkinson Disease
Virtual Exercises in Patients With Parkinson's Disease.
Introduction: Although the motor changes are well determined in Parkinson's disease (PD), few studies describe the effects the virtual exercises on the clinical and functional outcomes in this disease.
- Trial name
- NCT02023034
- Testing
- Virtual exercises
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Faculdade Evangelica do Parana
Hyperlipidemias
Daily Inclusion of Eggs in a Heart-Healthful Dietary Pattern in Hyperlipidemic Adults
This randomized, cross-over design, controlled trial will assess the effects of 8 weeks of daily inclusion of 2 whole eggs in the Dietary Approaches to Stop Hypertension (DASH) eating plan, compared with their exclusion, on…
- Trial name
- NCT05807334
- Testing
- DASH eating plan with eggs, DASH eating plan without eggs
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Griffin Hospital
Lung Diseases
Comparison of 133Xe Scintigraphy With 19F MRI
The central hypothesis and current observation is that PFx gases used as contrast agents readily provide functional images of the lung airways including important regional ventilation information such as ventilation defect…
- Trial name
- NCT03532334
- Testing
- Perfluorinated Gas/Oxygen Mixture
- Where
- United States
- Sponsor
- Hal C Charles
Neurologic Disorder, Multiple Sclerosis
Effectiveness of Powerball System in People With Multiple Sclerosis
There is a high percentage of impairment in the upper limbs (UL) in patients with multiple sclerosis (MS), being muscle strength and hand dexterity a determining factor for the preservation of functional activities, constituting…
- Trial name
- EMPOW (NCT05895734)
- Testing
- NDS-Powerball®,, Conventional treatment
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Universidad Rey Juan Carlos
Hypercholesterolemia
Pharmacokinetic and Tolerability of Alirocumab SAR236553 (REGN727) in Patients With Hepatic Impairment and in Healthy Subjects
Primary Objective: Study the effect of mild or moderate hepatic impairment on the pharmacokinetics of alirocumab SAR236553 (REGN727).
- Trial name
- NCT01670734
- Testing
- alirocumab SAR236553 (REGN727)
- Where
- 2 sites in France, Moldova
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sanofi
Myocardial Infarction, Anemia
Conservative Versus Liberal Red Cell Transfusion in Myocardial Infarction Trial: The CRIT Pilot
The purpose of this trial is to determine whether a conservative or a liberal blood transfusion strategy is better for patients with a heart attack and a low blood count.
- Trial name
- CRIT (NCT00126334)
- Testing
- Packed Red Blood Cell Transfusion
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- Medstar Health Research Institute
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