Clinical trials: Condition
Prediabetes, Normoglycemic
Effect of a Collagen Hydrolysate on Postprandial Blood Glucose Profile, Gastric Emptying and GLP-1 Release in Normoglycemic and Prediabetic Subjects
Aim of the study is to investigate the postprandial response on blood glucose, insulin, C-peptide, incretin response and gastric emptying after intake of collagen hydrolysate compared to placebo in normoglycemic and in…
- Trial name
- NCT06789263
- Testing
- Collagen hydrolyzed peptides
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rousselot BVBA
Myocardial Infarction
Improving Door-to-Balloon Time in STEMI
The investigators prospectively determined the impact on median door-to-balloon time of a protocol mandating (1) emergency department physician activation of the catheterization lab and (2) immediate transfer of the patient to an…
- Trial name
- EHART (NCT00800163)
- Testing
- ED Activation/Immediate Transfer
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- St. Francis Hospitals & Health Centers
Follicular Lymphoma
A Study Of PF-05280586 (Rituximab-Pfizer) Or MabThera® (Rituximab-EU) For The First-Line Treatment Of Patients With CD20-Positive, Low Tumor Burden, Follicular Lymphoma (REFLECTIONS B328-06)
This study will compare the safety and effectiveness of PF-05280586 versus rituximab-EU in patients with CD20-positive, low tumor burden follicular lymphoma.
- Trial name
- NCT02213263
- Testing
- PF-05280586, MabThera®
- Where
- 423 sites in United States, Austria and 28 more
- Volunteers
- 394 people
- Sponsor
- Pfizer
Early-stage Parkinson's Disease
Evaluation of the Tolerance and Acceptability of Rasagiline in the Treatment of Early-stage Parkinson's Disease
Title: Evaluation of the tolerance and acceptability of Rasagiline in the treatment of early-stage Parkinson's disease. Type of study: Phase IV Study objectives: Principal objective: To evaluate the tolerance and acceptability of…
- Trial name
- ACTOR (NCT01048229)
- Testing
- Rasagiline, Pramipexole
- Volunteers
- 112 people
- Sponsor
- Qualissima
Pulmonary Hypertension
Persistent Pulmonary Hypertension After Percutaneous Mitral Commissurotomy
To identify clinical, echocardiographic, and hemodynamic parameters which can predict persistent PH after PMC, and also to determine the impact of persistent PH on the clinical outcomes.
- Trial name
- NCT04083729
- Testing
- Percutaneous Mitral Commissurotomy
- Volunteers
- 62 people
- Sponsor
- Assiut University
COPD Exacerbation, COPD
The COPD CARE Study: Evaluating the Impact of a Virtual-First COPD Service on Major Cardiac and Respiratory Events
A 12 month interventional study of up to 1,050 people with COPD to determine if the NuvoAir virtual-first clinical service leads to fewer moderate and severe COPD exacerbations and cardiac events, reduces healthcare utilization…
- Conditions
- COPD Exacerbation, COPD, Cardio/Pulm: Heart Failure
- Trial name
- NCT06379529
- Testing
- NuvoAir clinical service
- Volunteers
- 1,050 people
- Sponsor
- NuvoAir Medical PC
STEMI
Prognostic Value of Lactate Levels in Patients With STEMI Undergoing Primary PCI
To assess the prognostic value of systemic arterial lactate levels in patients with ST segment elevation myocardial infarction undergoing primary PCI and correlate with the results of primary PCI and 30 days MACE follow up.
- Trial name
- NCT05503329
- Testing
- arterial lactate level
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Ahmed Maher Teaching Hospital
Polycythemia Vera
A Phase 1 Study of XL019 in Adults With Polycythemia Vera
The purpose of this study is to evaluate the safety and tolerability of the JAK2 inhibitor XL019 administered orally in adults with Polycythemia Vera.
- Trial name
- NCT00595829
- Testing
- XL019
- Where
- 5 sites in United States
- Volunteers
- 3 people
- Sponsor
- Exelixis
Renal Insufficiency, Chronic
Effect of Pre- and Probiotics on P-cresol Plasma Levels in Patients Bearing a Kidney Allograft
The purpose of this study is to establish whether a short treatment with the synbiotic combination Probinul neutro® may decrease the plasma concentration of the uremic toxin p-cresol in patients bearing a kidney allograft.
- Trial name
- NCT02179229
- Testing
- CONTROL, SYNBIOTIC
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Federico II University
Female Sexual Dysfunction
Viveve Geneveve Treatment of the Vaginal Introitus to Evaluate Safety and Efficacy
This study is evaluating the safety and efficacy of the Geneveve Treatment for women experiencing diminished sexual function following vaginal childbirth.
- Trial name
- VIVEVE II (NCT03479229)
- Testing
- Geneveve Treatment
- Where
- 21 sites in United States, Canada
- Volunteers
- 250 people
- Sponsor
- Viveve Inc.
Refractory Schizophrenia
An Adaptive Phase II/III, Two-Part, Double-Blind, Randomized, Placebo-controlled, Dose-Finding, Multi-center Study of the Safety and Efficacy of NaBen®, as an Add-on Therapy With Clozapine, for Residual Symptoms of Refractory Schizophrenia in Adults
This is an adaptive, Phase II/III study in 2 parts (i.e. Part 1 (dose ranging) and Part 2 (Hypothesis testing)). NaBen® is granted Breakthrough Therapy Designation by US FDA as treatment for refractory schizophrenia.
- Trial name
- NCT03094429
- Testing
- NaBen®
- Where
- United States
- Volunteers
- 287 people
- Sponsor
- SyneuRx International (Taiwan) Corp
Human Immunodeficiency Virus, HIV Infections
Cross-disciplinary HIV Integrated Mental Health Support Intervention
The proposed project seeks to develop and test an intervention to improve engagement in HIV and mental health care for young Black gay, bisexual and other men who have sex with men (YB-GBMSM) in Ryan White clinics.
- Trial name
- CHIMES (NCT04833829)
- Testing
- CHIMES Intervention, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 850 people
- Sponsor
- Emory University
Methamphetamine Dependence, Substance Abuse
Varenicline vs Placebo for the Treatment of Methamphetamine Dependence
Methamphetamine (MA) abuse is the fastest growing drug problem in the United States and is responsible for significant public health complications, including HIV infection.
- Conditions
- Methamphetamine Dependence, Substance Abuse, Methamphetamine Abuse
- Trial name
- RAVEN (NCT01011829)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Autism Spectrum Disorder (ASD), Pain Perception
Quantitative Sensory Testing to Study Pain Perception in Autism
This study aims at assess sensory perception, and pain perception, in neurodivergent children and adolescent in the autism spectrum.
- Trial name
- PPiA (NCT06659731)
- Testing
- Quantitative Sensory testing (QST), EEG
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Multiple Myeloma
A Study of JNJ-54767414 (Daratumumab) in Combination With Lenalidomide and Dexamethasone in Japanese Participants With Previously Untreated Multiple Myeloma Who Are Ineligible for High-dose Therapy and Autologous Stem Cell Transplantation
The purpose of this study is to evaluate the safety of daratumumab when combined with lenalidomide and dexamethasone in Japanese participants with newly diagnosed multiple myeloma who are not candidates for high-dose chemotherapy…
- Trial name
- NCT02918331
- Testing
- Daratumumab (16 mg/kg), Lenalidomide, Dexamethasone
- Where
- 5 sites in Japan
- Volunteers
- 7 people
- Sponsor
- Janssen Pharmaceutical K.K.
Celiac Disease, Wheat Hypersensitivity
Changes in Intestinal Permeability 4 Hours After Gluten Challenge
This study evaluates why people with celiac disease and non-celiac gluten/wheat sensitivity develop rapid onset symptoms within hours of gluten exposure. Half of subjects will be given gluten and half will not.
- Conditions
- Celiac Disease, Wheat Hypersensitivity, Gluten Sensitivity, Gluten Enteropathy
- Trial name
- NCT03288831
- Testing
- Gluten
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
COVID-19, Dysglycemia
Can Intensive Insulin Therapy Improve Outcomes of COVID-19 Patients
Evaluation of the reciprocal relation between hyperglycemia/diabetes mellitus (HG/DM) and COVID-19 disease and the effect of mode of insulin therapy; intensive (IIT) or conventional (CIT) on patients' outcomes All patients…
- Trial name
- NCT05441631
- Testing
- Insulin, Subcutaneous Insulin
- Where
- Egypt
- Volunteers
- 436 people
- Sponsor
- Benha University
Hypertension
Crossover Study to Evaluate the Comparative Bioavailability of Two Fixed Dose Combination Tablet Formulations of Amlodipine and Losartan in Health Volunteers
The purpose of this study is to evaluate the comparative bioavailability of two fixed dose combination tablet formulations of amlodipine and losartan in healthy volunteers.
- Trial name
- NCT01648231
- Testing
- Reference Treatment: 1 x 5mg amlodipine tablet and 1 x 100mg losartan tablet administered in fasted state, Fixed Dose Combination 1: 1 x 5mg amlodipine / 100mg losartan tablet administered in fasted state, Fixed Dose Combination 2: 1 x 5mg amlodipine / 100mg losartan tablet administered in fasted state
- Where
- Australia
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Osteoarthritis, Overweight or Obesity
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
The YDAN master protocol will support two independent studies, J3R-MC-YOA1 and J3R-MC-YOA2. Each study will investigate how well and safely Eloralintide (LY3841136) works in adults with obesity or overweight who have…
- Trial name
- ENLIGHTEN-4 (NCT07353931)
- Testing
- Eloralintide
- Where
- 153 sites in United States, Argentina and 12 more
- Volunteers
- 900 people
- Sponsor
- Eli Lilly and Company
Leukemia
Comparison of Laboratory Test Results of Minimal-Residual Disease in Samples From Patients With Acute Myeloid Leukemia
RATIONALE: Diagnostic procedures that find residual disease may help predict if the disease will come back in patients diagnosed with acute myeloid leukemia.
- Trial name
- NCT01498302
- Testing
- diagnostic laboratory biomarker analysis, flow cytometry
- Volunteers
- 10 people
- Sponsor
- Children's Oncology Group
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