Clinical trials: Condition
Skin Cancer, Mucosal Neoplasm of Oral Cavity
Alpha Radiation Emitters Device for the Treatment of Cutaneous, Mucosal and Superficial Soft Tissue Neoplasia (DaRT)
A unique approach for cancer treatment employing intratumoral diffusing alpha radiation emitter device for superficial cutaneous, mucosal or soft tissue neoplasia
- Conditions
- Skin Cancer, Mucosal Neoplasm of Oral Cavity, Soft Tissue Neoplasm
- Trial name
- NCT03886181
- Testing
- Device: Radiation: Diffusing Alpha Radiation Emitters Therapy (DaRT)
- Where
- Italy
- Volunteers
- 2 people
- Sponsor
- Alpha Tau Medical LTD.
Acute Lymphoblastic Leukemia
Neurostimulation In Adult Survivors of Childhood Acute Lymphoblastic Leukemia (ALL)
Long-term survivors of ALL are at-risk for neurocognitive impairment, particularly in the area of executive functioning. Relatively limited research has focused on interventions for improving neurocognitive outcomes in long-term…
- Trial name
- NCT04007601
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- St. Jude Children's Research Hospital
Down Syndrome
Inspiratory Muscle Training and Physical Fitness in Children With Down Syndrome Randomized Control Trial
The purpose of this study is to investigate the effect of inspiratory muscle training on physical fitness in Down syndrome children.
- Trial name
- NCT04767412
- Testing
- aerobic exercise training, inspiratory muscle training
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Work-Related Musculoskeletal Disorders
The Impact of Back-supporting Exoskeletons for Manual Order Picking in Danish Warehouses - The RELAX Project
This study investigates the long-term effects of implementing a passive back-support exoskeleton during manual order-picking work in a real-world warehouse environment.
- Trial name
- RELAX (NCT07561112)
- Testing
- Use of an occupational passive back-exoskeleton
- Where
- Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Spinal Muscular Atrophy
An Open-label Safety, Tolerability, and Dose-range Finding Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy (SMA)
This objectives of this study are to evaluate the safety, tolerability, and pharmacokinetics of a single dose of nusinersen (ISIS 396443) administered intrathecally to participants with Spinal Muscular Atrophy (SMA).
- Trial name
- SMNRx (NCT01494701)
- Testing
- nusinersen
- Where
- 4 sites in United States
- Volunteers
- 28 people
- Sponsor
- Biogen
Mental Disorders, Substance Use Disorders
Promoting Recovery by Overcoming Self-stigma in Mental Health Disorders With a Narrative Enhancement and Cognitive Therapy (NECT) Group Intervention
This study will evaluate whether Narrative Enhancement and Cognitive Therapy (NECT) can promote recovery among adults living with severe mental health disorders, including substance use disorders.
- Trial name
- NCT07735481
- Testing
- Narrative Enhancement Cognitive Therapy, Control Group Sessions
- Where
- Switzerland
- Volunteers
- 106 people
- Sponsor
- Louise Penzenstadler
Breast Carcinoma
Stakeholder Assessment of Implementing the Commission on Cancer Operative Standards for Cancer Surgery
This study investigates the barriers to implementing breast Synoptic Operative Reports. Information from this study may help researchers identify performance objectives for the breast Synoptic Operative Reports to be adopted…
- Trial name
- NCT05583981
- Testing
- Interview
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Cerebral Palsy, Hip Dysplasia
Pain Injection Versus Epidural Anesthesia for Hip Surgery in Pediatric Patients With Cerebral Palsy
Pain management in pediatric patients presents a difficult challenge. Unlike adults, pediatric patients often cannot communicate their pain management needs clearly.
- Conditions
- Cerebral Palsy, Hip Dysplasia, Pain, Postoperative
- Trial name
- NCT06189781
- Testing
- Ropivacaine injection, Bupivacaine, lidocaine, ropivacaine
- Where
- 4 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of California, Los Angeles
Dissociative Disorders
Psychotherapy and Pharmacotherapy in Dissociative Disorders
The purpose of this observational study is to measure the efficacy of a specific combined treatment (psychotherapy and pharmacotherapy) on patients with dissociative disorders, in terms of patients with a favorable outcome by…
- Trial name
- NCT00630981
- Testing
- Psychotherapy, Pharmacological treatment (Quetiapine and/or Escitalopram)
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Espace Hogan
ADHD
Testing a New Method to Improve Informed Consent in Prison Research
Understanding of informed consent is often limited in prison, due to unique challenges faced by detained people. This study will test a modified "teach-to-goal" informed consent process compared to standard procedures.
- Trial name
- Spark BATIR (NCT06378281)
- Testing
- Modified teach-to-goal informed consent
- Where
- 2 sites in Switzerland
- Volunteers
- 100 people
- Sponsor
- Stéphanie Baggio
Acne Vulgaris
Trial of Clindamycin / Benzoyl Peroxide Gel in Subjects With Acne
This is a Randomized, Double-Blind, Controlled Study to evaluate the Safety and Efficacy of a clindamycin / benzoyl peroxide gel in Subjects with Acne Vulgaris
- Trial name
- NCT00776919
- Testing
- clindamycin / benzoyl peroxide gel, clindamycin gel, BPO gel
- Where
- 24 sites in United States, Belize and 1 more
- Volunteers
- 1,315 people
- Sponsor
- Stiefel, a GSK Company
Atelectasis, Lung Ultrasonography Score
Can Atelectasis Be Prevented With Oxygen Reserve Index (ORI) Monitoring?
This single-center randomized controlled trial aims to evaluate whether intraoperative monitoring using the Oxygen Reserve Index (ORI) reduces the incidence of postoperative atelectasis, as assessed by lung ultrasound (LUS), in…
- Conditions
- Atelectasis, Lung Ultrasonography Score, Hyperoxia
- Trial name
- NCT07050719
- Testing
- Peripheral Oxygen Saturation (SpO₂) Group, Peripheral Oxygen Saturation and Oxygen Reserve Index (SpO₂-ORI) Group
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Antalya Training and Research Hospital
Rheumatoid Arthritis
A Study to Assess the Receptor Occupancy of CD86 and CD80 in Subjects With Rheumatoid Arthritis Initiating Abatacept
The purpose of this study is to characterize CD86 receptor occupancy in subjects with rheumatoid arthritis (RA) receiving abatacept.
- Trial name
- NCT01339481
- Testing
- abatacept
- Where
- 7 sites in United States
- Volunteers
- 26 people
- Sponsor
- Astellas Pharma Inc
Hepatitis C
HCV Test and Treat Utilizing Simplified HCV Patient Education
The study hypothesis is that the test and treat model utilizing video-based patient education will have higher rates of hepatitis C virus (HCV) treatment initiation and treatment completion.
- Trial name
- NCT05582681
- Testing
- Cepheid POC HCV Viremia (RNA) test, HCV education from a health care provider, Glecaprevir and Pibrentasvir
- Where
- 3 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Oculopharyngeal Muscular Dystrophy
Safety Tolerability and Efficacy Study of Cabaletta to Treat Oculopharyngeal Muscular Dystrophy (OPMD) Patients
The Purpose of this study is to assess the Safety, Tolerability and Efficacy of Intravenous Cabaletta® in Oculopharyngeal Muscular Dystrophy (OPMD) Patients.
- Trial name
- HOPEMD (NCT02015481)
- Testing
- Cabaletta
- Where
- 4 sites in United States, Canada and 1 more
- Volunteers
- 25 people
- Sponsor
- Bioblast Pharma Ltd.
Parkinson Disease, Idiopathic
Parkinson Disease: A Model of National Digital Interventions to Prevent or Slow a Rise of Non-Communicable
According to Parkinson's Disease Medical Center of Excellence's project which was registered Parkinson's disease patients in 2008-2011, it was found that there were more than 60,000 people with Parkinson's disease in Thailand…
- Trial name
- PDRegistry (NCT06609681)
- Where
- Thailand
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Roongrooj Bhidayasiri
Obesity, Child Obesity
Feeding the fAmiLy: the Intergenerational approaCh to fIght obesiTY (FACILITY)
The FACILITY STUDY is aimed at evaluating maternal and children social, cultural, economic and lifestyle-related risk factors for the development of childhood overweight, obesity and early adiposity rebound (EAR).
- Conditions
- Obesity, Child Obesity, Maternal Obesity, Overweight
- Trial name
- FACILITY (NCT06179381)
- Volunteers
- 269 people
- Sponsor
- Buzzi Children's Hospital
Left Ventricular Dysfunction, Heart Failure
Effects of Left Ventricular Pacing Optimilization on Cardiac Perfusion, Contractile Force, and Clinical Performance in Patients With Ventricular Dysfunction and Heart Failure
To compare a surgical approach of LV lead placement for BIV pacing with the conventional transvenous approach by assessment of differences on the effects on cardiac perfusion and relate this to the clinical cardiac function.
- Trial name
- CONTRACT (NCT00551681)
- Testing
- biventricular pacemaker with epicardial left ventricular lead, transvenous left ventricular lead placement
- Where
- Netherlands
- Volunteers
- 52 people
- Sponsor
- R&D Cardiologie
Diabetes Mellitus, Type 2
Examining Genetic Influence on Response to Beta-Blocker Medications in People With Type 2 Diabetes
Beta-blockers are medications used to treat cardiovascular disease (CVD) symptoms, including high blood pressure and chest pain.
- Trial name
- NCT00925119
- Testing
- Atenolol
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Maryland, Baltimore
Digestive System Cancer, Digestive System Neoplasm
Nutritional Psychological Intervention and Vomit-free Management on Survival and Quality of Life in Advanced Gastrointestinal Tumors
Aims to observe and evaluate the impact of survival and quality of life of patients with gastrointestinal tumors such as advanced esophageal, gastric, liver, pancreatic, and colorectal cancers through nutritional-psychological…
- Trial name
- NCT06223230
- Testing
- Nutritional psychological interventions and vomit-free management
- Where
- China
- Volunteers
- 316 people
- Sponsor
- Renmin Hospital of Wuhan University
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