Clinical trials: Conditioned Pain Modulation
Hypnosis, Endocannabinoids
The Effect of Hypnosis on Blood Concentrations of Endocannabinoids
Introduction: Many interventions such as hypnosis, mindfulness meditation, conditioned pain modulation and placebos have been shown to effectively reduce pain both in the laboratory and in clinical settings.
- Conditions
- Hypnosis, Endocannabinoids, Analgesia
- Trial name
- NCT03407937
- Testing
- Hypnosis, Meditation, Conditioned pain modulation
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Chronic Pain
Reference Values and Clinical Screening Test of Diffuse Noxious Inhibitory Controls (DNIC)
Chronic pain (CP) is disabling for people triggering important costs for society. A deficit of diffuse noxious inhibitory controls (DNIC) is one of the CP mechanisms.
- Trial name
- DNIC (NCT03376867)
- Testing
- Conditioned pain modulation
- Where
- Canada
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Pain Thresholds, Healthy Adult Participants
Evaluation of Psychophysical Responses After Mechanical Stimulation.
This study evaluates the test-retest reliability of psychophysical responses to non-injurious sharp stimuli applied via a robotic system.
- Trial name
- NCT07774429
- Testing
- Robot-controlled non-injurious mechanical stimulation
- Where
- Argentina
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Fibromyalgia (FM), Quantitative Sensory Testing
Investigation of Pain Modulation Phenotypes in Female Patients With Fibromyalgia
Fibromyalgia is characterized by altered pain processing, including impaired descending pain inhibition and central sensitization.
- Conditions
- Fibromyalgia (FM), Quantitative Sensory Testing, Central Sensitization, PRESSURE PAIN THRESHOLD
- Trial name
- NCT07640607
- Testing
- Quantitative Sensory Tests(QST) protocol, Clinical Scales
- Volunteers
- 82 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Catastrophizing Pain, Pain, Somatic
The Association Between Conditioned Pain Modulation and Pain Catastrophizing in Chronic Low Back Pain
This study evaluates the potential association between pain catastrophizing thoughts and the ability to dampen pain via endogenous descending inhibition.
- Conditions
- Catastrophizing Pain, Pain, Somatic, Chronic Low Back Pain
- Trial name
- NCT03644810
- Testing
- PPT measurement, Pain catastrophizing scale, Cold Pressor Test
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Pain
Influence of Percutaneous Electrolysis on Endogenous Pain Modulation
Percutaneous electrolysis is a minimally invasive approach that consists in the application of a galvanic current through an acupuncture needle.
- Trial name
- NCT04710992
- Testing
- Isolated needling procedure, Low intensity percutaneous electrolysis, High intensity percutaneous electrolysis
- Where
- Spain
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Healthy Volunteers
Effects of Cerebral and Peripheral Electrical Stimulation on Conditioned Pain Modulation in Healthy Subjects.
The Neuromatrix pain model and new findings on pain chronification process point to a greater efficacy of treatments that address central and peripheral rather than only peripheral structures.
- Trial name
- NCT03752502
- Testing
- Transcranial direct current stimulation (tDCS), Peripheral electrical stimulation (PES)
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Piauí
Headache, Migraine, Migraine
Mind and Body Approaches to Pain Reduction in Youth With Migraine
The overarching objective of this protocol is to identify and understand the neural and pain processing mechanisms by which youth with migraine improve in response to preventive treatment.
- Conditions
- Headache, Migraine, Migraine, Migraine Disorders, Headache
- Trial name
- NCT03472092
- Testing
- Cognitive Behavioral Therapy (CBT), Amitriptyline, Biofeedback-Assisted Relaxation Training (BART)
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Osteo Arthritis Shoulders, Osteoarthritis Shoulder
Endogenous Pain Modulation Study
Rationale: Although most patients experience significant pain relief after total shoulder arthroplasty (TSA), pain persists for some patients even after surgery.
- Trial name
- EPM (NCT05861960)
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Reinier Haga Orthopedisch Centrum
Habituation
Conditioned Pain Modulation Using Painful Cutaneous Electrical Stimulation or Simply Habituation?
Painful cutaneous electrical stimulation (PCES) and corresponding evoked potentials led to a significant pain relief and decrease of evoked potentials and has been used to analyze conditioned pain modulation (CPM).
- Trial name
- NCT03237650
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Low Back Pain, Compare Pain Modulation Assessments in Pain-free Cohorts
Pain Modulation - Experimental Assessments Using Different Modalities
The goal of this study is to investigate how different painful stimuli are processed and modulated in the nervous system. In various pain conditions, including low back pain, often no specific source can be identified as the…
- Trial name
- NCT04323293
- Testing
- Cold Water Bath, Neutral Water Bath
- Where
- Switzerland
- Volunteers
- 705 people, healthy volunteers welcome
- Sponsor
- Schweinhardt Petra
Pain
The Influence of Expectations, Attention and the Test Paradigm on the Efficacy of the Pain Processing System
Conditioned pain modulation (CPM) is the endogenous pain relief mechanism responsible for the "pain-inhibits-pain" phenomenon. This mechanism can be activated experimentally, and its efficiency evaluated by experimental pain…
- Trial name
- CPM_AWARE (NCT05161286)
- Where
- Belgium
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Ghent
Healthy
Pain Inhibitory Effects of Other Pain Induced by Mechanical Pressure at Different Intensities
The objective is to estimate the effects on pain thresholds of a painful mechanical stimulus on the upper trapezius at moderate intensity compared to mild intensity or non-painful.
- Trial name
- NCT05730166
- Testing
- Mechanical Conditioning stimulus
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Josue Fernandez Carnero
Chronic Pain
DNIC Using Deep Learning and Artificial Intelligence
Chronic pain (CP) is disabling for people triggering important costs for society. A deficit of diffuse noxious inhibitory controls (DNIC) is one of the CP mechanisms.
- Trial name
- NCT04896827
- Testing
- Conditioned pain modulation test
- Where
- Canada
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Kinesiophobia
Impact of Kinesiophobia on Descending Corticospinal and Bulbospinal Projections
Fear of movement (kinesiophobia) is a phenomenon commonly observed in people suffering from chronic pain. The aims of this project are to better understand the neurophysiological basis of this phenomenon, in particular 1) the…
- Trial name
- EchoKinésio (NCT05161832)
- Testing
- Nocebo
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Hemophilia
Conditioned Pain Modulation in Patients With Hemophilia
Introduction: Hemophilic arthropathy is characterized by functional alterations, disabling physical sequelae, and chronic pain. Conditioned pain modulation describes the net effect of endogenous pathways that enhance or diminish…
- Trial name
- NCT06267209
- Testing
- Observational group
- Where
- Spain
- Volunteers
- 51 people
- Sponsor
- Investigación en Hemofilia y Fisioterapia
Chronic Pain, Central Sensitisation
Childhood Adversity, Inflammatory Reactivity and Persistent Pain
The goal of this observational study is to investigate how adverse experiences during childhood are linked to people experiencing persistent pain and fatigue in adulthood. The questions the investigators aim to answer are: 1.
- Conditions
- Chronic Pain, Central Sensitisation, Immune Response, Adverse Childhood Experiences
- Trial name
- CAIR (NCT06127693)
- Testing
- Tetravalent Influenza Vaccine, High-frequency electrical stimulation
- Where
- South Africa
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
Chronic Low-back Pain
Conditioned Pain Modulation in Localized vs Widespread Chronic Low Back Pain
This study aims to compare function of the body's endogenous pain modulation system between people with localized low back pain versus widespread body pain.
- Trial name
- NCT05972395
- Testing
- Localized vs Widespread Mechanical Pain Hypersensitivity
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ahram Canadian University
Musculoskeletal Pain, Neck Pain
Pain Modulatory Profiles in Massage for Individuals With Neck Pain
One in ten adults experience widespread pain. Neck pain, for example, is a prevalent condition with a high rate of recurrence that affects between 10.4% and 21.3% of the population annually.
- Trial name
- NCT03534739
- Testing
- Pain Inducing Massage, Light Touch Massage, Coldpressor
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Florida
Healthy Adult
Exploring Pain Modulation With TMS and Repeated Pain Conditioning in Healthy Individuals
Conditioned pain modulation (CPM) is the behavioral measure of diffuse noxious inhibitory control (DNIC), an endogenous pain inhibitory pathway in which pain inhibits pain.
- Trial name
- NCT06726018
- Testing
- Conditioned Pain Modulation (CPM)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Priyanka Rana, PT, MPT, PhD