Clinical trials: Conduct
Influenza, Human
Testing Multiple Behavioral Science Strategies to Increase Flu-Shot Rates
This research aims to identify which behavioral science strategies are most effective at increasing flu vaccination rates overall and based on patients' individual characteristics.
- Trial name
- NCT04565353
- Testing
- Flu shot text messages
- Where
- 2 sites in United States
- Volunteers
- 74,811 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Type II Diabetes
Measuring the Preferences of Patients With Type II Diabetes Using Best-worst Scaling and Discrete Choice Experiment
In 2012, the FDA Center for Devices and Radiological Health (CDRH) issued guidance to clarify the principal benefit-risk factors FDA considers during the reviews for premarket approval applications and de novo classification…
- Trial name
- NCT02637622
- Testing
- Best-Worst Scaling (Case 2), Discrete Choice Experiment
- Where
- United States
- Volunteers
- 1,103 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Non-small Cell Lung Cancer
Study of Pralatrexate vs. Erlotinib for Non-Small Cell Lung Cancer After at Least 1 Prior Platinum-based Treatment
The purpose of this clinical study is to determine the effectiveness (ability to provide beneficial treatment of the disease) and safety of pralatrexate compared to erlotinib when given to non-small cell lung cancer (NSCLC)…
- Trial name
- NCT00606502
- Testing
- Pralatrexate, Erlotinib, Vitamin B12
- Where
- 47 sites in United States, Argentina and 4 more
- Volunteers
- 201 people
- Sponsor
- Spectrum Pharmaceuticals, Inc
Obesity
Food Preference Following Bariatric Surgery
Roux-en-Y gastric bypass (RYGB) decreases appetite, caloric intake, glycemia, and body weight, all of which are maintained long term.It is controversial whether, after RYGB, patients choose to eat less high fat and sugary foods…
- Trial name
- NCT03363581
- Testing
- Food Preference
- Where
- Ireland
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Suicide, Accidental Injuries
Family Safety Net - Aim 3: Randomized Control Trial
Our parallel group clinical trial of the Family Safety Net (FSN) intervention addresses two main questions: Is the Family Safety Net (FSN) intervention feasible and acceptable in two formats: motivational interviewing (FSN MI)…
- Conditions
- Suicide, Accidental Injuries, Firearm Injury
- Trial name
- FSN (NCT05657119)
- Testing
- MI FSN - Lethal Means Reduction, Scripted FSN - Lethal Means Reduction, General Firearm Safety Intervention - General Firearm Safety
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Attention Deficit Disorder With Hyperactivity
Safety, Tolerability and Efficacy of SPD503 in Treating ADHD in Children Aged 6-17
The purpose of this study is to determine the effects of SPD503 compared to placebo on tasks of sustained attention in children and adolescents aged 6-17 diagnosed with ADHD.
- Trial name
- NCT00150592
- Testing
- SPD503 (Guanfacine HCl)
- Volunteers
- 182 people
- Sponsor
- Shire
Post Traumatic Stress Disorder, Relational Problems
Brief Cognitive Behavioral Conjoint Therapy for PTSD With Adjunctive Intranasal Oxytocin
In 2019 VA mandated that all Veterans seeking mental health care have access to flexible family mental health services in VA (VHA directive 1163.04).
- Trial name
- CBCT+OT (NCT05207436)
- Testing
- Oxytocin nasal spray, Brief Cognitive-Behavioral Conjoint Therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- San Diego Veterans Healthcare System
Obesity, Overweight
Does Motivational Interviewing Improve Behavioral Weight Loss Outcomes for Obesity?
The purpose of this study is to determine whether adding motivational interviewing (MI) to a behavioural weight loss program (BWLP) results in improved weight loss for adults who are overweight or obese.
- Trial name
- BWLP+MI (NCT02649634)
- Testing
- Motivational Interviewing, Attention Control
- Volunteers
- 135 people
- Sponsor
- University of Calgary
Alcohol Problem, Harm Reduction
Game-Based Intervention to Reduce Alcohol-Related Harms Among Sexual and Gender Minority Youth
This is a randomized controlled trial to examine the efficacy of a game-based intervention to reduce alcohol-related harms among sexual and gender minority youth.
- Conditions
- Alcohol Problem, Harm Reduction, Alcohol-Related Harm
- Trial name
- NCT06215664
- Testing
- Singularities Game, Food4Thought
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Dementia, Alzheimer Disease
Efficacy Study of Kinto Care Coaching for Dementia Family Caregivers
The goal of this clinical trial is to evaluate Kinto's Care Coaching intervention for dementia caregivers. The main questions it aims to answer are: Does the intervention help caregivers to address their general caregiving goals…
- Conditions
- Dementia, Alzheimer Disease, Lewy Body Disease, Vascular Dementia
- Trial name
- NCT05916664
- Testing
- Kinto Care Coaching
- Where
- United States
- Volunteers
- 495 people, healthy volunteers welcome
- Sponsor
- Kinto
Acute Exercise, Heat Exposure
The Influence of Capsaicin Gel During Exercise Within the Heat
The purpose of this study is to examine the human thermoregulatory impact of applying a commercially available capsaicin gel to the skin prior to moderate intensity walking under heated conditions.
- Trial name
- NCT05298202
- Testing
- Capsaicin, Control Gel, Exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Heart Failure
Myeloperoxidase (MPO) Inhibitor A_Zeneca for Heart Failure With Preserved Ejection Fraction (HFpEF)
Researchers are studying the effect of a single dose of oral myeloperoxidase on heart failure versus placebo.
- Trial name
- NCT03611153
- Testing
- AZD4831 Oral Myeloperoxidase Inhibitor
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Cocaine Use Disorder
Treatment With Lorcaserin for Cocaine Use: The TLC Study
This project is a placebo-controlled, double-blind randomized trial evaluating the feasibility, tolerability, acceptability and adherence for lorcaserin among actively using, men who have sex with men (MSM) with cocaine use…
- Trial name
- TLC (NCT03192995)
- Testing
- lorcaserin, Substance use counseling, ACASI
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Glenn-Milo Santos
Heart Failure With Reduced Ejection Fraction, HIV Infections
Heart Failure Polypill at a Safety Net Hospital
A novel four-drug regimen for heart failure with reduced ejection fraction (HFrEF) extends patients' life expectancy by an average of 6 years compared to traditional therapies, in addition to improving quality of life.
- Trial name
- NCT06029712
- Testing
- Heart failure polypill, Control Rx
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of California, San Francisco
Mental Health Wellness
Testing a Wellness App for First Responders, Military Personnel and Veterans
The purpose of the research study is to trial a smart phone application, the GUIDE App, to better understand its impact on social connectedness, personal growth and mental health/wellness among first responders, soldiers, and…
- Trial name
- NCT06336967
- Testing
- GUIDE
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Diabetes Mellitus
Using Digital Health, Financial Incentives, and Community Health Worker Support to Change Health Behavior
This randomized controlled trial tests how digital health monitoring with financial incentives (DFI) and community health worker (CHW) support may affect how a person manages their diabetes.
- Trial name
- NCT03939793
- Testing
- IMPaCT Community Health Worker, Digital health monitoring with financial incentives, Usual Care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Pennsylvania
ADHD, Stimulant-Induced Euphoria
Prevention of Stimulant-Induced Euphoria With an Opioid Receptor Antagonist
The purpose of this study is to a) assess the efficacy of naltrexone in preventing stimulant-induced euphoria in adults with ADHD, b) assess whether naltrexone will interfere with the clinical efficacy of stimulants in treating…
- Trial name
- NCT01673594
- Testing
- SODAS MPH, Naltrexone
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Massachusetts General Hospital
Attention Deficit Hyperactivity Disorder
Improving Sleep and Daytime Functioning Among Children Diagnosed With Attention Deficit Hyperactivity Disorder (ADHD)
This study will test the efficacy of a systematic, multi-modal intervention protocol designed to improve sleep functioning and subsequent alleviation of daytime cognitive and behavioral difficulties among children diagnosed with…
- Trial name
- NCT00867451
- Testing
- Sleep Intervention, Melatonin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Smoking, Pain
Pain and Smoking Study
This purpose of this study is to test the telephone delivery of a cognitive behavioral intervention (CBI), for smoking cessation among Veteran smokers with chronic pain
- Conditions
- Smoking, Pain, Smoking Cessation
- Trial name
- PASS (NCT02971137)
- Testing
- Smoking Cessation plus CBI, Smoking Cessation Standard
- Where
- 2 sites in United States
- Volunteers
- 371 people
- Sponsor
- VA Office of Research and Development
Tobacco Use, Cigar Smoking
The Effect of Sweet Flavoring on the Rewarding and Reinforcing Value of Cigarillo Use Among Young Adults
This within-subjects study aims to evaluate the subjective rewarding value, the relative reinforcing value, and the absolute reinforcing value of sweet flavored cigarillos across three separate laboratory visits among 86 young…
- Trial name
- FLAV (NCT05092919)
- Testing
- Flavor
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
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