Clinical trials: Conduct
HIV, Opioid Dependence
Testing a Community-Friendly Risk Reduction Intervention for Injection Drug Users
To conduct a randomized clinical trial (RCT) of a community-friendly behavioral intervention designed to reduce HIV risk behavior among injection drug users (IDUs) in drug treatment by comparing risk-behavior outcomes of four…
- Trial name
- NCT01741350
- Testing
- Community-friendly Health Recovery Program, Time-and-Attention-Matched Control Condition
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- University of Connecticut
Self-regulation, Binge Eating
Using Mobile Technology to Better Understand and Measure Self-Regulation
This study will evaluate the extent to which we can engage and manipulate putative targets within the self-regulation domain outside of laboratory settings in samples of smokers and overweight/obese individuals with binge eating…
- Conditions
- Self-regulation, Binge Eating, Smoking
- Trial name
- NCT03352713
- Testing
- Laddr
- Where
- United States
- Volunteers
- 185 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Depression, Anxiety
Potency and Precision Investigation
The overarching goal of this study is to establish initial proof of mechanism for precision interventions in an adult population.
- Trial name
- PAPI (NCT06240091)
- Testing
- DISC-MA
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- Woebot Health
Anxiety, Depression
COVID-19 and the Healthy Minds Program for Educators
This study is a randomized controlled trial (RCT) of the four-week Healthy Minds Program (HMP) app Foundations training in employees of a mid-size urban school district in the United States during the summer of 2020, in the midst…
- Conditions
- Anxiety, Depression, Psychological Stress, Psychological Distress
- Trial name
- CAHMP-ED (NCT04426318)
- Testing
- Healthy Minds Program Foundations Training
- Where
- United States
- Volunteers
- 698 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cerebral Palsy, Hemiplegia
Intensive Unimanual (CIMT) and Bimanual Training (HABIT) in Children With Hemiplegia
A randomized control trial examining the relationship between changes in hand function and brain plasticity following intensive therapy.
- Conditions
- Cerebral Palsy, Hemiplegia, Children
- Trial name
- NCT02918890
- Testing
- Constraint-induced Movement Therapy, Hand-arm Bimanual Intensive Therapy
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Teachers College, Columbia University
Pregnancy, Sexually Transmitted Infections
Teen Video Study to Reduce Risky Driving and Sexual Behavior in Adolescents
The purpose of this study is to measure the effects of an interactive video on adolescent risky behaviors and outcomes, with one video intended to reduce teen pregnancies and the other intended to reduce automobile accidents.
- Conditions
- Pregnancy, Sexually Transmitted Infections, Automobile Accidents
- Trial name
- TVS (NCT02049710)
- Testing
- Seventeen Days, Driving Skills for Life
- Where
- 3 sites in United States
- Volunteers
- 1,317 people
- Sponsor
- Carnegie Mellon University
Anxiety Generalized, Quality of Life
A Problem Solving Intervention for Hospice Caregivers
Hospice care is conceptualized as quality compassionate care for people facing a life-limiting illness, with services that cover clinical care, pain management, and emotional and spiritual support tailored to patients' and…
- Conditions
- Anxiety Generalized, Quality of Life, Depression
- Trial name
- NCT03712410
- Testing
- PISCES
- Where
- United States
- Volunteers
- 523 people, healthy volunteers welcome
- Sponsor
- George Demiris, PhD
Acute Coronary Syndrome
Positive Psychology to Improve Healthy Behaviors After an Acute Coronary Syndrome
In this proof-of-concept study, the investigators will assess the ease and usefulness of a positive psychology program in patients with acute coronary syndrome and less-than-optimal adherence to health behaviors.
- Trial name
- PEACE II (NCT02004158)
- Testing
- Positive psychology intervention
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts General Hospital
Physical Activity
Milk Protein Feeding After Aerobic Exercise in Older Adults With Pre-diabetes Taking the Biguanide Metformin
The investigators propose that post-exercise milk protein feeding will enhance the mitochondrial protein synthesis (biogenesis) response to an exercise-training program.
- Trial name
- NCT02552355
- Testing
- Metformin, Carbohydrate Beverage, Protein Beverage
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Smoking
PK/PD Comparison of Guanfacine ER and IR
Evaluate whether a 4mg/day or 6/mg day dose of extended-release guanfacine produces pharmacokinetic/dynamic (PK/PD) properties similar to 3mg/day immediate release guanfacine.
- Trial name
- NCT01904526
- Testing
- Guanfacine
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Yale University
Depression
Preventing Depression in the Children of Depressed African American Mothers
The purpose of the study is to adapt and test the Preventive Intervention Project for urban African American mothers with depression and their children.
- Trial name
- NCT00904917
- Testing
- Prevention Intervention Project, Psychoeducation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Children's Hospital of Philadelphia
Obesity
Approaches for Improving Long-term Weight Loss
The purpose of this study is to examine two approaches for improving long-term weight loss success. All participants will receive a 12-week, in-person standard behavioral weight loss program followed by either 12 weeks of yoga…
- Trial name
- NCT03799289
- Testing
- Behavioral weight loss followed by yoga instruction, Behavioral weight loss followed by cooking/dietary education instruction
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Cannabis Use Disorder, Cannabis Withdrawal
Progesterone for Cannabis Withdrawal
Sex and gender differences in behavioral, biological, and clinical correlates of substance use disorders are myriad, yet there exists a dearth of gender-informed treatment options.
- Trial name
- NCT03430050
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Medical University of South Carolina
Nicotine Dependence, Cigarette Smoking
New Approaches to Smoking Cessation in Heavy Drinkers
The purpose of this study is to develop and test an integrated cognitive-behavioral intervention for smoking and alcohol among heavy drinking smokers.
- Conditions
- Nicotine Dependence, Cigarette Smoking, Alcohol Consumption, Heavy Drinking
- Trial name
- NCT02151591
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Yale University
Alzheimer Disease, Psychotic Disorders
Antipsychotic Discontinuation in Alzheimer's Disease
In patients with Alzheimer's disease (AD) who respond to antipsychotic treatment of psychosis and/or agitation/aggression, the relapse risk after discontinuation is not established.
- Conditions
- Alzheimer Disease, Psychotic Disorders, Agitation, Aggression
- Trial name
- ADAD (NCT00417482)
- Testing
- risperidone
- Where
- 7 sites in United States
- Volunteers
- 180 people
- Sponsor
- New York State Psychiatric Institute
Depressive Disorder
Memantine Augmentation of Antidepressants
This study is evaluating the efficacy and safety of the drug memantine (trade name NAMENDA) as an augmentation agent for the treatment of depression in people who are not fully responding to antidepressant medications.
- Trial name
- NCT00344682
- Testing
- memantine
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Massachusetts, Worcester
Postpartum Period
Involving Men in Maternity Care in Burkina Faso
The uptake of postpartum contraception, postpartum care attendance and the practice of exclusive breastfeeding are low in Sub-Saharan Africa.
- Trial name
- NCT02309489
- Testing
- Partner involvement
- Where
- Burkina Faso
- Volunteers
- 1,144 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Substance Use Disorder
Varenicline Treatment for Cannabis Use Disorder
Marijuana is the most commonly used illicit drug. There is high demand for effective interventions for cannabis use disorder, yet few specific treatments for have been developed.
- Trial name
- NCT02892110
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Medical University of South Carolina
Epilepsy
Effect of Brivaracetam (BRV) on Nonpsychotic Behavioral Side Effects in Subjects Treated Previously With Levetiracetam (LEV)
Trial N01395 is to evaluate the reduction of nonpsychotic behavioral side effects in subjects with Epilepsy who switched to BRV 200 mg/day after discontinuing LEV due to such side effects; as well as the efficacy, safety and…
- Trial name
- NCT01653262
- Testing
- Brivaracetam
- Where
- 12 sites in United States, France and 3 more
- Volunteers
- 29 people
- Sponsor
- UCB Pharma SA
Depressive Disorder, Bipolar Disorder
Lithium for Suicidal Behavior in Mood Disorders
Observational evidence and findings from clinical trials conducted for other reasons suggest that lithium, a drug used for the treatment of bipolar disorder, and, to a lesser extent, depression, may reduce rates of suicides and…
- Conditions
- Depressive Disorder, Bipolar Disorder, Suicide, Suicide, Attempted
- Trial name
- Li+ (NCT01928446)
- Testing
- Lithium
- Where
- 28 sites in United States
- Volunteers
- 519 people
- Sponsor
- VA Office of Research and Development
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